The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

Science

Volumn 351, Issue 6276, 2016, Pages 933-939

  Choi, Gloria B ^a   Yim, Yeong S ^a   Wong, Helen ^b,c   Kim, Sangdoo ^d   Kim, Hyunju ^d   Kim, Sangwon V ^e   Hoeffer, Charles A ^b,c   Littman, Dan R ^e,f   Huh, Jun R ^d,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; INTERLEUKIN 17; MATERNAL ANTIBODY; MESSENGER RNA; RETINOIC ACID RECEPTOR; RETINOID RELATED ORPHAN RECEPTOR GAMMA; IL17A PROTEIN, MOUSE; RETINOIC ACID RECEPTOR GAMMA;

ANTIBODY; CELLS AND CELL COMPONENTS; GENETIC ANALYSIS; MENTAL HEALTH; MUTATION; PHENOTYPE; PREGNANCY; RODENT;

ARTICLE; AUTISM; BEHAVIOR DISORDER; BRAIN DEVELOPMENT; BRAIN LEVEL; FEMALE; FETAL BRAIN; GENE EXPRESSION; IMMUNE RESPONSE; MATERNAL IMMUNE ACTIVATION; MATERNAL SERUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; T LYMPHOCYTE; TH17 CELL; ABNORMALITIES; ANIMAL; ANIMAL BEHAVIOR; AUTISM SPECTRUM DISORDER; BEHAVIOR; BIOSYNTHESIS; BRAIN CORTEX; DRUG EFFECTS; FETOMATERNAL TRANSFUSION; GENETICS; IMMUNOLOGY; MALE; MUTATION; PHENOTYPE; PREGNANCY; PRENATAL EXPOSURE; SIGNAL TRANSDUCTION;

MUS; RODENTIA;

ANIMALS; ANTIBODIES, BLOCKING; AUTISM SPECTRUM DISORDER; BEHAVIOR, ANIMAL; BEHAVIORAL SYMPTOMS; CEREBRAL CORTEX; FEMALE; INTERLEUKIN-17; MALE; MATERNAL-FETAL EXCHANGE; MICE; MUTATION; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PHENOTYPE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; SIGNAL TRANSDUCTION; TH17 CELLS;

EID: 84959447961     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad0314     Document Type: Article

References (44)

1. H. O. Atladottir et al, J. Autism Dev. Disord. 40, 1423-1430 (2010).
2. P. H. Patterson, Behav. Brain Res. 204, 313-321 (2009).
3. A. S. Brown et al., Mol. Psychiatry 19, 259-264 (2014).
4. H. O. Atladottir et al., Pediatrics 124, 687-694 (2009).
5. P. Ashwood, S. Wills, J. Van de Water, J. Leukoc. Biol. 80, 1-15 (2006).
6. B. K. Lee et al., Brain Behav. Immun. 44, 100-105 (2015).
7. S. E. P. Smith, J. Li, K. Garbett, K. Mirnics, P. H. Patterson, J. Neurosci. 27, 10695-10702 (2007).
8. N. V. Malkova, C. Z. Yu, E. Y. Hsiao, M. J. Moore, P. H. Patterson, Brain Behav. Immun. 26, 607-616 (2012).
9. C. M. Wilke, K. Bishop, D. Fox, W. Zou, Trends Immunol. 32, 603-611 (2011).
10. N. Manel, D. Unutmaz, D. R. Littman, Nat. Immunol. 9, 641-649 (2008).
11. H. Spits, J. P. Di Santo, Nat. Immunol. 12, 21-27 (2011).
12. M. Lochner et al., J. Exp. Med. 205, 1381-1393 (2008).
13. I. I. Ivanov et al., Cell 126, 1121-1133 (2006).
14. L. Y. Al-Ayadhi, G. A. Mostafa, J. Neuroinflammation 9, 158 (2012).
15. K. Suzuki et al., PLOS ONE 6, e20470 (2011).
16. B. van der Zwaag et al., PLOS ONE 4, e5324 (2009).
17. M. Mandal, A. C. Marzouk, R. Donnelly, N. M. Ponzio, J. Reprod. Immunol. 87, 97-100 (2010).
18. E. Y. Hsiao, S. W. McBride, J. Chow, S. K. Mazmanian, P. H. Patterson, Proc. Natl. Acad. Sci. U.S.A. 109, 12776-12781 (2012).
19. V. K. Kuchroo, A. Awasthi, Eur. J. Immunol. 42, 2211-2214 (2012).
20. C. Dehay, H. Kennedy, Nat. Rev. Neurosci. 8, 438-450 (2007).
21. M. F. Casanova et al., Acta Neuropathol. Commun. 1, 67 (2013).
22. R. Stoner et al, N. Engl. J. Med. 370, 1209-1219 (2014).
23. J. De Miranda et al., MBio 1, e00176-10, e00176-19 (2010).
24. S. E. Smith, R. M. Elliott, M. P. Anderson, J. Neuroimmune Pharmacol. 7, 529-532 (2012).
25. B. J. Molyneaux, P. Arlotta, J. R. Menezes, J. D. Macklis, Nat. Rev. Neurosci. 8, 427-437 (2007).
26. E. A. Alcamo et al., Neuron 57, 364-377 (2008).
27. C. Englund et al., J. Neurosci. 25, 247-251 (2005).
28. M. Leid et al., Gene Expr. Patterns 4, 733-739 (2004).
29. J. J. Schwartzer et al., Transl. Psychiatry 3, e240 (2013).
30. N. Yee, R. K. Schwarting, E. Fuchs, M. WOhr, J. Psychiatr. Res. 46, 1199-1205 (2012).
31. E. Y. Hsiao et al., Cell 155, 1451-1463 (2013).
32. C. A. Hoeffer et al., Neuron 60, 832-845 (2008).
33. H. X. Wu, L. P. Jin, B. Xu, S. S. Liang, D. J. Li, Cell. Mol. Immunol. 11, 253-262 (2014).
34. A. Nakashima et al., Am. J. Reprod. Immunol. 63, 104-109 (2010).
35. E. A. Martfnez-Garcfa et al., Am. J. Reprod. Immunol. 65, 99-103 (2011).
36. G. Eberl, D. R. Littman, Science 305, 248-251 (2004).
37. Z. Sun et al., Science 288, 2369-2373 (2000).
38. J. R. Huh et al., Nature 472, 486-490 (2011).
39. Y. Iwakura, H. Ishigame, S. Saijo, S. Nakae, Immunity 34, 149-162 (2011).
40. E. Y. Hsiao, P. H. Patterson, Brain Behav. Immun. 25, 604-615 (2011).
41. L. A. Orosco et al., Nat. Commun. 5, 4692 (2014).
42. O. Penagarikano et al., Cell 147, 235-246 (2011).
43. S. G. Hymowitz et al, EMBO J. 20, 5332-5341 (2001).
44. X. Zhang, P. Angkasekwinai, C. Dong, H. Tang, Protein Cell 2, 26-40 (2011).