Optimized methods for targeted peptide-based quantification of human uridine 59-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry

Drug Metabolism and Disposition

Volumn 42, Issue 5, 2014, Pages 885-889

  Sato, Yuichiro ^a   Nagata, Masanori ^a   Tetsuka, Kazuhiro ^b   Tamura, Kouichi ^b   Miyashita, Aiji ^a   Kawamura, Akio ^a   Usui, Takashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCHOLATE SODIUM; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B10; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; OCTYL GLUCOSIDE; UNCLASSIFIED DRUG; UREA; URIDINE 5' DIPHOSPHATE GLUCURONOSYLTRANSFERASE ISOENZYME; ISOENZYME; PEPTIDE FRAGMENT; UGT2B7 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME DENATURATION; ENZYME SYNTHESIS; HUMAN; INSECT CELL; INTESTINE; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; LIVER MICROSOME; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; TEMPERATURE; CALIBRATION; ENZYMOLOGY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; PROTEIN DENATURATION; REPRODUCIBILITY;

CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINES; ISOENZYMES; KIDNEY; LIVER; MICROSOMES; PEPTIDE FRAGMENTS; PROTEIN DENATURATION; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84898813968     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.056291     Document Type: Article

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