Brief report: Dysregulated immune system in children with autism - Beneficial effects of intravenous immune globulin on autistic characteristics

Journal of Autism and Developmental Disorders

Volumn 26, Issue 4, 1996, Pages 439-452

  Gupta, Sudhir ^a   Aggarwal, Sudeepta ^a   Heads, Cathy ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DIPHENHYDRAMINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY;

ARTICLE; ATTENTION; AUTISM; CHILD; CLINICAL ARTICLE; CONVERSATION; ECHOLALIA; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; LINGUISTICS; LYMPHOCYTE SUBPOPULATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; READING; SOCIAL BEHAVIOR; SPEECH ARTICULATION; BLOOD; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOGLOBULIN G DEFICIENCY; IMMUNOLOGY; LYMPHOCYTE COUNT; NEUROPSYCHOLOGICAL TEST; PASSIVE IMMUNIZATION; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; TREATMENT OUTCOME;

AUTISTIC DISORDER; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IGA DEFICIENCY; IGG DEFICIENCY; IMMUNIZATION, PASSIVE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; NEUROPSYCHOLOGICAL TESTS; TREATMENT OUTCOME;

EID: 0030203370     PISSN: 01623257     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02172828     Document Type: Article

References (25)

1. American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., rev.). Washington, DC: Author.
2. Chapel, H., & Haeney, M. (Eds.). (1993). Essentials of clinical immunology (pp. 57-58). London: Blackwell.
3. Donaghy, M., Mills, K. R., Boniface, S. J., Sirmnons, J., Wright, I., Gregson, N., & Jacobs, J. (1994). Pure motor demyelinating neuropathy: deterioration after steroid treatment and improvement with intravenous immunoglobulin. Journal of Neurology, Neurosurgery, and Psychiatry, 57: 778-783.
4. Dwyer, J. M. (1992). Manipulating the immune system with immune globulin. New England Journal of Medicine, 326, 4104-4109.
5. Erkeller-Yuksel, F. M., Deneys, V., Yuksel, B., Hannet, I., Hulstaert, F., Hamilton, C., Mackinnon, H., Stokes, L. T., Munhyeshuli, V., Vanlangendonck, F., De Bruyere, M., Bach, B. A., & Lydyard, P. M. (1992). Age-related changes in human blood lymphocyte subpopulations. Journal of Pediatrics, 120, 216-222.
6. Gillberg, C., & Coleman, M. (Eds.). (1992). The biology of the autistic syndromes (2nd ed., pp. 218-225). London: Mac Keith Press.
7. Gupta, S. (1986). Current and potential future uses of intravenous gamma globulin in the treatment of autoimmune disorders. Immunology & Allergy Practice, 8, 370-377.
8. Herberman, R. B., & Ortaldo, J. R. (1981). Natural killer cells: Their role in defense against disease. Science, 214, 24-30.
9. Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 2217-250.
10. Koski, C. L. (1987). Complement fixing anti-peripheral myelin antibodies and C9 neoantigens in serum of patients with Guillain-Barre syndrome: Quantitation, kinetics and clinical correlation. Annals New York Academy of Science, 505, 319-325.
11. Menage, P., Thibault, G., Barthelemy, C., Lelord, G., & Bardos, P. (1992). CD4+CD45RA+ T lymphocyte deficiency in autistic children: Effect of a pyridoxine-magnesium treatment. Brain Dysfunction, 5, 326-333.
12. Mobini, N., Sarela, A., & Ahmed, A. R. (1995). Intravenous immunoglobulins in the therapy of autoimmune and systemic inflammatory disorders. Annals of Allergy, Asthma & Immunology, 74, 119-132.
13. H2 cells. Journal of Clinical Immunology, 15, 121-129.
14. Schwartz, S. A. (1990). Intravenous immunoglobulin (IVIG) for the therapy of autoimmune disorders. Journal of Clinical Immunology, 10, 81-89.
15. Singh, V. K., Warren, R. P., Odell, J. D., Warren, W. L., & Cole, P. (1993). Antibodies to myelin basic protein in children with autistic behavior. Brain, Behavior & Immunity, 7, 97-103.
16. Stubbs, E. G. (1976). Autistic children exhibit undetectable hemagglutination-inhibition antibody titers despite previous rubella vaccination. Journal of Autism and Childhood Schizophrenia, 6, 269-274.
17. Stubbs, E. G., Crawford, M. L., Burger, D. R., & Vandebork, A. A. (1977). Depressed lymphocyte responsiveness in autistic children. Journal of Autism and Childhood Schizophrenia, 7, 49-55.
18. Van der Meche, F. G. A., & Schmitz, P. I. M. (1992). A randomized trial comparing intravenous immunoglobulin and plasma exchange in Guillain-Barre syndrome. New England Journal of Medicine, 326, 1123-1129.
19. Warren, R. P., Foster, A., & Margaretten, N. C. (1987). Reduced natural killer cell activity in autism. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 333-335.
20. Warren, R. P., Foster, A., Margaretten, N. C., & Pace, N. C. (1986). Immune abnormalities in patients with autism. Journal of Autism and Developmental Disorders, 16, 189-197.
21. Warren, R. P., Yonk, L. J., Burger, R. A., Cole, P., Odell, J. D., Warren, W. L., White, E., & Singh, V. K. (1990). Deficiency of suppressor-inducer (CD4+CD45RA+) T cells in autism. Immunological Investigation, 19, 245-251.
22. Warren, R. P., Singh, V. K., Cole, P., Odell, J. D., Pingree, C. B., Warren, W. L., & White, E. (1991). Increased frequency of the null allele at the complement C4b locus in autism. Clinical and Experimental Immunology, 83, 438-440.
23. Weizman, A., Weizman, R., Szekely, G. A., Wijsenbeek, H., & Livni, E. (1982). Abnormal immune response to brain tissue antigen in the syndrome of autism. American Journal of Psychiatry, 139, 1462-1465.
24. Yman, L. (1991). Standardization of IgE antibody assays. Journal of International Federation of Clinical Chemistry, 3, 198-203.
25. Yonk, L. J., Warren, R. P., Burger, R. A., Cole, P., Odell, J. D., Warren, W. L., White, E., & Singh, V. K. (1990). CD4+ helper T cell depression in autism. Immunology Letters, 25, 314-346.