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Volumn 10, Issue , 2013, Pages

Focal brain inflammation and autism

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; CITALOPRAM; CORTICOTROPIN RELEASING FACTOR; LUTEOLIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METHYLPHENIDATE; MITOCHONDRIAL DNA; NEUROLEPTIC AGENT; NEUROTENSIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PSYCHOTROPIC AGENT; RAPAMYCIN; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR;

EID: 84875891902     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-46     Document Type: Review
Times cited : (141)

References (119)
  • 1
    • 80755163162 scopus 로고    scopus 로고
    • Decreased mitochondrial function and increased brain inflammation in bipolar disorder and other neuropsychiatric diseases
    • 10.1097/JCP.0b013e318239c190, 22020358
    • Theoharides TC, Zhang B, Conti P. Decreased mitochondrial function and increased brain inflammation in bipolar disorder and other neuropsychiatric diseases. J Clin Psychopharmacol 2011, 31:685-687. 10.1097/JCP.0b013e318239c190, 22020358.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 685-687
    • Theoharides, T.C.1    Zhang, B.2    Conti, P.3
  • 2
    • 84860222551 scopus 로고    scopus 로고
    • Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults
    • 10.1002/ana.22620, 22334391
    • Hagberg H, Gressens P, Mallard C. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann Neurol 2012, 71:444-457. 10.1002/ana.22620, 22334391.
    • (2012) Ann Neurol , vol.71 , pp. 444-457
    • Hagberg, H.1    Gressens, P.2    Mallard, C.3
  • 3
    • 67049118065 scopus 로고    scopus 로고
    • Epidemiology of pervasive developmental disorders
    • 10.1203/PDR.0b013e31819e7203, 19218885
    • Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009, 65:591-598. 10.1203/PDR.0b013e31819e7203, 19218885.
    • (2009) Pediatr Res , vol.65 , pp. 591-598
    • Fombonne, E.1
  • 4
    • 36048931014 scopus 로고    scopus 로고
    • Identification and evaluation of children with autism spectrum disorders
    • 10.1542/peds.2007-2361, 17967920
    • Johnson CP, Myers SM. Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007, 120:1183-1215. 10.1542/peds.2007-2361, 17967920.
    • (2007) Pediatrics , vol.120 , pp. 1183-1215
    • Johnson, C.P.1    Myers, S.M.2
  • 6
    • 42349095075 scopus 로고    scopus 로고
    • Advances in autism genetics: on the threshold of a new neurobiology
    • 10.1038/nrg2346, 2756414, 18414403
    • Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008, 9:341-355. 10.1038/nrg2346, 2756414, 18414403.
    • (2008) Nat Rev Genet , vol.9 , pp. 341-355
    • Abrahams, B.S.1    Geschwind, D.H.2
  • 7
    • 84869806599 scopus 로고    scopus 로고
    • Genetics: searching for answers
    • 10.1038/491S4a, 23136651
    • Williams SC. Genetics: searching for answers. Nature 2012, 491:S4-S6. 10.1038/491S4a, 23136651.
    • (2012) Nature , vol.491
    • Williams, S.C.1
  • 8
    • 0032693037 scopus 로고    scopus 로고
    • An infection-based model of neurodevelopmental damage
    • 10.1073/pnas.96.21.12102, 18419, 10518583
    • Hornig M, Weissenbock H, Horscroft N, Lipkin WI. An infection-based model of neurodevelopmental damage. Proc Natl Acad Sci USA 1999, 96:12102-12107. 10.1073/pnas.96.21.12102, 18419, 10518583.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12102-12107
    • Hornig, M.1    Weissenbock, H.2    Horscroft, N.3    Lipkin, W.I.4
  • 9
    • 84864520051 scopus 로고    scopus 로고
    • Modeling an autism risk factor in mice leads to permanent immune dysregulation
    • 10.1073/pnas.1202556109, 3411999, 22802640
    • Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH. Modeling an autism risk factor in mice leads to permanent immune dysregulation. Proc Natl Acad Sci USA 2012, 109:12776-12781. 10.1073/pnas.1202556109, 3411999, 22802640.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 12776-12781
    • Hsiao, E.Y.1    McBride, S.W.2    Chow, J.3    Mazmanian, S.K.4    Patterson, P.H.5
  • 10
    • 84858996163 scopus 로고    scopus 로고
    • Diagnosis and management of autism in childhood
    • 10.1136/bmj.d6238, 22021467
    • Blenner S, Reddy A, Augustyn M. Diagnosis and management of autism in childhood. BMJ 2011, 343:d6238. 10.1136/bmj.d6238, 22021467.
    • (2011) BMJ , vol.343
    • Blenner, S.1    Reddy, A.2    Augustyn, M.3
  • 11
    • 43149090795 scopus 로고    scopus 로고
    • What is new in autism?
    • 10.1097/WCO.0b013e3282f49579, 18317271
    • Rapin I, Tuchman RF. What is new in autism?. Curr Opin Neurol 2008, 21:143-149. 10.1097/WCO.0b013e3282f49579, 18317271.
    • (2008) Curr Opin Neurol , vol.21 , pp. 143-149
    • Rapin, I.1    Tuchman, R.F.2
  • 12
    • 37849037738 scopus 로고    scopus 로고
    • How environmental and genetic factors combine to cause autism: a redox/methylation hypothesis
    • 10.1016/j.neuro.2007.09.010, 18031821
    • Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M. How environmental and genetic factors combine to cause autism: a redox/methylation hypothesis. Neurotoxicology 2008, 29:190-201. 10.1016/j.neuro.2007.09.010, 18031821.
    • (2008) Neurotoxicology , vol.29 , pp. 190-201
    • Deth, R.1    Muratore, C.2    Benzecry, J.3    Power-Charnitsky, V.A.4    Waly, M.5
  • 13
    • 84858658531 scopus 로고    scopus 로고
    • Verbal ability, social stress, and anxiety in children with autistic disorder
    • 10.1177/1362361311425916, 3586791, 22087042
    • Lanni KE, Schupp CW, Simon D, Corbett BA. Verbal ability, social stress, and anxiety in children with autistic disorder. Autism 2012, 16:123-138. 10.1177/1362361311425916, 3586791, 22087042.
    • (2012) Autism , vol.16 , pp. 123-138
    • Lanni, K.E.1    Schupp, C.W.2    Simon, D.3    Corbett, B.A.4
  • 14
    • 77949368541 scopus 로고    scopus 로고
    • Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
    • 10.1097/WCO.0b013e328336a01f, 20087183
    • Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol 2010, 23:103-110. 10.1097/WCO.0b013e328336a01f, 20087183.
    • (2010) Curr Opin Neurol , vol.23 , pp. 103-110
    • Herbert, M.R.1
  • 15
    • 84875875783 scopus 로고    scopus 로고
    • Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
    • Goines PE, Ashwood P. Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment. Neurotoxicol Teratol 2012,
    • (2012) Neurotoxicol Teratol
    • Goines, P.E.1    Ashwood, P.2
  • 16
    • 84857190395 scopus 로고    scopus 로고
    • The role of immune dysfunction in the pathophysiology of autism
    • 10.1016/j.bbi.2011.08.007, 3418145, 21906670
    • Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 2012, 26:383-392. 10.1016/j.bbi.2011.08.007, 3418145, 21906670.
    • (2012) Brain Behav Immun , vol.26 , pp. 383-392
    • Onore, C.1    Careaga, M.2    Ashwood, P.3
  • 19
    • 0030988104 scopus 로고    scopus 로고
    • Mast cells and de novo angiogenesis: angiogenic capability of individual mast-cell mediators such as histamine, TNF, IL-8 and bFGF
    • Norrby K. Mast cells and de novo angiogenesis: angiogenic capability of individual mast-cell mediators such as histamine, TNF, IL-8 and bFGF. Inflamm Res 1997, 46(Suppl. 1):S7-S8.
    • (1997) Inflamm Res , vol.46 , Issue.SUPPL. 1
    • Norrby, K.1
  • 21
    • 0027925168 scopus 로고
    • New concepts about the mast cell
    • 10.1056/NEJM199301283280408, 8418407
    • Galli SJ. New concepts about the mast cell. N Engl J Med 1993, 328:257-265. 10.1056/NEJM199301283280408, 8418407.
    • (1993) N Engl J Med , vol.328 , pp. 257-265
    • Galli, S.J.1
  • 22
    • 58149123111 scopus 로고    scopus 로고
    • Autism, gut-blood-brain barrier and mast cells
    • Theoharides TC, Doyle R. Autism, gut-blood-brain barrier and mast cells. J Clin Psychopharm 2008, 28:479-483.
    • (2008) J Clin Psychopharm , vol.28 , pp. 479-483
    • Theoharides, T.C.1    Doyle, R.2
  • 23
    • 0027049701 scopus 로고
    • Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat
    • Kim KS, Wass CA, Cross AS, Opal SM. Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat. Lymphokine Cytokine Res 1992, 11:293-298.
    • (1992) Lymphokine Cytokine Res , vol.11 , pp. 293-298
    • Kim, K.S.1    Wass, C.A.2    Cross, A.S.3    Opal, S.M.4
  • 24
    • 79960228390 scopus 로고    scopus 로고
    • Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders
    • 10.1016/j.bbi.2011.02.011, 3313674, 21420487
    • Rossi CC, Van de Water J, Rogers SJ, Amaral DG. Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders. Brain Behav Immun 2011, 25:1123-1135. 10.1016/j.bbi.2011.02.011, 3313674, 21420487.
    • (2011) Brain Behav Immun , vol.25 , pp. 1123-1135
    • Rossi, C.C.1    Van de Water, J.2    Rogers, S.J.3    Amaral, D.G.4
  • 27
    • 84865597109 scopus 로고    scopus 로고
    • Maternal autoantibodies in autism
    • 10.1001/archneurol.2011.2506, 22689191
    • Braunschweig D, Van de Water J. Maternal autoantibodies in autism. Arch Neurol 2012, 69:693-699. 10.1001/archneurol.2011.2506, 22689191.
    • (2012) Arch Neurol , vol.69 , pp. 693-699
    • Braunschweig, D.1    Van de Water, J.2
  • 29
    • 53749093767 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?
    • 10.1371/journal.pone.0003331, 2556082, 18836528
    • Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?. PLoS One 2008, 3:e3331. 10.1371/journal.pone.0003331, 2556082, 18836528.
    • (2008) PLoS One , vol.3
    • Moussion, C.1    Ortega, N.2    Girard, J.P.3
  • 32
    • 84859378165 scopus 로고    scopus 로고
    • Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain
    • 10.4049/jimmunol.1101977, 22371395
    • Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, Girard JP. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol 2012, 188:3488-3495. 10.4049/jimmunol.1101977, 22371395.
    • (2012) J Immunol , vol.188 , pp. 3488-3495
    • Pichery, M.1    Mirey, E.2    Mercier, P.3    Lefrancais, E.4    Dujardin, A.5    Ortega, N.6    Girard, J.P.7
  • 33
    • 77952413047 scopus 로고    scopus 로고
    • Inflammasome signaling at the heart of central nervous system pathology
    • Chakraborty S, Kaushik DK, Gupta M, Basu A. Inflammasome signaling at the heart of central nervous system pathology. J Neurosci Res 2010, 88:1615-1631.
    • (2010) J Neurosci Res , vol.88 , pp. 1615-1631
    • Chakraborty, S.1    Kaushik, D.K.2    Gupta, M.3    Basu, A.4
  • 34
    • 33646716658 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process
    • 10.1073/pnas.0602210103, 1472518, 16682628
    • Donelan J, Boucher W, Papadopoulou N, Lytinas M, Papaliodis D, Theoharides TC. Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. Proc Natl Acad Sci USA 2006, 103:7759-7764. 10.1073/pnas.0602210103, 1472518, 16682628.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7759-7764
    • Donelan, J.1    Boucher, W.2    Papadopoulou, N.3    Lytinas, M.4    Papaliodis, D.5    Theoharides, T.C.6
  • 35
    • 34248150697 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone and the blood-brain-barrier
    • 10.2741/2174, 17127408
    • Theoharides TC, Konstantinidou A. Corticotropin-releasing hormone and the blood-brain-barrier. Front Biosci 2007, 12:1615-1628. 10.2741/2174, 17127408.
    • (2007) Front Biosci , vol.12 , pp. 1615-1628
    • Theoharides, T.C.1    Konstantinidou, A.2
  • 38
    • 84860517661 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin
    • Asadi S, Theoharides TC. Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. J Neuroinflam 2012, 9:85.
    • (2012) J Neuroinflam , vol.9 , pp. 85
    • Asadi, S.1    Theoharides, T.C.2
  • 39
    • 0015821329 scopus 로고
    • The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami
    • Carraway R, Leeman SE. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 1973, 248:6854-6861.
    • (1973) J Biol Chem , vol.248 , pp. 6854-6861
    • Carraway, R.1    Leeman, S.E.2
  • 40
    • 0034715059 scopus 로고    scopus 로고
    • Neurotensin: peptide for the next millennium
    • 10.1016/S0167-0115(00)00183-X, 11033059
    • Tyler-McMahon BM, Boules M, Richelson E. Neurotensin: peptide for the next millennium. Regul Pept 2000, 93:125-136. 10.1016/S0167-0115(00)00183-X, 11033059.
    • (2000) Regul Pept , vol.93 , pp. 125-136
    • Tyler-McMahon, B.M.1    Boules, M.2    Richelson, E.3
  • 41
    • 0023008229 scopus 로고
    • Generation of immunoreactive neurotensin(s) and enkephalin(s) by pepsin-treatment of plasma
    • Carraway RE, Singer EA, Ferris CF, Mitra SP. Generation of immunoreactive neurotensin(s) and enkephalin(s) by pepsin-treatment of plasma. Adv Exp Med Biol 1986, 198 Pt B:169-179.
    • (1986) Adv Exp Med Biol , vol.198 Pt B , pp. 169-179
    • Carraway, R.E.1    Singer, E.A.2    Ferris, C.F.3    Mitra, S.P.4
  • 42
    • 0032856498 scopus 로고    scopus 로고
    • Acute immobilization stress triggers skin mast cell degranulation via corticotropin-releasing hormone, neurotensin and substance P: a link to neurogenic skin disorders
    • Singh LK, Pang X, Alexacos N, Letourneau R, Theoharides TC. Acute immobilization stress triggers skin mast cell degranulation via corticotropin-releasing hormone, neurotensin and substance P: a link to neurogenic skin disorders. Brain Behav Immunity 1999, 13:225-239.
    • (1999) Brain Behav Immunity , vol.13 , pp. 225-239
    • Singh, L.K.1    Pang, X.2    Alexacos, N.3    Letourneau, R.4    Theoharides, T.C.5
  • 43
    • 0020005040 scopus 로고
    • Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels
    • 1250364, 6178820
    • Carraway R, Cochrane DE, Lansman JB, Leeman SE, Paterson BM, Welch HJ. Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol 1982, 323:403-414. 1250364, 6178820.
    • (1982) J Physiol , vol.323 , pp. 403-414
    • Carraway, R.1    Cochrane, D.E.2    Lansman, J.B.3    Leeman, S.E.4    Paterson, B.M.5    Welch, H.J.6
  • 45
    • 0033057942 scopus 로고    scopus 로고
    • Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C
    • 10.1016/S0162-3109(98)00064-2, 10102794
    • Barrocas AM, Cochrane DE, Carraway RE, Feldberg RS. Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C. Immunopharmacology 1999, 41:131-137. 10.1016/S0162-3109(98)00064-2, 10102794.
    • (1999) Immunopharmacology , vol.41 , pp. 131-137
    • Barrocas, A.M.1    Cochrane, D.E.2    Carraway, R.E.3    Feldberg, R.S.4
  • 46
    • 0026326474 scopus 로고
    • Rapid degradation of neutotensin by stimulated rat mast cells
    • 10.1016/0196-9781(91)90193-S, 1726119
    • Cochrane DE, Carraway RE, Boucher W, Feldberg RS. Rapid degradation of neutotensin by stimulated rat mast cells. Peptides 1991, 12:1187-1194. 10.1016/0196-9781(91)90193-S, 1726119.
    • (1991) Peptides , vol.12 , pp. 1187-1194
    • Cochrane, D.E.1    Carraway, R.E.2    Boucher, W.3    Feldberg, R.S.4
  • 47
    • 54549103514 scopus 로고    scopus 로고
    • New developments in mast cell biology
    • 10.1038/ni.f.216, 2856637, 18936782
    • Kalesnikoff J, Galli SJ. New developments in mast cell biology. Nat Immunol 2008, 9:1215-1223. 10.1038/ni.f.216, 2856637, 18936782.
    • (2008) Nat Immunol , vol.9 , pp. 1215-1223
    • Kalesnikoff, J.1    Galli, S.J.2
  • 48
    • 0033863170 scopus 로고    scopus 로고
    • Human mast cells and basophils as sources of cytokines
    • 10.1046/j.1365-2222.2000.00808.x, 10971465
    • Kobayashi H, Ishizuka T, Okayama Y. Human mast cells and basophils as sources of cytokines. Clin Exp Allergy 2000, 30:1205-1212. 10.1046/j.1365-2222.2000.00808.x, 10971465.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1205-1212
    • Kobayashi, H.1    Ishizuka, T.2    Okayama, Y.3
  • 49
    • 44349101991 scopus 로고    scopus 로고
    • Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    • 10.1038/nri2327, 2855166, 18483499
    • Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008, 8:478-486. 10.1038/nri2327, 2855166, 18483499.
    • (2008) Nat Rev Immunol , vol.8 , pp. 478-486
    • Galli, S.J.1    Grimbaldeston, M.2    Tsai, M.3
  • 50
    • 73349142022 scopus 로고    scopus 로고
    • A crucial door to the mast cell mystery knocked in
    • 10.4049/jimmunol.0990101, 2923095, 19923472
    • Kawakami T. A crucial door to the mast cell mystery knocked in. J Immunol 2009, 183:6861-6862. 10.4049/jimmunol.0990101, 2923095, 19923472.
    • (2009) J Immunol , vol.183 , pp. 6861-6862
    • Kawakami, T.1
  • 54
    • 0009330090 scopus 로고    scopus 로고
    • Definitive characterization of rat hypothalamic mast cells
    • 10.1016/0306-4522(95)00606-0, 8809807
    • Pang X, Letourneau R, Rozniecki JJ, Wang L, Theoharides TC. Definitive characterization of rat hypothalamic mast cells. Neuroscience 1996, 73:889-902. 10.1016/0306-4522(95)00606-0, 8809807.
    • (1996) Neuroscience , vol.73 , pp. 889-902
    • Pang, X.1    Letourneau, R.2    Rozniecki, J.J.3    Wang, L.4    Theoharides, T.C.5
  • 55
    • 0034094032 scopus 로고    scopus 로고
    • Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody
    • 10.1016/S0028-3908(00)00060-5, 10818259
    • Fassio A, Evans G, Grisshammer R, Bolam JP, Mimmack M, Emson PC. Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Neuropharmacology 2000, 39:1430-1442. 10.1016/S0028-3908(00)00060-5, 10818259.
    • (2000) Neuropharmacology , vol.39 , pp. 1430-1442
    • Fassio, A.1    Evans, G.2    Grisshammer, R.3    Bolam, J.P.4    Mimmack, M.5    Emson, P.C.6
  • 56
    • 82955198480 scopus 로고
    • New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?
    • Walker ME, Hatfield JK, Brown MA. New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?. Biochim Biophys Acta 1822, 2012:57-65.
    • (1822) Biochim Biophys Acta , vol.2012 , pp. 57-65
    • Walker, M.E.1    Hatfield, J.K.2    Brown, M.A.3
  • 57
    • 84864765533 scopus 로고    scopus 로고
    • Microglia and mast cells: two tracks on the road to neuroinflammation
    • 10.1096/fj.11-197194, 22516295
    • Skaper SD, Giusti P, Facci L. Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J 2012, 26:3103-3117. 10.1096/fj.11-197194, 22516295.
    • (2012) FASEB J , vol.26 , pp. 3103-3117
    • Skaper, S.D.1    Giusti, P.2    Facci, L.3
  • 58
    • 84868147790 scopus 로고    scopus 로고
    • Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide
    • 10.1098/rstb.2011.0391, 23108549
    • Skaper SD, Facci L. Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide. Philos Trans R Soc Lond B Biol Sci 2012, 367:3312-3325. 10.1098/rstb.2011.0391, 23108549.
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 3312-3325
    • Skaper, S.D.1    Facci, L.2
  • 59
    • 0035660771 scopus 로고    scopus 로고
    • Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines
    • 10.1006/nbdi.2001.0437, 11741401
    • Nagai A, Nakagawa E, Hatori K, Choi HB, McLarnon JG, Lee MA, Kim SU. Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines. Neurobiol Dis 2001, 8:1057-1068. 10.1006/nbdi.2001.0437, 11741401.
    • (2001) Neurobiol Dis , vol.8 , pp. 1057-1068
    • Nagai, A.1    Nakagawa, E.2    Hatori, K.3    Choi, H.B.4    McLarnon, J.G.5    Lee, M.A.6    Kim, S.U.7
  • 60
    • 84860611251 scopus 로고    scopus 로고
    • Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism
    • Morgan JT, Chana G, Abramson I, Semendeferi K, Courchesne E, Everall IP. Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism. Brain Res 2012, 1456:72-81.
    • (2012) Brain Res , vol.1456 , pp. 72-81
    • Morgan, J.T.1    Chana, G.2    Abramson, I.3    Semendeferi, K.4    Courchesne, E.5    Everall, I.P.6
  • 61
    • 84871280445 scopus 로고    scopus 로고
    • Evidence of microglial activation in autism and its possible role in brain underconnectivity
    • 10.1017/S1740925X12000142, 3523548, 22874006
    • Rodriguez JI, Kern JK. Evidence of microglial activation in autism and its possible role in brain underconnectivity. Neuron Glia Biol 2011, 7:205-213. 10.1017/S1740925X12000142, 3523548, 22874006.
    • (2011) Neuron Glia Biol , vol.7 , pp. 205-213
    • Rodriguez, J.I.1    Kern, J.K.2
  • 62
    • 25444484080 scopus 로고    scopus 로고
    • Neurotensin and the neurotensin receptor-3 in microglial cells
    • 10.1002/jnr.20477, 15957186
    • Martin S, Dicou E, Vincent JP, Mazella J. Neurotensin and the neurotensin receptor-3 in microglial cells. J Neurosci Res 2005, 81:322-326. 10.1002/jnr.20477, 15957186.
    • (2005) J Neurosci Res , vol.81 , pp. 322-326
    • Martin, S.1    Dicou, E.2    Vincent, J.P.3    Mazella, J.4
  • 64
    • 0037442515 scopus 로고    scopus 로고
    • Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia
    • Martin S, Vincent JP, Mazella J. Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. J Neurosci 2003, 23:1198-1205.
    • (2003) J Neurosci , vol.23 , pp. 1198-1205
    • Martin, S.1    Vincent, J.P.2    Mazella, J.3
  • 65
    • 77957200346 scopus 로고    scopus 로고
    • Targeting neurotensin as a potential novel approach for the treatment of autism
    • 10.1186/1742-2094-7-58, 2958902, 20920308
    • Ghanizadeh A. Targeting neurotensin as a potential novel approach for the treatment of autism. J Neuroinflammation 2010, 7:58. 10.1186/1742-2094-7-58, 2958902, 20920308.
    • (2010) J Neuroinflammation , vol.7 , pp. 58
    • Ghanizadeh, A.1
  • 68
    • 84859005372 scopus 로고    scopus 로고
    • A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures
    • 10.1038/mp.2011.165, 3317062, 22143005
    • Rossignol DA, Frye RE. A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012, 17(4):389-401. 10.1038/mp.2011.165, 3317062, 22143005.
    • (2012) Mol Psychiatry , vol.17 , Issue.4 , pp. 389-401
    • Rossignol, D.A.1    Frye, R.E.2
  • 69
    • 84857369274 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
    • 10.1038/mp.2010.136, 3285768, 21263444
    • Rossignol DA, Frye RE. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol. Psychiatry 2012, 17:290-314. 10.1038/mp.2010.136, 3285768, 21263444.
    • (2012) Mol. Psychiatry , vol.17 , pp. 290-314
    • Rossignol, D.A.1    Frye, R.E.2
  • 73
    • 84871326101 scopus 로고    scopus 로고
    • Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions
    • 10.1371/journal.pone.0049767, 3524249, 23284625
    • Zhang B, Asadi S, Weng Z, Sismanopoulos N, Theoharides TC. Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions. PLoS ONE 2012, 7(12):e49767. 10.1371/journal.pone.0049767, 3524249, 23284625.
    • (2012) PLoS ONE , vol.7 , Issue.12
    • Zhang, B.1    Asadi, S.2    Weng, Z.3    Sismanopoulos, N.4    Theoharides, T.C.5
  • 74
    • 77749330821 scopus 로고    scopus 로고
    • Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
    • 10.1128/MCB.01149-09, 2832488, 20065039
    • Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A. Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Mol Cell Biol 2010, 30:1357-1367. 10.1128/MCB.01149-09, 2832488, 20065039.
    • (2010) Mol Cell Biol , vol.30 , pp. 1357-1367
    • Lauritzen, K.H.1    Moldestad, O.2    Eide, L.3    Carlsen, H.4    Nesse, G.5    Storm, J.F.6    Mansuy, I.M.7    Bergersen, L.H.8    Klungland, A.9
  • 75
    • 84863101683 scopus 로고    scopus 로고
    • Perinatal stress, brain inflammation and risk of autism-Review and proposal
    • 10.1186/1471-2431-12-89, 3496584, 22747567
    • Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-Review and proposal. BMC Pediatr 2012, 12:89. 10.1186/1471-2431-12-89, 3496584, 22747567.
    • (2012) BMC Pediatr , vol.12 , pp. 89
    • Angelidou, A.1    Asadi, S.2    Alysandratos, K.D.3    Karagkouni, A.4    Kourembanas, S.5    Theoharides, T.C.6
  • 76
    • 68949159751 scopus 로고    scopus 로고
    • Autism: an emerging 'neuroimmune disorder' in search of therapy
    • Theoharides TC, Kempuraj D, Redwood L. Autism: an emerging 'neuroimmune disorder' in search of therapy. Exp Opin Pharmacother 2009, 10:2127-2143.
    • (2009) Exp Opin Pharmacother , vol.10 , pp. 2127-2143
    • Theoharides, T.C.1    Kempuraj, D.2    Redwood, L.3
  • 77
    • 84555208173 scopus 로고    scopus 로고
    • SnapShot: genetics of autism
    • 10.1016/j.neuron.2011.10.007, 22017998
    • Aldinger KA, Plummer JT, Qiu S, Levitt P. SnapShot: genetics of autism. Neuron 2011, 72:418. 10.1016/j.neuron.2011.10.007, 22017998.
    • (2011) Neuron , vol.72 , pp. 418
    • Aldinger, K.A.1    Plummer, J.T.2    Qiu, S.3    Levitt, P.4
  • 78
    • 79952313620 scopus 로고    scopus 로고
    • Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting
    • Betancur C. Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Res 2011, 1380:42-77.
    • (2011) Brain Res , vol.1380 , pp. 42-77
    • Betancur, C.1
  • 79
    • 84868198811 scopus 로고    scopus 로고
    • PTEN signaling in autism spectrum disorders
    • 10.1016/j.conb.2012.05.004, 22664040
    • Zhou J, Parada LF. PTEN signaling in autism spectrum disorders. Curr Opin Neurobiol 2012, 22(5):873-879. 10.1016/j.conb.2012.05.004, 22664040.
    • (2012) Curr Opin Neurobiol , vol.22 , Issue.5 , pp. 873-879
    • Zhou, J.1    Parada, L.F.2
  • 80
    • 84255160972 scopus 로고    scopus 로고
    • MTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
    • 10.1182/blood-2011-06-359984, 3245204, 22053105
    • Smrz D, Kim MS, Zhang S, Mock BA, Smrzova S, DuBois W, Simakova O, Maric I, Wilson TM, Metcalfe DD, Gilfillan AM. mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells. Blood 2011, 118:6803-6813. 10.1182/blood-2011-06-359984, 3245204, 22053105.
    • (2011) Blood , vol.118 , pp. 6803-6813
    • Smrz, D.1    Kim, M.S.2    Zhang, S.3    Mock, B.A.4    Smrzova, S.5    DuBois, W.6    Simakova, O.7    Maric, I.8    Wilson, T.M.9    Metcalfe, D.D.10    Gilfillan, A.M.11
  • 81
    • 82155166743 scopus 로고    scopus 로고
    • Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia
    • 10.2174/156720211798120990, 3254854, 22023617
    • Shang YC, Chong ZZ, Wang S, Maiese K. Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia. Curr Neurovasc Res 2011, 8:270-285. 10.2174/156720211798120990, 3254854, 22023617.
    • (2011) Curr Neurovasc Res , vol.8 , pp. 270-285
    • Shang, Y.C.1    Chong, Z.Z.2    Wang, S.3    Maiese, K.4
  • 82
    • 70349956425 scopus 로고    scopus 로고
    • A genome-wide linkage and association scan reveals novel loci for autism
    • 10.1038/nature08490, 2772655, 19812673
    • Weiss LA, Arking DE, Daly MJ, Chakravarti A. A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009, 461:802-808. 10.1038/nature08490, 2772655, 19812673.
    • (2009) Nature , vol.461 , pp. 802-808
    • Weiss, L.A.1    Arking, D.E.2    Daly, M.J.3    Chakravarti, A.4
  • 83
    • 67649249900 scopus 로고    scopus 로고
    • National patterns in the outpatient pharmacological management of children and adolescents with autism spectrum disorder
    • 10.1097/JCP.0b013e3181a20c8a, 19440093
    • Gerhard T, Chavez B, Olfson M, Crystal S. National patterns in the outpatient pharmacological management of children and adolescents with autism spectrum disorder. J Clin Psychopharmacol 2009, 29:307-310. 10.1097/JCP.0b013e3181a20c8a, 19440093.
    • (2009) J Clin Psychopharmacol , vol.29 , pp. 307-310
    • Gerhard, T.1    Chavez, B.2    Olfson, M.3    Crystal, S.4
  • 84
    • 79951611110 scopus 로고    scopus 로고
    • Evidence to practice: treatment of anxiety in individuals with autism spectrum disorders
    • 3035599, 21326652
    • Lang R, Mahoney R, El Zein F, Delaune E, Amidon M. Evidence to practice: treatment of anxiety in individuals with autism spectrum disorders. Neuropsychiatr Dis Treat 2011, 7:27-30. 3035599, 21326652.
    • (2011) Neuropsychiatr Dis Treat , vol.7 , pp. 27-30
    • Lang, R.1    Mahoney, R.2    El Zein, F.3    Delaune, E.4    Amidon, M.5
  • 85
    • 79955494719 scopus 로고    scopus 로고
    • A systematic review of early intensive intervention for autism spectrum disorders
    • 10.1542/peds.2011-0426, 21464190
    • Warren Z, McPheeters ML, Sathe N, Foss-Feig JH, Glasser A, Veenstra-Vanderweele J. A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics 2011, 127:e1303-e1311. 10.1542/peds.2011-0426, 21464190.
    • (2011) Pediatrics , vol.127
    • Warren, Z.1    McPheeters, M.L.2    Sathe, N.3    Foss-Feig, J.H.4    Glasser, A.5    Veenstra-Vanderweele, J.6
  • 86
    • 84855363732 scopus 로고    scopus 로고
    • Evidence-based treatment approach to autism spectrum disorders
    • 10.3928/00904481-20111007-08, 22066509
    • Munshi KR, Gonzalez-Heydrich J, Augenstein T, D'Angelo EJ. Evidence-based treatment approach to autism spectrum disorders. Pediatr Ann 2011, 40:569-574. 10.3928/00904481-20111007-08, 22066509.
    • (2011) Pediatr Ann , vol.40 , pp. 569-574
    • Munshi, K.R.1    Gonzalez-Heydrich, J.2    Augenstein, T.3    D'Angelo, E.J.4
  • 87
    • 79251557516 scopus 로고    scopus 로고
    • Psychopharmacology of autistic spectrum disorders in children and adolescents
    • 10.1016/j.pcl.2010.10.011, 21281850
    • Nazeer A. Psychopharmacology of autistic spectrum disorders in children and adolescents. Pediatr Clin North Am 2011, 58:85-97. 10.1016/j.pcl.2010.10.011, 21281850.
    • (2011) Pediatr Clin North Am , vol.58 , pp. 85-97
    • Nazeer, A.1
  • 88
    • 42549141631 scopus 로고    scopus 로고
    • Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability
    • 10.1089/cap.2007.0041, 18439113
    • Parikh MS, Kolevzon A, Hollander E. Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability. J Child Adolesc Psychopharmacol 2008, 18:157-178. 10.1089/cap.2007.0041, 18439113.
    • (2008) J Child Adolesc Psychopharmacol , vol.18 , pp. 157-178
    • Parikh, M.S.1    Kolevzon, A.2    Hollander, E.3
  • 89
    • 38149021973 scopus 로고    scopus 로고
    • Antipsychotics in the treatment of autism
    • 10.1172/JCI32483, 2171144, 18172517
    • Posey DJ, Stigler KA, Erickson CA, McDougle CJ. Antipsychotics in the treatment of autism. J Clin Invest 2008, 118:6-14. 10.1172/JCI32483, 2171144, 18172517.
    • (2008) J Clin Invest , vol.118 , pp. 6-14
    • Posey, D.J.1    Stigler, K.A.2    Erickson, C.A.3    McDougle, C.J.4
  • 90
    • 34548056141 scopus 로고    scopus 로고
    • Atypical antipsychotics in children with pervasive developmental disorders
    • 10.2165/00148581-200709040-00006, 17705564
    • Chavez B, Chavez-Brown M, Sopko MA, Rey JA. Atypical antipsychotics in children with pervasive developmental disorders. Paediatr Drugs 2007, 9:249-266. 10.2165/00148581-200709040-00006, 17705564.
    • (2007) Paediatr Drugs , vol.9 , pp. 249-266
    • Chavez, B.1    Chavez-Brown, M.2    Sopko, M.A.3    Rey, J.A.4
  • 91
    • 46649086988 scopus 로고    scopus 로고
    • Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders
    • McDougle CJ, Stigler KA, Erickson CA, Posey DJ. Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders. J Clin Psychiatry 2008, 69(Suppl 4):15-20.
    • (2008) J Clin Psychiatry , vol.69 , Issue.SUPPL. 4 , pp. 15-20
    • McDougle, C.J.1    Stigler, K.A.2    Erickson, C.A.3    Posey, D.J.4
  • 93
    • 35048883351 scopus 로고    scopus 로고
    • Risperidone: a review of its use in the treatment of irritability associated with autistic disorder in children and adolescents
    • 10.2165/00148581-200709050-00006, 17927305
    • Scott LJ, Dhillon S. Risperidone: a review of its use in the treatment of irritability associated with autistic disorder in children and adolescents. Paediatr Drugs 2007, 9:343-354. 10.2165/00148581-200709050-00006, 17927305.
    • (2007) Paediatr Drugs , vol.9 , pp. 343-354
    • Scott, L.J.1    Dhillon, S.2
  • 94
    • 79955078929 scopus 로고    scopus 로고
    • Aripiprazole: in the treatment of irritability associated with autistic disorder in pediatric patients
    • 10.2165/11207230-000000000-00000, 21500873
    • Curran MP. Aripiprazole: in the treatment of irritability associated with autistic disorder in pediatric patients. Paediatr Drugs 2011, 13:197-204. 10.2165/11207230-000000000-00000, 21500873.
    • (2011) Paediatr Drugs , vol.13 , pp. 197-204
    • Curran, M.P.1
  • 95
    • 27744466024 scopus 로고    scopus 로고
    • Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity
    • Research Units on Pediatric Psychparmacology Autism Network
    • Research Units on Pediatric Psychparmacology Autism Network Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry 2005, 62:1266-1274. Research Units on Pediatric Psychparmacology Autism Network.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 1266-1274
  • 97
    • 84893391547 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)
    • Williams K, Wheeler DM, Silove N, Hazell P. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Cochrane Database Syst Rev 2010, 8:CD004677.
    • (2010) Cochrane Database Syst Rev , vol.8
    • Williams, K.1    Wheeler, D.M.2    Silove, N.3    Hazell, P.4
  • 99
    • 66449126496 scopus 로고    scopus 로고
    • Citalopram treatment in children with autism spectrum disorders and high levels of repetitive behavior
    • 10.1001/archgenpsychiatry.2009.42, 19487622
    • Volkmar FR. Citalopram treatment in children with autism spectrum disorders and high levels of repetitive behavior. Arch Gen Psychiatry 2009, 66:581-582. 10.1001/archgenpsychiatry.2009.42, 19487622.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 581-582
    • Volkmar, F.R.1
  • 100
    • 79959252898 scopus 로고    scopus 로고
    • Developments in pediatric psychopharmacology: focus on stimulants, antidepressants, and antipsychotics
    • 10.4088/JCP.11r07064, 21658348
    • Correll CU, Kratochvil CJ, March JS. Developments in pediatric psychopharmacology: focus on stimulants, antidepressants, and antipsychotics. J Clin Psychiatry 2011, 72:655-670. 10.4088/JCP.11r07064, 21658348.
    • (2011) J Clin Psychiatry , vol.72 , pp. 655-670
    • Correll, C.U.1    Kratochvil, C.J.2    March, J.S.3
  • 101
    • 78649826428 scopus 로고    scopus 로고
    • Updates of mTOR inhibitors
    • 10.2174/187152010793498663, 2980558, 20812900
    • Zhou H, Luo Y, Huang S. Updates of mTOR inhibitors. Anticancer Agents Med Chem 2010, 10:571-581. 10.2174/187152010793498663, 2980558, 20812900.
    • (2010) Anticancer Agents Med Chem , vol.10 , pp. 571-581
    • Zhou, H.1    Luo, Y.2    Huang, S.3
  • 102
    • 79651475390 scopus 로고    scopus 로고
    • Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
    • 10.1016/j.molmed.2010.10.002, 3075964, 21115397
    • Ehninger D, Silva AJ. Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends Mol Med 2011, 17:78-87. 10.1016/j.molmed.2010.10.002, 3075964, 21115397.
    • (2011) Trends Mol Med , vol.17 , pp. 78-87
    • Ehninger, D.1    Silva, A.J.2
  • 103
    • 84868200593 scopus 로고    scopus 로고
    • Targeted treatment trials for tuberous sclerosis and autism: no longer a dream
    • 10.1016/j.conb.2012.04.008, 22560338
    • Sahin M. Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Curr Opin Neurobiol 2012, 22(5):895-901. 10.1016/j.conb.2012.04.008, 22560338.
    • (2012) Curr Opin Neurobiol , vol.22 , Issue.5 , pp. 895-901
    • Sahin, M.1
  • 104
    • 77954888764 scopus 로고    scopus 로고
    • Targeted treatments for cognitive and neurodevelopmental disorders in tuberous sclerosis complex
    • 10.1016/j.nurt.2010.05.001, 20643380
    • de Vries PJ. Targeted treatments for cognitive and neurodevelopmental disorders in tuberous sclerosis complex. Neurotherapeutics. 2010, 7:275-282. 10.1016/j.nurt.2010.05.001, 20643380.
    • (2010) Neurotherapeutics. , vol.7 , pp. 275-282
    • de Vries, P.J.1
  • 105
    • 84855931231 scopus 로고    scopus 로고
    • Pathways to drug development for autism spectrum disorders
    • 10.1038/clpt.2011.245, 22205199
    • Hampson DR, Gholizadeh S, Pacey LK. Pathways to drug development for autism spectrum disorders. Clin Pharmacol Ther 2012, 91:189-200. 10.1038/clpt.2011.245, 22205199.
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 189-200
    • Hampson, D.R.1    Gholizadeh, S.2    Pacey, L.K.3
  • 106
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer
    • Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000, 52:673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 107
    • 79952440161 scopus 로고    scopus 로고
    • Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
    • 10.1016/j.bbrc.2011.02.010, 21300025
    • Van Aller GS, Carson JD, Tang W, Peng H, Zhao L, Copeland RA, Tummino PJ, Luo L. Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun 2011, 406:194-199. 10.1016/j.bbrc.2011.02.010, 21300025.
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 194-199
    • Van Aller, G.S.1    Carson, J.D.2    Tang, W.3    Peng, H.4    Zhao, L.5    Copeland, R.A.6    Tummino, P.J.7    Luo, L.8
  • 108
    • 0034062416 scopus 로고    scopus 로고
    • Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells
    • 10.1046/j.1365-2222.2000.00768.x, 10718847
    • Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy 2000, 30:501-508. 10.1046/j.1365-2222.2000.00768.x, 10718847.
    • (2000) Clin Exp Allergy , vol.30 , pp. 501-508
    • Kimata, M.1    Shichijo, M.2    Miura, T.3    Serizawa, I.4    Inagaki, N.5    Nagai, H.6
  • 110
    • 76749083375 scopus 로고    scopus 로고
    • Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
    • 10.1186/1742-2094-7-3, 2819254, 20074346
    • Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation 2010, 7:3. 10.1186/1742-2094-7-3, 2819254, 20074346.
    • (2010) J Neuroinflammation , vol.7 , pp. 3
    • Dirscherl, K.1    Karlstetter, M.2    Ebert, S.3    Kraus, D.4    Hlawatsch, J.5    Walczak, Y.6    Moehle, C.7    Fuchshofer, R.8    Langmann, T.9
  • 111
    • 77958133125 scopus 로고    scopus 로고
    • Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice
    • 10.3945/jn.110.123273, 2937579, 20685893
    • Jang S, Dilger RN, Johnson RW. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 2010, 140:1892-1898. 10.3945/jn.110.123273, 2937579, 20685893.
    • (2010) J Nutr , vol.140 , pp. 1892-1898
    • Jang, S.1    Dilger, R.N.2    Johnson, R.W.3
  • 113
    • 56749169211 scopus 로고    scopus 로고
    • Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells
    • 2597265, 18806808
    • Kempuraj D, Tagen M, Iliopoulou BP, Clemons A, Vasiadi M, Boucher W, House M, Wolferg A, Theoharides TC. Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells. Br J Pharmacol 2008, 155:1076-1084. 2597265, 18806808.
    • (2008) Br J Pharmacol , vol.155 , pp. 1076-1084
    • Kempuraj, D.1    Tagen, M.2    Iliopoulou, B.P.3    Clemons, A.4    Vasiadi, M.5    Boucher, W.6    House, M.7    Wolferg, A.8    Theoharides, T.C.9
  • 114
    • 3242720446 scopus 로고    scopus 로고
    • The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells
    • 10.1016/j.bcp.2004.05.012, 15276069
    • Verbeek R, Plomp AC, van Tol EA, van Noort JM. The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. Biochem Pharmacol 2004, 68:621-629. 10.1016/j.bcp.2004.05.012, 15276069.
    • (2004) Biochem Pharmacol , vol.68 , pp. 621-629
    • Verbeek, R.1    Plomp, A.C.2    van Tol, E.A.3    van Noort, J.M.4
  • 115
    • 84984588922 scopus 로고    scopus 로고
    • Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction
    • 10.1016/j.etap.2010.07.003, 2992974, 21127717
    • Franco JL, Posser T, Missau F, Pizzolatti MG, Dos Santos AR, Souza DO, Aschner M, Rocha JB, Dafre AL, Farina M. Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction. Environ Toxicol Pharmacol 2010, 30:272-278. 10.1016/j.etap.2010.07.003, 2992974, 21127717.
    • (2010) Environ Toxicol Pharmacol , vol.30 , pp. 272-278
    • Franco, J.L.1    Posser, T.2    Missau, F.3    Pizzolatti, M.G.4    Dos Santos, A.R.5    Souza, D.O.6    Aschner, M.7    Rocha, J.B.8    Dafre, A.L.9    Farina, M.10
  • 116
    • 56049116002 scopus 로고    scopus 로고
    • Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation
    • 10.1016/j.neulet.2008.10.046, 18952146
    • Chen HQ, Jin ZY, Wang XJ, Xu XM, Deng L, Zhao JW. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neurosci Lett 2008, 448:175-179. 10.1016/j.neulet.2008.10.046, 18952146.
    • (2008) Neurosci Lett , vol.448 , pp. 175-179
    • Chen, H.Q.1    Jin, Z.Y.2    Wang, X.J.3    Xu, X.M.4    Deng, L.5    Zhao, J.W.6
  • 118
    • 84871372880 scopus 로고    scopus 로고
    • Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice
    • 10.1073/pnas.1210055109, 23213205
    • Sadakata T, Shinoda Y, Oka M, Sekine Y, Sato Y, Saruta C, Miwa H, Tanaka M, Itohara S, Furuichi T. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. Proc Natl Acad Sci USA 2012, 109(51):21104-21109. 10.1073/pnas.1210055109, 23213205.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.51 , pp. 21104-21109
    • Sadakata, T.1    Shinoda, Y.2    Oka, M.3    Sekine, Y.4    Sato, Y.5    Saruta, C.6    Miwa, H.7    Tanaka, M.8    Itohara, S.9    Furuichi, T.10
  • 119
    • 84863708123 scopus 로고    scopus 로고
    • A case series of a luteolin formulation (Neuroprotek®) in children with autism spectrum disorders
    • Theoharides TC, Asadi S, Panagiotidou S. A case series of a luteolin formulation (Neuroprotek®) in children with autism spectrum disorders. Intl J Immunopathol Pharmacol 2012, 25:317-323.
    • (2012) Intl J Immunopathol Pharmacol , vol.25 , pp. 317-323
    • Theoharides, T.C.1    Asadi, S.2    Panagiotidou, S.3


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