The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

Nature

Volumn 471, Issue 7339, 2011, Pages 513-518

  Ceol, Craig J ^a,i   Houvras, Yariv ^a,b,j   Jane Valbuena, Judit ^c,d   Bilodeau, Steve ^e   Orlando, David A ^e   Battisti, Valentine ^f   Fritsch, Lauriane ^f   Lin, William M ^c,d   Hollmann, Travis J ^g   Ferré, Fabrizio ^h   Bourque, Caitlin ^a   Burke, Christopher J ^a   Turner, Laura ^a   Uong, Audrey ^a   Johnson, Laura A ^c,d   Beroukhim, Rameen ^c,d   Mermel, Craig H ^c,d   Loda, Massimo ^g   Ait Si Ali, Slimane ^f   Garraway, Levi A ^c,d   Young, Richard A ^e   Zon, Leonard I ^a   more..

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^f Université Sorbonne Paris Cité   (France)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^j NEW YORK PRESBYTERIAN HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; DNA; HISTONE METHYLTRANSFERASE; SET DOMAIN BIFURCATED 1 PROTEIN; UNCLASSIFIED DRUG;

CANCER; CHROMOSOME; CYPRINID; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; PROTEIN; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CHROMOSOME 1; CONTROLLED STUDY; DNA SEQUENCE; GENE AMPLIFICATION; GENE MUTATION; GENETIC ANALYSIS; HOX GENE; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; MELANOMA; NONHUMAN; PRIORITY JOURNAL; ZEBRA FISH;

AGE OF ONSET; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMES, HUMAN, PAIR 1; DISEASE MODELS, ANIMAL; DNA COPY NUMBER VARIATIONS; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MELANOCYTES; MELANOMA; NEVUS; ONCOGENES; PROTEIN METHYLTRANSFERASES; PROTO-ONCOGENE PROTEINS B-RAF; ZEBRAFISH;

DANIO RERIO;

EID: 79953056443     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09806     Document Type: Article

References (23)

1. Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002). (Pubitemid 34716871)
2. Wan, P. T. et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855-867 (2004). (Pubitemid 38410730)
3. Pollock, P. M. et al. High frequency of BRAF mutations in nevi. Nature Genet. 33, 19-20 (2003). (Pubitemid 36068675)
4. Curtin, J. A. et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135-2147 (2005). (Pubitemid 41653105)
5. Garraway, L. A. et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117-122 (2005). (Pubitemid 40966196)
6. Lin, W. M. et al. Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 68, 664-673 (2008). (Pubitemid 351206741)
7. Patton, E. E. et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr. Biol. 15, 249-254 (2005). (Pubitemid 40205706)
8. Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
9. Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005). (Pubitemid 41117276)
10. Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
11. Santoriello, C. et al. Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells. Dis. Model. Mech. 2, 56-67 (2009).
12. Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005). (Pubitemid 41528093)
13. Mootha, V. K. et al. PGC-1a responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genet. 34, 267-273 (2003). (Pubitemid 36792858)
14. Bilodeau, S., Kagey, M. H., Frampton, G. M., Rahl, P. B. &Young, R. A. SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Genes Dev. 23, 2484-2489 (2009).
15. Wang, H. et al.mAMfacilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12, 475-487 (2003). (Pubitemid 37238933)
16. Fritsch, L. et al. A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex. Mol. Cell 37, 46-56 (2010).
17. Dalgliesh, G. L. et al. Systematic sequencing of renal carcinomareveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
18. van Haaften, G. et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genet. 41, 521-523 (2009).
19. Kwan, K. M. et al. The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs. Dev. Dyn. 236, 3088-3099 (2007). (Pubitemid 350175006)
20. Beroukhim, R. et al. Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc. Natl Acad. Sci. USA 104, 20007-20012 (2007).
21. Nisolle, M. et al. Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy. Hum. Reprod. 14, 2844-2850 (1999). (Pubitemid 29520705)
22. Perner, S. et al. EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia 10, 298-302 (2008). (Pubitemid 351328588)
23. Sarraf, S. A. &Stancheva, I. Methyl-CpG binding proteinMBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol. Cell 15, 595-605 (2004). (Pubitemid 39141786)