-
1
-
-
65449166411
-
Novel structural insights into class I and II histone deacetylases
-
Ficner,R. (2009) Novel structural insights into class I and II histone deacetylases. Curr. Top. Med. Chem., 9, 235-240.
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, pp. 235-240
-
-
Ficner, R.1
-
2
-
-
67650090545
-
Histone deacetylase inhibitors: potential in cancer therapy
-
Marks,P.A. et al. (2009) Histone deacetylase inhibitors: potential in cancer therapy. J. Cell. Biochem., 107, 600-608.
-
(2009)
J. Cell. Biochem.
, vol.107
, pp. 600-608
-
-
Marks, P.A.1
-
3
-
-
33745685866
-
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
-
Sharma,D. et al. (2006) Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res., 66, 6370-6378.
-
(2006)
Cancer Res.
, vol.66
, pp. 6370-6378
-
-
Sharma, D.1
-
4
-
-
33645768490
-
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
-
Pruitt,K. et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet., 2, e40.
-
(2006)
PLoS Genet.
, vol.2
-
-
Pruitt, K.1
-
5
-
-
67649399669
-
Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study
-
Traynor,A.M. et al. (2009) Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study. J. Thorac. Oncol., 4, 522-526.
-
(2009)
J. Thorac. Oncol.
, vol.4
, pp. 522-526
-
-
Traynor, A.M.1
-
6
-
-
58149242889
-
A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study
-
Luu,T.H. et al. (2008) A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study. Clin. Cancer Res., 14, 7138-7142.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 7138-7142
-
-
Luu, T.H.1
-
7
-
-
43049091153
-
A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study
-
Modesitt,S.C. et al. (2008) A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol. Oncol., 109, 182-186.
-
(2008)
Gynecol. Oncol.
, vol.109
, pp. 182-186
-
-
Modesitt, S.C.1
-
8
-
-
38149140216
-
Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer
-
Blumenschein,G.R. Jr et al. (2008) Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer. Invest. New Drugs, 26, 81-87.
-
(2008)
Invest. New Drugs
, vol.26
, pp. 81-87
-
-
Blumenschein Jr., G.R.1
-
9
-
-
0242442588
-
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer
-
Belinsky,S.A. et al. (2003) Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res., 63, 7089-7093.
-
(2003)
Cancer Res.
, vol.63
, pp. 7089-7093
-
-
Belinsky, S.A.1
-
10
-
-
55749101363
-
Histone deacetylase inhibitors in cancer therapy
-
Lee,M.J. et al. (2008) Histone deacetylase inhibitors in cancer therapy. Curr. Opin. Oncol., 20, 639-649.
-
(2008)
Curr. Opin. Oncol.
, vol.20
, pp. 639-649
-
-
Lee, M.J.1
-
11
-
-
34248193440
-
Histone deacetylase inhibitors in cancer therapy
-
Rasheed,W.K. et al. (2007) Histone deacetylase inhibitors in cancer therapy. Expert Opin. Investig. Drugs, 16, 659-678.
-
(2007)
Expert Opin. Investig. Drugs
, vol.16
, pp. 659-678
-
-
Rasheed, W.K.1
-
12
-
-
34249934238
-
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
-
Huang,Y. et al. (2007) Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc. Natl Acad. Sci. USA, 104, 8023-8028.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8023-8028
-
-
Huang, Y.1
-
13
-
-
73149118652
-
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes
-
Huang,Y. et al. (2009) Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clin. Cancer Res., 15, 7217-7228.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 7217-7228
-
-
Huang, Y.1
-
14
-
-
84856230241
-
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
-
Huang,Y. et al. (2012) Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells. Breast Cancer Res. Treat., 131, 777-789.
-
(2012)
Breast Cancer Res. Treat.
, vol.131
, pp. 777-789
-
-
Huang, Y.1
-
15
-
-
77449090884
-
Polyamine analogues targeting epigenetic gene regulation
-
Huang,Y. et al. (2009) Polyamine analogues targeting epigenetic gene regulation. Essays Biochem., 46, 95-110.
-
(2009)
Essays Biochem.
, vol.46
, pp. 95-110
-
-
Huang, Y.1
-
16
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi,Y. et al. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell, 119, 941-953.
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
-
17
-
-
25144519737
-
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
-
Lee,M.G. et al. (2005) An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature, 437, 432-435.
-
(2005)
Nature
, vol.437
, pp. 432-435
-
-
Lee, M.G.1
-
18
-
-
33846690407
-
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
-
Garcia-Bassets,I. et al. (2007) Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell, 128, 505-518.
-
(2007)
Cell
, vol.128
, pp. 505-518
-
-
Garcia-Bassets, I.1
-
19
-
-
77950868547
-
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
-
Lim,S. et al. (2010) Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis, 31, 512-520.
-
(2010)
Carcinogenesis
, vol.31
, pp. 512-520
-
-
Lim, S.1
-
20
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger,E. et al. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature, 437, 436-439.
-
(2005)
Nature
, vol.437
, pp. 436-439
-
-
Metzger, E.1
-
21
-
-
33746668727
-
Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells
-
Abukhdeir,A.M. et al. (2006) Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells. Breast Cancer Res. Treat., 99, 23-33.
-
(2006)
Breast Cancer Res. Treat.
, vol.99
, pp. 23-33
-
-
Abukhdeir, A.M.1
-
22
-
-
12444295406
-
A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells
-
Huang,Y. et al. (2003) A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells. Clin. Cancer Res., 9, 2769-2777.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 2769-2777
-
-
Huang, Y.1
-
23
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
-
Chou,T.C. et al. (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul., 22, 27-55.
-
(1984)
Adv. Enzyme Regul.
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
-
24
-
-
0035942271
-
Significance analysis of microarrays applied to the ionizing radiation response
-
Tusher,V.G. et al. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA, 98, 5116-5121.
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5116-5121
-
-
Tusher, V.G.1
-
25
-
-
78650897140
-
Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
-
Alexopoulou,A.N. et al. (2010) Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines. Breast Cancer Res., 12, R51.
-
(2010)
Breast Cancer Res.
, vol.12
-
-
Alexopoulou, A.N.1
-
26
-
-
54249097887
-
Agglomerative epigenetic aberrations are a common event in human breast cancer
-
Novak,P. et al. (2008) Agglomerative epigenetic aberrations are a common event in human breast cancer. Cancer Res., 68, 8616-8625.
-
(2008)
Cancer Res.
, vol.68
, pp. 8616-8625
-
-
Novak, P.1
-
27
-
-
69249124530
-
RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling
-
Liang,G. et al. (2009) RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. J. Biol. Chem., 284, 21719-21727.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21719-21727
-
-
Liang, G.1
-
28
-
-
33845209913
-
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
-
Neve,R.M. et al. (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell, 10, 515-527.
-
(2006)
Cancer Cell
, vol.10
, pp. 515-527
-
-
Neve, R.M.1
-
29
-
-
33847111684
-
Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation
-
Zhou,Q. et al. (2007) Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation. Cancer Biol. Ther., 6, 64-69.
-
(2007)
Cancer Biol. Ther.
, vol.6
, pp. 64-69
-
-
Zhou, Q.1
-
30
-
-
33847065486
-
The epigenomics of cancer
-
Jones,P.A. et al. (2007) The epigenomics of cancer. Cell, 128, 683-692.
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
-
31
-
-
80755173292
-
Epigenetics in breast cancer: what's new?
-
Huang,Y. et al. (2011) Epigenetics in breast cancer: what's new? Breast Cancer Res., 13, 225.
-
(2011)
Breast Cancer Res
, vol.13
, pp. 225
-
-
Huang, Y.1
-
32
-
-
0030764346
-
Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids
-
Wu,Q. et al. (1997) Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids. Mol. Cell. Biol., 17, 6598-6608.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6598-6608
-
-
Wu, Q.1
-
33
-
-
33746883125
-
p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction
-
Moll,U.M. et al. (2006) p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction. Oncogene, 25, 4725-4743.
-
(2006)
Oncogene
, vol.25
, pp. 4725-4743
-
-
Moll, U.M.1
-
34
-
-
0030029727
-
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family
-
Druey,K.M. et al. (1996) Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature, 379, 742-746.
-
(1996)
Nature
, vol.379
, pp. 742-746
-
-
Druey, K.M.1
-
35
-
-
0344528755
-
RGS proteins: more than just GAPs for heterotrimeric G proteins
-
De Vries,L. et al. (1999) RGS proteins: more than just GAPs for heterotrimeric G proteins. Trends Cell Biol., 9, 138-144.
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 138-144
-
-
De Vries, L.1
-
36
-
-
77950675541
-
Histone demethylase LSD1 regulates neural stem cell proliferation
-
Sun,G. et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol., 30, 1997-2005.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 1997-2005
-
-
Sun, G.1
-
37
-
-
48249112654
-
A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas Genes
-
Wiechec,E. et al. (2008) A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas. Genes. Chromosomes Cancer, 47, 766-780.
-
(2008)
Chromosomes Cancer
, vol.47
, pp. 766-780
-
-
Wiechec, E.1
-
38
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
Ozes,O.N. et al. (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature, 401, 82-85.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
-
39
-
-
3442901974
-
NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen
-
deGraffenried,L.A. et al. (2004) NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen. Ann. Oncol., 15, 885-890.
-
(2004)
Ann. Oncol.
, vol.15
, pp. 885-890
-
-
deGraffenried, L.A.1
-
40
-
-
0041589149
-
Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells
-
Gong,L. et al. (2003) Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene, 22, 4702-4709.
-
(2003)
Oncogene
, vol.22
, pp. 4702-4709
-
-
Gong, L.1
-
41
-
-
79958192452
-
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors
-
Yoon,K. et al. (2011) Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis, 32, 836-842.
-
(2011)
Carcinogenesis
, vol.32
, pp. 836-842
-
-
Yoon, K.1
-
42
-
-
84862545879
-
Molecular pathways: the role of NR4A orphan nuclear receptors in cancer
-
Mohan,H.M. et al. (2012) Molecular pathways: the role of NR4A orphan nuclear receptors in cancer. Clin. Cancer Res., 18, 3223-3228.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 3223-3228
-
-
Mohan, H.M.1
-
43
-
-
0036203716
-
Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest
-
Budhu,A.S. et al. (2002) Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. Mol. Cell. Biol., 22, 2632-2641.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2632-2641
-
-
Budhu, A.S.1
|