Recent advances in calorie restriction research on aging

Experimental Gerontology

Volumn 48, Issue 10, 2013, Pages 1049-1053

  Chung, K W ^a   Kim, D H ^a   Park, M H ^a   Choi, Y J ^a   Kim, N D ^a   Lee, J ^a   Yu, B P ^b   Chung, H Y ^a  

^a Pusan National University   (South Korea)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Aging interventions; Calorie restriction; CR mimetics; Epigenetics; Inflammation; Intermittent feeding; MTOR

Indexed keywords

CELL ADHESION MOLECULE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROSTAGLANDIN SYNTHASE; RAPAMYCIN; TRANSCRIPTION FACTOR FOXO; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANTIOXIDANT ACTIVITY; CALORIC RESTRICTION; CELL FUNCTION; CHROMATIN; CHRONIC INFLAMMATION; DIET RESTRICTION; DISEASE CONTROL; DNA MODIFICATION; DNA SEQUENCE; DRUG MECHANISM; ENVIRONMENTAL FACTOR; ENZYME INHIBITION; EPIGENETICS; EXPERIMENTAL ANIMAL; FEEDING BEHAVIOR; FUNCTIONAL DISEASE; GENE EXPRESSION REGULATION; GERIATRIC DISORDER; GOLD STANDARD; HISTONE MODIFICATION; HUMAN; INTRACELLULAR SIGNALING; LIFESPAN; LIFESTYLE; MEDICAL RESEARCH; MOLECULAR MECHANICS; NONHUMAN; NUTRITION; OXIDATION REDUCTION STATE; PHYSICAL ACTIVITY; PRIMATE; PRIORITY JOURNAL; REPRODUCIBILITY; REVIEW; TRANSCRIPTION INITIATION;

ANIMALIA; PRIMATES;

AGING INTERVENTIONS; CALORIE RESTRICTION; CR MIMETICS; EPIGENETICS; INFLAMMATION; INTERMITTENT FEEDING; MTOR;

AGING; ANIMALS; CALORIC RESTRICTION; EPIGENESIS, GENETIC; FEEDING BEHAVIOR; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MODELS, ANIMAL; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84883462446     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.11.007     Document Type: Review

References (54)

1. Ahmet I., Wan R., Mattson M.P., Lakatta E.G., Talan M. Cardioprotection by intermittent fasting in rats. Circulation 2005, 112:3115-3121.
2. Anderson R.M., Weindruch R. The caloric restriction paradigm: implications for healthy human aging. Am. J. Hum. Biol. 2012, 24:101-106.
3. Bhutani S., Klempel M.C., Berger R.A., Varady K.A. Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations. Obesity (Silver Spring) 2010, 18:2152-2159.
4. Bordone L., Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell Biol. 2005, 6:298-305.
5. Candore G., Caruso C., Jirillo E., Magrone T., Vasto S. Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement. Curr. Pharm. Des. 2010, 16:584-596.
6. Canto' C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol. Metab. 2009, 20:325-331.
7. Cevenini E., Caruso C., Candore G., Capri M., Nuzzo D., Duro G., Rizzo C., Colonna-Romano G., Lio D., Di Carlo D., Palmas M.G., Scurti M., Pini E., Franceschi C., Vasto S. Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr. Pharm. Des. 2010, 16:609-618.
8. Cevenini E., Bellavista E., Tieri P., Castellani G., Lescai F., Francesconi M., Mishto M., Santoro A., Valensin S., Salvioli S., Capri M., Zaikin A., Monti D., de Magalhães J.P., Franceschi C. Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies. Curr. Pharm. Des. 2010, 16:802-813.
9. Chiba T., Tsuchiya T., Komatsu T., Mori R., Hayashi H., Shimokawa I. Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases. Curr. Genomics 2010, 11:562-567.
10. Chiribau C.B., Cheng L., Cucoranu I.C., Yu Y.S., Clempus R.E., Sorescu D. FoxO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J. Biol. Chem. 2008, 283:8211-8217.
11. Chung H.Y., Jung K.J., Yu B.P. Molecular inflammation as an underlying mechanism of aging: the anti-inflammatory action of calorie restriction. Oxidative stress 2005, 387-419. Inflammation and Health. Marcel Dekker, NY. Y.J. Surh, L. Packer (Eds.).
12. Chung H.Y., Sung B., Jung K.J., Zou Y., Yu B.P. The molecular inflammatory process in aging. Antioxid. Redox Signal. 2006, 8:572-581.
13. Chung J.H., Seo A.Y., Chung S.W., Kim M.K., Leeuwenburgh C., Yu B.P., Chung H.Y. Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Res. Rev. 2008, 7:126-136.
14. Chung H.Y., Lee E.K., Choi Y.J., Kim J.M., Kim D.H., Zou Y., Kim C.H., Lee J., Kim H.S., Kim N.D., Jung J.H., Yu B.P. Molecular inflammation as an underlying mechanism of the aging process and age-related diseases. J. Dent. Res. 2011, 90:830-840.
15. Cohen D.E., Supinski A.M., Bonkowski M.S., Donmez G., Guarente L.P. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 2009, 23:2812-2817.
16. Descamps O., Riondel J., Ducros V., Roussel A.M. Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting. Mech. Ageing Dev. 2005, 126:1185-1191.
17. Ferrucci L., Ble A., Bandinelli S., Lauretani F., Suthers K., Guralnik J.M. A flame burning within. Aging Clin. Exp. Res. 2004, 16:240-243.
18. Foster K.G., Fingar D.C. Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J. Biol. Chem. 2010, 285:14071-14077.
19. Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., Heine-Suñer D., Cigudosa J.C., Urioste M., Benitez J., Boix-Chornet M., Sanchez-Aguilera A., Ling C., Carlsson E., Poulsen P., Vaag A., Stephan Z., Spector T.D., Wu Y.Z., Plass C., Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:10604-10609.
20. Frescas D., Valenti L., Accili D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J. Biol. Chem. 2005, 280:20589-20595.
21. GonzaD́lez O.A., Tobia C., Ebersole J.L., Novak M.J. Caloric restriction and chronic inflammatory diseases. Oral Dis. 2012, 18:16-31.
22. Goodrick C.L., Ingram D.K., Reynolds M.A., Freeman J.R., Cider N. Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Mech. Ageing Dev. 1990, 55:69-87.
23. Hedrick S.M. The cunning little vixen: FoxO and the cycle of life and death. Natl. Immunol. 2009, 10:1057-1063.
24. Holloszy J.O., Fontana L. Caloric restriction in humans. Exp. Gerontol. 2007, 42:709-712.
25. Hsieh E.A., Chai C.M., Hellerstein M.K. Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E965-E972.
26. Ingram D.K., Zhu M., Mamczarz J., Zou S., Lane M.A., Roth G.S., De Cabo R. Calorie restriction mimetics: an emerging research field. Aging Cell 2006, 5:97-108.
27. Johnson J.B., Summer W., Cutler R.G., Martin B., Hyun D.H., Dixit V.D., Pearson M., Nassar M., Telljohann R., Maudsley S., Carlson O., John S., Laub D.R., Mattson M.P. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic. Biol. Med. 2007, 42:665-674.
28. Kim H.J., Jung K.J., Yu B.P., Cho C.G., Choi J.S., Chung H.Y. Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech. Ageing Dev. 2002, 123:1589-1595.
29. Kim D.H., Kim J.Y., Yu B.P., Chung H.Y. The activation of NF-κB through Akt-induced FoxO1 phosphorylation during aging and its modulation by calorie restriction. Biogerontology 2008, 9:33-47.
30. Kobayashi Y., Furukawa-Hibi Y., Chen C., Horio Y., Isobe K., Ikeda K., Motoyama N. SIRT1 is critical regulator of FoxO-mediated transcription in response to oxidative stress. Int. J. Mol. Med. 2005, 16:237-243.
31. Li Y., Liu L., Tollefsbol T.O. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J. 2010, 24:1442-1453.
32. Li Y., Daniel M., Tollefsbol T.O. Epigenetic regulation of calorie restriction in aging. BMC Med. 2011, 9:98.
33. Longo V.D., Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol. Sci. 2010, 31:89-98.
34. Maria B., Manel E. Hot topics in epigenetic mechanisms of aging. Aging Cell 2012, 11:181-186.
35. Marinkovic D., Zhang X., Yalcin S., Luciano J.P., Brugnara C., Huber T., Ghaffari S. FoxO3 is required for the regulation of oxidative stress in erythropoiesis. J. Clin. Invest. 2007, 117:2133-2144.
36. Mattson M.P., Duan W., Lee J., Guo Z. Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech. Ageing Dev. 2001, 122:757-778.
37. McCay C.M., Crowell M.F., Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 1935, 10:63-79.
38. Nadon N.L., Strong R., Miller R.A., Nelson J., Javors M., Sharp Z.D., Peralba J.M., Harrison D.E. Design of aging intervention studies: the NIA Interventions Testing Program. Age 2008, 30:187-199.
39. Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317.
40. Park, D. Lee, E.K. Jang, E.J. Jeong, H.O. Kim, B.C. Ha, Y.M. Hong, S.E. Yu, B.P. Chung, H.Y. in press. Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome. AGE.
41. Quintas A., de Solís A.J., Díez-Guerra F.J., Carrascosa J.M., Bogónez E. Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction. Exp. Gerontol. 2012, 47:198-201.
42. Redman L.M., Ravussin E. Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes. Antioxid. Redox Signal. 2011, 14:275-287.
43. Reed J.L., De Souza M.J., Williams N.I. Effects of exercise combined with caloric restriction on inflammatory cytokines. Appl. Physiol. Nutr. Metab. 2010, 35:573-582.
44. Salih D.A., Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr. Opin. Cell Biol. 2008, 20:126-136.
45. Salminen A., Kaarniranta K. NF-kappaB signaling in the aging process. J. Clin. Immunol. 2009, 29:397-405.
46. Sharp Z.D., Strong R. The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity. J. Gerontol. A Biol. Sci. Med. Sci. 2010, 65:580-589.
47. Son T.G., Zou Y., Yu B.P., Lee J., Chung H.Y. Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction. Free Radic. Res. 2005, 39:283-289.
48. Stenvinkel P., Karimi M., Johansson S., Axelsson J., Suliman M., Lindholm B., Heimbürger O., Barany P., Alvestrand A., Nordfors L., Qureshi A.R., Ekström T.J., Schalling M. Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?. J. Intern. Med. 2007, 261:488-499.
49. Sung B., Park S., Yu B.P., Chung H.Y. Modulation of PPAR in aging, inflammation, and calorie restriction. J. Gerontol. A Biol. Sci. Med. Sci. 2004, 59:997-1006.
50. Varady K.A., Hellerstein M.K. Alternate-day fasting and chronic disease prevention: a review of human and animal trials1'2'3. Am. J. Clin. Nutr. 2007, 86:7-13.
51. Witte A.V., Fobker M., Gellner R., Knecht S., Flöel A. Caloric restriction improves memory in elderly humans. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(4):1255-1260.
52. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., Mayo M.W. Modulation of NFkappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004, 23:2369-2380.
53. Yu B.P. Why calorie restriction would work for human longevity. Biogerontology 2006, 7:179-182.
54. Yu B.P., Chung H.Y. The inflammatory process in aging. Rev. Clin. Gerontol. 2006, 16:179-187.