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Volumn 6, Issue 6, 2016, Pages

Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; CORTICOTROPIN RELEASING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6; MACROPHAGE ACTIVATING FACTOR; NEUROTENSIN; RISPERIDONE; TUMOR NECROSIS FACTOR; AUTACOID; AUTOANTIBODY; LUTEOLIN;

EID: 84994527318     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2016.77     Document Type: Review
Times cited : (184)

References (214)
  • 2
    • 84897376397 scopus 로고    scopus 로고
    • From Kanner to DSM-5: Autism as an evolving diagnostic concept
    • Volkmar FR, McPartland JC. From Kanner to DSM-5: autism as an evolving diagnostic concept. Annu Rev Clin Psychol 2014; 10: 193–212.
    • (2014) Annu Rev Clin Psychol , vol.10 , pp. 193-212
    • Volkmar, F.R.1    McPartland, J.C.2
  • 3
    • 67049118065 scopus 로고    scopus 로고
    • Epidemiology of pervasive developmental disorders
    • Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65: 591–598.
    • (2009) Pediatr Res , vol.65 , pp. 591-598
    • Fombonne, E.1
  • 4
    • 84944146721 scopus 로고    scopus 로고
    • Gene hunting in autism spectrum disorder: On the path to precision medicine
    • Geschwind DH, State MW. Gene hunting in autism spectrum disorder: on the path to precision medicine. Lancet Neurol 2015; 11: 1109–1120.
    • (2015) Lancet Neurol , vol.11 , pp. 1109-1120
    • Geschwind, D.H.1    State, M.W.2
  • 5
    • 84912101664 scopus 로고    scopus 로고
    • Autism spectrum disorders: From genes to neurobiology
    • Willsey AJ, State MW. Autism spectrum disorders: from genes to neurobiology. Curr Opin Neurobiol 2015; 30: 92–99.
    • (2015) Curr Opin Neurobiol , vol.30 , pp. 92-99
    • Willsey, A.J.1    State, M.W.2
  • 6
    • 84954364135 scopus 로고    scopus 로고
    • Behavioral phenotypes of genetic mouse models of autism
    • Kazdoba TM, Leach PT, Crawley JN. Behavioral phenotypes of genetic mouse models of autism. Genes Brain Behav 2015; 15: 7–26.
    • (2015) Genes Brain Behav , vol.15 , pp. 7-26
    • Kazdoba, T.M.1    Leach, P.T.2    Crawley, J.N.3
  • 7
    • 84929484987 scopus 로고    scopus 로고
    • An urgent need for experimental animal model of autism in drug development
    • Ruhela RK, Prakash A, Medhi B. An urgent need for experimental animal model of autism in drug development. Ann Neurosci 2015; 22: 44–49.
    • (2015) Ann Neurosci , vol.22 , pp. 44-49
    • Ruhela, R.K.1    Prakash, A.2    Medhi, B.3
  • 9
    • 84927535943 scopus 로고    scopus 로고
    • Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing bull terriers with a phenotype similar to autism
    • Tsilioni I, Dodman N, Petra AI, Taliou A, Francis K, Moon-Fanelli AA et al. Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing bull terriers with a phenotype similar to autism. Transl Psychiatry 2014; 4: e466.
    • (2014) Transl Psychiatry , vol.4
    • Tsilioni, I.1    Dodman, N.2    Petra, A.I.3    Taliou, A.4    Francis, K.5    Moon-Fanelli, A.A.6
  • 11
    • 84862160222 scopus 로고    scopus 로고
    • Global prevalence of autism and other pervasive developmental disorders
    • Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcin C et al. Global prevalence of autism and other pervasive developmental disorders. Autism Res 2012; 5: 160–179.
    • (2012) Autism Res , vol.5 , pp. 160-179
    • Elsabbagh, M.1    Divan, G.2    Koh, Y.J.3    Kim, Y.S.4    Kauchali, S.5    Marcin, C.6
  • 14
    • 77954925246 scopus 로고    scopus 로고
    • Medical comorbidities in autism: Challenges to diagnosis and treatment
    • Bauman ML. Medical comorbidities in autism: challenges to diagnosis and treatment. Neurotherapeutics 2010; 7: 320–327.
    • (2010) Neurotherapeutics , vol.7 , pp. 320-327
    • Bauman, M.L.1
  • 15
    • 84929833134 scopus 로고    scopus 로고
    • Trends in mental health care among children and adolescents
    • Olfson M, Druss BG, Marcus SC. Trends in mental health care among children and adolescents. N Engl J Med 2015; 372: 2029–2038.
    • (2015) N Engl J Med , vol.372 , pp. 2029-2038
    • Olfson, M.1    Druss, B.G.2    Marcus, S.C.3
  • 16
    • 84947866144 scopus 로고    scopus 로고
    • Brief report: Forecasting the economic burden of autism in 2015 and 2025 in the United States
    • Leigh JP, Du J. Brief report: forecasting the economic burden of autism in 2015 and 2025 in the United States. J Autism Dev Disord 2015; 12: 4135–4139.
    • (2015) J Autism Dev Disord , Issue.12 , pp. 4135-4139
    • Leigh, J.P.1    Du, J.2
  • 17
    • 84859005372 scopus 로고    scopus 로고
    • A review of research trends in physiological abnormalities in autism spectrum disorders: Immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures
    • Rossignol DA, Frye RE. A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012; 17: 389–401.
    • (2012) Mol Psychiatry , vol.17 , pp. 389-401
    • Rossignol, D.A.1    Frye, R.E.2
  • 19
    • 77949368541 scopus 로고    scopus 로고
    • Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
    • Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol 2010; 23: 103–110.
    • (2010) Curr Opin Neurol , vol.23 , pp. 103-110
    • Herbert, M.R.1
  • 20
    • 84935119657 scopus 로고    scopus 로고
    • Mast cells, mastocytosis, and related disorders
    • Theoharides TC, Valent P, Akin C. Mast cells, mastocytosis, and related disorders. N Engl J Med 2015; 373: 163–172.
    • (2015) N Engl J Med , vol.373 , pp. 163-172
    • Theoharides, T.C.1    Valent, P.2    Akin, C.3
  • 21
    • 84924980594 scopus 로고    scopus 로고
    • Mast cell-MrgprB2: Sensing secretagogues or a means to overreact?
    • Grimbaldeston MA. Mast cell-MrgprB2: sensing secretagogues or a means to overreact? Immunol Cell Biol 2015; 93: 221–223.
    • (2015) Immunol Cell Biol , vol.93 , pp. 221-223
    • Grimbaldeston, M.A.1
  • 22
    • 44349101991 scopus 로고    scopus 로고
    • Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity
    • Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008; 8: 478–486.
    • (2008) Nat Rev Immunol , vol.8 , pp. 478-486
    • Galli, S.J.1    Grimbaldeston, M.2    Tsai, M.3
  • 24
    • 84885801174 scopus 로고    scopus 로고
    • Allergic diseases in preschoolers are associated with psychological and behavioural problems
    • Chang HY, Seo JH, Kim HY, Kwon JW, Kim BJ, Kim HB et al. Allergic diseases in preschoolers are associated with psychological and behavioural problems. Allergy Asthma Immunol Res 2013; 5: 315–321.
    • (2013) Allergy Asthma Immunol Res , vol.5 , pp. 315-321
    • Chang, H.Y.1    Seo, J.H.2    Kim, H.Y.3    Kwon, J.W.4    Kim, B.J.5    Kim, H.B.6
  • 25
    • 84877904095 scopus 로고    scopus 로고
    • Is a subtype of autism an 'allergy of the brain'?
    • Theoharides TC. Is a subtype of autism an 'allergy of the brain'?. Clin Therap 2013; 35: 584–591.
    • (2013) Clin Therap , vol.35 , pp. 584-591
    • Theoharides, T.C.1
  • 28
  • 30
    • 84903710968 scopus 로고    scopus 로고
    • Overweight and obesity: Prevalence and correlates in a large clinical sample of children with autism spectrum disorder
    • Zuckerman KE, Hill AP, Guion K, Voltolina L, Fombonne E. Overweight and obesity: prevalence and correlates in a large clinical sample of children with autism spectrum disorder. J Autism Dev Disord 2014; 44: 1708–1719.
    • (2014) J Autism Dev Disord , vol.44 , pp. 1708-1719
    • Zuckerman, K.E.1    Hill, A.P.2    Guion, K.3    Voltolina, L.4    Fombonne, E.5
  • 31
    • 84991497504 scopus 로고    scopus 로고
    • Obesity and associated factors in youth with an autism spectrum disorder
    • pii: 1362361315616345; e-pub ahead of print
    • Granich J, Lin A, Hunt A, Wray J, Dass A, Whitehouse AJ. Obesity and associated factors in youth with an autism spectrum disorder. Autism 2016; pii: 1362361315616345; e-pub ahead of print.
    • (2016) Autism
    • Granich, J.1    Lin, A.2    Hunt, A.3    Wray, J.4    Dass, A.5    Whitehouse, A.J.6
  • 34
    • 68349160704 scopus 로고    scopus 로고
    • Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    • Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman JN et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009; 15: 940–945.
    • (2009) Nat Med , vol.15 , pp. 940-945
    • Liu, J.1    Divoux, A.2    Sun, J.3    Zhang, J.4    Clement, K.5    Glickman, J.N.6
  • 36
    • 84951823798 scopus 로고    scopus 로고
    • Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages
    • Zhou Y, Yu X, Chen H, Sjoberg S, Roux J, Zhang L et al. Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages. Cell Metab 2015; 22: 1045–1058.
    • (2015) Cell Metab , vol.22 , pp. 1045-1058
    • Zhou, Y.1    Yu, X.2    Chen, H.3    Sjoberg, S.4    Roux, J.5    Zhang, L.6
  • 37
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic dis-ease
    • Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic dis-ease. J Clin Invest 2011; 121: 2111–2117.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 38
    • 37849043344 scopus 로고    scopus 로고
    • Brief report: Plasma leptin levels are elevated in autism: Association with early onset phenotype?
    • Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P et al. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord 2007; 38: 169–175.
    • (2007) J Autism Dev Disord , vol.38 , pp. 169-175
    • Ashwood, P.1    Kwong, C.2    Hansen, R.3    Hertz-Picciotto, I.4    Croen, L.5    Krakowiak, P.6
  • 39
    • 84871280445 scopus 로고    scopus 로고
    • Evidence of microglial activation in autism and its possible role in brain underconnectivity
    • Rodriguez JI, Kern JK. Evidence of microglial activation in autism and its possible role in brain underconnectivity. Neuron Glia Biol 2011; 7: 205–213.
    • (2011) Neuron Glia Biol , vol.7 , pp. 205-213
    • Rodriguez, J.I.1    Kern, J.K.2
  • 40
    • 36849085256 scopus 로고    scopus 로고
    • Neurodevelopmental outcome of the late preterm infant
    • Adams-Chapman I. Neurodevelopmental outcome of the late preterm infant. Clin Perinatol 2006; 33: 947–964.
    • (2006) Clin Perinatol , vol.33 , pp. 947-964
    • Adams-Chapman, I.1
  • 41
    • 70450284554 scopus 로고    scopus 로고
    • The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined
    • Volpe JJ. The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined. Semin Pediatr Neurol 2009; 16: 167–178.
    • (2009) Semin Pediatr Neurol , vol.16 , pp. 167-178
    • Volpe, J.J.1
  • 42
    • 79954611574 scopus 로고    scopus 로고
    • Preterm birth and childhood psychiatric disorders
    • Pt 2 11 R–18R
    • Johnson S, Marlow N. Preterm birth and childhood psychiatric disorders. Pediatr Res 2011; 5, Pt 2 11 R–18R.
    • (2011) Pediatr Res , vol.5
    • Johnson, S.1    Marlow, N.2
  • 44
    • 42649127380 scopus 로고    scopus 로고
    • The modified checklist for autism in toddlers: A follow-up study investigating the early detection of autism spectrum disorders
    • Kleinman JM, Robins DL, Ventola PE, Pandey J, Boorstein HC, Esser EL et al. The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders. J Autism Dev Disord 2008; 38: 827–839.
    • (2008) J Autism Dev Disord , vol.38 , pp. 827-839
    • Kleinman, J.M.1    Robins, D.L.2    Ventola, P.E.3    Pandey, J.4    Boorstein, H.C.5    Esser, E.L.6
  • 45
    • 33748602091 scopus 로고    scopus 로고
    • Perinatal risk factors and infantile autism
    • Maimburg RD, Vaeth M. Perinatal risk factors and infantile autism. Acta Psychiatr Scand 2006; 114: 257–264.
    • (2006) Acta Psychiatr Scand , vol.114 , pp. 257-264
    • Maimburg, R.D.1    Vaeth, M.2
  • 46
    • 0036282993 scopus 로고    scopus 로고
    • Perinatal risk factors for infantile autism
    • Hultman CM, Sparen P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology 2002; 13: 417–423.
    • (2002) Epidemiology , vol.13 , pp. 417-423
    • Hultman, C.M.1    Sparen, P.2    Cnattingius, S.3
  • 47
    • 81555197565 scopus 로고    scopus 로고
    • Prenatal maternal stress associated with ADHD and autistic traits in early childhood
    • Ronald A, Pennell CE, Whitehouse AJ. Prenatal maternal stress associated with ADHD and autistic traits in early childhood. Front Psychol 2010; 1: 223.
    • (2010) Front Psychol , vol.1 , pp. 223
    • Ronald, A.1    Pennell, C.E.2    Whitehouse, A.J.3
  • 48
    • 84930943762 scopus 로고    scopus 로고
    • Association of autistic traits in adulthood with childhood abuse, interpersonal victimization, and posttraumatic stress
    • Roberts AL, Koenen KC, Lyall K, Robinson EB, Weisskopf MG. Association of autistic traits in adulthood with childhood abuse, interpersonal victimization, and posttraumatic stress. Child Abuse Negl 2015; 45: 135–142.
    • (2015) Child Abuse Negl , vol.45 , pp. 135-142
    • Roberts, A.L.1    Koenen, K.C.2    Lyall, K.3    Robinson, E.B.4    Weisskopf, M.G.5
  • 49
    • 84876916012 scopus 로고    scopus 로고
    • Association of maternal exposure to childhood abuse with elevated risk for autism in offspring
    • Roberts AL, Lyall K, Rich-Edwards JW, Ascherio A, Weisskopf MG. Association of maternal exposure to childhood abuse with elevated risk for autism in offspring. JAMA Psychiatry 2013; 70: 508–515.
    • (2013) JAMA Psychiatry , vol.70 , pp. 508-515
    • Roberts, A.L.1    Lyall, K.2    Rich-Edwards, J.W.3    Ascherio, A.4    Weisskopf, M.G.5
  • 50
    • 84922397817 scopus 로고    scopus 로고
    • An update on anxiety in youth with autism spectrum disorders
    • Vasa RA, Mazurek MO. An update on anxiety in youth with autism spectrum disorders. Curr Opin Psychiatry 2015; 28: 83–90.
    • (2015) Curr Opin Psychiatry , vol.28 , pp. 83-90
    • Vasa, R.A.1    Mazurek, M.O.2
  • 51
    • 80052044947 scopus 로고    scopus 로고
    • Anxiety disorders in children and adolescents with autistic spectrum disorders: A meta-analysis
    • van Steensel FJ, Bogels SM, Perrin S. Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clin Child Fam Psychol Rev 2011; 14: 302–317.
    • (2011) Clin Child Fam Psychol Rev , vol.14 , pp. 302-317
    • van Steensel, F.J.1    Bogels, S.M.2    Perrin, S.3
  • 52
    • 84867887468 scopus 로고    scopus 로고
    • The relationship between anxiety and repetitive behaviours in autism spectrum disorder
    • Rodgers J, Glod M, Connolly B, McConachie H. The relationship between anxiety and repetitive behaviours in autism spectrum disorder. J Autism Dev Disord 2012; 42: 2404–2409.
    • (2012) J Autism Dev Disord , vol.42 , pp. 2404-2409
    • Rodgers, J.1    Glod, M.2    Connolly, B.3    McConachie, H.4
  • 54
    • 0030250304 scopus 로고    scopus 로고
    • Neurotensin receptors in the human amygdaloid complex. Topographical and quantitative autoradiographic study
    • Lantos TA, Palkovits M, Rostene W, Berod A. Neurotensin receptors in the human amygdaloid complex. Topographical and quantitative autoradiographic study. J Chem Neuroanat 1996; 11: 209–217.
    • (1996) J Chem Neuroanat , vol.11 , pp. 209-217
    • Lantos, T.A.1    Palkovits, M.2    Rostene, W.3    Berod, A.4
  • 55
    • 84893953602 scopus 로고    scopus 로고
    • An autoradiographic study of neurotensin receptors in the human hypothalamus
    • Najimi M, Sarrieau A, Kopp N, Chigr F. An autoradiographic study of neurotensin receptors in the human hypothalamus. Acta Histochem 2014; 116: 382–389.
    • (2014) Acta Histochem , vol.116 , pp. 382-389
    • Najimi, M.1    Sarrieau, A.2    Kopp, N.3    Chigr, F.4
  • 56
    • 0036896468 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood-brain-barrier permeability induced by acute stress
    • Esposito P, Chandler N, Kandere-Grzybowska K, Basu S, Jacobson S, Connolly R et al. Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood-brain-barrier permeability induced by acute stress. J Pharmacol Exp Ther 2002; 303: 1061–1066.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1061-1066
    • Esposito, P.1    Chandler, N.2    Kandere-Grzybowska, K.3    Basu, S.4    Jacobson, S.5    Connolly, R.6
  • 57
    • 20444366589 scopus 로고    scopus 로고
    • Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor
    • Cao J, Papadopoulou N, Kempuraj D, Boucher WS, Sugimoto K, Cetrulo CL et al. Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol 2005; 174: 7665–7675.
    • (2005) J Immunol , vol.174 , pp. 7665-7675
    • Cao, J.1    Papadopoulou, N.2    Kempuraj, D.3    Boucher, W.S.4    Sugimoto, K.5    Cetrulo, C.L.6
  • 58
    • 34248150697 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone and the blood-brain-barrier
    • Theoharides TC, Konstantinidou A. Corticotropin-releasing hormone and the blood-brain-barrier. Front Biosci 2007; 12: 1615–1628.
    • (2007) Front Biosci , vol.12 , pp. 1615-1628
    • Theoharides, T.C.1    Konstantinidou, A.2
  • 59
    • 84953637134 scopus 로고    scopus 로고
    • Varez-Twose I et al. Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology
    • Hartmann K, Escribano L, Grattan C, Brockow K, Carter MC, varez-Twose I et al. Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J Allergy Clin Immunol 2016; 137: 35–45.
    • (2016) J Allergy Clin Immunol , vol.137 , pp. 35-45
    • Hartmann, K.1    Escribano, L.2    Grattan, C.3    Brockow, K.4    Carter, M.C.5
  • 61
    • 84880619970 scopus 로고    scopus 로고
    • Effect of stress on brain inflammation and multiple sclerosis
    • Karagkouni A, Alevizos M, Theoharides TC. Effect of stress on brain inflammation and multiple sclerosis. Autoimmun Rev 2013; 12: 947–953.
    • (2013) Autoimmun Rev , vol.12 , pp. 947-953
    • Karagkouni, A.1    Alevizos, M.2    Theoharides, T.C.3
  • 62
    • 84945446929 scopus 로고    scopus 로고
    • Asthma and allergies in children with autism spectrum disorders: Results from the CHARGE study
    • Lyall K, Van de Water J, Ashwood P, Hertz-Picciotto I. Asthma and allergies in children with autism spectrum disorders: results from the CHARGE study. Autism Res 2015; 8: 567–574.
    • (2015) Autism Res , vol.8 , pp. 567-574
    • Lyall, K.1    van de Water, J.2    Ashwood, P.3    Hertz-Picciotto, I.4
  • 63
    • 84941077725 scopus 로고    scopus 로고
    • Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: A systematic review and meta-analysis
    • Chen SW, Zhong XS, Jiang LN, Zheng XY, Xiong YQ, Ma SJ et al. Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: a systematic review and meta-analysis. Behav Brain Res 2015; 296: 61–69.
    • (2015) Behav Brain Res , vol.296 , pp. 61-69
    • Chen, S.W.1    Zhong, X.S.2    Jiang, L.N.3    Zheng, X.Y.4    Xiong, Y.Q.5    Ma, S.J.6
  • 64
    • 84930891400 scopus 로고    scopus 로고
    • Co-occurrence of autism and asthma in a nationally-representative sample of children in the United States
    • Kotey S, Ertel K, Whitcomb B. Co-occurrence of autism and asthma in a nationally-representative sample of children in the United States. J Autism Dev Disord 2014; 44: 3083–3088.
    • (2014) J Autism Dev Disord , vol.44 , pp. 3083-3088
    • Kotey, S.1    Ertel, K.2    Whitcomb, B.3
  • 65
    • 76349105709 scopus 로고    scopus 로고
    • Autism spectrum disorders and mastocytosis
    • Theoharides TC. Autism spectrum disorders and mastocytosis. Int J Immuno-pathol Pharmacol 2009; 22: 859–865.
    • (2009) Int J Immuno-Pathol Pharmacol , vol.22 , pp. 859-865
    • Theoharides, T.C.1
  • 66
    • 81055156273 scopus 로고    scopus 로고
    • Importance of allergy in asthma: An epidemiologic perspective
    • Douwes J, Brooks C, van DC, Pearce N. Importance of allergy in asthma: an epidemiologic perspective. Curr Allergy Asthma Rep 2011; 11: 434–444.
    • (2011) Curr Allergy Asthma Rep , vol.11 , pp. 434-444
    • Douwes, J.1    Brooks, C.2    Van, D.C.3    Pearce, N.4
  • 67
    • 84879614882 scopus 로고    scopus 로고
    • Prevalence and clinical significance of rare antinuclear antibody patterns
    • Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev 2013; 12: 998–1003.
    • (2013) Autoimmun Rev , vol.12 , pp. 998-1003
    • Vermeersch, P.1    Bossuyt, X.2
  • 68
    • 84864385195 scopus 로고    scopus 로고
    • Updated assessment of the prevalence, spectrum and case definition of autoimmune disease
    • Hayter SM, Cook MC. Updated assessment of the prevalence, spectrum and case definition of autoimmune disease. Autoimmun Rev 2012; 11: 754–765.
    • (2012) Autoimmun Rev , vol.11 , pp. 754-765
    • Hayter, S.M.1    Cook, M.C.2
  • 69
    • 33746907748 scopus 로고    scopus 로고
    • Parental report of health conditions and health care use among children with and without autism: National Survey of Children's Health
    • Gurney JG, McPheeters ML, Davis MM. Parental report of health conditions and health care use among children with and without autism: National Survey of Children's Health. Arch Pediatr Adolesc Med 2006; 160: 825–830.
    • (2006) Arch Pediatr Adolesc Med , vol.160 , pp. 825-830
    • Gurney, J.G.1    McPheeters, M.L.2    Davis, M.M.3
  • 72
    • 77952076387 scopus 로고    scopus 로고
    • Autism spectrum disorders and allergy: Observation from a pediatric allergy/immunology clinic
    • Jyonouchi H. Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic. Exp Rev Clin Immunol 2010; 6: 397–411.
    • (2010) Exp Rev Clin Immunol , vol.6 , pp. 397-411
    • Jyonouchi, H.1
  • 73
    • 82955181219 scopus 로고    scopus 로고
    • Brief report: "allergic symptoms" in children with autism spectrum disorders. More than meets the eye?
    • Angelidou A, Alysandratos KD, Asadi S, Zhang B, Francis K, Vasiadi M et al. Brief report: "allergic symptoms" in children with autism spectrum disorders. More than meets the eye?. J Autism Dev Disord 2011; 41: 1579–1585.
    • (2011) J Autism Dev Disord , vol.41 , pp. 1579-1585
    • Angelidou, A.1    Alysandratos, K.D.2    Asadi, S.3    Zhang, B.4    Francis, K.5    Vasiadi, M.6
  • 74
    • 84873410954 scopus 로고    scopus 로고
    • Mental health comorbidity in patients with atopic dermatitis
    • Yaghmaie P, Koudelka CW, Simpson EL. Mental health comorbidity in patients with atopic dermatitis. J Allergy Clin Immunol 2013; 131: 428–433.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 428-433
    • Yaghmaie, P.1    Koudelka, C.W.2    Simpson, E.L.3
  • 75
    • 84908138102 scopus 로고    scopus 로고
    • Is atopy in early childhood a risk factor for ADHD and ASD? A longitudinal study
    • Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH et al. Is atopy in early childhood a risk factor for ADHD and ASD? a longitudinal study. J Psychosom Res 2014; 77: 316–321.
    • (2014) J Psychosom Res , vol.77 , pp. 316-321
    • Chen, M.H.1    Su, T.P.2    Chen, Y.S.3    Hsu, J.W.4    Huang, K.L.5    Chang, W.H.6
  • 78
    • 84874142161 scopus 로고    scopus 로고
    • Role and relevance of mast cells in fungal infections
    • Saluja R, Metz M, Maurer M. Role and relevance of mast cells in fungal infections. Front Immunol 2012; 3: 146.
    • (2012) Front Immunol , vol.3 , pp. 146
    • Saluja, R.1    Metz, M.2    Maurer, M.3
  • 79
    • 67650660998 scopus 로고    scopus 로고
    • Aspergillus fumigatus induces immunoglobulin E-independent mast cell degranulation
    • Urb M, Pouliot P, Gravelat FN, Olivier M, Sheppard DC. Aspergillus fumigatus induces immunoglobulin E-independent mast cell degranulation. J Infect Dis 2009; 200: 464–472.
    • (2009) J Infect Dis , vol.200 , pp. 464-472
    • Urb, M.1    Pouliot, P.2    Gravelat, F.N.3    Olivier, M.4    Sheppard, D.C.5
  • 80
    • 33749337450 scopus 로고    scopus 로고
    • Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism
    • Olynych TJ, Jakeman DL, Marshall JS. Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. J Allergy Clin Immunol 2006; 118: 837–843.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 837-843
    • Olynych, T.J.1    Jakeman, D.L.2    Marshall, J.S.3
  • 82
    • 70449713915 scopus 로고    scopus 로고
    • Van RN, Kappler JW et al. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    • McKee AS, Munks MW, MacLeod MK, Fleenor CJ, van RN, Kappler JW et al. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 2009; 183: 4403–4414.
    • (2009) J Immunol , vol.183 , pp. 4403-4414
    • McKee, A.S.1    Munks, M.W.2    Macleod, M.K.3    Fleenor, C.J.4
  • 83
    • 84875648076 scopus 로고    scopus 로고
    • Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
    • Goines PE, Ashwood P. Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol 2012; 36: 67–81.
    • (2012) Neurotoxicol Teratol , vol.36 , pp. 67-81
    • Goines, P.E.1    Ashwood, P.2
  • 84
    • 84908395017 scopus 로고    scopus 로고
    • Environmental toxicants and autism spectrum disorders: A systematic review
    • Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 2014; 4: e360.
    • (2014) Transl Psychiatry , vol.4
    • Rossignol, D.A.1    Genuis, S.J.2    Frye, R.E.3
  • 85
    • 85073253361 scopus 로고    scopus 로고
    • Autism spectrum disorders and identified toxic land fills: Co-occurrence across States
    • Ming X, Brimacombe M, Malek JH, Jani N, Wagner GC. Autism spectrum disorders and identified toxic land fills: co-occurrence across States. Environ Health Insights 2008; 2: 55–59.
    • (2008) Environ Health Insights , vol.2 , pp. 55-59
    • Ming, X.1    Brimacombe, M.2    Malek, J.H.3    Jani, N.4    Wagner, G.C.5
  • 86
    • 84955194961 scopus 로고    scopus 로고
    • Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders
    • Wong CT, Wais J, Crawford DA. Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders. Eur J Neurosci 2015; 42: 2742–2760.
    • (2015) Eur J Neurosci , vol.42 , pp. 2742-2760
    • Wong, C.T.1    Wais, J.2    Crawford, D.A.3
  • 87
    • 84937109189 scopus 로고    scopus 로고
    • Maternal chemical and drug intolerances: Potential risk factors for autism and attention deficit hyperactivity disorder (ADHD)
    • Heilbrun LP, Palmer RF, Jaen CR, Svoboda MD, Miller CS, Perkins J. Maternal chemical and drug intolerances: potential risk factors for autism and attention deficit hyperactivity disorder (ADHD). J Am Board Fam Med 2015; 28: 461–470.
    • (2015) J am Board Fam Med , vol.28 , pp. 461-470
    • Heilbrun, L.P.1    Palmer, R.F.2    Jaen, C.R.3    Svoboda, M.D.4    Miller, C.S.5    Perkins, J.6
  • 88
    • 80053051344 scopus 로고    scopus 로고
    • Cognitive function of 6-year old children exposed to mold-contaminated homes in early postnatal period. Prospective birth cohort study in Poland
    • Jedrychowski W, Maugeri U, Perera F, Stigter L, Jankowski J, Butscher M et al. Cognitive function of 6-year old children exposed to mold-contaminated homes in early postnatal period. Prospective birth cohort study in Poland. Physiol Behav 2011; 104: 989–995.
    • (2011) Physiol Behav , vol.104 , pp. 989-995
    • Jedrychowski, W.1    Maugeri, U.2    Perera, F.3    Stigter, L.4    Jankowski, J.5    Butscher, M.6
  • 89
    • 70350501195 scopus 로고    scopus 로고
    • Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure
    • Empting LD. Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure. Toxicol Ind Health 2009; 25: 577–581.
    • (2009) Toxicol Ind Health , vol.25 , pp. 577-581
    • Empting, L.D.1
  • 92
    • 81855192715 scopus 로고    scopus 로고
    • Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
    • Tomljenovic L, Shaw CA. Do aluminum vaccine adjuvants contribute to the rising prevalence of autism? J Inorg Biochem 2011; 105: 1489–1499.
    • (2011) J Inorg Biochem , vol.105 , pp. 1489-1499
    • Tomljenovic, L.1    Shaw, C.A.2
  • 93
    • 70349194352 scopus 로고    scopus 로고
    • Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain
    • Kumar V, Bal A, Gill KD. Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain. Toxicology 2009; 264: 137–144.
    • (2009) Toxicology , vol.264 , pp. 137-144
    • Kumar, V.1    Bal, A.2    Gill, K.D.3
  • 94
    • 84862907373 scopus 로고    scopus 로고
    • Stress proteins and glial cell functions during chronic aluminium exposures: Protective role of curcumin
    • Sood PK, Nahar U, Nehru B. Stress proteins and glial cell functions during chronic aluminium exposures: protective role of curcumin. Neurochem Res 2012; 37: 639–646.
    • (2012) Neurochem Res , vol.37 , pp. 639-646
    • Sood, P.K.1    Nahar, U.2    Nehru, B.3
  • 95
    • 79961167250 scopus 로고    scopus 로고
    • DNA released from dying host cells mediates aluminum adjuvant activity
    • Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel CKobiyama K et al. DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med 2011; 17: 996–1002.
    • (2011) Nat Med , vol.17 , pp. 996-1002
    • Marichal, T.1    Ohata, K.2    Bedoret, D.3    Mesnil, C.4    Sabatel Ckobiyama, K.5
  • 96
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mito-chondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W et al. Circulating mito-chondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104–107.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3    Sumi, Y.4    Sursal, T.5    Junger, W.6
  • 97
    • 77954115305 scopus 로고    scopus 로고
    • Mast cells in allergy and infection: Versatile effector and regulatory cells in innate and adaptive immunity
    • Galli SJ, Tsai M. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 2010; 40: 1843–1851.
    • (2010) Eur J Immunol , vol.40 , pp. 1843-1851
    • Galli, S.J.1    Tsai, M.2
  • 98
    • 77952868792 scopus 로고    scopus 로고
    • Mast cell-orchestrated immunity to pathogens
    • Abraham SN St, John AL. Mast cell-orchestrated immunity to pathogens. Nat Rev Immunol 2010; 10: 440–452.
    • (2010) Nat Rev Immunol , vol.10 , pp. 440-452
    • Abrahamst, S.N.1    John, A.L.2
  • 99
    • 84873589349 scopus 로고    scopus 로고
    • TLR signaling in mast cells: Common and unique features
    • Sandig H, Bulfone-Paus S. TLR signaling in mast cells: common and unique features. Front Immunol 2012; 3: 185.
    • (2012) Front Immunol , vol.3 , pp. 185
    • Sandig, H.1    Bulfone-Paus, S.2
  • 100
    • 84871326101 scopus 로고    scopus 로고
    • Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions
    • Zhang B, Asadi S, Weng Z, Sismanopoulos N, Theoharides TC. Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions. PLoS One 2012; 7: e49767.
    • (2012) Plos One , vol.7
    • Zhang, B.1    Asadi, S.2    Weng, Z.3    Sismanopoulos, N.4    Theoharides, T.C.5
  • 101
    • 84860517661 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin
    • Asadi S, Theoharides TC. Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. J Neuroinflammation 2012; 9: 85.
    • (2012) J Neuroinflammation , vol.9 , pp. 85
    • Asadi, S.1    Theoharides, T.C.2
  • 102
    • 84884703311 scopus 로고    scopus 로고
    • The "missing link" in auto-immunity and autism: Extracellular mitochondrial components secreted from activated live mast cells
    • Theoharides TC, Asadi S, Panagiotidou S, Weng Z. The "missing link" in auto-immunity and autism: Extracellular mitochondrial components secreted from activated live mast cells. Autoimmun Rev 2013; 12: 1136–1142.
    • (2013) Autoimmun Rev , vol.12 , pp. 1136-1142
    • Theoharides, T.C.1    Asadi, S.2    Panagiotidou, S.3    Weng, Z.4
  • 103
    • 77749330821 scopus 로고    scopus 로고
    • Mito-chondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegenera-tion, and impaired behavior
    • Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF et al. Mito-chondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegenera-tion, and impaired behavior. Mol Cell Biol 2010; 30: 1357–1367.
    • (2010) Mol Cell Biol , vol.30 , pp. 1357-1367
    • Lauritzen, K.H.1    Moldestad, O.2    Eide, L.3    Carlsen, H.4    Nesse, G.5    Storm, J.F.6
  • 105
    • 84857369274 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in autism spectrum disorders: A systematic review and meta-analysis
    • Rossignol DA, Frye RE. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry 2012; 17: 290–314.
    • (2012) Mol Psychiatry , vol.17 , pp. 290-314
    • Rossignol, D.A.1    Frye, R.E.2
  • 106
    • 47949107183 scopus 로고    scopus 로고
    • The development of allergic inflammation
    • Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008; 454: 445–454.
    • (2008) Nature , vol.454 , pp. 445-454
    • Galli, S.J.1    Tsai, M.2    Piliponsky, A.M.3
  • 107
    • 84860222551 scopus 로고    scopus 로고
    • Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults
    • Hagberg H, Gressens P, Mallard C. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann Neurol 2012; 71: 444–457.
    • (2012) Ann Neurol , vol.71 , pp. 444-457
    • Hagberg, H.1    Gressens, P.2    Mallard, C.3
  • 108
    • 84873279865 scopus 로고    scopus 로고
    • The role of the innate immune system in psychiatric disorders
    • Jones KA, Thomsen C. The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci 2013; 53: 52–62.
    • (2013) Mol Cell Neurosci , vol.53 , pp. 52-62
    • Jones, K.A.1    Thomsen, C.2
  • 109
    • 3042731246 scopus 로고    scopus 로고
    • Is damage in central nervous system due to inflammation?
    • Chavarria A, Alcocer-Varela J. Is damage in central nervous system due to inflammation? Autoimmun Rev 2004; 3: 251–260.
    • (2004) Autoimmun Rev , vol.3 , pp. 251-260
    • Chavarria, A.1    Alcocer-Varela, J.2
  • 110
    • 84922616643 scopus 로고    scopus 로고
    • Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells
    • Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, Lopez-Aranda M et al. Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Rep 2014; 3: 725–734.
    • (2014) Stem Cell Rep , vol.3 , pp. 725-734
    • Le Belle, J.E.1    Sperry, J.2    Ngo, A.3    Ghochani, Y.4    Laks, D.R.5    Lopez-Aranda, M.6
  • 111
    • 84857190395 scopus 로고    scopus 로고
    • The role of immune dysfunction in the pathophysiology of autism
    • Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 2012; 26: 383–392.
    • (2012) Brain Behav Immun , vol.26 , pp. 383-392
    • Onore, C.1    Careaga, M.2    Ashwood, P.3
  • 112
    • 84937558111 scopus 로고    scopus 로고
    • Immune mediators in the brain and peripheral tissues in autism spectrum disorder
    • Estes ML, McAllister AK. Immune mediators in the brain and peripheral tissues in autism spectrum disorder. Nat Rev Neurosci 2015; 16: 469–486.
    • (2015) Nat Rev Neurosci , vol.16 , pp. 469-486
    • Estes, M.L.1    McAllister, A.K.2
  • 113
    • 84892588761 scopus 로고    scopus 로고
    • Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring
    • Bauman MD, Iosif AM, Smith SE, Bregere C, Amaral DG, Patterson PH. Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biol Psychiatry 2014; 75: 332–341.
    • (2014) Biol Psychiatry , vol.75 , pp. 332-341
    • Bauman, M.D.1    Iosif, A.M.2    Smith, S.E.3    Bregere, C.4    Amaral, D.G.5    Patterson, P.H.6
  • 115
    • 84865597109 scopus 로고    scopus 로고
    • Maternal autoantibodies in autism
    • Braunschweig D, Van de Water J. Maternal autoantibodies in autism. Arch Neurol 2012; 69: 693–699.
    • (2012) Arch Neurol , vol.69 , pp. 693-699
    • Braunschweig, D.1    van de Water, J.2
  • 117
    • 79960228390 scopus 로고    scopus 로고
    • Detection of plasma auto-antibodies to brain tissue in young children with and without autism spectrum disorders
    • Rossi CC, Van de Water J, Rogers SJ, Amaral DG. Detection of plasma auto-antibodies to brain tissue in young children with and without autism spectrum disorders. Brain Behav Immun 2011; 25: 1123–1135.
    • (2011) Brain Behav Immun , vol.25 , pp. 1123-1135
    • Rossi, C.C.1    van de Water, J.2    Rogers, S.J.3    Amaral, D.G.4
  • 118
    • 84942198757 scopus 로고    scopus 로고
    • The crucial role of mast cells in blood-brain barrier alterations
    • Ribatti D. The crucial role of mast cells in blood-brain barrier alterations. Exp Cell Res 2015; 338: 119–125.
    • (2015) Exp Cell Res , vol.338 , pp. 119-125
    • Ribatti, D.1
  • 119
    • 84880764625 scopus 로고    scopus 로고
    • The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children
    • Mostafa GA, Al-Ayadhi LY. The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children. J Neuroimmunol 2013; 261: 77–81.
    • (2013) J Neuroimmunol , vol.261 , pp. 77-81
    • Mostafa, G.A.1    Al-Ayadhi, L.Y.2
  • 122
    • 84977763636 scopus 로고    scopus 로고
    • Children with Autism Spectrum Disorders, who improved with a luteolin containing dietary formulation, show reduced serum levels of TNF and IL-6
    • Tsilioni I, Taliou A, Francis K, Theoharides TC. Children with Autism Spectrum Disorders, who improved with a luteolin containing dietary formulation, show reduced serum levels of TNF and IL-6. Transl Psychiatry 2015; 5: e647.
    • (2015) Transl Psychiatry , vol.5
    • Tsilioni, I.1    Taliou, A.2    Francis, K.3    Theoharides, T.C.4
  • 123
    • 78649322790 scopus 로고    scopus 로고
    • Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome
    • Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2011; 25: 40–45.
    • (2011) Brain Behav Immun , vol.25 , pp. 40-45
    • Ashwood, P.1    Krakowiak, P.2    Hertz-Picciotto, I.3    Hansen, R.4    Pessah, I.5    van de Water, J.6
  • 125
    • 84902741281 scopus 로고    scopus 로고
    • Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: The Early Markers for Autism (EMA) study: A case-control study
    • Zerbo O, Yoshida C, Grether JK, Van de Water J, Ashwood P, Delorenze GN et al. Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study. J Neuroinflammation 2014; 11: 113.
    • (2014) J Neuroinflammation , vol.11 , pp. 113
    • Zerbo, O.1    Yoshida, C.2    Grether, J.K.3    van de Water, J.4    Ashwood, P.5    Delorenze, G.N.6
  • 126
    • 84857191889 scopus 로고    scopus 로고
    • Increased midgestational IFN-gamma, IL-4 and IL-5 in women bearing a child with autism: A case-control study
    • Goines PE, Croen LA, Braunschweig D, Yoshida CK, Grether J, Hansen R et al. Increased midgestational IFN-gamma, IL-4 and IL-5 in women bearing a child with autism: a case-control study. Mol Autism 2011; 2: 13.
    • (2011) Mol Autism , vol.2 , pp. 13
    • Goines, P.E.1    Croen, L.A.2    Braunschweig, D.3    Yoshida, C.K.4    Grether, J.5    Hansen, R.6
  • 127
    • 34247401706 scopus 로고    scopus 로고
    • Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice
    • Nakae S, Suto H, Berry GJ, Galli SJ. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 2007; 109: 3640–3648.
    • (2007) Blood , vol.109 , pp. 3640-3648
    • Nakae, S.1    Suto, H.2    Berry, G.J.3    Galli, S.J.4
  • 128
    • 84907202723 scopus 로고    scopus 로고
    • Intersection of population variation and autoimmunity genetics in human T cell activation
    • Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science 2014; 345: 1254665.
    • (2014) Science , vol.345
    • Ye, C.J.1    Feng, T.2    Kwon, H.K.3    Raj, T.4    Wilson, M.T.5    Asinovski, N.6
  • 129
    • 84946082735 scopus 로고    scopus 로고
    • IL-17 producing mast cells promote the expansion of myeloid-derived suppressor cells in a mouse allergy model of colorectal cancer
    • Chen X, Churchill MJ, Nagar KK, Tailor YH, Chu T, Rush BS et al. IL-17 producing mast cells promote the expansion of myeloid-derived suppressor cells in a mouse allergy model of colorectal cancer. Oncotarget 2015; 6: 32966–32979.
    • (2015) Oncotarget , vol.6 , pp. 32966-32979
    • Chen, X.1    Churchill, M.J.2    Nagar, K.K.3    Tailor, Y.H.4    Chu, T.5    Rush, B.S.6
  • 130
    • 84863100133 scopus 로고    scopus 로고
    • Elevated serum levels of interleukin-17 A in children with autism
    • Al-Ayadhi LY, Mostafa GA. Elevated serum levels of interleukin-17 A in children with autism. J Neuroinflammation 2012; 9: 158.
    • (2012) J Neuroinflammation , vol.9 , pp. 158
    • Al-Ayadhi, L.Y.1    Mostafa, G.A.2
  • 131
    • 84939493493 scopus 로고    scopus 로고
    • Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma
    • Akintunde ME, Rose M, Krakowiak P, Heuer L, Ashwood P, Hansen R et al. Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma. J Neuroimmunol 2015; 286: 33–41.
    • (2015) J Neuroimmunol , vol.286 , pp. 33-41
    • Akintunde, M.E.1    Rose, M.2    Krakowiak, P.3    Heuer, L.4    Ashwood, P.5    Hansen, R.6
  • 132
    • 84959447961 scopus 로고    scopus 로고
    • The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring
    • pii: aad0314
    • Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV et al. The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring. Science 2016; pii: aad0314.
    • (2016) Science
    • Choi, G.B.1    Yim, Y.S.2    Wong, H.3    Kim, S.4    Kim, H.5    Kim, S.V.6
  • 134
    • 35148872226 scopus 로고    scopus 로고
    • Maternal immune activation alters fetal brain development through interleukin-6
    • Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 2007; 27: 10695–10702.
    • (2007) J Neurosci , vol.27 , pp. 10695-10702
    • Smith, S.E.1    Li, J.2    Garbett, K.3    Mirnics, K.4    Patterson, P.H.5
  • 135
    • 0038094519 scopus 로고    scopus 로고
    • Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice
    • Huang M, Pang X, Karalis K, Theoharides TC. Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Cardiovasc Res 2003; 59: 241–249.
    • (2003) Cardiovasc Res , vol.59 , pp. 241-249
    • Huang, M.1    Pang, X.2    Karalis, K.3    Theoharides, T.C.4
  • 137
    • 0036674526 scopus 로고    scopus 로고
    • Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients
    • Theoharides TC, Boucher W, Spear K. Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol 2002; 128: 344–350.
    • (2002) Int Arch Allergy Immunol , vol.128 , pp. 344-350
    • Theoharides, T.C.1    Boucher, W.2    Spear, K.3
  • 138
    • 18844436185 scopus 로고    scopus 로고
    • IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis
    • Brockow K, Akin C, Huber M, Metcalfe DD. IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis. Clin Immunol 2005; 115: 216–223.
    • (2005) Clin Immunol , vol.115 , pp. 216-223
    • Brockow, K.1    Akin, C.2    Huber, M.3    Metcalfe, D.D.4
  • 139
    • 84953371082 scopus 로고    scopus 로고
    • Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression
    • Mayado A, Teodosio C, Garcia-Montero AC, Matito A, Rodriguez-Caballero A, Morgado JM et al. Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression. Leukemia 2015; 30: 124–130.
    • (2015) Leukemia , vol.30 , pp. 124-130
    • Mayado, A.1    Teodosio, C.2    Garcia-Montero, A.C.3    Matito, A.4    Rodriguez-Caballero, A.5    Morgado, J.M.6
  • 140
    • 81355146671 scopus 로고    scopus 로고
    • Amniotic fluid chemokines and autism spectrum disorders: An exploratory study utilizing a Danish Historic Birth Cohort
    • Abdallah MW, Larsen N, Grove J, Norgaard-Pedersen B, Thorsen P, Mortensen EL et al. Amniotic fluid chemokines and autism spectrum disorders: an exploratory study utilizing a Danish Historic Birth Cohort. Brain Behav Immun 2012; 26: 170–176.
    • (2012) Brain Behav Immun , vol.26 , pp. 170-176
    • Abdallah, M.W.1    Larsen, N.2    Grove, J.3    Norgaard-Pedersen, B.4    Thorsen, P.5    Mortensen, E.L.6
  • 141
    • 84860583269 scopus 로고    scopus 로고
    • Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells
    • Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD et al. Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol 2012; 159: 23–32.
    • (2012) Int Arch Allergy Immunol , vol.159 , pp. 23-32
    • Zhang, B.1    Weng, Z.2    Sismanopoulos, N.3    Asadi, S.4    Therianou, A.5    Alysandratos, K.D.6
  • 142
    • 33645232376 scopus 로고    scopus 로고
    • Immunological findings in autism
    • Cohly HH, Panja A. Immunological findings in autism. Int Rev Neurobiol 2005; 71: 317–341.
    • (2005) Int Rev Neurobiol , vol.71 , pp. 317-341
    • Cohly, H.H.1    Panja, A.2
  • 145
    • 0034750434 scopus 로고    scopus 로고
    • Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression
    • Jyonouchi H, Sun S, Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol 2001; 120: 170–179.
    • (2001) J Neuroimmunol , vol.120 , pp. 170-179
    • Jyonouchi, H.1    Sun, S.2    Le, H.3
  • 147
    • 84862170482 scopus 로고    scopus 로고
    • Aberrant NF-kappaB expression in autism spectrum condition: A mechanism for neuroinflammation
    • Young AM, Campbell E, Lynch S, Suckling J, Powis SJ. Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation. Front Psychiatry 2011; 2: 27.
    • (2011) Front Psychiatry , vol.2 , pp. 27
    • Young, A.M.1    Campbell, E.2    Lynch, S.3    Suckling, J.4    Powis, S.J.5
  • 148
    • 80052858901 scopus 로고    scopus 로고
    • Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways
    • Ziats MN, Rennert OM. Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways. PLoS One 2011; 6: e24691.
    • (2011) Plos One , vol.6
    • Ziats, M.N.1    Rennert, O.M.2
  • 150
    • 84942526430 scopus 로고    scopus 로고
    • Microglia plasticity during health and disease: An immunological perspective
    • Shemer A, Erny D, Jung S, Prinz M. Microglia plasticity during health and disease: an immunological perspective. Trends Immunol 2015; 36: 614–624.
    • (2015) Trends Immunol , vol.36 , pp. 614-624
    • Shemer, A.1    Erny, D.2    Jung, S.3    Prinz, M.4
  • 152
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 2012; 74: 691–705.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1    Lehrman, E.K.2    Kautzman, A.G.3    Koyama, R.4    Mardinly, A.R.5    Yamasaki, R.6
  • 153
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005; 57: 67–81.
    • (2005) Ann Neurol , vol.57 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 154
    • 77955684004 scopus 로고    scopus 로고
    • Microglial activation and increased microglial density observed in the dorso-lateral prefrontal cortex in autism
    • Morgan JT, Chana G, Pardo CA, Achim C, Semendeferi K, Buckwalter J et al. Microglial activation and increased microglial density observed in the dorso-lateral prefrontal cortex in autism. Biol Psychiatry 2010; 68: 368–376.
    • (2010) Biol Psychiatry , vol.68 , pp. 368-376
    • Morgan, J.T.1    Chana, G.2    Pardo, C.A.3    Achim, C.4    Semendeferi, K.5    Buckwalter, J.6
  • 155
    • 84908144786 scopus 로고    scopus 로고
    • Stereological study of amyg-dala glial populations in adolescents and adults with autism spectrum disorder
    • Morgan JT, Barger N, Amaral DG, Schumann CM. Stereological study of amyg-dala glial populations in adolescents and adults with autism spectrum disorder. PLoS One 2014; 9: e110356.
    • (2014) Plos One , vol.9
    • Morgan, J.T.1    Barger, N.2    Amaral, D.G.3    Schumann, C.M.4
  • 156
    • 84923384915 scopus 로고    scopus 로고
    • Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
    • Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun 2014; 5: 5748.
    • (2014) Nat Commun , vol.5 , pp. 5748
    • Gupta, S.1    Ellis, S.E.2    Ashar, F.N.3    Moes, A.4    Bader, J.S.5    Zhan, J.6
  • 157
    • 84937641555 scopus 로고    scopus 로고
    • Role of microglia in autism: Recent advances
    • Takano T. Role of microglia in autism: recent advances. Dev Neurosci 2015; 37: 195–202.
    • (2015) Dev Neurosci , vol.37 , pp. 195-202
    • Takano, T.1
  • 158
    • 84946471921 scopus 로고    scopus 로고
    • Microglia in the pathogenesis of autism spectrum dis-orders
    • Koyama R, Ikegaya Y. Microglia in the pathogenesis of autism spectrum dis-orders. Neurosci Res 2015; 100: 1–5.
    • (2015) Neurosci Res , vol.100 , pp. 1-5
    • Koyama, R.1    Ikegaya, Y.2
  • 159
    • 0036319613 scopus 로고    scopus 로고
    • Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microglia
    • Wang W, Ji P, Riopelle RJ, Dow KE. Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microglia. J Neurochem 2002; 80: 287–294.
    • (2002) J Neurochem , vol.80 , pp. 287-294
    • Wang, W.1    Ji, P.2    Riopelle, R.J.3    Dow, K.E.4
  • 160
    • 0037442515 scopus 로고    scopus 로고
    • Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia
    • Martin S, Vincent JP, Mazella J. Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. J Neurosci 2003; 23: 1198–1205.
    • (2003) J Neurosci , vol.23 , pp. 1198-1205
    • Martin, S.1    Vincent, J.P.2    Mazella, J.3
  • 161
    • 84859267166 scopus 로고    scopus 로고
    • Sortilin: A receptor to regulate neuronal viability and function
    • Nykjaer A, Willnow TE. Sortilin: a receptor to regulate neuronal viability and function. Trends Neurosci 2012; 35: 261–270.
    • (2012) Trends Neurosci , vol.35 , pp. 261-270
    • Nykjaer, A.1    Willnow, T.E.2
  • 163
    • 77957200346 scopus 로고    scopus 로고
    • Targeting neurotensin as a potential novel approach for the treatment of autism
    • Ghanizadeh A. Targeting neurotensin as a potential novel approach for the treatment of autism. J Neuroinflammation 2010; 7: 58.
    • (2010) J Neuroinflammation , vol.7 , pp. 58
    • Ghanizadeh, A.1
  • 165
    • 85011045053 scopus 로고    scopus 로고
    • Roles of mTOR signaling in brain development
    • Lee dY. Roles of mTOR signaling in brain development. Exp Neurobiol 2015; 24: 177–185.
    • (2015) Exp Neurobiol , vol.24 , pp. 177-185
    • Dy, L.1
  • 166
    • 84890669424 scopus 로고    scopus 로고
    • Role of the PTEN signaling pathway in autism spectrum disorder
    • Lv JW, Cheng TL, Qiu ZL, Zhou WH. Role of the PTEN signaling pathway in autism spectrum disorder. Neurosci Bull 2013; 29: 773–778.
    • (2013) Neurosci Bull , vol.29 , pp. 773-778
    • Lv, J.W.1    Cheng, T.L.2    Qiu, Z.L.3    Zhou, W.H.4
  • 167
    • 84961209822 scopus 로고    scopus 로고
    • The role of mTOR signalling in neu-rogenesis, insights from tuberous sclerosis complex
    • Tee AR, Sampson JR, Pal DK, Bateman JM. The role of mTOR signalling in neu-rogenesis, insights from tuberous sclerosis complex. Semin Cell Dev Biol 2016; 52: 12–20.
    • (2016) Semin Cell Dev Biol , vol.52 , pp. 12-20
    • Tee, A.R.1    Sampson, J.R.2    Pal, D.K.3    Bateman, J.M.4
  • 168
    • 44449141488 scopus 로고    scopus 로고
    • Activation and function of the mTORC1 pathway in mast cells
    • Kim MS, Kuehn HS, Metcalfe DD, Gilfillan AM. Activation and function of the mTORC1 pathway in mast cells. J Immunol 2008; 180: 4586–4595.
    • (2008) J Immunol , vol.180 , pp. 4586-4595
    • Kim, M.S.1    Kuehn, H.S.2    Metcalfe, D.D.3    Gilfillan, A.M.4
  • 169
    • 84902553958 scopus 로고    scopus 로고
    • Histamine induces upregulated expression of histamine receptors and increases release of inflammatory mediators from microglia
    • Dong H, Zhang W, Zeng X, Hu G, Zhang H, He S et al. Histamine induces upregulated expression of histamine receptors and increases release of inflammatory mediators from microglia. Mol Neurobiol 2014; 49: 1487–1500.
    • (2014) Mol Neurobiol , vol.49 , pp. 1487-1500
    • Dong, H.1    Zhang, W.2    Zeng, X.3    Hu, G.4    Zhang, H.5    He, S.6
  • 170
    • 84861369452 scopus 로고    scopus 로고
    • Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling
    • Zhang S, Zeng X, Yang H, Hu G, He S. Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling. Cell Physiol Biochem 2012; 29: 931–940.
    • (2012) Cell Physiol Biochem , vol.29 , pp. 931-940
    • Zhang, S.1    Zeng, X.2    Yang, H.3    Hu, G.4    He, S.5
  • 171
    • 84924191380 scopus 로고    scopus 로고
    • Neuroinflammation, microglia and mast cells in the pathophysiology of neurocognitive disorders: A review
    • Skaper SD, Facci L, Giusti P. Neuroinflammation, microglia and mast cells in the pathophysiology of neurocognitive disorders: a review. CNS Neurol Disord Drug Targets 2014; 13: 1654–1666.
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , pp. 1654-1666
    • Skaper, S.D.1    Facci, L.2    Giusti, P.3
  • 172
    • 85012995229 scopus 로고    scopus 로고
    • Suppression of brain mast cells degranulation inhibits microglial activation and central nervous system inflammation
    • in press
    • Dong H, Zhang X, Wang Y, Zhou X, Qian Y, Zhang S. Suppression of brain mast cells degranulation inhibits microglial activation and central nervous system inflammation. Mol Neurobiol 2016 (in press).
    • (2016) Mol Neurobiol
    • Dong, H.1    Zhang, X.2    Wang, Y.3    Zhou, X.4    Qian, Y.5    Zhang, S.6
  • 173
    • 84931471107 scopus 로고    scopus 로고
    • The variation of psychopharmacological prescription rates for people with autism spectrum disorder (ASD) in 30 Countries
    • Wong AY, Hsia Y, Chan EW, Murphy DG, Simonoff E, Buitelaar JK et al. The variation of psychopharmacological prescription rates for people with autism spectrum disorder (ASD) in 30 Countries. Autism Res 2014; 7: 543–554.
    • (2014) Autism Res , vol.7 , pp. 543-554
    • Wong, A.Y.1    Hsia, Y.2    Chan, E.W.3    Murphy, D.G.4    Simonoff, E.5    Buitelaar, J.K.6
  • 174
    • 84887091459 scopus 로고    scopus 로고
    • Psychotropic medication use and polypharmacy in children with autism spectrum disorders
    • Spencer D, Marshall J, Post B, Kulakodlu M, Newschaffer C, Dennen T et al. Psychotropic medication use and polypharmacy in children with autism spectrum disorders. Pediatrics 2013; 132: 833–840.
    • (2013) Pediatrics , vol.132 , pp. 833-840
    • Spencer, D.1    Marshall, J.2    Post, B.3    Kulakodlu, M.4    Newschaffer, C.5    Dennen, T.6
  • 175
    • 84904667222 scopus 로고    scopus 로고
    • Psychotropic medication trends among children and adolescents with autism spectrum disorder in the Medicaid program
    • Schubart JR, Camacho F, Leslie D. Psychotropic medication trends among children and adolescents with autism spectrum disorder in the Medicaid program. Autism 2014; 18: 631–637.
    • (2014) Autism , vol.18 , pp. 631-637
    • Schubart, J.R.1    Camacho, F.2    Leslie, D.3
  • 176
    • 84922398484 scopus 로고    scopus 로고
    • An update on pharmacotherapy for autism spectrum disorder in children and adolescents
    • Young NJ, Findling RL. An update on pharmacotherapy for autism spectrum disorder in children and adolescents. Curr Opin Psychiatry 2015; 28: 91–101.
    • (2015) Curr Opin Psychiatry , vol.28 , Issue.9 , pp. 1-101
    • Young, N.J.1    Findling, R.L.2
  • 177
    • 84911481236 scopus 로고    scopus 로고
    • Child, parent, and service predictors of psychotropic polypharmacy among adolescents and young adults with an autism spectrum disorder
    • Lake JK, Weiss JA, Dergal J, Lunsky Y. Child, parent, and service predictors of psychotropic polypharmacy among adolescents and young adults with an autism spectrum disorder. J Child Adolesc Psychopharmacol 2014; 24: 486–493.
    • (2014) J Child Adolesc Psychopharmacol , vol.24 , pp. 486-493
    • Lake, J.K.1    Weiss, J.A.2    Dergal, J.3    Lunsky, Y.4
  • 178
    • 84863725814 scopus 로고    scopus 로고
    • Unwanted interactions among psychotropic drugs and other treatments for autism spectrum disorders
    • Theoharides TC, Asadi S. Unwanted interactions among psychotropic drugs and other treatments for autism spectrum disorders. J Clin Psychopharmacol 2012; 32: 437–440.
    • (2012) J Clin Psychopharmacol , vol.32 , pp. 437-440
    • Theoharides, T.C.1    Asadi, S.2
  • 179
    • 84883741375 scopus 로고    scopus 로고
    • Developing new pharmacotherapies for autism
    • Ecker C, Spooren W, Murphy D. Developing new pharmacotherapies for autism. J Intern Med 2013; 274: 308–320.
    • (2013) J Intern Med , vol.274 , pp. 308-320
    • Ecker, C.1    Spooren, W.2    Murphy, D.3
  • 180
    • 77954896514 scopus 로고    scopus 로고
    • Immune therapy in autism: Historical experience and future directions with immunomodulatory therapy
    • Chez MG, Guido-Estrada N. Immune therapy in autism: historical experience and future directions with immunomodulatory therapy. Neurotherapeutics 2010; 7: 293–301.
    • (2010) Neurotherapeutics , vol.7 , pp. 293-301
    • Chez, M.G.1    Guido-Estrada, N.2
  • 181
    • 84982143309 scopus 로고    scopus 로고
    • Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study
    • in press
    • Liew Z, Ritz B, Virk J, Olsen J. Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: a Danish national birth cohort study. Autism Res 2015 (in press).
    • (2015) Autism Res
    • Liew, Z.1    Ritz, B.2    Virk, J.3    Olsen, J.4
  • 183
    • 77956184652 scopus 로고    scopus 로고
    • Adaptive and innate immune responses in autism: Rationale for therapeutic use of intravenous immunoglobulin
    • Gupta S, Samra D, Agrawal S. Adaptive and innate immune responses in autism: rationale for therapeutic use of intravenous immunoglobulin. J Clin Immunol 2010; 30(Suppl 1): S90–S96.
    • (2010) J Clin Immunol , vol.30 , pp. S90-S96
    • Gupta, S.1    Samra, D.2    Agrawal, S.3
  • 184
    • 84989884148 scopus 로고    scopus 로고
    • Impact of immunoglobulin therapy in pediatric disease: A review of immune mechanisms
    • in press
    • Wong PH, White KM. Impact of immunoglobulin therapy in pediatric disease: a review of immune mechanisms. Clin Rev Allergy Immunol 2015 (in press).
    • (2015) Clin Rev Allergy Immunol
    • Wong, P.H.1    White, K.M.2
  • 185
    • 0031978921 scopus 로고    scopus 로고
    • Intravenous immunoglobulin treatment of children with autism
    • Plioplys AV. Intravenous immunoglobulin treatment of children with autism. J Child Neurol 1998; 13: 79–82.
    • (1998) J Child Neurol , vol.13 , pp. 79-82
    • Plioplys, A.V.1
  • 186
    • 0030203370 scopus 로고    scopus 로고
    • Dysregulated immune system in children with autism: Beneficial effects of intravenous immune globulin on autistic char-acteristics
    • Gupta S, Aggarwal S, Heads C. Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic char-acteristics. J Autism Dev Disord 1996; 26: 439–452.
    • (1996) J Autism Dev Disord , vol.26 , pp. 439-452
    • Gupta, S.1    Aggarwal, S.2    Heads, C.3
  • 189
    • 84865648884 scopus 로고    scopus 로고
    • Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction
    • Heuer LS, Rose M, Ashwood P, Van de Water J. Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction. J Neuroimmunol 2012; 251: 94–102.
    • (2012) J Neuroimmunol , vol.251 , pp. 94-102
    • Heuer, L.S.1    Rose, M.2    Ashwood, P.3    van de Water, J.4
  • 190
    • 84899485309 scopus 로고    scopus 로고
    • The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages
    • Siniscalco D, Bradstreet JJ, Cirillo A, Antonucci N. The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages. J Neuroinflammation 2014; 11: 78.
    • (2014) J Neuroinflammation , vol.11 , pp. 78
    • Siniscalco, D.1    Bradstreet, J.J.2    Cirillo, A.3    Antonucci, N.4
  • 192
    • 84888861958 scopus 로고    scopus 로고
    • Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: A multisite randomized clinical trial
    • King BH, Dukes K, Donnelly CL, Sikich L, McCracken JT, Scahill L et al. Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: a multisite randomized clinical trial. JAMA Pediatr 2013; 167: 1045–1052.
    • (2013) JAMA Pediatr , vol.167 , pp. 1045-1052
    • King, B.H.1    Dukes, K.2    Donnelly, C.L.3    Sikich, L.4    McCracken, J.T.5    Scahill, L.6
  • 194
    • 84880914412 scopus 로고    scopus 로고
    • A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic dis-orders
    • Ghanizadeh A, Moghimi-Sarani E. A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic dis-orders. BMC Psychiatry 2013; 13: 196.
    • (2013) BMC Psychiatry , vol.13 , pp. 196
    • Ghanizadeh, A.1    Moghimi-Sarani, E.2
  • 195
    • 84930200195 scopus 로고    scopus 로고
    • Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
    • Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O et al. Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neurosci Biobehav Rev 2015; 55: 294–321.
    • (2015) Neurosci Biobehav Rev , vol.55 , pp. 294-321
    • Deepmala, S.J.1    Kumar, N.2    Delhey, L.3    Berk, M.4    Dean, O.5
  • 196
    • 84964306146 scopus 로고    scopus 로고
    • N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irrit-ability in autism: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety
    • Nikoo M, Radnia H, Farokhnia M, Mohammadi MR, Akhondzadeh S. N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irrit-ability in autism: a randomized, double-blind, placebo-controlled clinical trial of efficacy and safety. Clin Neuropharmacol 2015; 38: 11–17.
    • (2015) Clin Neuropharmacol , vol.38 , pp. 11-17
    • Nikoo, M.1    Radnia, H.2    Farokhnia, M.3    Mohammadi, M.R.4    Akhondzadeh, S.5
  • 197
    • 84877905373 scopus 로고    scopus 로고
    • An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders
    • Taliou A, Zintzaras E, Lykouras L, Francis K. An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther 2013; 35: 592–602.
    • (2013) Clin Ther , vol.35 , pp. 592-602
    • Taliou, A.1    Zintzaras, E.2    Lykouras, L.3    Francis, K.4
  • 198
    • 84863708123 scopus 로고    scopus 로고
    • A case series of a luteolin formulation (Neuroprotek®) in children with autism spectrum disorders
    • Theoharides TC, Asadi S, Panagiotidou S. A case series of a luteolin formulation (Neuroprotek®) in children with autism spectrum disorders. Intl J Immunopathol Pharmacol 2012; 25: 317–323.
    • (2012) Intl J Immunopathol Pharmacol , vol.25 , pp. 317-323
    • Theoharides, T.C.1    Asadi, S.2    Panagiotidou, S.3
  • 199
    • 84935075885 scopus 로고    scopus 로고
    • Brain "fog," inflammation and obesity: Key aspects of neuropsychiatric disorders improved by luteolin
    • Theoharides TC, Stewart JM, Hatziagelaki E, Kolaitis G. Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci 2015; 9: 225.
    • (2015) Front Neurosci , vol.9 , pp. 225
    • Theoharides, T.C.1    Stewart, J.M.2    Hatziagelaki, E.3    Kolaitis, G.4
  • 200
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer
    • Middleton EJ, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000; 52: 673–751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.J.1    Kandaswami, C.2    Theoharides, T.C.3
  • 201
    • 77249168715 scopus 로고    scopus 로고
    • A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
    • Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 2010; 107: 2687–2692.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2687-2692
    • Jang, S.W.1    Liu, X.2    Yepes, M.3    Shepherd, K.R.4    Miller, G.W.5    Liu, Y.6
  • 202
    • 84880326713 scopus 로고    scopus 로고
    • Reduced social inter-action, behavioural flexibility and BDNF signalling in the BTBR T+ tf/J strain, a mouse model of autism
    • Scattoni ML, Martire A, Cartocci G, Ferrante A, Ricceri L. Reduced social inter-action, behavioural flexibility and BDNF signalling in the BTBR T+ tf/J strain, a mouse model of autism. Behav Brain Res 2013; 251: 35–40.
    • (2013) Behav Brain Res , vol.251 , pp. 35-40
    • Scattoni, M.L.1    Martire, A.2    Cartocci, G.3    Ferrante, A.4    Ricceri, L.5
  • 203
    • 84859565377 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome
    • Johnson RA, Lam M, Punzo AM, Li H, Lin BR, Ye K et al. 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. J Appl Physiol 2012; 112: 704–710.
    • (2012) J Appl Physiol , vol.112 , pp. 704-710
    • Johnson, R.A.1    Lam, M.2    Punzo, A.M.3    Li, H.4    Lin, B.R.5    Ye, K.6
  • 204
    • 84927170323 scopus 로고    scopus 로고
    • Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders
    • Theoharides T, Athanassiou M, Panagiotidou S, Doyle R. Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders. J Neuroimmunol 2015; 279: 33–38.
    • (2015) J Neuroimmunol , vol.279 , pp. 33-38
    • Theoharides, T.1    Athanassiou, M.2    Panagiotidou, S.3    Doyle, R.4
  • 205
    • 0034062416 scopus 로고    scopus 로고
    • Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells
    • Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy 2000; 30: 501–508.
    • (2000) Clin Exp Allergy , vol.30 , pp. 501-508
    • Kimata, M.1    Shichijo, M.2    Miura, T.3    Serizawa, I.4    Inagaki, N.5    Nagai, H.6
  • 206
    • 23744474477 scopus 로고    scopus 로고
    • Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells
    • Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N et al. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol 2005; 145: 934–944.
    • (2005) Br J Pharmacol , vol.145 , pp. 934-944
    • Kempuraj, D.1    Madhappan, B.2    Christodoulou, S.3    Boucher, W.4    Cao, J.5    Papadopoulou, N.6
  • 207
    • 84926244926 scopus 로고    scopus 로고
    • The novel flavone tetra-methoxyluteolin is a potent inhibitor of human mast cells
    • Weng Z, Patel A, Panagiotidou S, Theoharidess TC. The novel flavone tetra-methoxyluteolin is a potent inhibitor of human mast cells. J Allergy Clin Immunol 2014; 14: 1044–1052.
    • (2014) J Allergy Clin Immunol , vol.14 , pp. 1044-1052
    • Weng, Z.1    Patel, A.2    Panagiotidou, S.3    Theoharidess, T.C.4
  • 208
    • 76749083375 scopus 로고    scopus 로고
    • Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
    • Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y et al. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation 2010; 7: 3.
    • (2010) J Neuroinflammation , vol.7 , pp. 3
    • Dirscherl, K.1    Karlstetter, M.2    Ebert, S.3    Kraus, D.4    Hlawatsch, J.5    Walczak, Y.6
  • 209
    • 44949125522 scopus 로고    scopus 로고
    • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
    • Jang S, Kelley KW, Johnson RW. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci USA 2008; 105: 7534–7539.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7534-7539
    • Jang, S.1    Kelley, K.W.2    Johnson, R.W.3
  • 210
    • 56049116002 scopus 로고    scopus 로고
    • Luteolin protects dopa-minergic neurons from inflammation-induced injury through inhibition of microglial activation
    • Chen HQ, Jin ZY, Wang XJ, Xu XM, Deng L, Zhao JW. Luteolin protects dopa-minergic neurons from inflammation-induced injury through inhibition of microglial activation. Neurosci Lett 2008; 448: 175–179.
    • (2008) Neurosci Lett , vol.448 , pp. 175-179
    • Chen, H.Q.1    Jin, Z.Y.2    Wang, X.J.3    Xu, X.M.4    Deng, L.5    Zhao, J.W.6
  • 211
    • 70449643365 scopus 로고    scopus 로고
    • Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism
    • Parker-Athill E, Luo D, Bailey A, Giunta B, Tian J, Shytle RD et al. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. J Neuroimmunol 2009; 217: 20–27.
    • (2009) J Neuroimmunol , vol.217 , pp. 20-27
    • Parker-Athill, E.1    Luo, D.2    Bailey, A.3    Giunta, B.4    Tian, J.5    Shytle, R.D.6
  • 212
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood M, nielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 2007; 45: 2179–2205.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M.1    Nielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 213
    • 84896393412 scopus 로고    scopus 로고
    • Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin
    • Theoharides TC, Conti P, Economu M. Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin. J Clin Psychopharmacol 2014; 34: 187–189.
    • (2014) J Clin Psychopharmacol , vol.34 , pp. 187-189
    • Theoharides, T.C.1    Conti, P.2    Economu, M.3


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