A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L

Journal of Medicinal Chemistry

Volumn 56, Issue 22, 2013, Pages 8972-8983

  Anglin, Justin L ^a   Song, Yongcheng ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; DOT1L PROTEIN; HISTONE LYSINE METHYLTRANSFERASE; HISTONE LYSINE METHYLTRANSFERASE INHIBITOR; MIXED LINEAGE LEUKEMIA PROTEIN; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; BIOCHEMISTRY; BIOLOGICAL ACTIVITY; CANCER PROGNOSIS; COMPETITIVE INHIBITION; DRUG HALF LIFE; DRUG POTENCY; DRUG TARGETING; EMBRYO DEVELOPMENT; GENE CONTROL; GENETIC TRANSCRIPTION; HISTONE METHYLATION; HUMAN; IC 50; IN VIVO STUDY; LEUKEMIA CELL LINE; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PROTEIN LOCALIZATION; REVIEW; STRUCTURAL GENOMICS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DISEASE; ENZYME INHIBITORS; HISTONES; HUMANS; LYSINE; METHYLTRANSFERASES;

EID: 84889240753     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4007752     Document Type: Review

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