Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: Different susceptibility for UGT isoforms and UGT1A1/7 variantss

Drug Metabolism and Disposition

Volumn 42, Issue 2, 2014, Pages 229-238

  Ishii, Yuji ^a   Koba, Hiroki ^a   Kinoshita, Kousuke ^a   Oizaki, Toshiya ^a   Iwamoto, Yuki ^a   Takeda, Shuso ^a,f   Miyauchi, Yuu ^a   Nishimura, Yoshio ^a   Egoshi, Natsuki ^a   Taura, Futoshi ^a,g   Morimoto, Satoshi ^a   Ikushiro, Shin'Ichi ^b   Nagata, Kiyoshi ^c   Yamazoe, Yasushi ^d   MacKenzie, Peter I ^e   Yamada, Hideyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e FLINDERS MEDICAL CENTRE   (Australia)

^f HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^g UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DRUG METABOLITE; ENZYME VARIANT; FIRTECAN; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; HYMECROMONE; IRINOTECAN; ISOENZYME; SEROTONIN; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG GLUCURONIDATION; ENZYME ACTIVITY; ENZYME KINETICS; GENE MUTATION; MAXIMAL VELOCITY; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SF9 CELL;

BIOTRANSFORMATION; CAMPTOTHECIN; CATALYSIS; CYTOCHROME P-450 CYP3A; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; HYMECROMONE; ISOENZYMES; KINETICS; MUTATION; PROTEIN INTERACTION MAPPING; SEROTONIN; SF9 CELLS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 84891757158     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.054833     Document Type: Article

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