NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)

Blood

Volumn 99, Issue 10, 2002, Pages 3857-3860

  Rosati, Roberto ^a,b,c,d,e   La Starza, Roberta ^a,b,c,d,e   Veronese, Angelo ^a,b,c,d,e   Aventin, Ana ^a,b,c,d,e   Schwienbacher, Christine ^a,b,c,d,e   Vallespi, Teresa ^a,b,c,d,e   Negrini, Massimo ^a,b,c,d,e   Martelli, Massimo F ^a,b,c,d,e   Mecucci, Cristina ^a,b,c,d,e,f  

^a UNIVERSITY OF PERUGIA   (Italy)

^b Department of Radiation Oncology   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

^d University Hospital Sant Pau   (Spain)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f POLICLINICO MONTELUCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 8; CYTOGENETICS; DNA RESTRICTION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DISRUPTION; GENE FUSION; GENE STRUCTURE; HUMAN; HUMAN CELL; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0037093259     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.10.3857     Document Type: Article

References (23)

1. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)
2. NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia
3. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35; p15.5) in de novo childhood acute myeloid leukemia
4. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
5. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
6. t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF)
7. The inv(11)(p15q22) chromosome translocation of the novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase RNA gene, DDX10
8. The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
9. The t(4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia
10. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
11. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome
12. Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2
13. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia
14. MOZ is fused to p300 in an acute monocytic leukemia with t(8;22)
15. The t(6; 8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
16. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)
17. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
18. t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: Characterization of a new subset of T acute lymphoblastic leukaemia
19. NSD3, a new set-domain containing gene, maps to 8p12 and is amplified in human breast cancer cell lines
20. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
21. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
22. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity