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Volumn 66, Issue 7, 2006, Pages 3541-3549

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; HISTONE H3; LYSINE;

EID: 33645751058     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2481     Document Type: Article
Times cited : (253)

References (49)
  • 1
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 2
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 3
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999;21:163-7.
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 4
    • 0037115392 scopus 로고    scopus 로고
    • Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
    • Fahrner JA, Eguchi S, Herman JG, Baylin SB. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res 2002;62:7213-8.
    • (2002) Cancer Res , vol.62 , pp. 7213-7218
    • Fahrner, J.A.1    Eguchi, S.2    Herman, J.G.3    Baylin, S.B.4
  • 5
    • 0037215568 scopus 로고    scopus 로고
    • Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer
    • Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol 2003;23:206-15.
    • (2003) Mol Cell Biol , vol.23 , pp. 206-215
    • Kondo, Y.1    Shen, L.2    Issa, J.P.3
  • 6
    • 0037112369 scopus 로고    scopus 로고
    • Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′- deoxycytidine
    • Nguyen CT, Weisenberger DJ, Velicescu M, et al. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Res 2002;62:6456-61.
    • (2002) Cancer Res , vol.62 , pp. 6456-6461
    • Nguyen, C.T.1    Weisenberger, D.J.2    Velicescu, M.3
  • 7
    • 0036889153 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure
    • Ghoshal K, Datta J, Majumder S, et al. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol 2002;22:8302-19.
    • (2002) Mol Cell Biol , vol.22 , pp. 8302-8319
    • Ghoshal, K.1    Datta, J.2    Majumder, S.3
  • 8
    • 0037672689 scopus 로고    scopus 로고
    • An epigenetic road map for histone lysine methylation
    • Lachner M, O'Sullivan RJ, Jenuwein T. An epigenetic road map for histone lysine methylation. J Cell Sci 2003;116:2117-24.
    • (2003) J Cell Sci , vol.116 , pp. 2117-2124
    • Lachner, M.1    O'Sullivan, R.J.2    Jenuwein, T.3
  • 9
    • 0036532202 scopus 로고    scopus 로고
    • Histone methylation in transcriptional control
    • Kouzarides T. Histone methylation in transcriptional control. Curr Opin Genet Dev 2002;12:198-209.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 198-209
    • Kouzarides, T.1
  • 10
    • 0036682364 scopus 로고    scopus 로고
    • Gene silencing: Trans-histone regulatory pathway in chromatin
    • Briggs SD, Xiao T, Sun ZW, et al. Gene silencing: trans-histone regulatory pathway in chromatin. Nature 2002;418:498-1.
    • (2002) Nature , vol.418 , pp. 498-501
    • Briggs, S.D.1    Xiao, T.2    Sun, Z.W.3
  • 12
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma Proc Natl Acad Sci U S A 1998;95:6870-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3
  • 13
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • Suzuki H, Watkins DN, Jair KW, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004;36:417-22.
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3
  • 14
    • 0036613250 scopus 로고    scopus 로고
    • A genomic screen for genes up-regulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    • Suzuki H, Gabrielson E, Chen W, et al. A genomic screen for genes up-regulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002;31:141-9.
    • (2002) Nat Genet , vol.31 , pp. 141-149
    • Suzuki, H.1    Gabrielson, E.2    Chen, W.3
  • 15
    • 0242552587 scopus 로고    scopus 로고
    • GATA-4 and GATA-5 transcription factor genes and potential down-stream antitumor target genes are epigenetically silenced in colorectal and gastric cancer
    • Akiyama Y, Watkins DN, Suzuki H, et al. GATA-4 and GATA-5 transcription factor genes and potential down-stream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol 2003;23:8429-39.
    • (2003) Mol Cell Biol , vol.23 , pp. 8429-8439
    • Akiyama, Y.1    Watkins, D.N.2    Suzuki, H.3
  • 16
    • 1042300236 scopus 로고    scopus 로고
    • Generation and characterization of methyl-lysine histone antibodies
    • Perez-Burgos L, Peters AH, Opravil S, et al. Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol 2004;376:234-54.
    • (2004) Methods Enzymol , vol.376 , pp. 234-254
    • Perez-Burgos, L.1    Peters, A.H.2    Opravil, S.3
  • 18
    • 0242668706 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in X inactivation
    • Plath K, Fang J, Mlynarczyk-Evans SK, et al. Role of histone H3 lysine 27 methylation in X inactivation. Science 2003;300:131-5.
    • (2003) Science , vol.300 , pp. 131-135
    • Plath, K.1    Fang, J.2    Mlynarczyk-Evans, S.K.3
  • 19
    • 0037387711 scopus 로고    scopus 로고
    • Establishment of histone h3 methylation on the inactive x chromosome requires transient recruitment of eed-enxl polycomb group complexes
    • Silva J, Mak W, Zvetkova I, et al. Establishment of histone h3 methylation on the inactive x chromosome requires transient recruitment of eed-enxl polycomb group complexes. Dev Cell 2003;4:481-95.
    • (2003) Dev Cell , vol.4 , pp. 481-495
    • Silva, J.1    Mak, W.2    Zvetkova, I.3
  • 20
    • 1842733449 scopus 로고    scopus 로고
    • HP1 and the dynamics of heterochromatin maintenance
    • Maison C, Almouzni G. HP1 and the dynamics of heterochromatin maintenance. Nat Rev Mol Cell Biol 2004;5:296-304.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 296-304
    • Maison, C.1    Almouzni, G.2
  • 21
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • Cao R, Wang L, Wang H, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002;298:1039-43.
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3
  • 22
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 2003;100:11606-11.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3
  • 23
    • 18644382388 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally S, Dhanasekaran SM, Zhou M, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002;419:624-9.
    • (2002) Nature , vol.419 , pp. 624-629
    • Varambally, S.1    Dhanasekaran, S.M.2    Zhou, M.3
  • 24
    • 8544226964 scopus 로고    scopus 로고
    • Loss of estrogen receptor signaling triggers epigenetic silencing of down-stream targets in breast cancer
    • Leu YW, Yan PS, Fan M, et al. Loss of estrogen receptor signaling triggers epigenetic silencing of down-stream targets in breast cancer. Cancer Res 2004;64:8184-92.
    • (2004) Cancer Res , vol.64 , pp. 8184-8192
    • Leu, Y.W.1    Yan, P.S.2    Fan, M.3
  • 25
    • 0031984480 scopus 로고    scopus 로고
    • SET domain proteins modulate chromatin domains in eu- and heterochromatin
    • Jenuwein T, Laible G, Dorn R, Reuter G. SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell Mol Life Sci 1998;54:80-93.
    • (1998) Cell Mol Life Sci , vol.54 , pp. 80-93
    • Jenuwein, T.1    Laible, G.2    Dorn, R.3    Reuter, G.4
  • 26
    • 0037099413 scopus 로고    scopus 로고
    • G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
    • Tachibana M, Sugimoto K, Nozaki M, et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev 2002;16:1779-91.
    • (2002) Genes Dev , vol.16 , pp. 1779-1791
    • Tachibana, M.1    Sugimoto, K.2    Nozaki, M.3
  • 27
    • 0035816682 scopus 로고    scopus 로고
    • Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
    • Tachibana M, Sugimoto K, Fukushima T, Shinkai Y. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem 2001;276:25309-17.
    • (2001) J Biol Chem , vol.276 , pp. 25309-25317
    • Tachibana, M.1    Sugimoto, K.2    Fukushima, T.3    Shinkai, Y.4
  • 28
    • 0347955358 scopus 로고    scopus 로고
    • Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
    • Rice JC, Briggs SD, Ueberheide B, et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell 2003;12:1591-8.
    • (2003) Mol Cell , vol.12 , pp. 1591-1598
    • Rice, J.C.1    Briggs, S.D.2    Ueberheide, B.3
  • 29
    • 18344390653 scopus 로고    scopus 로고
    • DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    • Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 2002;416:552-6.
    • (2002) Nature , vol.416 , pp. 552-556
    • Rhee, I.1    Bachman, K.E.2    Park, B.H.3
  • 30
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science 2001;293:1074-80.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 31
    • 10644221120 scopus 로고    scopus 로고
    • Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome
    • Chadwick BP, Willard HF. Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc Natl Acad Sci U S A 2004;101:17450-5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17450-17455
    • Chadwick, B.P.1    Willard, H.F.2
  • 32
    • 0042626332 scopus 로고    scopus 로고
    • Heterochromatin: Stable and unstable invasions at home and abroad
    • Fahrner JA, Baylin SB. Heterochromatin: stable and unstable invasions at home and abroad. Genes Dev 2003;17:1805-12.
    • (2003) Genes Dev , vol.17 , pp. 1805-1812
    • Fahrner, J.A.1    Baylin, S.B.2
  • 33
    • 0041624239 scopus 로고    scopus 로고
    • Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: A mammalian cell culture model of gene variegation
    • Ayyanathan K, Lechner MS, Bell P, et al. Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes Dev 2003;17:1855-69.
    • (2003) Genes Dev , vol.17 , pp. 1855-1869
    • Ayyanathan, K.1    Lechner, M.S.2    Bell, P.3
  • 34
    • 0036849262 scopus 로고    scopus 로고
    • Epigenetic consequences of nucleosome dynamics
    • Ahmad K, Henikoff S. Epigenetic consequences of nucleosome dynamics. Cell 2002;111:281-4.
    • (2002) Cell , vol.111 , pp. 281-284
    • Ahmad, K.1    Henikoff, S.2
  • 35
    • 0037058948 scopus 로고    scopus 로고
    • Histone H3 variants specify modes of chromatin assembly
    • Ahmad K, Henikoff S. Histone H3 variants specify modes of chromatin assembly. Proc Natl Acad Sci U S A 2002;99 Suppl 4:16477-84.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.SUPPL. 4 , pp. 16477-16484
    • Ahmad, K.1    Henikoff, S.2
  • 36
    • 0036299092 scopus 로고    scopus 로고
    • The histone variant H3.3 marks active chromatin by replication- independent nucleosome assembly
    • Ahmad K, Henikoff S. The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell 2002;9:1191-200.
    • (2002) Mol Cell , vol.9 , pp. 1191-1200
    • Ahmad, K.1    Henikoff, S.2
  • 37
    • 1242342240 scopus 로고    scopus 로고
    • Histone H3.3 is enriched in covalent modifications associated with active chromatin
    • McKittrick E, Gafken PR, Ahmad K, Henikoff S. Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A 2004;101:1525-30.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1525-1530
    • McKittrick, E.1    Gafken, P.R.2    Ahmad, K.3    Henikoff, S.4
  • 38
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004;119:941-53.
    • (2004) Cell , vol.119 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3
  • 39
    • 24144462170 scopus 로고    scopus 로고
    • LSD1 demethylates repressive histone marks to promoter androgen-receptor-dependent transcription
    • Metzger E, Wissman M, Yin N, et al. LSD1 demethylates repressive histone marks to promoter androgen-receptor-dependent transcription. Nature 2005;437:436-9.
    • (2005) Nature , vol.437 , pp. 436-439
    • Metzger, E.1    Wissman, M.2    Yin, N.3
  • 40
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999;21:103-7.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 41
    • 4444283219 scopus 로고    scopus 로고
    • Cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
    • Sun FL, Haynes K, Simpson CL, et al. cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol 2004;24:8210-20.
    • (2004) Mol Cell Biol , vol.24 , pp. 8210-8220
    • Sun, F.L.1    Haynes, K.2    Simpson, C.L.3
  • 42
    • 12144289862 scopus 로고    scopus 로고
    • From silencing to gene expression: Real-time analysis in single cells
    • Janicki SM, Tsukamoto T, Salghetti SE, et al. From silencing to gene expression: real-time analysis in single cells. Cell 2004;116:683-98.
    • (2004) Cell , vol.116 , pp. 683-698
    • Janicki, S.M.1    Tsukamoto, T.2    Salghetti, S.E.3
  • 43
    • 0030909701 scopus 로고    scopus 로고
    • DNA methylation changes in hematologic malignancies: Biologic and clinical implications
    • Issa JP, Baylin SB, Herman JG. DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia 1997;11 Suppl 1:57-11.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 1 , pp. 57-111
    • Issa, J.P.1    Baylin, S.B.2    Herman, J.G.3
  • 44
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002;20:2429-40.
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 45
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic thereapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic thereapy. Nature 2004;429:457-63.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 46
    • 0036135014 scopus 로고    scopus 로고
    • Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
    • Liang G, Chan MF, Tomigahara Y, et al. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol 2002;22:480-91.
    • (2002) Mol Cell Biol , vol.22 , pp. 480-491
    • Liang, G.1    Chan, M.F.2    Tomigahara, Y.3
  • 47
    • 0035891265 scopus 로고    scopus 로고
    • A histone H3 methyltransferase Controls DNA methylation in Neurospora crassa
    • Tamaru H, Selker EU. A histone H3 methyltransferase Controls DNA methylation in Neurospora crassa. Nature 2001;414:277-83.
    • (2001) Nature , vol.414 , pp. 277-283
    • Tamaru, H.1    Selker, E.U.2
  • 48
    • 0037143444 scopus 로고    scopus 로고
    • Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation
    • Johnson L, Cao X, Jacobsen S. Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation. Curr Biol 2002;12:1360-7.
    • (2002) Curr Biol , vol.12 , pp. 1360-1367
    • Johnson, L.1    Cao, X.2    Jacobsen, S.3
  • 49
    • 0037041422 scopus 로고    scopus 로고
    • Control of CpNpG DNA methylation by the KRYP-TONITE histone H3 methyltransferase
    • Jackson JP, Lindroth AM, Cao X, Jacobsen SE. Control of CpNpG DNA methylation by the KRYP-TONITE histone H3 methyltransferase. Nature 2002;416:556-60.
    • (2002) Nature , vol.416 , pp. 556-560
    • Jackson, J.P.1    Lindroth, A.M.2    Cao, X.3    Jacobsen, S.E.4


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