Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

Leukemia

Volumn 27, Issue 4, 2013, Pages 813-822

  Chen, L ^a,b   Deshpande, A J ^a,c   Banka, D ^a,c   Bernt, K M ^a,c   Dias, S ^a,c   Buske, C ^d   Olhava, E J ^e   Daigle, S R ^e   Richon, V M ^e   Pollock, R M ^e   Armstrong, S A ^a,c,f  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e EPIZYME INC   (United States)

^f HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

CALM AF10; Dot1l; EPZ004777; leukemia; MLL fusions; MLL AF10

Indexed keywords

CLATHRIN ASSEMBLY LYMPHOID MYELOID LEUKEMIA; MIXED LINEAGE LEUKEMIA PROTEIN; ONCOPROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMOSOME TRANSLOCATION; GENE CLUSTER; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; HUMANS; METHYLTRANSFERASES; MICE; MICE, MUTANT STRAINS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84876143288     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.327     Document Type: Article

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