Brief report: "Allergic symptoms" in children with autism spectrum disorders. more than meets the eye?

Journal of Autism and Developmental Disorders

Volumn 41, Issue 11, 2011, Pages 1579-1585

  Angelidou, Asimenia ^a,b   Alysandratos, Konstantinos Dionysios ^a,b   Asadi, Shahrzad ^a   Zhang, Bodi ^a   Francis, Konstantinos ^b   Vasiadi, Magdalini ^a,b   Kalogeromitros, Dimitrios ^b   Theoharides, Theoharis C ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Allergy; Autism; Brain; Food intolerance; Inflammation; Mast cells

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; IMMUNOGLOBULIN E; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROTENSIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1;

ADAPTIVE IMMUNITY; ALLERGY; ARTICLE; ASTHMA; ATOPIC DERMATITIS; AUTISM; BLOOD BRAIN BARRIER; CELL ACTIVATION; CELL FUNCTION; CEREBROSPINAL FLUID ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ENCEPHALITIS; ENVIRONMENTAL EXPOSURE; FAMILY HISTORY; FOOD ALLERGY; HUMAN; IMMUNE SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; INFECTION; INNATE IMMUNITY; INTESTINE; INTESTINE MUCOSA PERMEABILITY; MAST CELL; MASTOCYTOSIS; NEUROTOXICITY; NUTRITIONAL INTOLERANCE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN BINDING; RHINITIS; SKIN ALLERGY; SKIN TEST; SKIN TINGLING; STRESS; URTICARIA; WHEEZING;

BRAIN; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; HUMANS; HYPERSENSITIVITY; MAST CELLS; MASTOCYTOSIS; RISK FACTORS;

EID: 82955181219     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-010-1171-z     Document Type: Article

References (83)

1. NJ Abbott 2000 Inflammatory mediators and modulation of blood-brain barrier permeability Cellular and Molecular Neurobiology 20 131 147 10696506 10.1023/A:1007074420772 (Pubitemid 30091452)
2. C Akin P Valent L Escribano 2006 Urticaria pigmentosa and mastocytosis: the role of immunophenotyping in diagnosis and determining response to treatment Current allergy and asthma reports 6 4 282 288 16822380 10.1007/s11882-006- 0061-0 (Pubitemid 44056824)
3. Akin, C., Valent, P., Metcalfe, D.D. (2010). Mast cell activation syndrome: Proposed diagnostic criteria. The Journal of Allergy and Clinical Immunology, 126(6), 1099-1104.
4. A Angelidou, et al. 2010 Neurotensin is increased in serum of young children with autistic disorder Journal of neuroinflammation 7 48 20731814 10.1186/1742-2094-7-48
5. K Asadullah W Sterry HD Volk 2003 Interleukin-10 therapy-review of a new approach Pharmacological Reviews 55 241 269 12773629 10.1124/pr.55.2.4 (Pubitemid 36666048)
6. P Ashwood S Wills J Van de Water 2006 The immune response in autism: a new frontier for autism research Journal of Leukocyte Biology 80 1 1 15 16698940 10.1189/jlb.1205707 (Pubitemid 44841805)
7. P Ashwood, et al. 2008 Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes Journal of Neuroimmunology 204 149 153 18762342 10.1016/j.jneuroim.2008.07.006
8. B Bakkaloglu, et al. 2008 Atopic features in early childhood autism European Journal of Paediatrics Neurology 12 476 479 10.1016/j.ejpn.2007.12.008
9. SC Bischoff 2007 Role of mast cells in allergic and non-allergic immune responses:comparison of human and murine data Nature Reviews Immunology 7 2 93 104 17259966 10.1038/nri2018 (Pubitemid 46174857)
10. U Blank J Rivera 2004 The ins and outs of IgE-dependent mast-cell exocytosis Trends Immunology 25 266 273 10.1016/j.it.2004.03.005 (Pubitemid 38501673)
11. MF Blaxill 2004 What's going on? The question of time trends in autism Public Health Reports 119 6 536 551 15504445 10.1016/j.phr.2004.09.003 (Pubitemid 39468809)
12. M Boso, et al. 2010 Seasonal fluctuations in problem behaviors among young adults with autism and intellectual disability Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 16 5 CR213 CR216
13. T Buie, et al. 2010 Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report Pediatrics 125 Suppl 1 S1 S18 20048083 10.1542/peds.2009-1878C
14. M Cabanlit S Wills P Goines P Ashwood J Van de Water 2007 Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder Annals of the New York Academy of Sciences 1107 92 103 17804536 10.1196/annals.1381.010 (Pubitemid 47528785)
15. J Cao, et al. 2005 Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor Journal of Immunology 174 7665 7675 (Pubitemid 40806271)
16. M Castells 2006 Mast cell mediators in allergic inflammation and mastocytosis Immunology and allergy clinics of North America 26 3 465 485 16931289 10.1016/j.iac.2006.05.005 (Pubitemid 44255875)
17. MG Chez T Dowling PB Patel P Khanna M Kominsky 2007 Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children Pediatric Neurology 36 6 361 365 17560496 10.1016/j.pediatrneurol.2007.01.012 (Pubitemid 46873913)
18. GP Chrousos 1995 The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation New England Journal of Medicine 332 1351 1362 7715646 10.1056/NEJM199505183322008
19. P Conti, et al. 1997 Impact of Rantes and MCP-1 chemokines on in vivo basophilic mast cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase Blood 89 4120 4127 9166854 (Pubitemid 27220960)
20. BA Corbett CW Schupp S Levine S Mendoza 2009 Comparing cortisol, stress, and sensory sensitivity in children with autism Autism Research 2 1 39 49 19358306 10.1002/aur.64
21. BA Corbett CW Schupp D Simon N Ryan S Mendoza 2010 Elevated cortisol during play is associated with age and social engagement in children with autism Molecular Autism 1 1 13 20875126 10.1186/2040-2392-1-13
22. LA Croen JK Grether CK Yoshida R Odouli J Van de Water 2005 Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study Archives of Pediatrics and Adolescent Medicine 159 2 151 157 15699309 10.1001/archpedi.159.2.151 (Pubitemid 40194181)
23. K Dirscherl, et al. 2010 Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype Journal of Neuroinflammation 7 1 3 20074346 10.1186/1742-2094-7-3
24. MA Dommergues J Patkai JC Renauld P Evrard P Gressens 2000 Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium Annals of Neurology 47 1 54 63 10632101 10.1002/1531-8249(200001)47:1<54::AID-ANA10>3.0.CO;2-Y (Pubitemid 30033650)
25. J Donelan W Boucher N Papadopoulou M Lytinas D Papaliodis TC Theoharides 2006 Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process Proceedings of the National Academy of Sciences of the United States of America 103 7759 7764 16682628 10.1073/pnas.0602210103
26. SJ Dunn, et al. 1993 Serotypic and genotypic characterization of human serotype 10 rotaviruses from asymptomatic neonates Journal of Clinical Microbiology 31 1 165 169 8380181 (Pubitemid 23006604)
27. CA Erickson KA Stigler MR Corkins DJ Posey JF Fitzgerald CJ Mc Dougle 2005 Gastrointestinal factors in autistic disorder: a critical review Journal of Autism and Developmental Disorders 35 6 713 727 16267642 10.1007/s10803-005- 0019-4
28. A Farhadi JZ Fields A Keshavarzian 2007 Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation World Journal of Gastroenterology 13 22 3027 3030 17589915 (Pubitemid 47045457)
29. E Fombonne 2009 Epidemiology of pervasive developmental disorders Pediatric Research 65 6 591 598 19218885 10.1203/PDR.0b013e31819e7203
30. EE Forbes, et al. 2008 IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity Journal of Experimental Medicine 205 4 897 913 18378796 10.1084/jem.20071046 (Pubitemid 351549886)
31. SJ Galli J Kalesnikoff MA Grimbaldeston AM Piliponsky CM Williams M Tsai 2005 Mast cells as "tunable" effector and immunoregulatory cells: recent advances Annual Review of Immunology 23 749 786 15771585 10.1146/annurev.immunol.21.120601.141025 (Pubitemid 40563184)
32. T Gebhardt, et al. 2005 Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1 Gut 54 7 928 934 15951536 10.1136/gut.2004.054650 (Pubitemid 40873903)
33. A Gillott PJ Standen 2007 Levels of anxiety and sources of stress in adults with autism Journal of Intellectual Disabilities 11 4 359 370 18029412 10.1177/1744629507083585 (Pubitemid 350120860)
34. P Goines J Van de Water 2010 The immune system's role in the biology of autism Current Opinion in Neurology 23 2 111 117 20160651 10.1097/WCO. 0b013e3283373514
35. P Grandjean PJ Landrigan 2006 Developmental neurotoxicity of industrial chemicals Lancet 368 9553 2167 2178 17174709 10.1016/S0140-6736(06)69665-7 (Pubitemid 44894541)
36. JG Gurney ML Mc Pheeters MM Davis 2006 Parental report of health conditions and health care use among children with and without autism: National Survey of Children's Health Archives of Pediatrics and Adolescent Medicine 160 8 825 830 16894082 10.1001/archpedi.160.8.825 (Pubitemid 44199242)
37. MR Herbert 2010 Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders Current Opinion in Neurology 23 2 103 110 20087183 10.1097/WCO.0b013e328336a01f
38. I Hertz-Picciotto HY Park M Dostal A Kocan T Trnovec R Sram 2008 Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development Basic & Clinical Pharmacology & Toxicology 102 2 146 154 10.1111/j.1742-7843.2007.00190.x (Pubitemid 351143438)
39. ST Holgate R Polosa 2008 Treatment strategies for allergy and asthma Nature Reviews Immunology 8 3 218 230 18274559 10.1038/nri2262 (Pubitemid 351323290)
40. S Jang KW Kelley RW Johnson 2008 Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 Proceedings of the National Academy of Sciences of the United States of America 105 21 7534 7539 18490655 10.1073/pnas.0802865105 (Pubitemid 351830053)
41. CP Johnson SM Myers 2007 Identification and evaluation of children with autism spectrum disorders Pediatrics 120 5 1183 1215 17967920 10.1542/peds.2007-2361 (Pubitemid 350085561)
42. H Jyonouchi 2009 Food allergy and autism spectrum disorders: is there a link? Current Allergy and Asthma Reports 9 3 194 201 19348719 10.1007/s11882-009-0029-y
43. H Jyonouchi 2010 Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic Expert Review of Clinical Immunology 6 3 397 411 20441426
44. H Jyonouchi L Geng A Cushing-Ruby H Quraishi 2008 Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study Journal of Neuroinflammation 5 52 19025588 10.1186/1742-2094-5-52
45. K Kandere-Grzybowska, et al. 2003 IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells Journal of Immunology 171 9 4830 4836 (Pubitemid 37310604)
46. AP Kaplan M Greaves 2009 Pathogenesis of chronic urticaria Clinical and Experimental Allergy 39 6 777 787 19400905 10.1111/j.1365-2222.2009.03256.x
47. D Kempuraj, et al. 2008 Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells British Journal of Pharmacology 155 1076 1084 18806808 10.1038/bjp.2008.356
48. D Kempuraj, et al. 2010 Mercury induces inflammatory mediator release from human mast cells Journal of Neuroinflammation 7 1 20 20222982 10.1186/1742-2094-7-20
49. MD Kogan, et al. 2009 Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007 Pediatrics 5 124 1395 1403 10.1542/peds.2009-1522
50. S Kraft JP Kinet 2007 New developments in FcepsilonRI regulation, function and inhibition Nature Reviews Immunology 7 5 365 378 17438574 10.1038/nri2072 (Pubitemid 46674486)
51. M Kulka L Alexopoulou RA Flavell DD Metcalfe 2004 Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3 The Journal of Allergy and Clinical Immunology 114 1 174 182 15241362 10.1016/j.jaci.2004.03.049 (Pubitemid 39005135)
52. O Kwon, et al. 2002 Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl (PCB 153) in human mast cells requires NF-kappa B activation Biological and Pharmaceutical Bulletin 25 9 1165 1168 12230110 10.1248/bpb.25.1165 (Pubitemid 39655157)
53. M Larsson B Weiss S Janson J Sundell CG Bornehag 2009 Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age NeuroToxicology 30 5 822 831 19822263 10.1016/j.neuro.2009.01.011
54. SE Levy DS Mandell RT Schultz 2009 Autism Lancet 374 9701 1627 1638 19819542 10.1016/S0140-6736(09)61376-3
55. SE Levy MC Souders RF Ittenbach E Giarelli AE Mulberg JA Pinto-Martin 2007 Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders Biological Psychiatry 61 4 492 497 17207470 10.1016/j.biopsych.2006.07.013 (Pubitemid 46185339)
56. X Li, et al. 2009 Elevated immune response in the brain of autistic patients Journal of Neuroimmunology 207 1-2 111 116 19157572 10.1016/j.jneuroim.2008.12.002
57. ES Magalhaes F Pinto-Mariz S Bastos-Pinto AT Pontes EA Prado LC Deazevedo 2009 Immune allergic response in Asperger syndrome Journal of Neuroimmunology 216 1-2 108 112 19840888 10.1016/j.jneuroim.2009.09.015
58. JL Matson AM Kozlowski 2010 Autistic regression Research in Autism Spectrum Disorders 4 340 345 10.1016/j.rasd.2009.10.009
59. A Minagar JS Alexander 2003 Blood-brain barrier disruption in multiple sclerosis Multiple Sclerosis 9 6 540 549 14664465 10.1191/1352458503ms965oa (Pubitemid 37479401)
60. GA Mostafa RT Hamza HH El-Shahawi 2008 Allergic manifestations in autistic children: Relation to disease severity Journal of Pediatric Neurology 6 2 115 123 (Pubitemid 351818452)
61. E Novembre, et al. 2008 Urticaria and urticaria related skin condition/disease in children European Annals of Allergy and Clinical Immunology 40 1 5 13 18700329 (Pubitemid 351975063)
62. JJ Rozniecki V Dimitriadou M Lambracht-Hall X Pang TC Theoharides 1999 Morphological and functional demonstration of rat dura mast cell-neuron interactions in vitro and in vivo Brain Research 849 1 15 10592282 10.1016/S0006-8993(99)01855-7
63. R Sacco, et al. 2010 Principal pathogenetic components and biological endophenotypes in autism spectrum disorders Autism Research 3 5 237 252 20878720 10.1002/aur.151
64. HS Singer CM Morris PN Williams DY Yoon JJ Hong AW Zimmerman 2006 Antibrain antibodies in children with autism and their unaffected siblings Journal of Neuroimmunology 178 1-2 149 155 16842863 10.1016/j.jneuroim.2006.05. 025 (Pubitemid 44314179)
65. A Slominski, et al. 2001 Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors Federation of American Societies for Experimental Biology 15 1678 1693 (Pubitemid 32730215)
66. D Soon, et al. 2007 A study of subtle blood brain barrier disruption in a placebo-controlled trial of natalizumab in relapsing remitting multiple sclerosis Journal of Neurology 254 3 306 314 17277910 10.1007/s00415-006-0356-z (Pubitemid 46399190)
67. GA Stefanatos 2008 Regression in autistic spectrum disorders Neuropsychology Review 18 4 305 319 18956241 10.1007/s11065-008-9073-y
68. LA Stone, et al. 1995 Blood-brain barrier disruption on contrast-enhanced MRI in patients with mild relapsing-remitting multiple sclerosis: Relationship to course, gender, and age Neurology 45 1122 1126 7783875
69. TC Theoharides 2009 Autism spectrum disorders and mastocytosis International Journal of Immunopathology and Pharmacology 22 4 859 865 20074449
70. TC Theoharides DE Cochrane 2004 Critical role of mast cells in inflammatory diseases and the effect of acute stress Journal of Neuroimmunology 146 1 12 14698841 10.1016/j.jneuroim.2003.10.041 (Pubitemid 38032950)
71. TC Theoharides R Doyle K Francis P Conti D Kalogeromitros 2008 Novel therapeutic targets for autism Trends in Pharmacological Sciences 29 8 375 382 18606459 10.1016/j.tips.2008.06.002
72. TC Theoharides D Kalogeromitros 2006 The critical role of mast cell in allergy and inflammation Annals of the New York Academy of Sciences 1088 78 99 17192558 10.1196/annals.1366.025 (Pubitemid 47092046)
73. TC Theoharides D Kempuraj L Redwood 2009 Autism: an emerging 'neuroimmune disorder' in search of therapy Experimental Opinion on Pharmacotherapy 10 13 2127 2143 10.1517/14656560903107789
74. TC Theoharides D Kempuraj M Tagen P Conti D Kalogeromitros 2007 Differential release of mast cell mediators and the pathogenesis of inflammation Immunological Reviews 217 65 78 17498052 10.1111/j.1600-065X.2007.00519.x (Pubitemid 46718152)
75. TC Theoharides A Konstantinidou 2007 Corticotropin-releasing hormone and the blood-brain-barrier Frontiers in Bioscience 12 1615 1628 17127408 10.2741/2174 (Pubitemid 46846794)
76. P Valent, et al. 2001 Diagnostic criteria and classification of mastocytosis: a consensus proposal Leukemia Research 25 603 625 11377686 10.1016/S0145-2126(01)00038-8 (Pubitemid 32506768)
77. S Varadaradjalou, et al. 2003 Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells European Journal of Immunology 33 899 906 12672055 10.1002/eji.200323830 (Pubitemid 36546677)
78. DL Vargas C Nascimbene C Krishnan AW Zimmerman CA Pardo 2005 Neuroglial activation and neuroinflammation in the brain of patients with autism Annals of Neurology 57 1 67 81 15546155 10.1002/ana.20315 (Pubitemid 40053317)
79. A Vojdani AW Campbell E Anyanwu A Kashanian K Bock E Vojdani 2002 Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A Journal of Neuroimmunology 129 1-2 168 177 12161033 10.1016/S0165-5728(02)00180-7 (Pubitemid 34874922)
80. LA Weiss DE Arking MJ Daly A Chakravarti 2009 A genome-wide linkage and association scan reveals novel loci for autism Nature 461 7265 802 808 19812673 10.1038/nature08490
81. S Wills M Cabanlit J Bennett P Ashwood DG Amaral J Van de Water 2008 Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders Brain, Behavior, and Immunology 23 64 74 10.1016/j.bbi.2008.07.007
82. HA Young DA Geier MR Geier 2008 Thimerosal exposure in infants and neurodevelopmental disorders: an assessment of computerized medical records in the Vaccine Safety Datalink Journal of the Neurological Sciences 271 1-2 110 118 18482737 10.1016/j.jns.2008.04.002
83. M Zappella 2010 Autistic regression with and without EEG abnormalities followed by favourable outcome Brain and Development 32 9 739 745 20708360 10.1016/j.braindev.2010.05.004