Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with Korean red ginseng

Journal of Ginseng Research

Volumn 35, Issue 4, 2011, Pages 457-461

  Heo, Jae Hyeok ^a   Lee, Soon Tae ^b,c   Oh, Min Jung ^b,c   Park, Hyun Jung ^b,c   Shim, Ji Young ^b,c   Chu, Kon ^b,c   Kim, Manho ^b,c  

^a Seoul Medical Center   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Alzheimer disease; Korean red ginseng; Long term effect; Panax ginseng

Indexed keywords

PANAX GINSENG;

EID: 84930478521     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2011.35.4.457     Document Type: Article

References (17)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005;366:2112-2117.
2. Wisniewski T. Is amyloid-β-peptide immunization clinically effective in patients with Alzheimer's disease? Nat Clin Pract Neurol 2005;1:84-85.
3. Akhondzadeh S, Abbasi SH. Herbal medicine in the treatment of Alzheimer's disease. Am J Alzheimers Dis Other Demen 2006;21:113-118.
4. Sorensen H, Sonne J. A double-masked study of the effects of ginseng on cognitive functions. Curr Ther Res 1996;57:959-968.
5. Scholey A, Ossoukhova A, Owen L, Ibarra A, Pipingas A, He K, Roller M, Stough C. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology (Berl) 2010;212:345-356.
6. Lee ST, Chu K, Sim JY, Heo JH, Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-226.
7. Heo JH, Lee ST, Chu K, Oh MJ, Park HJ, Shim JY, Kim M. An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease. Eur J Neurol 2008;15:865-868.
8. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
9. Nam KY. The comparative understanding between red ginseng and white ginsengs, processed ginsengs (Panax ginseng C.A. Meyer). J Ginseng Res 2005;29:1-18.
10. Burns A, Gauthier S, Perdomo C. Efficacy and safety of donepezil over 3 years: an open-label, multicentre study in patients with Alzheimer's disease. Int J Geriatr Psychiatry 2007;22:806-812.
11. Minthon L, Wallin AK, Eriksson S, Wattmo C, Andreasen N. Long-term rivastigmine treatment in a routine clinical setting. Acta Neurol Scand 2009;119:180-185.
12. Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, Edwards S, Hardyman W, Raftery J, Crome P et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 2004;363:2105-2115.
13. Kanaya K, Abe S, Sakai M, Fujii H, Iwamoto T. Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: relating to changes attributable to differences in apolipoprotein E phenotype. Geriatr Gerontol Int 2010;10:25-31.
14. Liu L, Hoang-Gia T, Wu H, Lee MR, Gu L, Wang C, Yun BS, Wang Q, Ye S, Sung CK. Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats. Brain Res 2011;1382:147-154.
15. Zhao R, Zhang Z, Song Y, Wang D, Qi J, Wen S. Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3β pathway in ginsenoside Rb1's attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation. J Ethnopharmacol 2011;133:1109-1116.
16. Zhang JT, Liu Y, Qu ZW, Zhang XL, Xiao HL. Influence of ginsenoside Rb1 and Rg1 on some central neurotransmitter receptors and protein biosynthesis in the mouse brain. Yao Xue Xue Bao 1988;23:12-16.
17. Ying Y, Zhang JT, Shi CZ, Qu ZW, Liu Y. Study on the nootropic mechanism of ginsenoside Rb1 and Rg1: influence on mouse brain development. Yao Xue Xue Bao 1994;29:241-245.