Induction of the UDP-Glucuronosyltransferase 1A1 during the perinatal period can cause neurodevelopmental toxicity

Molecular Pharmacology

Volumn 90, Issue 3, 2016, Pages 265-274

  Hirashima, Rika ^a   Michimae, Hirofumi ^a   Takemoto, Hiroaki ^a   Sasaki, Aya ^a   Kobayashi, Yoshinori ^a   Itoh, Tomoo ^a   Tukey, Robert H ^b   Fujiwara, Ryoichi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALAMETHICIN; BILIRUBIN; CARBAMAZEPINE; CYANIDE; GLUCURONOSYLTRANSFERASE 1A1; MESSENGER RNA; PHENYTOIN; SYNAPSIN I; SYNAPTOPHYSIN; THYROXINE; 16ALPHA CYANOPREGNENOLONE; GLUCURONOSYLTRANSFERASE; UGT1A1 ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; BILIRUBIN BLOOD LEVEL; CELL MIGRATION; CEREBELLUM GRANULAR LAYER; CONTROLLED STUDY; DOSE RESPONSE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MENTAL DISEASE; MOUSE; NEUROTOXICITY; NONHUMAN; PERINATAL PERIOD; PRENATAL PERIOD; PRIORITY JOURNAL; THERAPY EFFECT; THYROXINE BLOOD LEVEL; THYROXINE METABOLISM; ANIMAL; BIOSYNTHESIS; BLOOD; BRAIN; BREAST MILK; C57BL MOUSE; CELL MOTION; CHEMISTRY; DEVELOPMENTAL GENE; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NEWBORN; PATHOLOGY; PREGNANCY; PRENATAL EXPOSURE; ROTAROD TEST; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CARBAMAZEPINE; CELL MOVEMENT; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DEVELOPMENTAL; GLUCURONOSYLTRANSFERASE; HUMANS; MICE, INBRED C57BL; MICE, TRANSGENIC; MILK, HUMAN; NEURODEVELOPMENTAL DISORDERS; PHENYTOIN; PREGNANCY; PREGNENOLONE CARBONITRILE; PRENATAL EXPOSURE DELAYED EFFECTS; RNA, MESSENGER; ROTAROD PERFORMANCE TEST; THYROXINE;

EID: 84984799760     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.116.104174     Document Type: Article

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