The promise and peril of chemical probes

Nature Chemical Biology

Volumn 11, Issue 8, 2015, Pages 536-541

  Arrowsmith, Cheryl H ^a,b   Audia, James E ^c   Austin, Christopher ^d   Baell, Jonathan ^e   Bennett, Jonathan ^f   Blagg, Julian ^g   Bountra, Chas ^h   Brennan, Paul E ^h,i   Brown, Peter J ^a   Bunnage, Mark E ^j   Buser Doepner, Carolyn ^k   Campbell, Robert M ^l   Carter, Adrian J ^m   Cohen, Philip ⁿ   Copeland, Robert A ^o   Cravatt, Ben ^p   Dahlin, Jayme L ^q   Dhanak, Dashyant ^r   Edwards, Aled M ^a   Frye, Stephen V ^s   Gray, Nathanael ^t   Grimshaw, Charles E ^u   Hepworth, David ^j   Howe, Trevor ^r   Huber, Kilian V M ^v   Jin, Jian ^w   Knapp, Stefan ^h,i   Kotz, Joanne D ^x   Kruger, Ryan G ^k   Lowe, Derek ^y   Mader, Mary M ^l   Marsden, Brian ^h   Mueller Fahrnow, Anke ^z   Müller, Susanne ^h,i   O'Hagan, Ronan C ^f   Overington, John P ^aa,ab   Owen, Dafydd R ^j   Rosenberg, Saul H ^ac   Roth, Brian ^ad   Ross, Ruth ^ae   Schapira, Matthieu ^a,ae   Schreiber, Stuart L ^x   Shoichet, Brian ^af   Sundström, Michael ^ag,ah   Superti Furga, Giulio ^v,ai   Taunton, Jack ^af,aj   Toledo Sherman, Leticia ^ak   Walpole, Chris ^al   Walters, Michael A ^am   Willson, Timothy M ^s,ad   Workman, Paul ^g   Young, Robert N ^an   Zuercher, William J ^s,ad   more..

^a Structural Genomics Consortium   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Department of Structural Biology   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e MONASH UNIVERSITY   (Australia)

^f MERCK RESEARCH LABORATORIES   (United States)

^g INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

^j PFIZER INC   (United States)

^k GLAXOSMITHKLINE   (United States)

^l ELI LILLY AND COMPANY   (United States)

^m BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

ⁿ UNIVERSITY OF DUNDEE   (United Kingdom)

^o EPIZYME INC   (United States)

^p SCRIPPS RESEARCH INSTITUTE   (United States)

^q MAYO GRADUATE SCHOOL   (United States)

^r JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^s UNIVERSITY OF NORTH CAROLINA   (United States)

^t HARVARD MEDICAL SCHOOL   (United States)

^u Takeda San Diego Inc   (United States)

^v ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^w MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^x BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^y VERTEX PHARMACEUTICALS   (United States)

^z BAYER PHARMA AG   (Germany)

^aa WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ab Stratified Medical   (United Kingdom)

^ac ABBVIE INC   (United States)

^ad University of North Carolina   (United States)

^ae UNIVERSITY OF TORONTO   (Canada)

^af UNIVERSITY OF CALIFORNIA   (United States)

^ag KAROLINSKA INSTITUTE   (Sweden)

^ah KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^ai MEDICAL UNIVERSITY OF VIENNA   (Austria)

^aj UNIVERSITY OF CALIFORNIA   (United States)

^ak CHDI MANAGEMENT CHDI FOUNDATION   (United States)

^al MCGILL UNIVERSITY   (Canada)

^am UNIVERSITY OF MINNESOTA   (United States)

^an SIMON FRASER UNIVERSITY   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

REAGENT; RESVERATROL; MOLECULAR LIBRARY; MOLECULAR PROBE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ATHEROSCLEROSIS; CLINICAL PRACTICE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COMMUNITY; CYTOLOGY; DRUG DEVELOPMENT; HEALTH CARE QUALITY; IN VITRO STUDY; MEDICINAL CHEMISTRY; MOLECULAR WEIGHT; NOTE; PATENT; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PUBLICATION; SCIENTIFIC LITERATURE; CHEMISTRY; DEVICES; ETHICS; HUMAN; INFORMATION DISSEMINATION; INTERNET; MEDICAL RESEARCH; MOLECULAR LIBRARY; MOLECULAR PROBE; PHARMACOLOGY; PROCEDURES; SENSITIVITY AND SPECIFICITY;

BIOMEDICAL RESEARCH; HUMANS; INFORMATION DISSEMINATION; INTELLECTUAL PROPERTY; INTERNET; MOLECULAR PROBES; MOLECULAR WEIGHT; SENSITIVITY AND SPECIFICITY; SMALL MOLECULE LIBRARIES;

EID: 84937416706     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1867     Document Type: Note

References (39)

1. Martinez Molina, D. et al. Science 341, 84-87 (2013).
2. Thirumurugan, P., Matosiuk, D. & Jozwiak, K. Chem. Rev. 113, 4905-4979 (2013).
3. Baell, J. & Walters, M.A. Nature 513, 481-483 (2014).
4. Bunnage, M.E., Chekler, E.L. & Jones, L.H. Nat. Chem. Biol. 9, 195-199 (2013).
5. Frye, S.V. Nat. Chem. Biol. 6, 159-161 (2010).
6. Workman, P. & Collins, I. Chem. Biol. 17, 561-577 (2010).
7. Sassano, M.F., Doak, A.K., Roth, B.L. & Shoichet, B.K. J. Med. Chem. 56, 2406-2414 (2013).
8. Weiss, W.A., Taylor, S.S. & Shokat, K.M. Nat. Chem. Biol. 3, 739-744 (2007).
9. Sweis, R.F. ACS Med. Chem. Lett. 6, 618-621 (2015).
10. Clark, K. et al. Proc. Natl. Acad. Sci. USA 109, 16986-16991 (2012).
11. Simon, G.M., Niphakis, M.J. & Cravatt, B.F. Nat. Chem. Biol. 9, 200-205 (2013).
12. Collins, J.L. et al. J. Med. Chem. 45, 1963-1966 (2002).
13. Hong, C. & Tontonoz, P. Nat. Rev. Drug Discov. 13, 433-444 (2014).
14. Filippakopoulos, P. & Knapp, S. Nat. Rev. Drug Discov. 13, 337-356 (2014).
15. Garnier, J.M., Sharp, P.P. & Burns, C.J. Expert Opin. Ther. Pat. 24, 185-199 (2014).
16. Edwards, A.M. et al. Nature 470, 163-165 (2011).
17. Liu, X. et al. Clin. Cancer Res. 18, 510-523 (2012).
18. Hidaka, H., Inagaki, M., Kawamoto, S. & Sasaki, Y. Biochemistry 23, 5036-5041 (1984).
19. Tamaoki, T. et al. Biochem. Biophys. Res. Commun. 135, 397-402 (1986).
20. Knapp, S. & Sundstrom, M. Curr. Opin. Pharmacol. 17, 58-63 (2014).
21. Vlahos, C.J., Matter, W.F., Hui, K.Y. & Brown, R.F. J. Biol. Chem. 269, 5241-5248 (1994).
22. Workman, P., Clarke, P.A., Raynaud, F.I. & van Montfort, R.L. Cancer Res. 70, 2146-2157 (2010).
23. Yu, P.B. et al. Nat. Chem. Biol. 4, 33-41 (2008).
24. Zhou, G. et al. J. Clin. Invest. 108, 1167-1174 (2001).
25. Vogt, J., Traynor, R. & Sapkota, G.P. Cell. Signal. 23, 1831-1842 (2011).
26. Glazer, R.I. et al. Biochem. Biophys. Res. Commun. 135, 688-694 (1986).
27. Tan, J. et al. Genes Dev. 21, 1050-1063 (2007).
28. Greiner, D., Bonaldi, T., Eskeland, R., Roemer, E. & Imhof, A. Nat. Chem. Biol. 1, 143-145 (2005).
29. Cherblanc, F.L., Chapman, K.L., Brown, R. & Fuchter, M.J. Nat. Chem. Biol. 9, 136-137 (2013).
30. Cherblanc, F.L. et al. J. Med. Chem. 56, 8616-8625 (2013).
31. Leverson, J.D. et al. Sci. Transl. Med. 7, 279ra240 (2015).
32. Vogler, M. et al. Cell Death Differ. 16, 1030-1039 (2009).
33. Zeiger, E., Prokopetz, A. & Walters, D.B. Accountability in Research 3, 45-46 (1993).
34. Ahn, K. et al. J. Pharmacol. Exp. Ther. 338, 114-124 (2011).
35. Zhang, J. et al. Nature 463, 501-506 (2010).
36. Davies, S.P., Reddy, H., Caivano, M. & Cohen, P. Biochem. J. 351, 95-105 (2000).
37. Pinelli, A. et al. J. Med. Chem. 48, 5509-5519 (2005).
38. Göttlicher, M. et al. EMBO J. 20, 6969-6978 (2001).
39. Pacholec, M. et al. J. Biol. Chem. 285, 8340-8351 (2010).