-
1
-
-
0029416901
-
The polycomb and trithorax group proteins of drosophila: Trans-regulators of homeotic gene function
-
Kennison JA. The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet 1995; 29: 289-303.
-
(1995)
Annu Rev Genet
, vol.29
, pp. 289-303
-
-
Kennison, J.A.1
-
2
-
-
33847084602
-
Genome regulation by polycomb and trithorax proteins
-
Schuettenbruger B, Chourrout D, Vervoort M, Leblanc B, Cavalli G. Genome regulation by Polycomb and Trithorax proteins. Cell 2007; 128: 735-745.
-
(2007)
Cell
, vol.128
, pp. 735-745
-
-
Schuettenbruger, B.1
Chourrout, D.2
Vervoort, M.3
Leblanc, B.4
Cavalli, G.5
-
3
-
-
0021880669
-
A group of genes controlling the special expression of the bithorax complex in drosophila
-
Jürgens G. A group of genes controlling the special expression of the bithorax complex in Drosophila. Nature 1985; 316: 153-155.
-
(1985)
Nature
, vol.316
, pp. 153-155
-
-
Jürgens, G.1
-
4
-
-
0028869112
-
Altered hox expression and segmental identity in mll-mutant mice
-
Yu BD, Hess JL, Horning SE, Brown GAJ, Korsmeyer SJ. Altered Hox expression and segmental identity in Mll-mutant mice. Nature 1995; 378: 505-508.
-
(1995)
Nature
, vol.378
, pp. 505-508
-
-
Yu, B.D.1
Hess, J.L.2
Horning, S.E.3
Brown, G.A.J.4
Korsmeyer, S.J.5
-
5
-
-
0029891279
-
A role for mel-18, a polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton
-
Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H. A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development 1996; 122: 1513-1522.
-
(1996)
Development
, vol.122
, pp. 1513-1522
-
-
Akasaka, T.1
Kanno, M.2
Balling, R.3
Mieza, M.A.4
Taniguchi, M.5
Koseki, H.6
-
6
-
-
0030218039
-
The polycomb-group homolog bmi-1 is a regulator of murine hox gene expression
-
van der Lugt NM, Alkema M, Berns A, Deschamps J. The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech Dev 1996; 58: 153-164.
-
(1996)
Mech Dev
, vol.58
, pp. 153-164
-
-
Van Der Lugt, N.M.1
Alkema, M.2
Berns, A.3
Deschamps, J.4
-
7
-
-
0031049215
-
Altered cellular proliferation and mesoderm patterning in polycomb-m33-deficient mice
-
Coré N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, Djabali M. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 1997; 124: 721-729.
-
(1997)
Development
, vol.124
, pp. 721-729
-
-
Coré, N.1
Bel, S.2
Gaunt, S.J.3
Aurrand-Lions, M.4
Pearce, J.5
Fisher, A.6
Djabali, M.7
-
8
-
-
33646882068
-
Polycomb complexes repress developmental regulators in murine embryonic stem cells
-
Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441: 349-353.
-
(2006)
Nature
, vol.441
, pp. 349-353
-
-
Boyer, L.A.1
Plath, K.2
Zeitlinger, J.3
Brambrink, T.4
Medeiros, L.A.5
Lee, T.I.6
Levine, S.S.7
Wernig, M.8
Tajonar, A.9
Ray, M.K.10
Bell, G.W.11
Otte, A.P.12
Vidal, M.13
Gifford, D.K.14
Young, R.A.15
Jaenisch, R.16
-
9
-
-
33646865180
-
Control of developmental regulators by polycomb in human embryonic stem cells
-
Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006; 125: 301-313.
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
Jenner, R.G.2
Boyer, L.A.3
Guenther, M.G.4
Levine, S.S.5
Kumar, R.M.6
Chevalier, B.7
Johnstone, S.E.8
Cole, M.F.9
Isono, K.10
Koseki, H.11
Fuchikami, T.12
Abe, K.13
Murray, H.L.14
Zucker, J.P.15
Yuan, B.16
Bell, G.W.17
Herbolsheimer, E.18
Hannett, N.M.19
Sun, K.20
Odom, D.T.21
Otte, A.P.22
Volkert, T.L.23
Bartel, D.P.24
Melton, D.A.25
Gifford, D.K.26
Jaenisch, R.27
Young, R.A.28
more..
-
10
-
-
24344454298
-
Delving into the diversity of facultative heterochromatin: The epigenetics of the inactive x chromosome
-
Heard E. Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome. Curr Opin Genet Dev 2005; 15: 482-489.
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 482-489
-
-
Heard, E.1
-
12
-
-
0037150730
-
Polycomb repression: From cellular memory to cellular proliferation and cancer
-
Jacobs JJ, van Lohuizen M. Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta 2002; 1602: 151-161.
-
(2002)
Biochim Biophys Acta
, vol.1602
, pp. 151-161
-
-
Jacobs, J.J.1
Van Lohuizen, M.2
-
13
-
-
33750379420
-
Polycomb silencers control cell fate, development and cancer
-
Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6: 846-856.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 846-856
-
-
Sparmann, A.1
Van Lohuizen, M.2
-
14
-
-
77956222562
-
Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer
-
Sauvageau M, Sauvageau G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 2010; 7: 299-213.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 213-299
-
-
Sauvageau, M.1
Sauvageau, G.2
-
15
-
-
8844265508
-
Epigenetic regulation of cellular memory by the polycomb and trithorax group proteins
-
Ringrose L, Paro R. Epigenetic regulation of cellular memory by the Polycomb and trithorax group proteins. Annu Rev Genet 2004; 38: 413-443.
-
(2004)
Annu Rev Genet
, vol.38
, pp. 413-443
-
-
Ringrose, L.1
Paro, R.2
-
16
-
-
33845786515
-
The control of histone lysine methylation in epigenetic regulation
-
Völkel P, Angrand PO. The control of histone lysine methylation in epigenetic regulation. Biochimie 2007; 89: 1-20.
-
(2007)
Biochimie
, vol.89
, pp. 1-20
-
-
Völkel, P.1
Angrand, P.O.2
-
17
-
-
18644383738
-
Histone methyltransferase activity of the drosophila polycomb group repressor complex
-
Müller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller EL, O’Connor MB, Kingston RE, Simon JA. Histone methyltransferase activity of the Drosophila Polycomb group repressor complex. Cell 2002; 111: 197-208.
-
(2002)
Cell
, vol.111
, pp. 197-208
-
-
Müller, J.1
Hart, C.M.2
Francis, N.J.3
Vargas, M.L.4
Sengupta, A.5
Wild, B.6
Miller, E.L.7
O’Connor, M.B.8
Kingston, R.E.9
Simon, J.A.10
-
18
-
-
34648834735
-
Pcl-prc2 is needed to generate high levels of h3-k27 trimethylation at polycomb target genes
-
Nekrasov M, Klymenko T, Fraterman S, Papp B, Oktaba K, Köcher T, Cohen A, Stunnenberg HG, Wilm M, Müller J. Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J 2007; 26: 4078-4088.
-
(2007)
EMBO J
, vol.26
, pp. 4078-4088
-
-
Nekrasov, M.1
Klymenko, T.2
Fraterman, S.3
Papp, B.4
Oktaba, K.5
Köcher, T.6
Cohen, A.7
Stunnenberg, H.G.8
Wilm, M.9
Müller, J.10
-
19
-
-
3042801308
-
Suz12 is required for both the histone methyltransferase activity and the silencing function of the eed-ezh2 complex
-
Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 2004; 15: 57-67.
-
(2004)
Mol Cell
, vol.15
, pp. 57-67
-
-
Cao, R.1
Zhang, Y.2
-
20
-
-
23344450547
-
Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes
-
Ketel CS, Andersen EF, Vargas ML, Suh J, Strome S, Simon JA. Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol Cell Biol 2005; 25: 6857-6868.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6857-6868
-
-
Ketel, C.S.1
Andersen, E.F.2
Vargas, M.L.3
Suh, J.4
Strome, S.5
Simon, J.A.6
-
21
-
-
7244234099
-
Role of histone h2a ubiquitination in polycomb silencing
-
Wang H, Wang LJ, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y. Role of histone H2A ubiquitination in polycomb silencing. Nature 2004; 431: 873-978.
-
(2004)
Nature
, vol.431
, pp. 873-978
-
-
Wang, H.1
Wang, L.J.2
Erdjument-Bromage, H.3
Vidal, M.4
Tempst, P.5
Jones, R.S.6
Zhang, Y.7
-
22
-
-
29144487990
-
Role of bmi-1 and ring1a in h2a ubiquitylation and hox gene silencing
-
Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005; 20: 845-854.
-
(2005)
Mol Cell
, vol.20
, pp. 845-854
-
-
Cao, R.1
Tsukada, Y.2
Zhang, Y.3
-
23
-
-
8144230178
-
Suz12 is essential for mouse development and for ezh2 histone methyltransferase activity
-
Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 2004; 23: 4061-4071.
-
(2004)
EMBO J
, vol.23
, pp. 4061-4071
-
-
Pasini, D.1
Bracken, A.P.2
Jensen, M.R.3
Lazzerini Denchi, E.4
Helin, K.5
-
24
-
-
20144363347
-
The murine polycomb group protein eed is required for global histone h3 lysine-27 methylation
-
Montgomery ND, Yee D, Chen A, Kalantry S, Chamberlain SJ, Otte AP, Magnuson T. The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol 2005; 15: 942-947.
-
(2005)
Curr Biol
, vol.15
, pp. 942-947
-
-
Montgomery, N.D.1
Yee, D.2
Chen, A.3
Kalantry, S.4
Chamberlain, S.J.5
Otte, A.P.6
Magnuson, T.7
-
25
-
-
36248930485
-
Molecular and functional mapping of eed motifs required for prc2-dependent histone methylation
-
Montgomery ND, Yee D, Montgomery SA, Magnuson T. Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. J Mol Biol 2007; 374: 1145-1157.
-
(2007)
J Mol Biol
, vol.374
, pp. 1145-1157
-
-
Montgomery, N.D.1
Yee, D.2
Montgomery, S.A.3
Magnuson, T.4
-
26
-
-
66249121737
-
Aebp2 as a potential targeting protein for polycomb repression complex prc2
-
Kim H, Kang K, Kim J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res 2009; 37: 2940-2950.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 2940-2950
-
-
Kim, H.1
Kang, K.2
Kim, J.3
-
27
-
-
75349104610
-
Polycomb-like 2 associates with prc2 and regulates transcriptional networks during mouse embryonic stem cell self-renew al and differentiation
-
Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renew al and differentiation. Cell Stem Cell 2010; 6: 153-166.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 153-166
-
-
Walker, E.1
Chang, W.Y.2
Hunkapiller, J.3
Cagney, G.4
Garcha, K.5
Torchia, J.6
Krogan, N.J.7
Reiter, J.F.8
Stanford, W.L.9
-
28
-
-
72249119297
-
Jarid2/jumonji coordinates control of prc2 enzymatic activity and target gene occupancy in pluripotent cells
-
Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 2009; 139: 1290-1302.
-
(2009)
Cell
, vol.139
, pp. 1290-1302
-
-
Peng, J.C.1
Valouev, A.2
Swigut, T.3
Zhang, J.4
Zhao, Y.5
Sidow, A.6
Wysocka, J.7
-
29
-
-
76749083433
-
Jarid2 and prc2, partners in regulating gene expression
-
Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev 2010; 24: 368-380.
-
(2010)
Genes Dev
, vol.24
, pp. 368-380
-
-
Li, G.1
Margueron, R.2
Ku, M.3
Chambon, P.4
Bernstein, B.E.5
Reinberg, D.6
-
30
-
-
0037421847
-
Structure and catalytic mechanism of the human histone methyltransferase set7/9
-
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 2003; 421: 652-656.
-
(2003)
Nature
, vol.421
, pp. 652-656
-
-
Xiao, B.1
Jing, C.2
Wilson, J.R.3
Walker, P.A.4
Vasisht, N.5
Kelly, G.6
Howell, S.7
Taylor, I.A.8
Blackburn, G.M.9
Gamblin, S.J.10
-
31
-
-
77952488976
-
Structural biology of human h3k9 methyltransferases
-
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, CampagnaSlater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M. Structural biology of human H3K9 methyltransferases. PLoS One 2010; 5: e8570.
-
(2010)
Plos One
, vol.5
-
-
Wu, H.1
Min, J.2
Lunin, V.V.3
Antoshenko, T.4
Dombrovski, L.5
Zeng, H.6
Allali-Hassani, A.7
Campagnaslater, V.8
Vedadi, M.9
Arrowsmith, C.H.10
Plotnikov, A.N.11
Schapira, M.12
-
32
-
-
55949132133
-
Ezh1 and ezh2 maintain repressive chromatin through different mechanisms
-
Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell 2008; 32: 503-518.
-
(2008)
Mol Cell
, vol.32
, pp. 503-518
-
-
Margueron, R.1
Li, G.2
Sarma, K.3
Blais, A.4
Zavadil, J.5
Woodcock, C.L.6
Dynlacht, B.D.7
Reinberg, D.8
-
33
-
-
0142105414
-
Ezh2 is downstream of the prb-e2f pathway, essential for proliferation and amplified in cancer
-
Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22: 5323-5335.
-
(2003)
EMBO J
, vol.22
, pp. 5323-5335
-
-
Bracken, A.P.1
Pasini, D.2
Capra, M.3
Prosperini, E.4
Colli, E.5
Helin, K.6
-
34
-
-
33646870495
-
Genome-wide mapping of polycomb target genes unravels their roles in cell fate transitions
-
Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006; 20: 1123-1136.
-
(2006)
Genes Dev
, vol.20
, pp. 1123-1136
-
-
Bracken, A.P.1
Dietrich, N.2
Pasini, D.3
Hansen, K.H.4
Helin, K.5
-
35
-
-
55449105221
-
Genomewide analysis of prc1 and prc2 occupancy identifies two classes of bivalent domains
-
Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H, Bernstein BE. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet 2008; 4: e1000242.
-
(2008)
Plos Genet
, vol.4
-
-
Ku, M.1
Koche, R.P.2
Rheinbay, E.3
Mendenhall, E.M.4
Endoh, M.5
Mikkelsen, T.S.6
Presser, A.7
Nusbaum, C.8
Xie, X.9
Chi, A.S.10
Adli, M.11
Kasif, S.12
Ptaszek, L.M.13
Cowan, C.A.14
Lander, E.S.15
Koseki, H.16
Bernstein, B.E.17
-
36
-
-
18644382388
-
The polycomb group protein ezh2 is involved in progression of prostate cancer
-
Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419: 624-629.
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
Barrette, T.R.4
Kumar-Sinha, C.5
Sanda, M.G.6
Ghosh, D.7
Pienta, K.J.8
Sewalt, R.G.9
Otte, A.P.10
Rubin, M.A.11
Chinnaiyan, A.M.12
-
37
-
-
0141816752
-
Ezh2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003; 100: 11606-11611.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
Shen, R.4
Ota, I.5
Tomlins, S.A.6
Ghosh, D.7
Sewalt, R.G.8
Otte, A.P.9
Hayes, D.F.10
Sabel, M.S.11
Livant, D.12
Weiss, S.J.13
Rubin, M.A.14
Chinnaiyan, A.M.15
-
38
-
-
84925409213
-
Exp ression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
-
Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A, Aas T, Otte AP Akslen LA, Exp ression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. J Clin Oncol 2006; 24: 268-273.
-
(2006)
J Clin Oncol
, vol.24
, pp. 268-273
-
-
Collett, K.1
Eide, G.E.2
Arnes, J.3
Stefansson, I.M.4
Eide, J.5
Braaten, A.6
Aas, T.7
Otte, A.P.8
Akslen, L.A.9
-
39
-
-
33644822360
-
Ezh2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
-
Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA, Salvesen HB, Otte AP, Akslen LA. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24: 268-273.
-
(2006)
J Clin Oncol
, vol.24
, pp. 268-273
-
-
Bachmann, I.M.1
Halvorsen, O.J.2
Collett, K.3
Stefansson, I.M.4
Straume, O.5
Haukaas, S.A.6
Salvesen, H.B.7
Otte, A.P.8
Akslen, L.A.9
-
40
-
-
29344445843
-
Increased expression of the polycomb group gene, ezh2, in transitional cell carcinoma of the bladder
-
Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res 2005; 11: 8570-8576.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8570-8576
-
-
Raman, J.D.1
Mongan, N.P.2
Tickoo, S.K.3
Boorjian, S.A.4
Scherr, D.S.5
Gudas, L.J.6
-
41
-
-
38649092006
-
Expression of the polycomb group protein ezh2 and its relation to outcome in patients with urothelial carcinoma of the bladder
-
Hinz S, Kempkensteffen C, Christoph F, Hoffmann M, Krause H, Schrader M, Schostak M, Miller K, Weikert S. Expression of the polycomb group protein EZH2 and its relation to outcome in patients with urothelial carcinoma of the bladder. J Cancer Res Clin Oncol 2008; 134: 331-336.
-
(2008)
J Cancer Res Clin Oncol
, vol.134
, pp. 331-336
-
-
Hinz, S.1
Kempkensteffen, C.2
Christoph, F.3
Hoffmann, M.4
Krause, H.5
Schrader, M.6
Schostak, M.7
Miller, K.8
Weikert, S.9
-
42
-
-
84862983558
-
Increased ezh2 protein expression is associated with invasive urothelial carcinoma of the bladder
-
Wang H, Albadine R, Magheli A, Guzzo TJ, Ball MW, Hinz S, Schoenberg MP, Netto GJ, Gonzalgo ML. Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladder. Urol Oncol 2012; 30: 428-433.
-
(2012)
Urol Oncol
, vol.30
, pp. 428-433
-
-
Wang, H.1
Albadine, R.2
Magheli, A.3
Guzzo, T.J.4
Ball, M.W.5
Hinz, S.6
Schoenberg, M.P.7
Netto, G.J.8
Gonzalgo, M.L.9
-
43
-
-
29344439946
-
Expression levels of the ezh2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
-
Weikert S, Christoph F, Köllermann J, Müller M, Schrader M, Miller K, Krause H. Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med 2005; 16: 349-353.
-
(2005)
Int J Mol Med
, vol.16
, pp. 349-353
-
-
Weikert, S.1
Christoph, F.2
Köllermann, J.3
Müller, M.4
Schrader, M.5
Miller, K.6
Krause, H.7
-
44
-
-
77956277833
-
Ezh2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of tgf-beta1 and is a predictor of outcome in ovarian carcinoma patients
-
Rao ZY, Cai MY, Yang GF, He LR, Mai SJ, Hua WF, Liao YJ, Deng HX, Chen YC, Guan XY, Zeng YX, Kung HF, Xie D. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis 2010; 31: 1576-1583.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1576-1583
-
-
Rao, Z.Y.1
Cai, M.Y.2
Yang, G.F.3
He, L.R.4
Mai, S.J.5
Hua, W.F.6
Liao, Y.J.7
Deng, H.X.8
Chen, Y.C.9
Guan, X.Y.10
Zeng, Y.X.11
Kung, H.F.12
Xie, D.13
-
45
-
-
78650493658
-
Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells
-
Li H, Cai Q, Godwin AK, Zhang R. Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Mol Cancer Res 2010; 8: 1610-1618.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 1610-1618
-
-
Li, H.1
Cai, Q.2
Godwin, A.K.3
Zhang, R.4
-
46
-
-
84868316043
-
Expression of ezh2 in renal cell carcinoma as a novel prognostic marker
-
Lee HW, Choe M. Expression of EZH2 in renal cell carcinoma as a novel prognostic marker. Pathol Int 2012; 62: 735-741.
-
(2012)
Pathol Int
, vol.62
, pp. 735-741
-
-
Lee, H.W.1
Choe, M.2
-
47
-
-
84890308623
-
Ezh2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma
-
Behrens C, Solis LM, Lin H, Yuan P, Tang X, Kadara H, Riquelme E, Galindo H, Moran CA, Kalhor N, Swisher SG, Simon GR, Stewart DJ, Lee J., Wistuba II. EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma. Clin Cancer Res 2013; 19: 6556-6565.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6556-6565
-
-
Behrens, C.1
Solis, L.M.2
Lin, H.3
Yuan, P.4
Tang, X.5
Kadara, H.6
Riquelme, E.7
Galindo, H.8
Moran, C.A.9
Kalhor, N.10
Swisher, S.G.11
Simon, G.R.12
Stewart, D.J.13
Lee, J.14
Wistuba, I.I.15
-
48
-
-
84878741641
-
Prc2 overexpression and prc2-target gene repression relating to poorer prognosis in small cell lung cancer
-
Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep 2013; 3: 1911.
-
(2013)
Sci Rep
, vol.3
, pp. 1911
-
-
Sato, T.1
Kaneda, A.2
Tsuji, S.3
Isagawa, T.4
Yamamoto, S.5
Fujita, T.6
Yamanaka, R.7
Tanaka, Y.8
Nukiwa, T.9
Marquez, V.E.10
Ishikawa, Y.11
Ichinose, M.12
Aburatani, H.13
-
49
-
-
77953978709
-
Distinctive expression of the polycomb group proteins bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance
-
Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Konishi J, Oizumi S, Kaga K, Matsuno Y, Nishimura M, Dosaka-Akita H. Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance. Cancer 2010; 116: 3015-3024.
-
(2010)
Cancer
, vol.116
, pp. 3015-3024
-
-
Kikuchi, J.1
Kinoshita, I.2
Shimizu, Y.3
Kikuchi, E.4
Konishi, J.5
Oizumi, S.6
Kaga, K.7
Matsuno, Y.8
Nishimura, M.9
Dosaka-Akita, H.10
-
50
-
-
84861557861
-
The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma
-
Lv Y, Yuan C, Xiao X, Wang X, Ji X, Yu H, Wu Z, Zhang J. The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma. Oncol Rep 2012; 28: 147-154.
-
(2012)
Oncol Rep
, vol.28
, pp. 147-154
-
-
Lv, Y.1
Yuan, C.2
Xiao, X.3
Wang, X.4
Ji, X.5
Yu, H.6
Wu, Z.7
Zhang, J.8
-
51
-
-
34548645031
-
Alterations of dna methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
-
Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y, Kato H, Mizuno Y, Yokoe M, Sugauchi F, Hirashima N, Orito E, Osada H, Ueda R, Guo Y, Chen X, Issa JP, Sekido Y. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res 2007; 37: 974-983.
-
(2007)
Hepatol Res
, vol.37
, pp. 974-983
-
-
Kondo, Y.1
Shen, L.2
Suzuki, S.3
Kurokawa, T.4
Masuko, K.5
Tanaka, Y.6
Kato, H.7
Mizuno, Y.8
Yokoe, M.9
Sugauchi, F.10
Hirashima, N.11
Orito, E.12
Osada, H.13
Ueda, R.14
Guo, Y.15
Chen, X.16
Issa, J.P.17
Sekido, Y.18
-
52
-
-
77957193274
-
Clinical significance of polycomb gene expression in brain tumors
-
Crea F, Hurt EM, Farrar WL. Clinical significance of Polycomb gene expression in brain tumors. Mol Cancer 2010; 9: 265.
-
(2010)
Mol Cancer
, vol.9
, pp. 265
-
-
Crea, F.1
Hurt, E.M.2
Farrar, W.L.3
-
53
-
-
84885164072
-
Enhancer of zeste homolog 2 expression is associated with metastasis and adverse clinical outcome in clear cell renal cell carcinoma: A comparative study and review of the literature
-
Xu B, Abourbih S, Sircar K, Kassouf W, Mansure JJ, Aprikian A, Tanguay S, Brimo F. Enhancer of zeste homolog 2 expression is associated with metastasis and adverse clinical outcome in clear cell renal cell carcinoma: a comparative study and review of the literature. Arch Pathol Lab Med 2013; 137: 1326-1336.
-
(2013)
Arch Pathol Lab Med
, vol.137
, pp. 1326-1336
-
-
Xu, B.1
Abourbih, S.2
Sircar, K.3
Kassouf, W.4
Mansure, J.J.5
Aprikian, A.6
Tanguay, S.7
Brimo, F.8
-
54
-
-
33744519651
-
Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer
-
Matsukawa Y, Semba S, Kato H, Ito A, Yanagihara K, Yokozaki H. Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Cancer Sci 2006; 97: 484-491.
-
(2006)
Cancer Sci
, vol.97
, pp. 484-491
-
-
Matsukawa, Y.1
Semba, S.2
Kato, H.3
Ito, A.4
Yanagihara, K.5
Yokozaki, H.6
-
55
-
-
78651241548
-
Aberrant expression of ezh2 is associated with a poor outcome and p53 alteration in squamous cell carcinoma of the esophagus
-
Yamada A, Fujii S, Daiko H, Nishimura M, Chiba T, Ochiai A. Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus. Int J Oncol 2011; 38: 345-353.
-
(2011)
Int J Oncol
, vol.38
, pp. 345-353
-
-
Yamada, A.1
Fujii, S.2
Daiko, H.3
Nishimura, M.4
Chiba, T.5
Ochiai, A.6
-
56
-
-
58149214373
-
Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
-
Ougolkov AV, Bilim VN, Billadeau DD. Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res 2008; 14: 6790-6796.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6790-6796
-
-
Ougolkov, A.V.1
Bilim, V.N.2
Billadeau, D.D.3
-
57
-
-
34447335892
-
Expression of polycomb group protein ezh2 in nevi and melanoma
-
McHugh JB, Fullen DR, Ma L, Kleer CG, Su LD. Expression of polycomb group protein EZH2 in nevi and melanoma. J Cutan Pathol 2007; 34: 597-600.
-
(2007)
J Cutan Pathol
, vol.34
, pp. 597-600
-
-
McHugh, J.B.1
Fullen, D.R.2
Ma, L.3
Kleer, C.G.4
Su, L.D.5
-
58
-
-
79957568143
-
Mir-101 is down-regulated in glioblastoma resulting in ezh2-induced proliferation, migration, and angiogenesis
-
Smits M, Nilsson J, Mir SE, van der Stoop PM, Hulleman E, Niers JM, de Witt Hamer PC, Marquez VE, Cloos J, Krichevsky AM, Noske DP, Tannous BA Würdinger T, miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget 2010; 1: 710-720.
-
(2010)
Oncotarget
, vol.1
, pp. 710-720
-
-
Smits, M.1
Nilsson, J.2
Mir, S.E.3
Van Der Stoop, P.M.4
Hulleman, E.5
Niers, J.M.6
De Witt Hamer, P.C.7
Marquez, V.E.8
Cloos, J.9
Krichevsky, A.M.10
Noske, D.P.11
Tannous, B.A.12
Würdinger, T.13
-
59
-
-
84856533341
-
Ezh2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with hdac1/hdac2 and snail to inhibit e-cadherin
-
Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene 2012; 31: 583-594.
-
(2012)
Oncogene
, vol.31
, pp. 583-594
-
-
Tong, Z.T.1
Cai, M.Y.2
Wang, X.G.3
Kong, L.L.4
Mai, S.J.5
Liu, Y.H.6
Zhang, H.B.7
Liao, Y.J.8
Zheng, F.9
Zhu, W.10
Liu, T.H.11
Bian, X.W.12
Guan, X.Y.13
Lin, M.C.14
Zeng, M.S.15
Zeng, Y.X.16
Kung, H.F.17
Xie, D.18
-
60
-
-
79955119487
-
Pharmacologic disruption of polycomb repressive complex 2 inhibits tumorigenicity and tumor progression in prostate cancer
-
Crea F, Hurt EM, Mathews LA, Cabarcas SM, Sun L, Marquez VE, Danesi R, Farrar WL. Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer. Mol Cancer 2011; 10: 40.
-
(2011)
Mol Cancer
, vol.10
, pp. 40
-
-
Crea, F.1
Hurt, E.M.2
Mathews, L.A.3
Cabarcas, S.M.4
Sun, L.5
Marquez, V.E.6
Danesi, R.7
Farrar, W.L.8
-
61
-
-
26844520965
-
Akt-mediated phosphorylation of ezh2 suppresses methylation of lysine 27 in histone h3
-
Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 2005; 310: 306-310.
-
(2005)
Science
, vol.310
, pp. 306-310
-
-
Cha, T.L.1
Zhou, B.P.2
Xia, W.3
Wu, Y.4
Yang, C.C.5
Chen, C.T.6
Ping, B.7
Otte, A.P.8
Hung, M.C.9
-
62
-
-
84896894869
-
Ezh2 expands breast stem cells through activation of notch1 signaling
-
Gonzalez ME, Moore HM, Li X, Toy KA, Huang W, Sabel MS, Kidwell KM, Kleer CG. EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proc Natl Acad Sci U S A 2014; 111: 3098-3103.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 3098-3103
-
-
Gonzalez, M.E.1
Moore, H.M.2
Li, X.3
Toy, K.A.4
Huang, W.5
Sabel, M.S.6
Kidwell, K.M.7
Kleer, C.G.8
-
63
-
-
70349238717
-
Targeted overexpression of ezh2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia
-
Li X, Gonzalez ME, Toy K, Filzen T, Merajver SD, Kleer CG. Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia. Am J Pathol 2009; 175: 1246-1254.
-
(2009)
Am J Pathol
, vol.175
, pp. 1246-1254
-
-
Li, X.1
Gonzalez, M.E.2
Toy, K.3
Filzen, T.4
Merajver, S.D.5
Kleer, C.G.6
-
64
-
-
30544454697
-
The polycomb group protein enhancer of zeste homolog 2 (ezh 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype
-
Croonquist PA, Van Ness B. The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype. Oncogene 2005; 24: 6269-6280.
-
(2005)
Oncogene
, vol.24
, pp. 6269-6280
-
-
Croonquist, P.A.1
Van Ness, B.2
-
65
-
-
33646596977
-
The gene for polycomb group protein enhancer of zeste homolog 2 (ezh2) is amplified in late-stage prostate cancer
-
Saramaki OR, Tammela TL, Martikainen PM, Vessella RL, Visakorpi T. The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer. Genes Chromosomes Cancer 2006; 45: 639-645.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 639-645
-
-
Saramaki, O.R.1
Tammela, T.L.2
Martikainen, P.M.3
Vessella, R.L.4
Visakorpi, T.5
-
66
-
-
85027937746
-
Mek–erk pathway regulates ezh2 overexpression in association with aggressive breast cancer subtypes
-
Fujii S, Tokita K, Wada N, Ito K, Yamauchi C, Ito Y, Ochiai A. MEK–ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes. Oncogene 2011; 30: 4118-4128.
-
(2011)
Oncogene
, vol.30
, pp. 4118-4128
-
-
Fujii, S.1
Tokita, K.2
Wada, N.3
Ito, K.4
Yamauchi, C.5
Ito, Y.6
Ochiai, A.7
-
67
-
-
1542426648
-
Amplification and overexpression of e2f3 in human bladder cancer
-
Feber A, Clark J, Goodwin G, Dodson AR, Smith PH, Fletcher A, Edwards S, Flohr P, Falconer A, Roe T, Kovacs G, Dennis N, Fisher C, Wooster R, Huddart R, Foster CS, Cooper CS. Amplification and overexpression of E2F3 in human bladder cancer. Oncogene 2004; 23: 1627-1630.
-
(2004)
Oncogene
, vol.23
, pp. 1627-1630
-
-
Feber, A.1
Clark, J.2
Goodwin, G.3
Dodson, A.R.4
Smith, P.H.5
Fletcher, A.6
Edwards, S.7
Flohr, P.8
Falconer, A.9
Roe, T.10
Kovacs, G.11
Dennis, N.12
Fisher, C.13
Wooster, R.14
Huddart, R.15
Foster, C.S.16
Cooper, C.S.17
-
68
-
-
3342974830
-
E2f3 amplification and overexpression is associated with invasive tu mor growth and rapid tumor cell proliferation in urinary bladder cancer
-
Oeggerli M, Tomovska S, Schraml P, CalvanoForte D, Schafroth S, Simon R, Gasser T, Mihatsch MJ, Sauter G. E2F3 amplification and overexpression is associated with invasive tu mor growth and rapid tumor cell proliferation in urinary bladder cancer. Oncogene 2004; 23: 5616-5623.
-
(2004)
Oncogene
, vol.23
, pp. 5616-5623
-
-
Oeggerli, M.1
Tomovska, S.2
Schraml, P.3
Calvanoforte, D.4
Schafroth, S.5
Simon, R.6
Gasser, T.7
Mihatsch, M.J.8
Sauter, G.9
-
69
-
-
84881561661
-
Genomic deregulation of the e2f/rb pathway leads to activation of the oncogene ezh2 in small cell lung cancer
-
Coe BP, Thu KL, Aviel-Ronen S, Vucic EA, Gazdar AF, Lam S, Tsao MS, Lam WL. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS One 2013; 8: e71670.
-
(2013)
Plos One
, vol.8
-
-
Coe, B.P.1
Thu, K.L.2
Aviel-Ronen, S.3
Vucic, E.A.4
Gazdar, A.F.5
Lam, S.6
Tsao, M.S.7
Lam, W.L.8
-
70
-
-
84859189630
-
Myc enforces overexpression of ezh2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms
-
Koh CM, Iwata T, Zheng Q, Bethel C, Yegnasubramanian S, De Marzo AM. Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms. Oncotarget 2011; 2: 669-683.
-
(2011)
Oncotarget
, vol.2
, pp. 669-683
-
-
Koh, C.M.1
Iwata, T.2
Zheng, Q.3
Bethel, C.4
Yegnasubramanian, S.5
De Marzo, A.M.6
-
71
-
-
77956285565
-
Ets transcription factors control transcription of ezh2 and epigenetic silencing of the tumor suppressor gene nkx3.1 in prostate cancer
-
Kunderfranco P, Mello-Grand M, Cangemi R, Pellini S, Mensah A, Albertini V, Malek A, Chiorino G, Catapano CV, Carbone GM. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 2010; 5: e10547.
-
(2010)
Plos One
, vol.5
-
-
Kunderfranco, P.1
Mello-Grand, M.2
Cangemi, R.3
Pellini, S.4
Mensah, A.5
Albertini, V.6
Malek, A.7
Chiorino, G.8
Catapano, C.V.9
Carbone, G.M.10
-
72
-
-
84876518140
-
Nf-ya underlies ezh2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells
-
Garipov A, Li H, Bitler BG, Thapa RJ, Balachandran S, Zhang R. NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells. Mol Cancer Res 2013; 11: 360-369.
-
(2013)
Mol Cancer Res
, vol.11
, pp. 360-369
-
-
Garipov, A.1
Li, H.2
Bitler, B.G.3
Thapa, R.J.4
Balachandran, S.5
Zhang, R.6
-
73
-
-
84878791222
-
Role of stat3 and vitamin d receptor in ezh2-mediated invasion of human colorectal cancer
-
Lin YW, Ren LL, Xiong H, Du W, Yu YN, Sun TT, Weng YR, Wang Z., Wang JL, Wang YC, Cui Y, Sun DF, Han ZG, Shen N, Zou W, Xu J, Chen HY, Cao W, Hong J, Fang JY. Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer. J Pathol 2013; 230: 277-290.
-
(2013)
J Pathol
, vol.230
, pp. 277-290
-
-
Lin, Y.W.1
Ren, L.L.2
Xiong, H.3
Du, W.4
Yu, Y.N.5
Sun, T.T.6
Weng, Y.R.7
Wang, Z.8
Wang, J.L.9
Wang, Y.C.10
Cui, Y.11
Sun, D.F.12
Han, Z.G.13
Shen, N.14
Zou, W.15
Xu, J.16
Chen, H.Y.17
Cao, W.18
Hong, J.19
Fang, J.Y.20
more..
-
74
-
-
78549291781
-
Ancca/atad2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of b-myb and ezh2
-
Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res 2010; 70: 9402-9412.
-
(2010)
Cancer Res
, vol.70
, pp. 9402-9412
-
-
Kalashnikova, E.V.1
Revenko, A.S.2
Gemo, A.T.3
Andrews, N.P.4
Tepper, C.G.5
Zou, J.X.6
Cardiff, R.D.7
Borowsky, A.D.8
Chen, H.W.9
-
75
-
-
65249101694
-
Ezh2 is a mediator of ews/fli1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
-
Richter GH, Plehm S, Fasan A, Rossler S, Unland R, Bennani-Baiti IM, Hotfilder M, Lowel D, von Luettichau I, Mossbrugger I, QuintanillaMartinez L, Kovar H, Staege MS, Muller-Tidow C, Burdach S. EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation. Proc Natl Acad Sci U S A 2009; 106: 5324-5329.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 5324-5329
-
-
Richter, G.H.1
Plehm, S.2
Fasan, A.3
Rossler, S.4
Unland, R.5
Bennani-Baiti, I.M.6
Hotfilder, M.7
Lowel, D.8
Von Luettichau, I.9
Mossbrugger, I.10
Quintanillamartinez, L.11
Kovar, H.12
Staege, M.S.13
Muller-Tidow, C.14
Burdach, S.15
-
76
-
-
84862907872
-
The braf(v600e) causes widespread alterations in gene methylation in the genome of melanoma cells
-
Hou P, Liu D, Dong J, Xing M. The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells. Cell Cycle 2012; 11: 286-295.
-
(2012)
Cell Cycle
, vol.11
, pp. 286-295
-
-
Hou, P.1
Liu, D.2
Dong, J.3
Xing, M.4
-
77
-
-
78651454089
-
Ezh2 promotes expansion of breast tumor initiating cells through activation of raf1-beta-catenin signaling
-
Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-beta-catenin signaling. Cancer Cell 2011; 19: 86-100.
-
(2011)
Cancer Cell
, vol.19
, pp. 86-100
-
-
Chang, C.J.1
Yang, J.Y.2
Xia, W.3
Chen, C.T.4
Xie, X.5
Chao, C.H.6
Woodward, W.A.7
Hsu, J.M.8
Hortobagyi, G.N.9
Hung, M.C.10
-
78
-
-
84860758213
-
Downregulation of the mir-25 and mir-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein ezh2
-
Esposito F, Tornincasa M, Pallante P, Federico A, Borbone E, Pierantoni GM, Fusco A. Downregulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2. J Clin Endocrinol Metab 2012; 97: E710-718.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. E710-E718
-
-
Esposito, F.1
Tornincasa, M.2
Pallante, P.3
Federico, A.4
Borbone, E.5
Pierantoni, G.M.6
Fusco, A.7
-
79
-
-
61349112251
-
Myc stimulates ezh2 expression by repression of its negative regulator mir-26a
-
Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF, Möller P, Stilgenbauer S, Pollack JR, Wirth T. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 2008; 112: 4202-4212.
-
(2008)
Blood
, vol.112
, pp. 4202-4212
-
-
Sander, S.1
Bullinger, L.2
Klapproth, K.3
Fiedler, K.4
Kestler, H.A.5
Barth, T.F.6
Möller, P.7
Stilgenbauer, S.8
Pollack, J.R.9
Wirth, T.10
-
80
-
-
80052999610
-
Critical role of c-myc in acute myeloid leukemia involving direct regulation of mir-26a and histone methyltransferase ezh2
-
Salvatori B, Iosue I, Djodji Damas N, Mangiavacchi A, Chiaretti S, Messina M, Padula F, Guarini A, Bozzoni I, Fazi F, Fatica A. Critical role of c-Myc in acute myeloid leukemia involving direct regulation of miR-26a and histone methyltransferase EZH2. Genes Cancer 2011; 2: 585-592.
-
(2011)
Genes Cancer
, vol.2
, pp. 585-592
-
-
Salvatori, B.1
Iosue, I.2
Djodji Damas, N.3
Mangiavacchi, A.4
Chiaretti, S.5
Messina, M.6
Padula, F.7
Guarini, A.8
Bozzoni, I.9
Fazi, F.10
Fatica, A.11
-
81
-
-
78651411120
-
Mir26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of ezh2
-
Lu J, He ML, Wang L, Chen Y, Liu X, Dong Q, Chen YC, Peng Y, Yao KT, Kung HF, Li XP. MiR26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res 2011; 71: 225-233.
-
(2011)
Cancer Res
, vol.71
, pp. 225-233
-
-
Lu, J.1
He, M.L.2
Wang, L.3
Chen, Y.4
Liu, X.5
Dong, Q.6
Chen, Y.C.7
Peng, Y.8
Yao, K.T.9
Kung, H.F.10
Li, X.P.11
-
82
-
-
84864501561
-
Microrna-98 and microrna-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma
-
Huang SD, Yuan Y, Zhuang CW, Li BL, Gong DJ, Wang SG, Zeng ZY, Cheng HZ. MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma. Mol Cancer 2012; 11: 51.
-
(2012)
Mol Cancer
, vol.11
, pp. 51
-
-
Huang, S.D.1
Yuan, Y.2
Zhuang, C.W.3
Li, B.L.4
Gong, D.J.5
Wang, S.G.6
Zeng, Z.Y.7
Cheng, H.Z.8
-
83
-
-
79957552560
-
Enhancer of zeste homolog 2 (ezh2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by mir-26a, mir-101, and mir-98
-
Alajez NM, Shi W, Hui AB, Bruce J, Lenarduzzi M, Ito E, Yue S, O'Sullivan B, Liu FF. Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98. Cell Death Dis 2010; 1: e85.
-
(2010)
Cell Death Dis
, vol.1
-
-
Alajez, N.M.1
Shi, W.2
Hui, A.B.3
Bruce, J.4
Lenarduzzi, M.5
Ito, E.6
Yue, S.7
O'sullivan, B.8
Liu, F.F.9
-
84
-
-
58149239686
-
Genomic loss of microrna-101 leads to overexpression of histone methyltransferase ezh2 in cancer
-
Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim J., Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008; 322: 1695-1699.
-
(2008)
Science
, vol.322
, pp. 1695-1699
-
-
Varambally, S.1
Cao, Q.2
Mani, R.S.3
Shankar, S.4
Wang, X.5
Ateeq, B.6
Laxman, B.7
Cao, X.8
Jing, X.9
Ramnarayanan, K.10
Brenner, J.C.11
Yu, J.12
Kim, J.13
Han, B.14
Tan, P.15
Kumar-Sinha, C.16
Lonigro, R.J.17
Palanisamy, N.18
Maher, C.A.19
Chinnaiyan, A.M.20
more..
-
85
-
-
65549083102
-
The putative tumor suppressor microrna-101 modulates the cancer epigenome by repressing the polycomb group protein ezh2
-
Friedman JM, Liang G, Liu CC, Wolff EM, Tsai YC, Ye W, Zhou X, Jones PA. The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res 2009; 69: 2623-2629.
-
(2009)
Cancer Res
, vol.69
, pp. 2623-2629
-
-
Friedman, J.M.1
Liang, G.2
Liu, C.C.3
Wolff, E.M.4
Tsai, Y.C.5
Ye, W.6
Zhou, X.7
Jones, P.A.8
-
86
-
-
77955717754
-
Microrna-101 is down-regulated in gastric cancer and involved in cell migration and invasion
-
Wang HJ, Ruan HJ, He XJ, Ma YY, Jiang XT, Xia YJ, Ye ZY, Tao HQ. MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion. Eur J Cancer 2010; 46: 2295-2303.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2295-2303
-
-
Wang, H.J.1
Ruan, H.J.2
He, X.J.3
Ma, Y.Y.4
Jiang, X.T.5
Xia, Y.J.6
Ye, Z.Y.7
Tao, H.Q.8
-
87
-
-
80054940941
-
The tumor suppressor gene rap1gap is silenced by mir101-mediated ezh2 overexpression in invasive squamous cell carcinoma
-
Banerjee R, Mani RS, Russo N, Scanlon CS, Tsodikov A, Jing X, Cao Q, Palanisamy N, Metwally T, Inglehart RC, Tomlins S, Bradford C, Carey T, Wolf G, Kalyana-Sundaram S, Chinnaiyan AM, Varambally S, D'Silva NJ. The tumor suppressor gene rap1GAP is silenced by miR101-mediated EZH2 overexpression in invasive squamous cell carcinoma. Oncogene 2011; 30: 4339-4349.
-
(2011)
Oncogene
, vol.30
, pp. 4339-4349
-
-
Banerjee, R.1
Mani, R.S.2
Russo, N.3
Scanlon, C.S.4
Tsodikov, A.5
Jing, X.6
Cao, Q.7
Palanisamy, N.8
Metwally, T.9
Inglehart, R.C.10
Tomlins, S.11
Bradford, C.12
Carey, T.13
Wolf, G.14
Kalyana-Sundaram, S.15
Chinnaiyan, A.M.16
Varambally, S.17
D'silva, N.J.18
-
88
-
-
79953029421
-
Microrna-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2
-
Zhang J., Guo JF, Liu DL, Liu Q, Wang JJ. MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2. J Thorac Oncol 2011; 6: 671-678.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 671-678
-
-
Zhang, J.1
Guo, J.F.2
Liu, D.L.3
Liu, Q.4
Wang, J.J.5
-
89
-
-
84887154961
-
Mir-101 inhibits melanoma cell invasion and proliferation by targeting mitf and ezh2
-
Luo C, Merz PR, Chen Y, Dickes E, Pscherer A, Schadendorf D, Eichmüller SB. MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2. Cancer Lett 2013; 341: 240-247.
-
(2013)
Cancer Lett
, vol.341
, pp. 240-247
-
-
Luo, C.1
Merz, P.R.2
Chen, Y.3
Dickes, E.4
Pscherer, A.5
Schadendorf, D.6
Eichmüller, S.B.7
-
90
-
-
84855191863
-
The putative tumour suppressor microrna-124 modulates hepatocellular carcinoma cell aggressiveness by repressing rock2 and ezh2
-
Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 2012; 61: 278-289.
-
(2012)
Gut
, vol.61
, pp. 278-289
-
-
Zheng, F.1
Liao, Y.J.2
Cai, M.Y.3
Liu, Y.H.4
Liu, T.H.5
Chen, S.P.6
Bian, X.W.7
Guan, X.Y.8
Lin, M.C.9
Zeng, Y.X.10
Kung, H.F.11
Xie, D.12
-
91
-
-
84905174595
-
Microrna-124 inhibits proliferation and induces apoptosis by directly repressing ezh2 in gastric cancer
-
Xie L, Zhang Z, Tan Z, He R, Zeng X, Xie Y, Li S, Tang G, Tang H He X, microRNA-124 inhibits proliferation and induces apoptosis by directly repressing EZH2 in gastric cancer. Mol Cell Biochem 2014; 392: 153-159.
-
(2014)
Mol Cell Biochem
, vol.392
, pp. 153-159
-
-
Xie, L.1
Zhang, Z.2
Tan, Z.3
He, R.4
Zeng, X.5
Xie, Y.6
Li, S.7
Tang, G.8
Tang, H.9
He, X.10
-
92
-
-
84873711992
-
Mir-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes
-
Luo C, Tetteh PW, Merz PR, Dickes E, Abukiwan A, Hotz-Wagenblatt A, Holland-Cunz S, Sinnberg T, Schittek B, Schadendorf D, Diederichs S, Eichmüller SB. miR-137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes. J Invest Dermatol 2013; 133: 768-775.
-
(2013)
J Invest Dermatol
, vol.133
, pp. 768-775
-
-
Luo, C.1
Tetteh, P.W.2
Merz, P.R.3
Dickes, E.4
Abukiwan, A.5
Hotz-Wagenblatt, A.6
Holland-Cunz, S.7
Sinnberg, T.8
Schittek, B.9
Schadendorf, D.10
Diederichs, S.11
Eichmüller, S.B.12
-
93
-
-
80054884390
-
Microrna-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines
-
Liu X, Wang C, Chen Z, Jin Y, Wang Y, Kolokythas A, Dai Y, Zhou X. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J 2011; 440: 23-31.
-
(2011)
Biochem J
, vol.440
, pp. 23-31
-
-
Liu, X.1
Wang, C.2
Chen, Z.3
Jin, Y.4
Wang, Y.5
Kolokythas, A.6
Dai, Y.7
Zhou, X.8
-
94
-
-
84879567465
-
Suppression of tumorigenicity by microrna-138 through inhibition of ezh2-cdk4/6prb-e2f1 signal loop in glioblastoma multiforme
-
Qiu S, Huang D, Yin D, Li F, Li X, Kung HF, Peng Y. Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6pRb-E2F1 signal loop in glioblastoma multiforme. Biochim Biophys Acta 2013; 1832: 1697-1707.
-
(2013)
Biochim Biophys Acta
, vol.1832
, pp. 1697-1707
-
-
Qiu, S.1
Huang, D.2
Yin, D.3
Li, F.4
Li, X.5
Kung, H.F.6
Peng, Y.7
-
95
-
-
84872816163
-
Mir-138 inhibits tumor growth through repression of ezh2 in nonsmall cell lung cancer
-
Zhang H, Zhang H, Zhao M, Lv Z, Zhang X, Qin X, Wang H, Wang S, Su J, Lv X, Liu H, Du W, Zhou W, Chen X, Fei K. MiR-138 inhibits tumor growth through repression of EZH2 in nonsmall cell lung cancer. Cell Physiol Biochem 2013; 31: 56-65.
-
(2013)
Cell Physiol Biochem
, vol.31
, pp. 56-65
-
-
Zhang, H.1
Zhang, H.2
Zhao, M.3
Lv, Z.4
Zhang, X.5
Qin, X.6
Wang, H.7
Wang, S.8
Su, J.9
Lv, X.10
Liu, H.11
Du, W.12
Zhou, W.13
Chen, X.14
Fei, K.15
-
96
-
-
84866040307
-
Mir-214 targets betacatenin pathway to suppress invasion, stemlike traits and recurrence of human hepatocellular carcinoma
-
Xia H, Ooi LL, Hui KM. MiR-214 targets betacatenin pathway to suppress invasion, stemlike traits and recurrence of human hepatocellular carcinoma. PLoS One 2012; 7: e44206.
-
(2012)
Plos One
, vol.7
-
-
Xia, H.1
Ooi, L.L.2
Hui, K.M.3
-
97
-
-
84863343713
-
Loss of let-7 up-regulates ezh2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by br-dim
-
Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, Hwang C, Gupta N, Chitale D, Sakr WA, Menon M, Sarkar FH. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One 2012; 7: e33729.
-
(2012)
Plos One
, vol.7
-
-
Kong, D.1
Heath, E.2
Chen, W.3
Cher, M.L.4
Powell, I.5
Heilbrun, L.6
Li, Y.7
Ali, S.8
Sethi, S.9
Hassan, O.10
Hwang, C.11
Gupta, N.12
Chitale, D.13
Sakr, W.A.14
Menon, M.15
Sarkar, F.H.16
-
98
-
-
84868130868
-
Let7a inhibits proliferation and induces apoptosis by targeting ezh2 in nasopharyngeal carcinoma cells
-
Cai K, Wan Y, Sun G, Shi L, Bao X, Wang Z. Let7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncol Rep 2012; 28: 2101-2106.
-
(2012)
Oncol Rep
, vol.28
, pp. 2101-2106
-
-
Cai, K.1
Wan, Y.2
Sun, G.3
Shi, L.4
Bao, X.5
Wang, Z.6
-
99
-
-
84883462991
-
Mir-144 downregulation increases bladder cancer cell proliferation by targeting ezh2 and regulating wnt signaling
-
Guo Y, Ying L, Tian Y, Yang P, Zhu Y, Wang Z, Qiu F, Lin J. miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling. FEBS J 2013; 280: 4531-4538.
-
(2013)
FEBS J
, vol.280
, pp. 4531-4538
-
-
Guo, Y.1
Ying, L.2
Tian, Y.3
Yang, P.4
Zhu, Y.5
Wang, Z.6
Qiu, F.7
Lin, J.8
-
100
-
-
75749124332
-
Somatic mutations altering ezh2 (tyr641) in follicular and diffuse large b-cell lymphomas of germinal-center origin
-
Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, Boyle M, Woolcock BW, Kuchenbauer F, Yap D, Humphries RK, Griffith OL, Shah S, Zhu H, Kimbara M, Shashkin P, Charlot JF, Tcherpakov M, Corbett R, Tam A, Varhol R, Smailus D, Moksa M, Zhao Y, Delaney A, Qian H, Birol I, Schein J, Moore R, Holt R, Horsman DE, Connors JM, Jones S, Aparicio S, Hirst M, Gascoyne RD, Marra MA. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42: 181-185.
-
(2010)
Nat Genet
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
Mungall, A.J.4
An, J.5
Goya, R.6
Paul, J.E.7
Boyle, M.8
Woolcock, B.W.9
Kuchenbauer, F.10
Yap, D.11
Humphries, R.K.12
Griffith, O.L.13
Shah, S.14
Zhu, H.15
Kimbara, M.16
Shashkin, P.17
Charlot, J.F.18
Tcherpakov, M.19
Corbett, R.20
Tam, A.21
Varhol, R.22
Smailus, D.23
Moksa, M.24
Zhao, Y.25
Delaney, A.26
Qian, H.27
Birol, I.28
Schein, J.29
Moore, R.30
Holt, R.31
Horsman, D.E.32
Connors, J.M.33
Jones, S.34
Aparicio, S.35
Hirst, M.36
Gascoyne, R.D.37
Marra, M.A.38
more..
-
101
-
-
79952167230
-
Somatic mutations at ezh2 y641 act dominantly through a mechanism of selectively altered prc2 catalytic activity, to increase h3k27 trimethylation
-
Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011; 117: 2451-2459.
-
(2011)
Blood
, vol.117
, pp. 2451-2459
-
-
Yap, D.B.1
Chu, J.2
Berg, T.3
Schapira, M.4
Cheng, S.W.5
Moradian, A.6
Morin, R.D.7
Mungall, A.J.8
Meissner, B.9
Boyle, M.10
Marquez, V.E.11
Marra, M.A.12
Gascoyne, R.D.13
Humphries, R.K.14
Arrowsmith, C.H.15
Morin, G.B.16
Aparicio, S.A.17
-
102
-
-
84902665681
-
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene ezh2 in lymphomagenesis
-
Berg T, Thoene S, Yap D, Wee T, Schoeler N, Rosten P, Lim E, Bilenky M, Mungall AJ, Oellerich T, Lee S, Lai CK, Umlandt P, Salmi A, Chang H, Yue L, Lai D, Cheng SW, Morin RD, Hirst M, Serve H, Marra MA, Morin GB, Gascoyne RD, Aparicio SA, Humphries RK. A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood 2014; 123: 3914-3924.
-
(2014)
Blood
, vol.123
, pp. 3914-3924
-
-
Berg, T.1
Thoene, S.2
Yap, D.3
Wee, T.4
Schoeler, N.5
Rosten, P.6
Lim, E.7
Bilenky, M.8
Mungall, A.J.9
Oellerich, T.10
Lee, S.11
Lai, C.K.12
Umlandt, P.13
Salmi, A.14
Chang, H.15
Yue, L.16
Lai, D.17
Cheng, S.W.18
Morin, R.D.19
Hirst, M.20
Serve, H.21
Marra, M.A.22
Morin, G.B.23
Gascoyne, R.D.24
Aparicio, S.A.25
Humphries, R.K.26
more..
-
103
-
-
84863165348
-
Mutation of a677 in histone methyltransferase ezh2 in human b-cell lymphoma promotes hypertrimethylation of histone h3 on lysine 27 (h3k27)
-
McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y, Smitheman KN, Ott HM, Pappalardi MB, Allen KE, Chen SB, Della Pietra A 3rd, Dul E, Hughes AM, Gilbert SA, Thrall SH, Tummino PJ, Kruger RG, Brandt M, Schwartz B, Creasy CL. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci U S A 2012; 109: 2989-2994.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 2989-2994
-
-
McCabe, M.T.1
Graves, A.P.2
Ganji, G.3
Diaz, E.4
Halsey, W.S.5
Jiang, Y.6
Smitheman, K.N.7
Ott, H.M.8
Pappalardi, M.B.9
Allen, K.E.10
Chen, S.B.11
Della Pietra, A.12
Dul, E.13
Hughes, A.M.14
Gilbert, S.A.15
Thrall, S.H.16
Tummino, P.J.17
Kruger, R.G.18
Brandt, M.19
Schwartz, B.20
Creasy, C.L.21
more..
-
104
-
-
84866597616
-
A687v ezh2 is a gain-of-function mutation found in lymphoma patients
-
Majer CR, Jin L, Scott MP, Knutson SK, Kuntz KW, Keilhack H, Smith JJ, Moyer MP, Richon VM, Copeland RA, Wigle TJ. A687V EZH2 is a gain-of-function mutation found in lymphoma patients. FEBS Lett 2012; 586: 3448-3451.
-
(2012)
FEBS Lett
, vol.586
, pp. 3448-3451
-
-
Majer, C.R.1
Jin, L.2
Scott, M.P.3
Knutson, S.K.4
Kuntz, K.W.5
Keilhack, H.6
Smith, J.J.7
Moyer, M.P.8
Richon, V.M.9
Copeland, R.A.10
Wigle, T.J.11
-
105
-
-
84918547001
-
A687v ezh2 is a driver of histone h3 lysine 27 (h3k27) hypertrimethylation
-
Ott HM, Graves AP, Pappalardi MB, Huddleston M, Halsey WS, Hughes AM, Groy A, Dul E, Jiang Y, Bai Y, Annan R, Verma SK, Knight SD, Kruger RG, Dhanak D, Schwartz B, Tummino PJ, Creasy CL, McCabe MT. A687V EZH2 Is a Driver of Histone H3 Lysine 27 (H3K27) Hypertrimethylation. Mol Cancer Ther 2014; 13: 3062-3073.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 3062-3073
-
-
Ott, H.M.1
Graves, A.P.2
Pappalardi, M.B.3
Huddleston, M.4
Halsey, W.S.5
Hughes, A.M.6
Groy, A.7
Dul, E.8
Jiang, Y.9
Bai, Y.10
Annan, R.11
Verma, S.K.12
Knight, S.D.13
Kruger, R.G.14
Dhanak, D.15
Schwartz, B.16
Tummino, P.J.17
Creasy, C.L.18
McCabe, M.T.19
-
106
-
-
34250729138
-
Functional demarcation of active and silent chromatin domains in human hox loci by noncoding rnas
-
Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007; 129: 1311-1323.
-
(2007)
Cell
, vol.129
, pp. 1311-1323
-
-
Rinn, J.L.1
Kertesz, M.2
Wang, J.K.3
Squazzo, S.L.4
Xu, X.5
Brugmann, S.A.6
Goodnough, L.H.7
Helms, J.A.8
Farnham, P.J.9
Segal, E.10
Chang, H.Y.11
-
107
-
-
77951118936
-
Reprograms chromatin state to promote cancer metastasis
-
Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, Wang Y, Brzoska P, Kong B, Li R, West RB, van de Vijver MJ, Sukumar S, Chang HY. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464: 1071-1076.
-
(2010)
Nature
, vol.464
, pp. 1071-1076
-
-
Gupta, R.A.1
Shah, N.2
Wang, K.C.3
Kim, J.4
Horlings, H.M.5
Wong, D.J.6
Tsai, M.C.7
Hung, T.8
Argani, P.9
Rinn, J.L.10
Wang, Y.11
Brzoska, P.12
Kong, B.13
Li, R.14
West, R.B.15
Van De Vijver, M.J.16
Sukumar, S.17
Chang, H.Y.18
Long Non-Coding, R.H.19
-
108
-
-
80054029971
-
Long noncoding rna hotair regulates polycomb dependent chromatin modification and is associated with poor prognosis in colorectal cancers
-
Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M. Long noncoding RNA HOTAIR regulates polycomb dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res 2011; 71: 6320-6326.
-
(2011)
Cancer Res
, vol.71
, pp. 6320-6326
-
-
Kogo, R.1
Shimamura, T.2
Mimori, K.3
Kawahara, K.4
Imoto, S.5
Sudo, T.6
Tanaka, F.7
Shibata, K.8
Suzuki, A.9
Komune, S.10
Miyano, S.11
Mori, M.12
-
109
-
-
84885403598
-
The long noncoding rna hotair contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(waf1/cip1) expression
-
Liu Z, Sun M, Lu K, Liu J, Zhang M, Wu W, De W, Wang Z, Wang R. The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression. PLoS One 2013; 8: e77293.
-
(2013)
Plos One
, vol.8
-
-
Liu, Z.1
Sun, M.2
Lu, K.3
Liu, J.4
Zhang, M.5
Wu, W.6
De, W.7
Wang, Z.8
Wang, R.9
-
110
-
-
84875890253
-
Hotair is a negative prognostic factor and exhibits prooncogenic activity in pancreatic cancer
-
Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits prooncogenic activity in pancreatic cancer. Oncogene 2013; 32: 1616-1625.
-
(2013)
Oncogene
, vol.32
, pp. 1616-1625
-
-
Kim, K.1
Jutooru, I.2
Chadalapaka, G.3
Johnson, G.4
Frank, J.5
Burghardt, R.6
Kim, S.7
Safe, S.8
-
111
-
-
80055046798
-
High expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
-
Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, Shang JL, Gao CF, Zhang FR, Wang F, Sun SH. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 2011; 54: 1679-1689.
-
(2011)
Hepatology
, vol.54
, pp. 1679-1689
-
-
Yang, F.1
Zhang, L.2
Huo, X.S.3
Yuan, J.H.4
Xu, D.5
Yuan, S.X.6
Zhu, N.7
Zhou, W.P.8
Yang, G.S.9
Wang, Y.Z.10
Shang, J.L.11
Gao, C.F.12
Zhang, F.R.13
Wang, F.14
Sun, S.H.15
Long Noncoding, R.N.A.16
-
112
-
-
79961202865
-
Transcriptome sequencing across a prostate cancer cohort identifies pcat-1, an unannotated lincrna implicated in disease progression
-
Prensner JR, Iyer MK, Balbin OA, Dhanasekaran SM, Cao Q, Brenner JC, Laxman B, Asangani IA, Grasso CS, Kominsky HD, Cao X, Jing X, Wang X, Siddiqui J, Wei JT, Robinson D, Iyer HK, Palanisamy N, Maher CA, Chinnaiyan AM. Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol 2011; 29: 742-749.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 742-749
-
-
Prensner, J.R.1
Iyer, M.K.2
Balbin, O.A.3
Dhanasekaran, S.M.4
Cao, Q.5
Brenner, J.C.6
Laxman, B.7
Asangani, I.A.8
Grasso, C.S.9
Kominsky, H.D.10
Cao, X.11
Jing, X.12
Wang, X.13
Siddiqui, J.14
Wei, J.T.15
Robinson, D.16
Iyer, H.K.17
Palanisamy, N.18
Maher, C.A.19
Chinnaiyan, A.M.20
more..
-
113
-
-
84876714385
-
Long non-coding rna h19 increases bladder cancer metastasis by associating with ezh2 and inhibiting e-cadherin expression
-
Luo M, Li Z, Wang W, Zeng Y, Liu Z, Qiu J. Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett 2013; 333: 213-221.
-
(2013)
Cancer Lett
, vol.333
, pp. 213-221
-
-
Luo, M.1
Li, Z.2
Wang, W.3
Zeng, Y.4
Liu, Z.5
Qiu, J.6
-
114
-
-
84879574789
-
Linc-ubc1 physically associates with polycomb repressive complex 2 (prc2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer
-
He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, Luo J, Yu H, Huang J, Lin T. linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. Biochim Biophys Acta 2013; 1832: 1528-1537.
-
(2013)
Biochim Biophys Acta
, vol.1832
, pp. 1528-1537
-
-
He, W.1
Cai, Q.2
Sun, F.3
Zhong, G.4
Wang, P.5
Liu, H.6
Luo, J.7
Yu, H.8
Huang, J.9
Lin, T.10
-
115
-
-
0034070298
-
The human ezh2 gene: Genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders
-
Cardoso C, Mignon C, Hetet G, Grandchamps B, Fontes M, Colleaux L. The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders. Eur J Hum Genet 2000; 8: 174-180.
-
(2000)
Eur J Hum Genet
, vol.8
, pp. 174-180
-
-
Cardoso, C.1
Mignon, C.2
Hetet, G.3
Grandchamps, B.4
Fontes, M.5
Colleaux, L.6
-
116
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene ezh2 in myeloid disorders
-
Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K, Zoi K, Ross FM, Reiter A, Hochhaus A, Drexler HG, Duncombe A, Cervantes F, Oscier D, Boultwood J, Grand FH, Cross NC. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726.
-
(2010)
Nat Genet
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
Hidalgo-Curtis, C.E.4
Bryant, C.5
Jones, A.V.6
Waghorn, K.7
Zoi, K.8
Ross, F.M.9
Reiter, A.10
Hochhaus, A.11
Drexler, H.G.12
Duncombe, A.13
Cervantes, F.14
Oscier, D.15
Boultwood, J.16
Grand, F.H.17
Cross, N.C.18
-
117
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene ezh2 in myelodysplastic syndromes
-
Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tönnissen ER, van der Heijden A, Scheele TN, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 2010; 42: 665-667.
-
(2010)
Nat Genet
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.2
Kuiper, R.P.3
Knops, R.4
Massop, M.5
Tönnissen, E.R.6
Van Der Heijden, A.7
Scheele, T.N.8
Vandenberghe, P.9
De Witte, T.10
Van Der Reijden, B.A.11
Jansen, J.H.12
-
118
-
-
80053135096
-
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: Utx, ezh2, and dnmt3a
-
Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O’Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011; 118: 3932-3941.
-
(2011)
Blood
, vol.118
, pp. 3932-3941
-
-
Jankowska, A.M.1
Makishima, H.2
Tiu, R.V.3
Szpurka, H.4
Huang, Y.5
Traina, F.6
Visconte, V.7
Sugimoto, Y.8
Prince, C.9
O’Keefe, C.10
Hsi, E.D.11
List, A.12
Sekeres, M.A.13
Rao, A.14
McDevitt, M.A.15
Maciejewski, J.P.16
-
119
-
-
77957987676
-
Novel homo- and hemizygous mutations in ezh2 in myeloid malignancies
-
Makishima H, Jankowska AM, Tiu RV, Szpurka H, Sugimoto Y, Hu Z, Saunthararajah Y, Guinta K, Keddache MA, Putnam P, Sekeres MA, Moliterno AR, List AF, McDevitt MA and Maciejewski JP. Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia 2010; 24: 1799-1804.
-
(2010)
Leukemia
, vol.24
, pp. 1799-1804
-
-
Makishima, H.1
Jankowska, A.M.2
Tiu, R.V.3
Szpurka, H.4
Sugimoto, Y.5
Hu, Z.6
Saunthararajah, Y.7
Guinta, K.8
Keddache, M.A.9
Putnam, P.10
Sekeres, M.A.11
Moliterno, A.R.12
List, A.F.13
McDevitt, M.A.14
Maciejewski, J.P.15
-
120
-
-
84888083126
-
Concurrent loss of ezh2 and tet2 cooperates in the pathogenesis of myelodysplastic disorders
-
Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med 2013; 210: 2627-2639.
-
(2013)
J Exp Med
, vol.210
, pp. 2627-2639
-
-
Muto, T.1
Sashida, G.2
Oshima, M.3
Wendt, G.R.4
Mochizuki-Kashio, M.5
Nagata, Y.6
Sanada, M.7
Miyagi, S.8
Saraya, A.9
Kamio, A.10
Nagae, G.11
Nakaseko, C.12
Yokote, K.13
Shimoda, K.14
Koseki, H.15
Suzuki, Y.16
Sugano, S.17
Aburatani, H.18
Ogawa, S.19
Iwama, A.20
more..
-
121
-
-
84907304074
-
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
-
Huether R, Dong L, Chen X, Wu G, Parker M, Wei L, Ma J, Edmonson MN, Hedlund EK, Rusch MC, Shurtleff SA, Mulder HL, Boggs K, Vadordaria B, Cheng J, Yergeau D, Song G, Becksfort J, Lemmon G, Weber C, Cai Z, Dang J, Walsh M, Gedman AL, Faber Z, Easton J, Gruber T, Kriwacki RW, Partridge JF, Ding L, Wilson RK, Mardis ER, Mullighan CG, Gilbertson RJ, Baker SJ, Zambetti G, Ellison DW, Zhang J, Downing JR. The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nat Commun 2014; 5: 3630.
-
(2014)
Nat Commun
, vol.5
, pp. 3630
-
-
Huether, R.1
Dong, L.2
Chen, X.3
Wu, G.4
Parker, M.5
Wei, L.6
Ma, J.7
Edmonson, M.N.8
Hedlund, E.K.9
Rusch, M.C.10
Shurtleff, S.A.11
Mulder, H.L.12
Boggs, K.13
Vadordaria, B.14
Cheng, J.15
Yergeau, D.16
Song, G.17
Becksfort, J.18
Lemmon, G.19
Weber, C.20
Cai, Z.21
Dang, J.22
Walsh, M.23
Gedman, A.L.24
Faber, Z.25
Easton, J.26
Gruber, T.27
Kriwacki, R.W.28
Partridge, J.F.29
Ding, L.30
Wilson, R.K.31
Mardis, E.R.32
Mullighan, C.G.33
Gilbertson, R.J.34
Baker, S.J.35
Zambetti, G.36
Ellison, D.W.37
Zhang, J.38
Downing, J.R.39
more..
-
122
-
-
84862777348
-
Driver mutations in histone h3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012; 482: 226-231.
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
Korshunov, A.2
Liu, X.Y.3
Jones, D.T.4
Pfaff, E.5
Jacob, K.6
Sturm, D.7
Fontebasso, A.M.8
Quang, D.A.9
Tönjes, M.10
Hovestadt, V.11
Albrecht, S.12
Kool, M.13
Nantel, A.14
Konermann, C.15
Lindroth, A.16
Jäger, N.17
Rausch, T.18
Ryzhova, M.19
Korbel, J.O.20
Hielscher, T.21
Hauser, P.22
Garami, M.23
Klekner, A.24
Bognar, L.25
Ebinger, M.26
Schuhmann, M.U.27
Scheurlen, W.28
Pekrun, A.29
Frühwald, M.C.30
Roggendorf, W.31
Kramm, C.32
Dürken, M.33
Atkinson, J.34
Lepage, P.35
Montpetit, A.36
Zakrzewska, M.37
Zakrzewski, K.38
Liberski, P.P.39
Dong, Z.40
Siegel, P.41
Kulozik, A.E.42
Zapatka, M.43
Guha, A.44
Malkin, D.45
Felsberg, J.46
Reifenberger, G.47
Von Deimling, A.48
Ichimura, K.49
Collins, V.P.50
Witt, H.51
Milde, T.52
Witt, O.53
Zhang, C.54
Castelo-Branco, P.55
Lichter, P.56
Faury, D.57
Tabori, U.58
Plass, C.59
Majewski, J.60
Pfister, S.M.61
Jabado, N.62
more..
-
123
-
-
84862777410
-
Jude children’s research hospital-washington university pediatric cancer genome project. Somatic histone h3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
-
Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, Zhang J, Gajjar A, Dyer MA, Mullighan CG, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Ellison DW, Zhang J, Baker SJ; St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 2012; 44: 251-253.
-
(2012)
Nat Genet
, vol.44
, pp. 251-253
-
-
Wu, G.1
Broniscer, A.2
McPachron, T.A.3
Lu, C.4
Paugh, B.S.5
Becksfort, J.6
Qu, C.7
Ding, L.8
Huether, R.9
Parker, M.10
Zhang, J.11
Gajjar, A.12
Dyer, M.A.13
Mullighan, C.G.14
Gilbertson, R.J.15
Mardis, E.R.16
Wilson, R.K.17
Downing, J.R.18
Ellison, D.W.19
Zhang, J.20
Baker, S.J.21
more..
-
124
-
-
84865863019
-
K27m mutation in histone h3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
-
Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, Bartels U, Albrecht S, Schwartzentruber J, Letourneau L, Bourgey M, Bourque G, Montpetit A, Bourret G, Lepage P, Fleming A, Lichter P, Kool M, von Deimling A, Sturm D, Korshunov A, Faury D, Jones DT, Majewski J, Pfister SM, Jabado N, Hawkins C. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol 2012; 124: 439-447.
-
(2012)
Acta Neuropathol
, vol.124
, pp. 439-447
-
-
Khuong-Quang, D.A.1
Buczkowicz, P.2
Rakopoulos, P.3
Liu, X.Y.4
Fontebasso, A.M.5
Bouffet, E.6
Bartels, U.7
Albrecht, S.8
Schwartzentruber, J.9
Letourneau, L.10
Bourgey, M.11
Bourque, G.12
Montpetit, A.13
Bourret, G.14
Lepage, P.15
Fleming, A.16
Lichter, P.17
Kool, M.18
Von Deimling, A.19
Sturm, D.20
Korshunov, A.21
Faury, D.22
Jones, D.T.23
Majewski, J.24
Pfister, S.M.25
Jabado, N.26
Hawkins, C.27
more..
-
125
-
-
84867606428
-
Hotspot mutations in h3f3a and idh1 define distinct epigenetic and biological subgroups of glioblastoma
-
Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012; 22: 425-437.
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
Witt, H.2
Hovestadt, V.3
Khuong-Quang, D.A.4
Jones, D.T.5
Konermann, C.6
Pfaff, E.7
Tönjes, M.8
Sill, M.9
Bender, S.10
Kool, M.11
Zapatka, M.12
Becker, N.13
Zucknick, M.14
Hielscher, T.15
Liu, X.Y.16
Fontebasso, A.M.17
Ryzhova, M.18
Albrecht, S.19
Jacob, K.20
Wolter, M.21
Ebinger, M.22
Schuhmann, M.U.23
Van Meter, T.24
Frühwald, M.C.25
Hauch, H.26
Pekrun, A.27
Radlwimmer, B.28
Niehues, T.29
Von Komorowski, G.30
Dürken, M.31
Kulozik, A.E.32
Madden, J.33
Donson, A.34
Foreman, N.K.35
Drissi, R.36
Fouladi, M.37
Scheurlen, W.38
Von Deimling, A.39
Monoranu, C.40
Roggendorf, W.41
Herold-Mende, C.42
Unterberg, A.43
Kramm, C.M.44
Felsberg, J.45
Hartmann, C.46
Wiestler, B.47
Wick, W.48
Milde, T.49
Witt, O.50
Lindroth, A.M.51
Schwartzentruber, J.52
Faury, D.53
Fleming, A.54
Zakrzewska, M.55
Liberski, P.P.56
Zakrzewski, K.57
Hauser, P.58
Garami, M.59
Klekner, A.60
Bognar, L.61
Morrissy, S.62
Cavalli, F.63
Taylor, M.D.64
Van Sluis, P.65
Koster, J.66
Versteeg, R.67
Volckmann, R.68
Mikkelsen, T.69
Aldape, K.70
Reifenberger, G.71
Collins, V.P.72
Majewski, J.73
Korshunov, A.74
Lichter, P.75
Plass, C.76
Jabado, N.77
Pfister, S.M.78
more..
-
126
-
-
84887617868
-
Reduced h3k27me3 and dna hypomethylation are major drivers of gene expression in k27m mutant pediatric high-grade gliomas
-
Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Højfeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Seker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monoranu CM, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C, Cho YJ, Pfister SM. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 2013; 24: 660-672.
-
(2013)
Cancer Cell
, vol.24
, pp. 660-672
-
-
Bender, S.1
Tang, Y.2
Lindroth, A.M.3
Hovestadt, V.4
Jones, D.T.5
Kool, M.6
Zapatka, M.7
Northcott, P.A.8
Sturm, D.9
Wang, W.10
Radlwimmer, B.11
Højfeldt, J.W.12
Truffaux, N.13
Castel, D.14
Schubert, S.15
Ryzhova, M.16
Seker-Cin, H.17
Gronych, J.18
Johann, P.D.19
Stark, S.20
Meyer, J.21
Milde, T.22
Schuhmann, M.23
Ebinger, M.24
Monoranu, C.M.25
Ponnuswami, A.26
Chen, S.27
Jones, C.28
Witt, O.29
Collins, V.P.30
Von Deimling, A.31
Jabado, N.32
Puget, S.33
Grill, J.34
Helin, K.35
Korshunov, A.36
Lichter, P.37
Monje, M.38
Plass, C.39
Cho, Y.J.40
Pfister, S.M.41
more..
-
127
-
-
84882273357
-
Evaluation of histone 3 lysine 27 trimethylation (h3k27me3) and enhancer of zest 2 (ezh2) in pediatric glial and glioneuronal tumors shows decreased h3k27me3 in h3f3a k27m mutant glioblastomas
-
Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A, Santi M, Thompson CB, Judkins AR. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol 2013; 23: 558-564.
-
(2013)
Brain Pathol
, vol.23
, pp. 558-564
-
-
Venneti, S.1
Garimella, M.T.2
Sullivan, L.M.3
Martinez, D.4
Huse, J.T.5
Heguy, A.6
Santi, M.7
Thompson, C.B.8
Judkins, A.R.9
-
128
-
-
84877785024
-
Inhibition of prc2 activity by a gain-of-function h3 mutation found in pediatric glioblastoma
-
Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 2013; 340: 857-861.
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.W.1
Müller, M.M.2
Koletsky, M.S.3
Cordero, F.4
Lin, S.5
Banaszynski, L.A.6
Garcia, B.A.7
Muir, T.W.8
Becher, O.J.9
Allis, C.D.10
-
129
-
-
84877299145
-
The histone h3.3k27m mutation in pediatric glioma reprograms h3k27 methylation and gene expression
-
Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev 2013; 27: 985-990.
-
(2013)
Genes Dev
, vol.27
, pp. 985-990
-
-
Chan, K.M.1
Fang, D.2
Gan, H.3
Hashizume, R.4
Yu, C.5
Schroeder, M.6
Gupta, N.7
Mueller, S.8
James, C.D.9
Jenkins, R.10
Sarkaria, J.11
Zhang, Z.12
-
130
-
-
34447544566
-
Integration of estrogen and wnt signaling circuits by the polycomb group protein ezh2 in breast cancer cells
-
Shi B, Liang J, Yang X, Wang Y, Zhao Y, Wu H, Sun L, Zhang Y, Chen Y, Li R, Zhang Y, Hong M, Shang Y. Integration of estrogen and Wnt signaling circuits by the Polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol 2007; 27: 5105-5119.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 5105-5119
-
-
Shi, B.1
Liang, J.2
Yang, X.3
Wang, Y.4
Zhao, Y.5
Wu, H.6
Sun, L.7
Zhang, Y.8
Chen, Y.9
Li, R.10
Zhang, Y.11
Hong, M.12
Shang, Y.13
-
131
-
-
80052222327
-
Context-specific regulation of nfkappab target gene expression by ezh2 in breast cancers
-
Lee ST, Li Z, Wu Z, Aau M, Guan P, Karuturi RK, Liou YC, Yu Q. Context-specific regulation of NFkappaB target gene expression by EZH2 in breast cancers. Mol Cell 2011; 43: 798-810.
-
(2011)
Mol Cell
, vol.43
, pp. 798-810
-
-
Lee, S.T.1
Li, Z.2
Wu, Z.3
Aau, M.4
Guan, P.5
Karuturi, R.K.6
Liou, Y.C.7
Yu, Q.8
-
132
-
-
84886310917
-
Paf and ezh2 induce wnt/beta-catenin signaling hyperactivation
-
Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI. PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation. Mol Cell 2013; 52: 193-205.
-
(2013)
Mol Cell
, vol.52
, pp. 193-205
-
-
Jung, H.Y.1
Jun, S.2
Lee, M.3
Kim, H.C.4
Wang, X.5
Ji, H.6
McCrea, P.D.7
Park, J.I.8
-
133
-
-
84871052080
-
Ezh2 oncogenic activity in castration-resistant prostate cancer cells is polycomb-independent
-
Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, Xu H, Cato L, Thornton JE, Gregory RI, Morrissey C, Vessella RL, Montironi R, Magi-Galluzzi C, Kantoff PW, Balk SP, Liu XS, Brown M. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012; 338: 1465-1469.
-
(2012)
Science
, vol.338
, pp. 1465-1469
-
-
Xu, K.1
Wu, Z.J.2
Groner, A.C.3
He, H.H.4
Cai, C.5
Lis, R.T.6
Wu, X.7
Stack, E.C.8
Loda, M.9
Liu, T.10
Xu, H.11
Cato, L.12
Thornton, J.E.13
Gregory, R.I.14
Morrissey, C.15
Vessella, R.L.16
Montironi, R.17
Magi-Galluzzi, C.18
Kantoff, P.W.19
Balk, S.P.20
Liu, X.S.21
Brown, M.22
more..
-
134
-
-
84879000598
-
Phosphorylation of ezh2 activates stat3 signaling via stat3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
-
Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, Oh YT, Kim H, Rheey J, Nakano I, Lee C, Joo KM, Rich JN, Nam DH, Lee J. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 2013; 23: 839-852.
-
(2013)
Cancer Cell
, vol.23
, pp. 839-852
-
-
Kim, E.1
Kim, M.2
Woo, D.H.3
Shin, Y.4
Shin, J.5
Chang, N.6
Oh, Y.T.7
Kim, H.8
Rheey, J.9
Nakano, I.10
Lee, C.11
Joo, K.M.12
Rich, J.N.13
Nam, D.H.14
Lee, J.15
-
135
-
-
84855323192
-
Prc2 directly methylates gata4 and represses its transcriptional activity
-
He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev 2012; 26: 37-42.
-
(2012)
Genes Dev
, vol.26
, pp. 37-42
-
-
He, A.1
Shen, X.2
Ma, Q.3
Cao, J.4
Von Gise, A.5
Zhou, P.6
Wang, G.7
Marquez, V.E.8
Orkin, S.H.9
Pu, W.T.10
-
136
-
-
84870308969
-
Ezh2 generates a methyl degron that is recognized by the dcaf1/ddb1/cul4 e3 ubiquitin ligase complex
-
Lee J., Lee J., Kim H, Kim K, Park H, Kim J., Lee SH, Kim IS, Kim J, Lee M, Chung CH, Seo SB, Yoon JB, Ko E, Noh DY, Kim KI, Kim KK, Baek SH. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell 2012; 48: 572-586.
-
(2012)
Mol Cell
, vol.48
, pp. 572-586
-
-
Lee, J.1
Lee, J.2
Kim, H.3
Kim, K.4
Park, H.5
Kim, J.6
Lee, S.H.7
Kim, I.S.8
Kim, J.9
Lee, M.10
Chung, C.H.11
Seo, S.B.12
Yoon, J.B.13
Ko, E.14
Noh, D.Y.15
Kim, K.I.16
Kim, K.K.17
Baek, S.H.18
-
137
-
-
78149285100
-
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of ezh2
-
Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat Cell Biol 2010; 12: 1108-1114.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1108-1114
-
-
Chen, S.1
Bohrer, L.R.2
Rai, A.N.3
Pan, Y.4
Gan, L.5
Zhou, X.6
Bagchi, A.7
Simon, J.A.8
Huang, H.9
-
138
-
-
78649807567
-
Phosphorylation of the prc2 component ezh2 is cell cycle-regulated and up-regulates its binding to ncrna
-
Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, Reinberg D. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev 2010; 24: 2615-2620.
-
(2010)
Genes Dev
, vol.24
, pp. 2615-2620
-
-
Kaneko, S.1
Li, G.2
Son, J.3
Xu, C.F.4
Margueron, R.5
Neubert, T.A.6
Reinberg, D.7
-
139
-
-
78650511231
-
Cdk1-dependent phosphorylation of ezh2 suppresses methylation of h3k27 and promotes osteogenic differentiation of human mesenchymal stem cells
-
Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol 2011; 13: 87-94.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 87-94
-
-
Wei, Y.1
Chen, Y.H.2
Li, L.Y.3
Lang, J.4
Yeh, S.P.5
Shi, B.6
Yang, C.C.7
Yang, J.Y.8
Lin, C.Y.9
Lai, C.C.10
Hung, M.C.11
-
140
-
-
80051496158
-
Cyclin-dependent kinase 1 (cdk1)-mediated phosphorylation of enhancer of zeste 2 (ezh2) regulates its stability
-
Wu SC, Zhang Y. Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability. J Biol Chem 2011; 286: 28511-28519.
-
(2011)
J Biol Chem
, vol.286
, pp. 28511-28519
-
-
Wu, S.C.1
Zhang, Y.2
-
141
-
-
84893414724
-
O-glcnacylation regulates ezh2 protein stability and function
-
Chu CS, Lo PW, Yeh YH, Hsu PH, Peng SH, Teng YC, Kang ML, Wong CH, Juan LJ. O-GlcNAcylation regulates EZH2 protein stability and function. Proc Natl Acad Sci U S A 2014; 111: 1355-1360.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 1355-1360
-
-
Chu, C.S.1
Lo, P.W.2
Yeh, Y.H.3
Hsu, P.H.4
Peng, S.H.5
Teng, Y.C.6
Kang, M.L.7
Wong, C.H.8
Juan, L.J.9
-
142
-
-
79951983645
-
Cancer stem cell epigenetics and chemoresistance
-
Crea F, Danesi R, Farrar WL. Cancer stem cell epigenetics and chemoresistance. Epigenomics 2009; 1: 63-79.
-
(2009)
Epigenomics
, vol.1
, pp. 63-79
-
-
Crea, F.1
Danesi, R.2
Farrar, W.L.3
-
143
-
-
49649114332
-
Cancer stem cells: The seeds of metastasis?
-
Hurt EM, Farrar WL. Cancer stem cells: the seeds of metastasis? Mol Interv 2008; 8: 140-142.
-
(2008)
Mol Interv
, vol.8
, pp. 140-142
-
-
Hurt, E.M.1
Farrar, W.L.2
-
144
-
-
79957563769
-
The roles of ezh2 in cell lineage commitment
-
Chou RH, Yu YL, Hung MC. The roles of EZH2 in cell lineage commitment. Am J Transl Res 2011; 15: 243-250.
-
(2011)
Am J Transl Res
, vol.15
, pp. 243-250
-
-
Chou, R.H.1
Yu, Y.L.2
Hung, M.C.3
-
145
-
-
84868016543
-
Ezh2: A pivotal regulator in controlling cell differentiation
-
Chen YH, Hung MC, Li LY. EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res 2012; 4: 364-375.
-
(2012)
Am J Transl Res
, vol.4
, pp. 364-375
-
-
Chen, Y.H.1
Hung, M.C.2
Li, L.Y.3
-
146
-
-
37349067098
-
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
-
Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008; 13: 69-80.
-
(2008)
Cancer Cell
, vol.13
, pp. 69-80
-
-
Lee, J.1
Son, M.J.2
Woolard, K.3
Donin, N.M.4
Li, A.5
Cheng, C.H.6
Kotliarova, S.7
Kotliarov, Y.8
Walling, J.9
Ahn, S.10
Kim, M.11
Totonchy, M.12
Cusack, T.13
Ene, C.14
Ma, H.15
Su, Q.16
Zenklusen, J.C.17
Zhang, W.18
Maric, D.19
Fine, H.A.20
more..
-
147
-
-
73649102464
-
Ezh2 is essential for glioblastoma cancer stem cell maintenance
-
Suvà ML, Riggi N, Janiszewska M, Radovanovic I, Provero P, Stehle JC, Baumer K, Le Bitoux MA, Marino D, Cironi L, Marquez VE, Clément V, Stamenkovic I. EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res 2009; 69: 9211-9218.
-
(2009)
Cancer Res
, vol.69
, pp. 9211-9218
-
-
Suvà, M.L.1
Riggi, N.2
Janiszewska, M.3
Radovanovic, I.4
Provero, P.5
Stehle, J.C.6
Baumer, K.7
Le Bitoux, M.A.8
Marino, D.9
Cironi, L.10
Marquez, V.E.11
Clément, V.12
Stamenkovic, I.13
-
148
-
-
84880857612
-
Chromatin regulator prc2 is a key regulator of epigenetic plasticity in glioblastoma
-
Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y and Kondo Y. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in Glioblastoma. Cancer Res 2013; 73: 4559-4570.
-
(2013)
Cancer Res
, vol.73
, pp. 4559-4570
-
-
Natsume, A.1
Ito, M.2
Katsushima, K.3
Ohka, F.4
Hatanaka, A.5
Shinjo, K.6
Sato, S.7
Takahashi, S.8
Ishikawa, Y.9
Takeuchi, I.10
Shimogawa, H.11
Uesugi, M.12
Okano, H.13
Kim, S.U.14
Wakabayashi, T.15
Issa, J.P.16
Sekido, Y.17
Kondo, Y.18
-
149
-
-
60149096212
-
Downregulation of ezh2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires brca1
-
Gonzalez ME, Li X, Toy K, DuPrie M, Ventura AC, Banerjee M, Ljungman M, Merajver SD, Kleer CG. Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1. Oncogene 2009; 28: 843-853.
-
(2009)
Oncogene
, vol.28
, pp. 843-853
-
-
Gonzalez, M.E.1
Li, X.2
Toy, K.3
Duprie, M.4
Ventura, A.C.5
Banerjee, M.6
Ljungman, M.7
Merajver, S.D.8
Kleer, C.G.9
-
150
-
-
79954471872
-
Ezh2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/cdkn1a expression
-
Fan T, Jiang S, Chung N, Alikhan A, Ni C, Lee CC, Hornyak TJ. EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. Mol Cancer Res 2011; 9: 418-429.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 418-429
-
-
Fan, T.1
Jiang, S.2
Chung, N.3
Alikhan, A.4
Ni, C.5
Lee, C.C.6
Hornyak, T.J.7
-
151
-
-
34247625135
-
Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
-
Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RK, Tan PB, Liu ET, Yu Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007; 21: 1050-1063.
-
(2007)
Genes Dev
, vol.21
, pp. 1050-1063
-
-
Tan, J.1
Yang, X.2
Zhuang, L.3
Jiang, X.4
Chen, W.5
Lee, P.L.6
Karuturi, R.K.7
Tan, P.B.8
Liu, E.T.9
Yu, Q.10
-
152
-
-
75749088216
-
Brca1-deficient mammary tumor cells are dependent on ezh2 expression and sensitive to polycomb repressive complex 2-inhibitor 3-deazaneplanocin a
-
Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen-Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM. BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A. Breast Cancer Res 2009; 11: R63.
-
(2009)
Breast Cancer Res
, vol.11
, pp. R63
-
-
Puppe, J.1
Drost, R.2
Liu, X.3
Joosse, S.A.4
Evers, B.5
Cornelissen-Steijger, P.6
Nederlof, P.7
Yu, Q.8
Jonkers, J.9
Van Lohuizen, M.10
Pietersen, A.M.11
-
153
-
-
79958822224
-
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: Implications for adoptive immunotherapy of cancer
-
Rao M, Chinnasamy N, Hong JA, Zhang Y, Zhang M, Xi S, Liu F, Marquez VE, Morgan RA, Schrump DS. Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. Cancer Res 2011; 71: 4192-4204.
-
(2011)
Cancer Res
, vol.71
, pp. 4192-4204
-
-
Rao, M.1
Chinnasamy, N.2
Hong, J.A.3
Zhang, Y.4
Zhang, M.5
Xi, S.6
Liu, F.7
Marquez, V.E.8
Morgan, R.A.9
Schrump, D.S.10
-
154
-
-
79951825513
-
Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress ezh2
-
Rizzo S, Hersey JM, Mellor P, Dai W, SantosSilva A, Liber D, Luk L, Titley I, Carden CP. Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2. Mol Cancer Ther 2011; 10: 325-335.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 325-335
-
-
Rizzo, S.1
Hersey, J.M.2
Mellor, P.3
Dai, W.4
Santossilva, A.5
Liber, D.6
Luk, L.7
Titley, I.8
Carden, C.P.9
-
155
-
-
67649371461
-
Dznep is a global histone methylation inhibitor that reactivates developmental genes not silenced by dna methylation
-
Miranda TB, Cortez CC, Yoo CB, Liang G, Abe M, Kelly TK, Marquez VE, Jones PA. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther 2009; 8: 1579-1588.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1579-1588
-
-
Miranda, T.B.1
Cortez, C.C.2
Yoo, C.B.3
Liang, G.4
Abe, M.5
Kelly, T.K.6
Marquez, V.E.7
Jones, P.A.8
-
156
-
-
79960367903
-
Chemogenetic analysis of human protein methyltransferases
-
Richon VM, Johnston D, Sneeringer CJ, Jin L, Majer CR, Elliston K, Jerva LF, Scott MP, Copeland RA. Chemogenetic analysis of human protein methyltransferases. Chem Biol Drug Des 2011; 78: 199-210.
-
(2011)
Chem Biol Drug Des
, vol.78
, pp. 199-210
-
-
Richon, V.M.1
Johnston, D.2
Sneeringer, C.J.3
Jin, L.4
Majer, C.R.5
Elliston, K.6
Jerva, L.F.7
Scott, M.P.8
Copeland, R.A.9
-
157
-
-
84867632489
-
A selective inhibitor of ezh2 blocks h3k27 methylation and kills mutant lymphoma cells
-
Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, Raimondi A, Majer CR, Song J, Scott MP, Jin L, Smith JJ, Olhava EJ, Chesworth R, Moyer MP, Richon VM, Copeland RA, Keilhack H, Pollock RM, Kuntz KW. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol 2012; 8: 890-896.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 890-896
-
-
Knutson, S.K.1
Wigle, T.J.2
Warholic, N.M.3
Sneeringer, C.J.4
Allain, C.J.5
Klaus, C.R.6
Sacks, J.D.7
Raimondi, A.8
Majer, C.R.9
Song, J.10
Scott, M.P.11
Jin, L.12
Smith, J.J.13
Olhava, E.J.14
Chesworth, R.15
Moyer, M.P.16
Richon, V.M.17
Copeland, R.A.18
Keilhack, H.19
Pollock, R.M.20
Kuntz, K.W.21
more..
-
158
-
-
84921318899
-
Selective inhibition of ezh2 by epz-6438 leads to potent antitumor activity in ezh2-mutant non-hodgkin lymphoma
-
Knutson SK, Kawano S, Minoshima Y, Warholic NM, Huang KC, Xiao Y, Kadowaki T, Uesugi M, Kuznetsov G, Kumar N, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Waters NJ, Smith JJ, Porter-Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Uenaka T, Pollock RM, Kuntz KW, Yokoi A, Keilhack H. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther 2014; 13: 842-854.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 842-854
-
-
Knutson, S.K.1
Kawano, S.2
Minoshima, Y.3
Warholic, N.M.4
Huang, K.C.5
Xiao, Y.6
Kadowaki, T.7
Uesugi, M.8
Kuznetsov, G.9
Kumar, N.10
Wigle, T.J.11
Klaus, C.R.12
Allain, C.J.13
Raimondi, A.14
Waters, N.J.15
Smith, J.J.16
Porter-Scott, M.17
Chesworth, R.18
Moyer, M.P.19
Copeland, R.A.20
Richon, V.M.21
Uenaka, T.22
Pollock, R.M.23
Kuntz, K.W.24
Yokoi, A.25
Keilhack, H.26
more..
-
159
-
-
84871841675
-
Selective inhibition of ezh2 by a small molecule inhibitor blocks tumor cells proliferation
-
Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, Zeng J, Li M, Fan H, Lin Y, Gu J, Ardayfio O, Zhang J., Yan X, Fang J, Mi Y, Zhang M, Zhou T, Feng G, Chen Z, Li G, Yang T, Zhao K, Liu X, Yu Z, Lu CX, Atadja P, Li E. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 2012; 109: 21360-21365.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 21360-21365
-
-
Qi, W.1
Chan, H.2
Teng, L.3
Li, L.4
Chuai, S.5
Zhang, R.6
Zeng, J.7
Li, M.8
Fan, H.9
Lin, Y.10
Gu, J.11
Ardayfio, O.12
Zhang, J.13
Yan, X.14
Fang, J.15
Mi, Y.16
Zhang, M.17
Zhou, T.18
Feng, G.19
Chen, Z.20
Li, G.21
Yang, T.22
Zhao, K.23
Liu, X.24
Yu, Z.25
Lu, C.X.26
Atadja, P.27
Li, E.28
more..
-
160
-
-
84879750981
-
An orally bioavailable chemical probe of the lysine methyltransferases ezh2 and ezh1
-
Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol 2013; 8: 1324-1334.
-
(2013)
ACS Chem Biol
, vol.8
, pp. 1324-1334
-
-
Konze, K.D.1
Ma, A.2
Li, F.3
Barsyte-Lovejoy, D.4
Parton, T.5
Macnevin, C.J.6
Liu, F.7
Gao, C.8
Huang, X.P.9
Kuznetsova, E.10
Rougie, M.11
Jiang, A.12
Pattenden, S.G.13
Norris, J.L.14
James, L.I.15
Roth, B.L.16
Brown, P.J.17
Frye, S.V.18
Arrowsmith, C.H.19
Hahn, K.M.20
Wang, G.G.21
Vedadi, M.22
Jin, J.23
more..
-
161
-
-
84870573126
-
Ezh2 inhibition as a therapeutic strategy for lymphoma with ezh2-activating mutations
-
McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, Liu Y, Graves AP, Della Pietra A 3rd, Diaz E, LaFrance LV, Mellinger M, Duquenne C, Tian X, Kruger RG, McHugh CF, Brandt M, Miller WH, Dhanak D, Verma SK, Tummino PJ, Creasy CL. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012; 492: 108-112.
-
(2012)
Nature
, vol.492
, pp. 108-112
-
-
McCabe, M.T.1
Ott, H.M.2
Ganji, G.3
Korenchuk, S.4
Thompson, C.5
Van Aller, G.S.6
Liu, Y.7
Graves, A.P.8
Della Pietra, A.9
Diaz, E.10
Lafrance, L.V.11
Mellinger, M.12
Duquenne, C.13
Tian, X.14
Kruger, R.G.15
McHugh, C.F.16
Brandt, M.17
Miller, W.H.18
Dhanak, D.19
Verma, S.K.20
Tummino, P.J.21
Creasy, C.L.22
more..
-
162
-
-
84884532954
-
Targeted disruption of the ezh2-eed complex inhibits ezh2-dependent cancer
-
Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 2013; 9: 643-650.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 643-650
-
-
Kim, W.1
Bird, G.H.2
Neff, T.3
Guo, G.4
Kerenyi, M.A.5
Walensky, L.D.6
Orkin, S.H.7
-
163
-
-
80053139713
-
(-)-epigallocatechin-3-gallate and dznep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells
-
Choudhury SR, Balasubramanian S, Chew YC, Han B, Marquez VE, Eckert RL. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis 2011; 32: 1525-132.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1525-2132
-
-
Choudhury, S.R.1
Balasubramanian, S.2
Chew, Y.C.3
Han, B.4
Marquez, V.E.5
Eckert, R.L.6
-
164
-
-
77950889840
-
Dietary omega-3 polyunsaturated fatty acids suppress expression of ezh2 in breast cancer cells
-
Dimri M, Bommi PV, Sahasrabuddhe AA, Khandekar JD, Dimri GP. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. Carcinogenesis 2010; 31: 489-495.
-
(2010)
Carcinogenesis
, vol.31
, pp. 489-495
-
-
Dimri, M.1
Bommi, P.V.2
Sahasrabuddhe, A.A.3
Khandekar, J.D.4
Dimri, G.P.5
-
165
-
-
77953289499
-
Curcumin induces downregulation of ezh2 expression through the mapk pathway in mda-mb-435 human breast cancer cells
-
Hua WF, Fu YS, Liao YJ, Xia WJ, Chen YC, Zeng YX, Kung HF, Xie D. Curcumin induces downregulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. Eur J Pharmacol 2010; 637: 16-21.
-
(2010)
Eur J Pharmacol
, vol.637
, pp. 16-21
-
-
Hua, W.F.1
Fu, Y.S.2
Liao, Y.J.3
Xia, W.J.4
Chen, Y.C.5
Zeng, Y.X.6
Kung, H.F.7
Xie, D.8
-
166
-
-
84859099474
-
Increased metastasis in patients with familial early-stage breast cancer and high ezh2 expression
-
risk for distant
-
Alford SH, Toy K, Merajver SD, Kleer CG. Increased metastasis in patients with familial early-stage breast cancer and high EZH2 expression. Breast Cancer Res Treat 2012; 132: risk for distant 429-437.
-
(2012)
Breast Cancer Res Treat
, vol.132
, pp. 429-437
-
-
Alford, S.H.1
Toy, K.2
Merajver, S.D.3
Kleer, C.G.4
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