Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

Clinical Epigenetics

Volumn 8, Issue 1, 2016, Pages 16-

  Morera, Ludovica ^a   Lübbert, Michael ^b,c   Jung, Manfred ^a,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Clinical trial; Demethylase inhibitors; Epigenetics; Histone demethylase; Histone methyltransferase; Histone modifications; Lysine methylation; Methylome; Methyltransferase inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; CPI 1205; CYTARABINE; DNA METHYLTRANSFERASE INHIBITOR; GSK 2816126; GSK 2879552; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE LSD1; HISTONE LYSINE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE DOT1L; RETINOIC ACID; TAZEMETOSTAT; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; DOT1L PROTEIN, HUMAN; ENZYME INHIBITOR; EZH2 PROTEIN, HUMAN; KDM1A PROTEIN, HUMAN; METHYLTRANSFERASE;

ACUTE MYELOBLASTIC LEUKEMIA; B CELL LYMPHOMA; CANCER THERAPY; DNA METHYLATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; EPIGENETICS; FOLLICULAR LYMPHOMA; HISTONE ACETYLATION; HISTONE DEMETHYLATION; HISTONE METHYLATION; HUMAN; LARGE CELL LYMPHOMA; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; SOLID TUMOR; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL (TOPIC); DRUG EFFECTS; ENZYMOLOGY; GENETIC EPIGENESIS; GENETICS; NEOPLASMS;

ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HISTONE DEMETHYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; METHYLTRANSFERASES; NEOPLASMS;

EID: 84994908511     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-016-0223-4     Document Type: Review

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