Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: Evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction

Molecular Pharmacology

Volumn 75, Issue 4, 2009, Pages 956-964

  Takeda, Shuso ^a   Ishii, Yuji ^a   Iwanaga, Megumi ^a   Nurrochmad, Arief ^a   Ito, Yuji ^f   Mackenzie, Peter I ^b   Nagata, Kiyoshi ^c   Yamazoe, Yasushi ^d   Oguri, Kazuta ^a,e   Yamada, Hideyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FLINDERS UNIVERSITY   (Australia)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^f KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; ALANINE; ANTIBODY; CYTOCHROME P450 3A4; GLUCURONOSYLTRANSFERASE 2B7; GLUTATHIONE TRANSFERASE; HISTIDINE; HYBRID PROTEIN; LEUCINE; LYSINE; METHIONINE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS LINKING; EPITOPE MAPPING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MICROSOME; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; CYTOCHROME P-450 CYP3A; GLUCURONOSYLTRANSFERASE; HUMANS; INSECTS; MALE; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RATS;

EID: 63849272821     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.052001     Document Type: Article

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