Complexities of glucuronidation affecting in vitro-in vivo extrapolation

Current Drug Metabolism

Volumn 3, Issue 6, 2002, Pages 623-646

  Lin, Jiunn H ^a   Wong, Bradley K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHOL; ALAMETHICIN; BUPRENORPHINE; CLOFIBRIC ACID; CODEINE; CYTOCHROME; DETERGENT; FLUCONAZOLE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; ISOENZYME; ISOFEZOLAC; KETOPROFEN; LAMOTRIGINE; LORAZEPAM; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NAPROXEN; PARACETAMOL; PHENOBARBITAL; PROBENECID; PROPOFOL; RIFAMPICIN; SALICYLAMIDE; SALICYLIC ACID; TACROLIMUS; UNINDEXED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID; VALPROIC ACID; ZIDOVUDINE; ZOMEPIRAC;

AEROBIC METABOLISM; ANIMAL CELL; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFUSION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG INHIBITION; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; LIVER CELL; MICROSOME; NONHUMAN; RAT; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG INTERACTIONS; GLUCURONOSYLTRANSFERASE; HUMANS; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 0036890353     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200023336992     Document Type: Review

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