Mapping the UDP-glucuronic acid binding site in UDP- glucuronosyltransferase-1A10 by homology-based modeling: Confirmation with biochemical evidence

Biochemistry

Volumn 47, Issue 28, 2008, Pages 7385-7392

  Banerjee, Rajat ^a   Pennington, Matthew W ^a   Garza, Amanda ^a   Owens, Ida S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINES; BINDING ENERGY; BIOCHEMISTRY; COMPUTER AIDED ANALYSIS; COMPUTER SYSTEMS; ESCHERICHIA COLI; FORECASTING; GLUCOSE; INTERNET PROTOCOLS; ORGANIC COMPOUNDS; SULFUR COMPOUNDS;

ACCEPTOR SUBSTRATE (GALACTOSE); AFFINITY LIGANDS; BINDING DATA; COMPETITIVE INHIBITION; COMPUTER MODELLING; ENDOPLASMIC RETICULUM (EI); ENVIRONMENTAL TOXICANTS; GALACTOSE (GLCN); GLUCURONIC ACIDS; GLUCURONIDES; HEXANOL; HOMOLOGY-BASED MODELING; LINEWEAVER BURK PLOTS; LIPOPHILIC (LP); SCATCHARD ANALYSIS; STRUCTURAL HOMOLOGY; STRUCTURAL STUDIES; UDP GLUCURONIC ACID (UDP GLCA); UDP-GLUCOSE;

BINDING SITES;

GLUCURONOSYLTRANSFERASE 1A10; URIDINE DIPHOSPHATE GLUCURONIC ACID;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HUMAN; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; BINDING SITES; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SOFTWARE; SPECTROPHOTOMETRY; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ESCHERICHIA COLI;

EID: 47249099038     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8006127     Document Type: Article

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