Protective effects of Anthocyanins against Amyloid beta-induced neurotoxicity in vivo and in vitro

Neurochemistry International

Volumn 80, Issue , 2015, Pages 51-59

  Badshah, Haroon ^a   Kim, Tae Hyun ^a   Kim, Myeong Ok ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

Alzheimer's disease; Anthocyanins; Mitochondrial apoptotic pathway; Neuroprotection

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTHOCYANIN; BETA SECRETASE 1; CALCIUM ION; CASPASE; CASPASE 3; CASPASE 9; CYTOCHROME C; PROTEIN BAX; TAU PROTEIN; AMYLOID BETA PROTEIN; NEUROPROTECTIVE AGENT;

ADULT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DEATH; CELL LINE; CELL VIABILITY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; HIPPOCAMPUS; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; SOYBEAN; WESTERN BLOTTING; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

GLYCINE MAX; RATTUS;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTHOCYANINS; CELL SURVIVAL; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84917707022     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.10.009     Document Type: Article

References (49)

1. B1 receptor in rats hypothalamus Neuropeptides 47 2013 347 353
2. Badshah H.; Kim T.H.; Kim M.J.; Ahmad A.; Ali T.; and Yoon G.H. Apomorphine attenuates ethanol-induced neurodegeneration in the adult rat cortex Neurochem. Int 74 2014 8 15
3. Benvenuti S.; Pellati F.; Melegari M.; and Bertelli D. Polyphenols, anthocyanins, ascorbic acid, and radical scavenging activity of Rubus, Ribes, and Aronia J. Food Sci 69 2004 164 169
4. Bojarski L.; Herms J.; and Kuznicki J. Calcium dysregulation in Alzheimer's disease Neurochem. Int 52 2008 621 633
5. Butterfield D.A. Amyloid beta-peptide [1-42]- associated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences Curr. Med. Chem 10 2003 2651 2659
6. Butterfield D.A.; Perluigi M.; and Sultana R. Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics Eur. J. Pharmacol 545 2006 39 50
7. Butterfield D.A.; Swomley A.M.; and Sultana R. Amyloid β-peptide 1-42-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression Antioxid. Redox Signal 19 2013 823 835
8. Cha M.Y.; Han S.H.; Son S.M.; Hong H.S.; Choi Y.J.; and Byun J. Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death PLoS ONE 7 2012 e34929
9. Crews L.; and Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer's disease Hum. Mol. Genet 19 2010 12 20
10. Debatin K.M.; Poncet D.; and Kroemer G. Chemotherapy: targeting the mitochondrial cell death pathway Oncogene 21 2002 8786 8803
11. Demuro A.; Mina E.; Kayed R.; Milton S.C.; Parker I.; and Glabe C.G. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers J. Biol. Chem 280 2005 17294 17300
12. Demuro A.; Parker I.; and Stutzmann G.E. Calcium signaling and amyloid toxicity in Alzheimer disease J. Biol. Chem 285 2010 12463 12468
13. Feng Z.; and Zhang J.T. Melatonin reduces amyloid beta-induced apoptosis in pheochromocytoma (PC12) cells J. Pineal Res 37 2004 257 266
14. He J.; and Giusti M.M. Anthocyanins: natural colorants with health-promoting properties Annu. Rev. Food Sci. Technol 1 2009 163 187
15. Hertmann T.; Bieger S.C.; Bruhl B.; Tienari P.J.; Ida N.; and Allsop D. Distinct sites of intracellular production for Alzheimer's disease A beta 40/42 amyloid peptides Nat. Med 3 1997 1016 1020
16. Hynd M.R.; Scott H.L.; and Dodd P.R. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease Neurochemm. Int 45 2004 583 595
17. Kadowaki H.; Nishitoh H.; Urano F.; Sadamitsu C.; Matsuzawa A.; and Takeda K. Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation Cell Death Differ 12 2005 19 24
18. Kawahara M.; Ohtsuka I.; Yokoyama S.; Kato-Negishi M.; and Sadakane Y. Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's β-amyloid protein Int. J. Alzheimers Dis 2011 2011 304583 10.4061/2011/304583
19. Kelsey N.; Hulick W.; Winter A.; Ross E.; and Linseman D. Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress Nutr. Neurosci 14 2011 249 259
20. Kwon S.H.; Ahn I.S.; Kim S.O.; Kong C.S.; Chung H.Y.; and Do M.S. Antiobesity and hypolipidemic effects of black soybean anthocyanins J. Med. Food 10 2007 552 556
21. LaFerla F.M.; and Oddo S. Alzheimer's disease: Aβ, tau and synaptic dysfunction Trends Mol. Med 11 2005 170 176
22. Lee H.G.; Perry G.; Moreira P.I.; Garrett M.R.; Liu Q.; and Zhu X. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends Mol. Med 11 2005 164 169
23. Ly J.D.; Grubb D.R.; and Lawen A. The mitochondrial membrane potential (Δψm) in apoptosis; an update Apoptosis 8 2003 115 128
24. Morales-Hernandez A.; Sanchez-Martin F.J.; Hortigon-Vinagre M.P.; Henao F.; and Merino J.M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis by disruption of intracellular calcium homeostasis in human neuronal cell line SHSY5Y Apoptosis 17 2012 1170 1181
25. Morishima Y.; Gotoh Y.; Zeig J.; Barret T.; Takano H.; and Flavell R. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand J. Neurosci 21 2001 7551 7560
26. Mortensen A. Carotenoids and other pigments as natural colorants Pure Appl. Chem 78 2006 1477 1491
27. Querfurth H.W.; and LaFerla F.M. Alzheimer's disease N. Engl. J. Med 362 2010 329 344
28. Reers M.; Smith T.W.; and Chen L.B. J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential Biochemistry 30 1991 4480 4486
29. Sastre M.; Klockgether T.; and Heneka M.T. Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms Int. J. Dev. Neurosci 24 2006 167 176
30. Satue-Gracia M.T.; Heinonen M.; and Frankel E.N. Anthocyanins as antioxidants on human low-density lipoprotein and lecithin liposome systems J. Agric. Food Chem 45 1997 3362 3367
31. Selvatici R.; Marani L.; Marino S.; and Siniscalchi A. In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease Neurochem. Int 63 2013 112 120
32. Serano-Pozo A.; Frosch M.P.; Masliah E.; and Hyman B.T. Neuropathological alterations in Alzheimer disease Cold Spring Harb. Perspect Med 1 2011 a006189 10.1101/cshperspect.a006189
33. B1receptors intracellular signaling in prenatal rat hippocampal neurons Mol. Neurobiol 48 2013 257 269
34. Shah S.A.; Lee H.Y.; Bressan R.A.; Yun D.J.; and Kim M.O. Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain Cell Death Dis 5 2014 1026
35. Shih P.H.; Wu C.H.; Yeh C.T.; and Yen G.C. Protective effects of anthocyanins against amyloid β-peptide-induced damage in neuro-2A cells J. Agric. Food Chem 59 2011 1683 1689
36. Simasko M.S.; Bovadjieva N.; De A.; and Saekar D.K. Effect of ethanol on calcium regulation in rat fetal hypothalamic cells in culture Brain Res 824 1999 89 96
37. Sultana R.; and Butterfield D.A. Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies J. Alzheimers Dis 33 2013 243 251
38. Sun G.Y.; Xia J.; Draczynska-Lusiak B.; Simonyi A.; and Sun A.Y. Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration Neuroreport 10 1999 93 96
39. Tarozzi A.; Morronia F.; Hreliab S.; Angelonib C.; Marchesia A.; and Cantelli-Fortia G. Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells Neurosci. Lett 424 2007 36 40
40. Tarozzi A.; Merlicco A.; Morroni F.; Franco F.; Cantelli-Fortia G.; and Teti G. Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity Neuroreport 19 2008 1483 1486
41. Ullah I.; Ullah N.; Naseer M.I.; Lee H.Y.; and Kim M.O. Neuroprotection with metformin and thymoquinone against ethanol-induced neurodegeneration in prenatal rat cortical neurons BMC Neurosci 13 2012 11
42. Ullah I.; Park H.Y.; and Kim M.O. Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons CNS Neurosci. Ther 20 2014 327 338
43. Uttara B.; Sing A.V.; Zamboni P.; and Mahajan R.T. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options Curr. Neuropharmacol 7 2009 65 74
44. Vepsalainen S.; Koivisto H.; Pekkarinen E.; Makinen P.; Dobson G.; and McDougall G.J. Anthocyanin-enriched bilberry and blackcurrants extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease J. Nutr. Biochem 24 2013 360 370
45. Wang H.; Nair M.G.; Strasburg G.M.; Chang Y.C.; Booren A.M.; and Gray J.I. Antioxidant and anti-inflammatory activities of anthocyanins and their aglycone, cyaniding, from tart cherries J. Nat. Prod 62 1999 294 296
46. Wang Y.J.; Zheng Y.L.; Lu J.; Chen G.Q.; Wang X.H.; and Feng J. Purple sweet potato color suppresses lipopolysaccharide-induced acute inflammatory response in mouse brain Neurochem. Int 56 2010 424 430
47. Ye J.; Meng X.; Yan C.; and Wang C. Effect of purple sweet potato anthocyanins on beta-amyloid-mediated PC-12 cells death by inhibition of oxidative stress Neurochem. Res 35 2010 357 365
48. Yin Y.I.; Bassit B.; Zhu L.; Yang X.; Wang C.; and Li Y.M. γ-secretase substrate concentration modulates the Aβ42/Aβ40 ratio: implications for Alzheimer's disease J. Biol. Chem 282 2007 23639 23644
49. Zhu W.; Jia Q.; Wang Y.; Zhang Y.; and Xia M. The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of a cAMP-PKA-dependent signaling pathway Free Radic. Biol. Med 52 2012 314 327