Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): A molecular modeling perspective

Drug Metabolism Reviews

Volumn 47, Issue 3, 2015, Pages 335-345

  Nair, Pramod C ^a   Meech, Robyn ^a   Mackenzie, Peter I ^a   McKinnon, Ross A ^a   Miners, John O ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

aglycone; homology model; molecular dynamics; structural waters; sugar selectivity; UDP glycosyltransferases; UDP sugar

Indexed keywords

GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B7; GLYCOSYLTRANSFERASE; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE SUGAR; GLUCURONOSYLTRANSFERASE; PLANT PROTEIN; PROTEIN BINDING;

ARABIDOPSIS THALIANA; ARTICLE; BARREL MEDIC; CLITORIA TERNATEA; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; GLUCURONIDATION; GRAPE; HUMAN; MOLECULAR MODEL; NONHUMAN; PROTEIN DATA BANK; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; METABOLISM; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

CARBOHYDRATE CONFORMATION; GLUCURONOSYLTRANSFERASE; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PLANT PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE SUGARS;

EID: 84940790979     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2015.1071835     Document Type: Article

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