A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats

Neurobiology of Aging

Volumn 36, Issue 1, 2015, Pages 344-351

  Cansev, Mehmet ^a   van Wijk, Nick ^b   Turkyilmaz, Mesut ^a   Orhan, Fulya ^a   Sijben, John W C ^b   Broersen, Laus M ^b  

^a ULUDAG UNIVERSITY   (Turkey)

^b Nutricia Nederland   (Netherlands)

Author keywords

Acetylcholine release; Aged rat; Alzheimer's disease; Choline acetyltransferase; Cholinergic neurotransmission; Fortasyn connect; Phospholipid; Souvenaid; Synaptic membrane

Indexed keywords

ACETYLCHOLINE; BRAIN PROTEIN; CHOLINE; CHOLINE ACETYLTRANSFERASE; MEMBRANE PHOSPHOLIPID; PHOSPHOLIPID; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN NOGO A; SYNAPSIN I; SYNAPTIC PROTEIN; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ACETYLCHOLINE TISSUE LEVEL; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; FORTASYN CONNECT DIET; HIPPOCAMPUS; IN VIVO STUDY; MALE; MEMBRANE FORMATION; MICRODIALYSIS; NERVE FIBER GROWTH; NONHUMAN; NUTRIENT CONTENT; PRESYNAPTIC NERVE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RAT; SYNAPTIC MEMBRANE; THERAPY EFFECT; TISSUE LEVEL; TREATMENT DURATION; WISTAR RAT; ALZHEIMER DISEASE; ANIMAL; ANIMAL FOOD; CHOLINERGIC NERVE CELL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SYNAPTIC TRANSMISSION;

ACETYLCHOLINE; ALZHEIMER DISEASE; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC NEURONS; DIET; HIPPOCAMPUS; MALE; RATS, WISTAR; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION;

EID: 84920609364     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.07.021     Document Type: Article

References (42)

1. Aïd S., Vancassel S., Linard A., Lavialle M., Guesnet P. Dietary docosahexaenoic acid [22: 6(n-3)] as a phospholipid or a triglyceride enhances the potassium chloride-evoked release of acetylcholine in rat hippocampus. J.Nutr. 2005, 135:1008-1013.
2. Aïd S., Vancassel S., Poumès-Ballihaut C., Chalon S., Guesnet P., Lavialle M. Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. J.Lipid Res. 2003, 44:1545-1551.
3. Arendt T. Synaptic degeneration in Alzheimer's disease. Acta Neuropathol. 2009, 118:167-179.
4. Beninger R.J., Tighe S.A., Jhamandas K. Effects of chronic manipulations of dietary choline on locomotor activity, discrimination learning and cortical acetylcholine release in aging adult Fisher 344 rats. Neurobiol. Aging 1984, 5:29-34.
5. Blochlinger S., Weinmann O., Schwab M.E., Thallmair M. Neuronal plasticity and formation of new synaptic contacts follow pyramidal lesions and neutralization of Nogo-A: a light and electron microscopic study in the pontine nuclei of adult rats. J.Comp. Neurol. 2001, 433:426-436.
6. Cansev M., Marzloff G., Sakamoto T., Ulus I.H., Wurtman R.J. Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Dev. Neurosci. 2009, 31:181-192.
7. Cansev M., Ulus I.H., Wang L., Maher T.J., Wurtman R.J. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease. Neurosci. Res. 2008, 62:206-209.
8. Cansev M., Wurtman R.J. Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. Neuroscience 2007, 148:421-431.
9. Chen M.S., Huber A.B., van der Haar M.E., Frank M., Schnell L., Spillmann A.A., Christ F., Schwab M.E. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000, 403:434-439.
10. Chesselet M.F. Presynaptic regulation of neurotransmitter release in the brain: facts and hypothesis. Neuroscience 1984, 12:347-375.
11. Cohen E.L., Wurtman R.J. Brain acetylcholine: control by dietary choline. Science 1976, 191:561-562.
12. de Waal H., Stam C.J., Lansbergen M.M., Wieggers R.L., Kamphuis P.J., Scheltens P., Maestú F., van Straaten E.C. The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. PLoS One 2014, 9:e86558.
13. de Wilde M.C., Penke B., van der Beek E.M., Kuipers A.A., Kamphuis P.J., Broersen L.M. Neuroprotective effects of a specific multi-nutrient intervention against Aβ42-induced toxicity in rats. J.Alzheimers Dis. 2011, 27:327-339.
14. Fadda F., Cocco S., Stancampiano R. Hippocampal acetylcholine release correlates with spatial learning performance in freely moving rats. Neuroreport 2000, 11:2265-2269.
15. Favrelière S., Perault M.C., Huguet F., De Javel D., Bertrand N., Piriou A., Durand G. DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. Neurobiol. Aging 2003, 24:233-243.
16. Folch J., Lees M., Sloane-Stanley G.H. Asimple method for the isolation and purification of total lipides from animal tissues. J.Biol. Chem. 1957, 226:497-509.
17. Gil V., Nicolas O., Mingorance A., Urena J.M., Tang B.L., Hirata T., Saez-Valero J., Ferrer I., Soriano E., del Rio J.A. Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. J.Neuropathol. Exp. Neurol. 2006, 65:433-444.
18. Holguin S., Huang Y., Liu J., Wurtman R. Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats. Behav. Brain Res. 2008, 191:11-16.
19. Holguin S., Martinez J., Chow C., Wurtman R. Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. FASEB J. 2008, 22:3938-3946.
20. Koivisto H., Grimm M.O., Rothhaar T.L., Berkecz R., Lütjohann D.D., Giniatullina R., Takalo M., Miettinen P.O., Lahtinen H.M., Giniatullin R., Penke B., Janáky T., Broersen L.M., Hartmann T., Tanila H. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition. J.Nutr. Biochem. 2014, 25:157-169.
21. Köppen A., Klein J., Erb C., Löffelholz K. Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. J.Pharmacol. Exp. Ther. 1997, 282:1139-1145.
22. Liu Y.Y., Jin W.L., Liu H.L., Ju G. Electron microscopic localization of Nogo-A at the postsynaptic active zone of the rat. Neurosci. Lett. 2003, 346:153-156.
23. Lopes da Silva S., Vellas B., Elemans S., Luchsinger J., Kamphuis P., Yaffe K., Sijben J., Groenendijk M., Stijnen T. Plasma nutrient status of patients with Alzheimer's disease: a systematic review and meta-analysis. Alzheimers Dement. 2013, 10:485-502.
24. Mi W., van Wijk N., Cansev M., Sijben J.W., Kamphuis P.J. Nutritional approaches in the risk reduction and management of Alzheimer's disease. Nutrition 2013, 29:1080-1989.
25. Nail-Boucherie K., Dourmap N., Jaffard R., Costentin J. Contextual fear conditioning is associated with an increase of acetylcholine release in the hippocampus of rat. Cog. Brain Res. 2000, 9:193-197.
26. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2004, Elsevier, San Diego. fifth ed.
27. Pooler A.M., Guez D.H., Benedictus R., Wurtman R.J. Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12. Neuroscience 2005, 134:207-214.
28. Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J.Nutr. 1993, 123:1939-1951.
29. Sakamoto T., Cansev M., Wurtman R.J. Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res. 2007, 1182:50-59.
30. Savelkoul P.J., Janickova H., Kuipers A.A., Hageman R.J., Kamphuis P.J., Dolezal V., Broersen L.M. Aspecific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses invitro. J.Neurochem. 2012, 120:631-640.
31. Scheltens P., Kamphuis P.J., Verhey F.R., Olde-Rikkert M.G., Wurtman R.J., Wilkinson D., Twisk J.W., Kurz A. Efficacy of a medical food in mild Alzheimer's disease: a randomized, controlled trial. Alzheimers Dement. 2010, 6:1-10.e1.
32. Scheltens P., Twisk J.W., Blesa R., Scarpini E., von Arnim C.A., Bongers A., Harrison J., Swinkels S.H., Stam C.J., de Waal H., Wurtman R.J., Wieggers R.L., Vellas B., Kamphuis P.J. Efficacy of souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. J.Alzheimers Dis. 2012, 31:225-236.
33. Sperling R.A., Aisen P.S., Beckett L.A., Bennett D.A., Craft S., Fagan A.M., Iwatsubo T., Jack C.R., Kaye J., Montine T.J., Park D.C., Reiman E.M., Rowe C.C., Siemers E., Stern Y., Yaffe K., Carrillo M.C., Thies B., Morrison-Bogorad M., Wagster M.V., Phelps C.H. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:280-292.
34. Svanborg A., Svennerholm L. Plasma total lipids, cholesterol, triglycerides, phospholipids and free fatty acids in a healthy Scandinavian population. Acta Med. Scand. 1961, 169:43-49.
35. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791.
36. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
37. Van Wijk N., Broersen L.M., de Wilde M.C., Hageman R.J., Groenendijk M., Sijben J.W., Kamphuis P.J. Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination. J.Alzheimers Dis. 2014, 38:459-479.
38. Wang L., Pooler A.M., Albrecht M.A., Wurtman R.J. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J.Mol. Neurosci. 2005, 27:137-145.
39. Wang L., Albrecht M.A., Wurtman R.J. Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat. Brain Res. 2007, 1133:42-48.
40. Wiesmann M., Jansen D., Zerbi V., Broersen L.M., Garthe A., Kiliaan A.J. Improved spatial learning strategy and memory in aged Alzheimer AbetaPPswe/PS1dE9 mice on a multi-nutrient diet. J.Alzheimers Dis. 2013, 37:233-245.
41. Wurtman R.J., Cansev M., Sakamoto T., Ulus I.H. Use of phosphatide precursors to promote synaptogenesis. Annu. Rev. Nutr. 2009, 29:59-87.
42. Wurtman R.J., Ulus I.H., Cansev M., Watkins C.J., Wang L., Marzloff G. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res. 2006, 1088:83-92.