Brief report: Plasma leptin levels are elevated in autism: Association with early onset phenotype?

Journal of Autism and Developmental Disorders

Volumn 38, Issue 1, 2008, Pages 169-175

  Ashwood, Paul ^a,b   Kwong, Christina ^b,d   Hansen, Robin ^a,b   Hertz Picciotto, Irva ^b   Croen, Lisa ^b,c   Krakowiak, Paula ^b   Walker, Wynn ^a   Pessah, Isaac N ^b   Van De Water, Judy ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Rosalind Franklin University of Medicine and Science ^*  (United States)

^d ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

Autism; Inflammation; Leptin; Regression

Indexed keywords

CYTOKINE; HORMONE; LEPTIN;

ADOLESCENT; ARTICLE; AUTISM; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; REMISSION; SIBLING; STATISTICAL SIGNIFICANCE;

ADOLESCENT; AGE OF ONSET; AUTISTIC DISORDER; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; LEPTIN; MALE; PHENOTYPE;

EID: 37849043344     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-006-0353-1     Document Type: Article

References (39)

1. Ashwood, P., Anthony, A., Torrente, F., & Wakefield, A. J. (2004). Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Journal of Clinical Immunology, 24, 664-673.
2. Banks, W. A. (2001). Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity. Current Pharma Design, 7, 125-133.
3. Banks, W. A. (2004). The many lives of leptin. Peptides, 25, 331-338.
4. Banks, W. A., & Lebel, C. R. (2002). Strategies for the delivery of leptin to the CNS. Journal of Drug Targeting, 10, 297-308.
5. Busso, N., So, A., Chobaz-Peclat, V., Morard, C., Martinez-Soria, E., Talabot-Ayer, D., & Gabay, C. (2002). Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. Journal of Immunology, 168, 875-882.
6. Caldefie-Chezet, F., Poulin, A., & Vasson, M. P. (2003). Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radical Research, 37, 809-814.
7. Chandra, R. K. (1980). Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. American Journal of Clinical Nutrition, 33, 13-16.
8. DiLavore, P. C., Lord, C., & Rutter, M. (1995). The pre-linguistic autism diagnostic observation schedule. Journal of Autism and Develpmental Disorders, 25, 355-379.
9. Fantuzzi, G., Sennello, J. A., Batra, A., Fedke, I., Lehr, H. A., Zeitz, M., & Siegmund, B. (2005). Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice. Clinical and Experimental Immunology, 142, 31-38.
10. Filipek, P. A., Accardo, P. J., Ashwal, S., Baranek, G. T., Cook, E. H. Jr., Dawson, G., Gordon, B., Gravel, J. S., Johnson, C. P., Kallen, R. J., Levy, S. E., Minshew, N. J., Ozonoff, S., Prizant, B. M., Rapin, I., Rogers, S. J., Stone, W. L., Teplin, S. W., Tuchman, R. F., & Volkmar, F. R. (2000). Practice parameter: screening and diagnosis of autism: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology, 55, 468-479.
11. Garcia-Mayor, R. V., Andrade, M. A., Rios, M., Lage, M., Dieguez, C., & Casanueva, F. F. (1997). Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. Journal of Clinical Endocrinology and Metabolism, 82, 2849-2855.
12. Gupta, S., Aggarwal, S., Rashanravan, B., & Lee, T. (1998). Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. Journal of Neuroimmunology, 85, 106-109.
13. Hammer, L. D., Kraemer, H. C., Wilson, D. M., Ritter, P. L., & Dornbusch, S. M. (1991). Standardized percentile curves of body-mass index for children and adolescents. American Journal of Diseases of Children, 145, 259-263.
14. Hertz-Picciotto, I., Croen, L. A., Hansen, R., Jones, C. R., Van de Water, J., & Pessah, I. N. (2006). The CHARGE study: An epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspectives, 114, 1119-1125.
15. Howard, J. K., Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A., Lechler, R. I., & Bloom, S. R. (1999). Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. Journal of Clinical Investigations, 104, 1051-1059.
16. Joseph, R. M., Tager-Flusberg, H., & Lord, C. (2002). Cognitive profiles and social-communicative functioning in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 43, 807-821.
17. Jyonouchi, H., Sun, S., & Itokazu, N. (2002). Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology, 46, 76-84.
18. Kastin, A. J., Pan, W., Maness, L. M., & Banks, W. A. (1999). Peptides crossing the blood-brain barrier: Some unusual observations. Brain Research, 848, 96-100.
19. Lainhart, J. E., Ozonoff, S., Coon, H., Krasny, L., Dinh, E., Nice, J., & McMahon, W. (2002). Autism, regression, and the broader autism phenotype. American Journal of Medical Genetics, 113, 231-237.
20. Lord, C., Leventhal, B. L., & Cook, E. H. Jr. (2001). Quantifying the phenotype in autism spectrum disorders. American Journal of Medical Genetics, 105, 36-38.
21. Lord, C., Pickles, A., McLennan, J., Rutter, M., Bregman, J., Folstein, S., Fombonne, E., Leboyer, M., & Minshew, N. (1997). Diagnosing autism: Analyses of data from the Autism Diagnostic Interview. Journal of Autism and Developmental Disorders, 27, 501-517.
22. Lord, C., Risi, S., Lambrecht, L., Cook, E. H. Jr., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205-223.
23. Mancuso, P., Gottschalk, A., Phare, S. M., Peters-Golden, M., Lukacs, N. W., & Huffnagle, G. B., (2002). Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. Journal of Immunology, 168, 4018-4024.
24. Matarese, G., Di Giacomo, A., Sanna, V., Lord, G. M., Howard, J. K., Di Tuoro, A., Bloom, S. R., Lechler, R. I., Zappacosta, S., & Fontana, S. (2001). Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. Journal of Immunoogyl 166, 5909-5916.
25. Matarese, G., Moschos, S., & Mantzoros, C. S., (2005). Leptin in immunology. Journal of Immunology, 174, 3137-3142.
26. Owley, T., McMahon, W., Cook, E. H., Laulhere, T., South, M., Mays, L. Z., Shernoff, E. S., Lainhart, J., Modahl, C. B., Corsello, C., Ozonoff, S., Risi, S., Lord, C., Leventhal, B. L., & Filipek, P. A., (2001). Multisite, double-blind, placebo-controlled trial of porcine secretin in autism. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 1293-1299.
27. Ozata, M., Ozdemir, I. C., & Licinio, J. (1999). Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. Journal of Clinical Endocrinology and Metabolism, 84, 3686-3695.
28. Pietrobelli, A., Faith, M. S., Allison, D. B., Gallagher, D., Chiumello, G., & Heymsfield, S. B. (1998). Body mass index as a measure of adiposity among children and adolescents: A validation study. Journal of Pediatrics, 132, 204-210.
29. Plioplys, A. V., Greaves, A., & Yoshida, W. (1989). Anti-CNS antibodies in childhood neurologic diseases. Neuropediatrics, 20, 93-102.
30. Richler, J., Luyster, R., Risi, S., Hsu, W.-L., Dawson, G., Bernier, R., Dunn, M., Hepburn, S., Hyman, S. L., McMahon, W. M., Goudie-Nice, J., Minshew, N., Rogers, S., Sigman, M., Spence, M. A., Goldberg. W. A., Tager-Flusberg, H., Volkmar, F. R., & Lord, C. (2006). Is there a 'regressive phenotype' of autism spectrum disorder associated with the measles-mumps-rubella vaccine? A CEA study. Journal of Autism and Developmental Disorders, 36, 299-316.
31. Sanchez-Margalet, V., Martin-Romero, C., Santos-Alvarez, J., Goberna, R., Najib, S., & Gonzalez-Yanes, C. (2003). Role of leptin as an immunomodulator of blood mononuclear cells: Mechanisms of action. Clinical and Experimental Immunology. 133, 11-19.
32. Sanna, V., Di Giacomo, A., La Cava, A., Lechler, R. I., Fontana, S., Zappacosta, S., & Matarese, G. (2003). Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. Journal of Clinical Investigation, 111, 241-250.
33. Singh, V. K., & Rivas, W. H. (2004). Prevalence of serum antibodies to caudate nucleus in autistic children. Neuroscience Letters, 355, 53-56.
34. Steinhausen, H. C., & Erdin, A. (1992). Abnormal psychosocial situations and ICD-10 diagnoses in children and adolescents attending a psychiatric service. Journal of Child Psychology and Psychiatry, 33, 731-740.
35. Steinman, L., Conlon, P., Maki, R., & Foster, A. (2003). The intricate interplay among body weight, stress, and the immune response to friend or foe. Journal of Clinical Investigation, 111, 183-185.
36. Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67-81.
37. Vojdani, A., Campbell, A. W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. (2002). Antibodies to neuron-specific antigens in children with autism: Possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. Journal of Neuroimmunology, 129, 168-177.
38. Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., & Chen, H. (2003). Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation, 112, 1821-1830.
39. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.