Recent findings in Alzheimer disease and nutrition focusing on epigenetics

Advances in Nutrition

Volumn 7, Issue 5, 2016, Pages 917-927

  Athanasopoulos, Dimitrios ^a   Karagiannis, George ^a   Tsolaki, Magda ^a,b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Greek Association of Alzheimer's Disease and Related Disorders   (Greece)

Author keywords

Aging; Alzheimer disease; DNA methylation; Epigenetics; Heavy metals; Histone modifications; Nutrigenomics; One carbon metabolism; Phytochemicals; Vitamins

Indexed keywords

CYANOCOBALAMIN;

ALZHEIMER DISEASE; DIET; DIET THERAPY; DNA METHYLATION; FEEDING BEHAVIOR; GENETIC EPIGENESIS; GENETICS; HUMAN;

ALZHEIMER DISEASE; DIET; DNA METHYLATION; EPIGENESIS, GENETIC; FEEDING BEHAVIOR; HUMANS; VITAMIN B 12;

EID: 84992735245     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.116.012229     Document Type: Review

References (107)

1. Alzheimer's Association. 2014 Alzheimer's disease facts and figures. Alzheimers Dement. 2014;10:e47-92.
2. Prince M, Wimo A, Guerchet M, Ali GC, Wu YT, Prina AM. World Alzheimer Report 2015: the global impact of dementia. London (UK): Alzheimer's Disease International; 2015.
3. Do Carmo S, Cuello AC. Modeling Alzheimer's disease in transgenic rats. Mol Neurodegener 2013;8:37.
4. Wang X, Huang T, Bu G, Xu H. Dysregulation of protein trafficking in neurodegeneration. Mol Neurodegener 2014;9:31.
5. Cummings JL, Isaacson RS, Schmitt FA, Velting DM. A practical algorithm for managing Alzheimer's disease: what, when, and why? Ann Clin Transl Neurol 2015;2:307-23.
6. Shewale SJ, Huebinger RM, Allen MS, Barber RC. The potential role of epigenetics in Alzheimer's disease etiology. Biol Syst 2013;2:114.
7. Balazs R. Epigenetic mechanisms in Alzheimer's disease. Degener Neurol Neuromuscul Dis 2014;4:85-102.
8. Landgrave-Gómez J, Mercado-Gómez O, Guevara-Guzmán R. Epigenetic mechanisms in neurological and neurodegenerative diseases. Front Cell Neurosci 2015;9:58.
9. Pezzi JC, Ens CM, Borba EM, Schumacher-Schuh AF, de Andrade FM, Chaves ML, Fiegenbaum M, Camozzato AL. DNA methyltransferase haplotype is associated with Alzheimer's disease. Neurosci Lett 2014;579:70-4.
10. Chouliaras L, Mastroeni D, Delvaux E, Grover A, Kenis G, Hof PR, Steinbusch HW, Coleman PD, Rutten BP, van den Hove DL. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol Aging 2013;34:2091-9.
11. Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al. Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging 2014;35:1850-4.
12. Wang J, Yu JT, Tan MS, Jiang T, Tan L. Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy. Ageing Res Rev 2013;12:1024-41.
13. Sheikh BN. Crafting the brain-role of histone acetyltransferases in neural development and disease. Cell Tissue Res 2014;356:553-73.
14. Sung YM, Lee T, Yoon H, DiBattista AM, Song JM, Sohn Y, Moffat EI, Turner RS, Jung M, Kim J, et al. Mercaptoacetamide-based class II HDAC inhibitor lowers Ab levels and improves learning and memory in a mouse model of Alzheimer's disease. Exp Neurol 2013;239:192-201.
15. Bhattacharjee S, Zhao Y, Lukiw WJ. Deficits in the microRNA-34aregulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD): an update. Front Aging Neurosci 2014;6:116.
16. Tan L, Yu JT, Tan L. Causes and consequences of microRNA dysregulation in neurodegenerative diseases. Mol Neurobiol 2015;51:1249-62.
17. Wainaina MN, Chen Z, Zhong C. Environmental factors in the development and progression of late-onset Alzheimer's disease. Neurosci Bull 2014;30:253-70.
18. Alashwal H, Dosunmu R, Zawia NH. Integration of genome-wide expression and methylation data: relevance to aging and Alzheimer's disease. Neurotoxicology 2012;33:1450-3.
19. Marques S, Outeiro TF. Epigenetics in Parkinson's and Alzheimer's diseases. Subcell Biochem 2013;61:507-25.
20. Nicolia V, Lucarelli M, Fuso A. Environment, epigenetics and neurodegeneration: focus on nutrition in Alzheimer's disease. Exp Gerontol 2015;68:8-12.
21. Kim J, Lee Y, Yang M. Environmental exposure to lead (Pb) and variations in its susceptibility. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32:159-85.
22. Bollati V, Galimberti D, Pergoli L, Dalla Valle E, Barretta F, Cortini F, Scarpini E, Bertazzi PA, Baccarelli A. DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun 2011;25:1078-83.
23. Dosunmu R, Alashwal H, Zawia NH. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech Ageing Dev 2012;133:435-43.
24. Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci 2015;9:124.
25. Tyler CR, Allan AM. The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review. Curr Environ Health Rep 2014;1:132-47.
26. Moore MR. Lead in drinking water in soft water areas-health hazards. Sci Total Environ 1977;7:109-15.
27. Bitra VR, Rapaka D, Mathala N, Akula A. Effect of wheat grass powder on aluminum induced Alzheimer's disease in Wistar rats. Asian Pac J Trop Med. 2014 Sep;7S1:S278-81.
28. Percy ME, Kruck TP, Pogue AI, Lukiw WJ. Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease. J Inorg Biochem 2011;105:1505-12.
29. Maruszak A, Pilarski A, Murphy T, Branch N, Thuret S. Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation? J Alzheimers Dis 2014;38:11-38.
30. McCord MC, Aizenman E. The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease. Front Aging Neurosci 2014;6:77.
31. Loef M, von Stillfried N, Walach H. Zinc diet and Alzheimer's disease: a systematic review. Nutr Neurosci 2012;15:2-12.
32. Joven J, Micol V, Segura-Carretero A, Alonso-Villaverde C, Menéndez JA. Bioactive Food Components Platform: polyphenols and the modulation of gene expression pathways: can we eat our way out of the danger of chronic disease? Crit Rev Food Sci Nutr 2014;54:985-1001.
33. Pal A, Siotto M, Prasad R, Squitti R. Towards a unified vision of copper involvement in Alzheimer's disease: a review connecting basic, experimental, and clinical research. J Alzheimers Dis 2015;44: 343-54.
34. Sun Y, Liu C, Liu Y, Hosokawa T, Saito T, Kurasaki M. Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells. J Environ Sci Health A Tox Hazard Subst Environ Eng 2014;49:1023-8.
35. Mohajeri MH, Troesch B, Weber P. Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia. Nutrition 2015;31:261-75.
36. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2012;27:592-600.
37. Chen H, Liu S, Ji L, Wu T, Ma F, Ji Y, Zhou Y, Zheng M, Zhang M, Huang G. Associations between Alzheimer's disease and blood homocysteine, vitamin B12 and folate: a case-control study. Curr Alzheimer Res 2015;12:88-94.
38. Araújo JR, Martel F, Borges N, Araújo JM, Keating E. Folates and aging: role in mild cognitive impairment, dementia and depression. Ageing Res Rev 2015;22:9-19.
39. Li W, Jiang M, Xiao Y, Zhang X, Cui S, Huang G. Folic acid inhibits Tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells. J Nutr Health Aging 2015;19:123-9.
40. Zheng M, Zhang M, Yang J, Zhao S, Qin S, Chen H, Gao Y, Huang G. Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study. J Clin Biochem Nutr 2014;54:122-8.
41. Bae S, Ulrich CM, Bailey LB, Malysheva O, Brown EC, Maneval DR, Neuhouser ML, Cheng TY, Miller JW, Zheng Y, et al. Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the women's health initiative observational study cohort. Epigenetics 2014;9:396-403.
42. Bollati V, Favero C, Albetti B, Tarantini L, Moroni A, Byun HM, Motta V, Conti DM, Tirelli AS, Vigna L, et al. Nutrients intake is associated with DNA methylation of candidate inflammatory genes in a population of obese subjects. Nutrients 2014;6:4625-39.
43. Vadnal J, Houston S, Bhatta S, Freeman E, McDonough J. Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. Exp Brain Res 2012;221:287-97.
44. Sánchez-Hernández D, Cho CE, Kubant R, Reza-López SA, Poon AN, Wang J, Huot PS, Smith CE, Anderson GH. Increasing vitamin A in post-weaning diets reduces food intake and body weight and modifies gene expression in brains of male rats born to dams fed a high multivitamin diet. J Nutr Biochem 2014;25:991-6.
45. Morris MC, Schneider JA, Li H, Tangney CC, Nag S, Bennett DA, Honer WG, Barnes LL. Brain tocopherols related to Alzheimer's disease neuropathology in humans. Alzheimers Dement 2015;11:32-9.
46. Harrison FE. A critical review of vitamin C for the prevention of agerelated cognitive decline and Alzheimer's disease. J Alzheimers Dis 2012;29:711-26.
47. Carr AC, Vissers MC. Synthetic or food-derived vitamin C: are they equally bioavailable? Nutrients 2013;5:4284-304.
48. Sadowska-Bartosz I, Bartosz G. Effect of antioxidants supplementation on aging and longevity. Biomed Res Int 2014;2014:404680.
49. Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 2014;83: 920-8.
50. Banerjee A, Khemka VK, Ganguly A, Roy D, Ganguly U, Chakrabarti S. Vitamin D and Alzheimer's disease: neurocognition to therapeutics. Int J Alzheimers Dis 2015;2015:192747.
51. Karlic H, Varga F. Impact of vitamin D metabolism on clinical epigenetics. Clin Epigenetics 2011;2:55-61.
52. Fetahu IS, Höbaus J, Kállay E. Vitamin D and the epigenome. Front Physiol 2014;5:164.
53. Cardoso BR, Roberts BR, Bush AI, Hare DJ. Selenium, selenoproteins and neurodegenerative diseases. Metallomics 2015;7:1213-28.
54. Solovyev ND. Importance of selenium and selenoprotein for brain function: from antioxidant protection to neuronal signalling. J Inorg Biochem 2015;153:1-12.
55. Speckmann B, Grune T. Epigenetic effects of selenium and their implications for health. Epigenetics 2015;10:179-90.
56. Wang X, Hjorth E, Vedin I, Eriksdotter M, Freund-Levi Y, Wahlund LO, Cederholm T, Palmblad J, Schultzberg M. Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study. J Lipid Res 2015;56:674-81.
57. Burdge GC. Lillycrop KA. Fatty acids and epigenetics. Curr Opin Clin Nutr Metab Care 2014;17:156-61.
58. Chiu S, Woodbury-Fariña MA, Shad MU, Husni M, Copen J, Bureau Y, Cernovsky Z, Hou JJ, Raheb H, Terpstra K, et al. The role of nutrientbased epigenetic changes in buffering against stress, aging, and Alzheimer's disease. Psychiatr Clin North Am 2014;37:591-623.
59. Martin SL, Hardy TM, Tollefsbol TO. Medicinal chemistry of the epigenetic diet and caloric restriction. Curr Med Chem 2013;20:4050-9.
60. Gerszon J, Rodacka A, Pucha1a M. Antioxidant properties of resveratrol and its protective effects in neurodegenerative diseases. Adv Cell Biol 2014;4.
61. Dauncey MJ. Genomic and epigenomic insights into nutrition and brain disorders. Nutrients. Nutrients 2013;5:887-914.
62. Grossi C, Rigacci S, Ambrosini S, Ed Dami T, Luccarini I, Traini C, Failli P, Berti A, Casamenti F, Stefani M. The polyphenol oleuropein aglycone protects TgCRND8 mice against Ab plaque pathology. PLoS One 2013;8:e71702.
63. Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Ed Dami T, Berti A, Stefani M, et al. Oleuropein aglycone protects against pyroglutamylated-3 amyloid-b toxicity: biochemical, epigenetic and functional correlates. Neurobiol Aging 2015;36: 648-63.
64. Hu S, Maiti P, Ma Q, Zuo X, Jones MR, Cole GM, Frautschy SA. Clinical development of curcumin in neurodegenerative disease. Expert Rev Neurother 2015;15:629-37.
65. Mastroiacovo D, Kwik-Uribe C, Grassi D, Necozione S, Raffaele A, Pistacchio L, Righetti R, Bocale R, Lechiara MC, Marini C, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial. Am J Clin Nutr 2015;101:538-48.
66. Kwik-Uribe C, Bektash RM. Cocoa flavanols: measurement, bioavailability and bioactivity. Asia Pac J Clin Nutr 2008;17(Suppl 1):280-3.
67. Heo JH, Lee ST, Oh MJ, Park HJ, Shim JY, Chu K, Kim M. Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with Korean red ginseng. J Ginseng Res 2011;35:457-61.
68. Lee MS, Yang EJ, Kim JI, Ernst E. Ginseng for cognitive function in Alzheimer's disease: a systematic review. J Alzheimers Dis 2009;18: 339-44.
69. Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-6.
70. Dineley KT, Jahrling JB, Denner L. Insulin resistance in Alzheimer's disease. Neurobiol Dis 2014;72:92-103.
71. Mecocci P, Tinarelli C, Schulz RJ, Polidori MC. Nutraceuticals in cognitive impairment and Alzheimer's disease. Front Pharmacol 2014;5:147.
72. Zhao SS, Yang WN, Jin H, Ma KG, Feng GF. Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZinduced SAD mice. Neurotoxicology 2015;51:166-71.
73. Gleason CE, Fischer BL, Dowling NM, Setchell KD, Atwood CS, Carlsson CM, Asthana S. Cognitive effects of soy isoflavones in patients with Alzheimer's disease. J Alzheimers Dis 2015;47:1009-19.
74. Unno K, Konishi T. Preventive effect of soybean on brain aging and amyloid-b accumulation: comprehensive analysis of brain gene expression. Recent Pat Food Nutr Agric 2015;7:83-91.
75. Wang C, Xie N, Zhang H, Li Y, Wang Y. Puerarin protects against b-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway. Neurochem Res 2014;39:2189-96.
76. Zhou Y, Xie N, Li L, Zou Y, Zhang X, Dong M. Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. Int J Neuropsychopharmacol 2014;17:635-44.
77. Blei T, Soukup ST, Schmalbach K, Pudenz M, Möller FJ, Egert B, Wörtz N, Kurrat A, Müller D, Vollmer G, et al. Dose-dependent effects of isoflavone exposure during early lifetime on the rat mammary gland: studies on estrogen sensitivity, isoflavone metabolism, and DNA methylation. Mol Nutr Food Res 2015;59:270-83.
78. Badshah H, Kim TH, Kim MO. Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro. Neurochem Int 2015;80:51-9.
79. Song N, Yang H, Pang W, Qie Z, Lu H, Tan L, Li H, Sun S, Lian F, Qin C, et al. Mulberry extracts alleviate ab 25-35-induced injury and change the gene expression profile in PC12 cells. Evid Based Complement Alternat Med 2014;2014:150617.
80. Huang HJ, Chen WL, Hsieh RH, Hsieh-Li HM. Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic Alzheimer's mice. Evid Based Complement Alternat Med 2014;2014:813672.
81. Gibellini L, Bianchini E, De Biasi S, Nasi M, Cossarizza A, Pinti M. Natural compounds modulating mitochondrial functions. Evid Based Complement Alternat Med 2015;2015:527209.
82. Ho L, Ferruzzi MG, Janle EM, Wang J, Gong B, Chen TY, Lobo J, Cooper B, Wu QL, Talcott ST, et al. Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease. FASEB J 2013;27:769-81.
83. Mazzio EA, Soliman KF. Epigenetics and nutritional environmental signals. Integr Comp Biol 2014;54:21-30.
84. Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology 2013;24:479-89.
85. Perrone L, Grant WB. Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer's disease incidence and prevalence. J Alzheimers Dis 2015;45:965-79.
86. Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement 2015;11:1007-14.
87. Chung KW, Kim DH, Park MH, Choi YJ, Kim ND, Lee J, Yu BP, Chung HY. Recent advances in calorie restriction research on aging. Exp Gerontol 2013;48:1049-53.
88. Grant WB. Trends in diet and Alzheimer's disease during the nutrition transition in Japan and developing countries. J Alzheimers Dis 2014; 38:611-20.
89. Rojanathammanee L, Puig KL, Combs CK. Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease. J Nutr 2013;143:597-605.
90. Subash S, Braidy N, Essa MM, Zayana AB, Ragini V, Al-Adawi S, Al-Asmi A, Guillemin GJ. Long-term (15 mo) dietary supplementation with pomegranates from Oman attenuates cognitive and behavioral deficits in a transgenic mice model of Alzheimer's disease. Nutrition 2015;31:223-9.
91. Langie SA, Achterfeldt S, Gorniak JP, Halley-Hogg KJ, Oxley D, van Schooten FJ, Godschalk RW, McKay JA, Mathers JC. Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring. FASEB J 2013;27:3323-34.
92. Craft S, Cholerton B, Baker LD. Insulin and Alzheimer's disease: untangling the web. J Alzheimers Dis 2013;33(Suppl 1):S263-75.
93. Taheri Tanjani P, Moradinazar M, Esmail Mottlagh M, Najafi F. The prevalence of diabetes mellitus (DM) type II among Iranian elderly population and its association with other age-related diseases, 2012. Arch Gerontol Geriatr 2015;60:373-9.
94. Cai H, Cong WN, Ji S, Rothman S, Maudsley S, Martin B. Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. Curr Alzheimer Res 2012;9:5-17.
95. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 2011;10:819-28.
96. Luchsinger JA, Cheng D, Tang MX, Schupf N, Mayeux R. Central obesity in the elderly is related to late-onset Alzheimer disease. Alzheimer Dis Assoc Disord 2012;26:101-5.
97. Cansev M, van Wijk N, Turkyilmaz M, Orhan F, Sijben JW, Broersen LM. Specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats. Neurobiol Aging 2015;36:344-51.
98. Remington R, Bechtel C, Larsen D, Samar A, Doshanjh L, Fishman P, Luo Y, Smyers K, Page R, Morrell C, et al. A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease. J Alzheimers Dis 2015;45:395-405.
99. Berti V, Murray J, Davies M, Spector N, Tsui WH, Li Y, Williams S, Pirraglia E, Vallabhajosula S, McHugh P, et al. Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals. J Nutr Health Aging 2015;19:413-23.
100. Dietary supplement fact sheets [Internet]. Bethesda (MD): National Institutes of health, Office of Dietary Supplements. c1995 [cited 2015 Sep 23]. Available from: https://ods.od.nih.gov/factsheets/.
101. Bowman GL. Ascorbic acid, cognitive function, and Alzheimer's disease: a current review and future direction. Biofactors 2012;38:114-22.
102. Agency for Toxic Substances and Disease Registry [Internet]. Atlanta (GA): U.S. Department of Health and Human Services. c2015 [cited 2016 May 10]. Available from: http://www.atsdr.cdc.gov.
103. Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. Plant foods and herbal sources of resveratrol. J Agric Food Chem 2002;50:3337-40.
104. Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm 2010;78:133-54.
105. Koz1owska A, Szostak-Wegierek D. Flavonoids: food sources and health benefits. Rocz Panstw Zakl Hig 2014;65:79-85.
106. A.D.A.M. Medical Encyclopedia [Internet]. Atlanta (GA): A.D.A.M., Inc. c2005 [cited 2016 May 10]. Available from: http://www.nlm. nih.gov/medlineplus/encyclopedia.html.
107. Phenol-Explorer. Database Polyphenol Content in Foods [Internet]. Paris (France): National Institute for Agricultural Research (INRA). c2009 [cited 2015 Sep 23]. Available from: http://phenol-explorer.eu.