The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27

Molecular and Cellular Biology

Volumn 27, Issue 6, 2007, Pages 2014-2026

  Tie, Feng ^a   Stratton, Carl A ^a   Kurzhals, Rebeccah L ^a   Harte, Peter J ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; HISTONE H3; HISTONE METHYLTRANSFERASE; ISOPROTEIN; LYSINE; MUTANT PROTEIN; PROTEIN ESC; PROTEIN ESCL; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DROSOPHILA MELANOGASTER; ENZYME SUBSTRATE COMPLEX; GENE; NONHUMAN; PARALOGY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; UBX GENE;

ANIMALS; CATTLE; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE DELETION; HISTONES; LYSINE; METHYLATION; NUCLEAR PROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 33947191081     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01822-06     Document Type: Article

References (45)

1. Breiling. A., E. Bonte, S. Ferrari, P. B. Becker, and R. Paro. 1999. The Drosophila Polycomb protein interacts with nucleosomal core particles in vitro via its repression domain. Mol. Cell. Biol. 19:8451-8460.
2. Brock, H., and C. L. Fisher. 2005. Maintenance of gene expression patterns. Dev. Dyn. 232:633-655.
3. Canaani, E., T. Nakamura, T. Rozovskaia, S. T. Smith, T. Mori, C. M. Croce, and A. Mazo. 2004. ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia. Br. J. Cancer 90:756-760.
4. Cao, R., L. Wang, H. Wang, L. Xia, H. Erdjument-Bromage, P. Tempst, R. S. Jones, and Y. Zhang. 2002. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298:1039-1043.
5. Cao, R., and Y. Zhang. 2004. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15:57-67.
6. Couture, J. F., E. Collazo, and R. C. Trievel. 2006. Molecular recognition of histone H3 by the WD40 protein WDR5. Nat. Struct. Mol. Biol. 13:698-703.
7. Czermin, B., R. Melfi, D. McCabe, V. Seitz, A. Imhof, and V. Pirrotta. 2002. Drosophila Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111:185-196.
8. Ebert, A., G. Schotta, S. Lein, S. Kubicek, V. Krauss, T. Jenuwein, and G. Reuter. 2004. Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev. 18:2973-2983.
9. Edmondson, D. G., M. M. Smith, and S. Y. Roth. 1996. Repression domain of the yeast global repressor TUP1 interacts directly with histones H3 and H4. Genes Dev. 10:1247-1259.
10. Fischle, W., Y. Wang, S. A. Jacobs, Y. Kim, C. D. Allis, and S. Khorasanizadeh. 2003. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev. 17:1870-1881.
11. Flores-Saaib, R. D., and A. J. Courey. 2000. Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression. Nucleic Acids Res. 28:4189-4196.
12. Furuyama, T., F. Tie, and P. J. Harte. 2003. Polycomb group proteins ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development. Genesis 35:114-124.
13. Ketel, C. S., E. F. Andersen, M. L. Vargas, J. Suh, S. Strome, and J. A. Simon. 2005. Subunit contributions to histone methyltransferase activities of fly and worm Polycomb group complexes. Mol. Cell. Biol. 25:6857-6868.
14. Kleer, C. G., Q. Cao, S. Varambally, R. Shen, I. Ota, S. A. Tomlins, D. Ghosh, R. G. Sewalt, A. P. Otte, D. F. Hayes, M. S. Sabel, D. Livant, S. J. Weiss, M. A. Rubin, and A. M. Chinnaiyan. 2003. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl. Acad. Sci. USA 100:11606-11611.
15. Kuzmichev, A., T. Jenuwein, P. Tempst, and D. Reinberg. 2004. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol. Cell 14:183-193.
16. Kuzmichev, A., K. Nishioka, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 2002. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of zeste protein. Genes Dev. 16:2893-2905.
17. Lessard, J., and G. Sauvageau. 2003. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423:255-260.
18. Levenstein, M. E., and J. T. Kadonaga. 2002. Biochemical analysis of chromatin containing recombinant Drosophila core histones. J. Biol. Chem. 277: 8749-8754.
19. Lorain, S., J.-P. Quivy, F. Monier-Gavelle, C. Scamps, Y. Lécluse, G. Almouzni, and M. Lipinski. 1998. Core histories and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. Mol. Cell. Biol. 18:5546-5556.
20. Maiato, H., C. E. Sunkel, and W. C. Earnshaw. 2003. Dissecting mitosis by RNAi in Drosophila tissue culture cells. Biol. Proced. Online 5:153-161.
21. Martin, C., R. Cao, and Y. Zhang. 2006. Substrate preferences of the EZH2 histone methyltranferase complex. J. Biol. Chem. 281:8365-8370.
22. Martin, C., and Y. Zhang. 2005. The diverse functions of histone lysine methylation. Nat. Rev. Mol. Cell Biol. 6:838-849.
23. Min, J., Y. Zhang, and R.-M. Xu. 2003. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 17:1823-1828.
24. Montgomery, N. D., D. Yee, A. Chen, S. Kalantry, S. J. Chamberlain, A. P. Otte, and T. Magnuson. 2005. The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr. Biol. 15:942-947.
25. Müller, J., C. M. Hart, N. J. Francis, M. L. Vargas, A. Sengupta, B. Wild, E. L. Miller, M. B. O'Connor, R. E. Kingston, and J. A. Simon. 2002. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex Cell 111:197-208.
26. Nekrasov, M., B. Wild, and J. Muller. 2005. Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep. 6:348-353.
27. Ng, J., R. Li, K. Morgan, and J. Simon. 1997. Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein. Mol. Cell. Biol. 17:6663-6672.
28. Parthun, M. R., J. Widom, and D. E. Gottschling. 1996. The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87:85-94.
29. Pasini, D., A. P. Bracken, M. R. Jensen, E. Lazzerini Denchi, and K. Helin. 2004. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23:4061-4071.
30. Peters, A. H., S. Kubicek, K. Mechtler, R. J. O'Sullivan, A. A. Derijck, L. Perez-Burgos, A. Kohlmaier, S. Opravil, M. Tachibana, Y. Shinkai, J. H. Martens, and T. Jenuwein. 2003. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12:1577-1589.
31. Poux, S., R. Melfi, and V. Pirrotta. 2001. Establishment of Polycomb silencing requires a transient interaction between PC and ESC. Genes Dev. 15: 2509-2514.
32. Ringrose, L., and R. Paro. 2004. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu. Rev. Genet. 38:413-443.
33. Ruthenburg, A. J., W. Wang, D. M. Graybosch, H. Li, C. D. Allis, D. J. Patel, and G. L. Verdine. 2006. Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat. Struct. Mol. Biol. 13:704-712.
34. Sathe, S. S., and P. J. Harte. 1995. The Drosophila Extra sex combs protein contains WD repeats essential for its function as a repressor of homeotic genes. Mech. Dev. 52:77-87.
35. Tie, F., T. Furuyama, and P. J. Harte. 1998. The Drosophila Polycomb-group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites. Development 125:3483-3496.
36. Tie, F., T. Furuyama, J. Prasad-Sinha, E. P. Jane, and P. J. Harte. 2001. The Drosophila Polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128:275-286.
37. Tie, F., J. Prasad-Sinha, A. Birve, A. Rasmuson-Lestander, and P. J. Harte. 2003. A 1 MDa ESC/E(Z) complex from Drosophila that contains Polycomblike and RPD3. Mol. Cell. Biol. 23:3352-3362.
38. Tie, F., A. P. Siebold, and P. J. Harte. 2005. The N-terminus of Drosophila ESC mediates its phosphorylation and dimerization. Biochem. Biophys. Res. Commun. 332:622-632.
39. Tyler, J. K., M. Bulger, R. T. Kamakaka, R. Kobayashi, and J. T. Kadonaga. 1996. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol. Cell. Biol. 16:6149-6159.
40. Varambally, S., S. M. Dhanasekaran, M. Zhou, T. R. Barrette, C. Kumar-Sinha, M. G. Sanda, D. Ghosh, K. J. Pienta, R. G. Sewalt, A. P. Otte, M. A. Rubin, and A. M. Chinnaiyan. 2002. The Polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419:624-629.
41. Vermaak, D., P. A. Wade, P. L. Jones, Y. B. Shi, and A. P. Wolffe. 1999. Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4 connection in the Xenopus oocyte. Mol. Cell. Biol. 19:5847-5860.
42. Verreault, A., P. D. Kaufman, R. Kobayashi, and B. Stillman. 1998. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Curr. Biol. 8:96-108.
43. Wang, L., N. Njahren, M. L. Vargas, E. F. Anderson, J. Benes, J. Zhang, E. L. Miller, R. S. Jones, and J. A. Simon. 2006. Alternative ESC and ESC-like subunits of a Polycomb group histone methyltransferase complex are differentially deployed during Drosophila development. Mol. Cell. Biol. 26:2637-2647.
44. Wysocka, J., T. Swigut, T. A. Milne, Y. Dou, X. Zhang, A. L. Burlingame, R. G. Roeder, A. H. Brivanlou, and C. D. Allis. 2005. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell 121:859-872.
45. Zhang, Q., N. Vo, and R. H. Goodman. 2000. Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Mol. Cell. Biol. 20::4970-4978.