Genetic diversity at the UGT1 locus is amplified by a novel 3′ alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity

Pharmacogenetics and Genomics

Volumn 17, Issue 12, 2007, Pages 1077-1089

  Girard, Hugo ^b   Lévesque, Eric ^b   Bellemare, Judith ^b   Journault, Kim ^b   Caillier, Bertrand ^b   Guillemette, Chantal ^a  

^a LAVAL UNIVERSITY   (Canada)

^b NONE

Author keywords

Alternative splicing SN 38; Glucuronosyltransferase; Mycophenolic acid; UGT

Indexed keywords

ANTIBODY; GLUCURONOSYLTRANSFERASE 1A1; ISOPROTEIN; MESSENGER RNA; BILIRUBIN URIDINE DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; BILIRUBIN URIDINE-DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; COMPLEMENTARY DNA; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; PRIMER DNA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; ENZYME ASSAY; EXON; GENE LOCUS; GENETIC VARIABILITY; GLUCURONIDATION; HUMAN; HUMAN TISSUE; MICROSOME; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; RAT; ANIMAL; BIOLOGICAL MODEL; CELL LINE; GENETIC TRANSFECTION; GENETICS; MACACA; METABOLISM; PHARMACOGENETICS; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA, COMPLEMENTARY; EXONS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; MACACA FASCICULARIS; MODELS, GENETIC; PHARMACOGENETICS; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANSFECTION; VARIATION (GENETICS);

EID: 38449095074     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3282f1f118     Document Type: Article

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