메뉴 건너뛰기




Volumn 33, Issue SUPPL. 1, 2013, Pages

Insulin and Alzheimer's disease: Untangling the web

Author keywords

Alzheimer's disease; diabetes; insulin; network analysis

Indexed keywords

AMYLOID BETA PROTEIN; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE;

EID: 84872580306     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-129042     Document Type: Review
Times cited : (104)

References (117)
  • 1
    • 0033857975 scopus 로고    scopus 로고
    • Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs
    • Kaiyala KJ, Prigeon RL, Kahn SE, Woods SC, Schwartz MW (2000) Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes 49, 1525-1533
    • (2000) Diabetes , vol.49 , pp. 1525-1533
    • Kaiyala, K.J.1    Prigeon, R.L.2    Kahn, S.E.3    Woods, S.C.4    Schwartz, M.W.5
  • 2
    • 0030664286 scopus 로고    scopus 로고
    • Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin
    • Banks WA, Jaspan JB, Huang W, Kastin AJ (1997) Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin. Peptides 18, 1423-1429
    • (1997) Peptides , vol.18 , pp. 1423-1429
    • Banks, W.A.1    Jaspan, J.B.2    Huang, W.3    Kastin, A.J.4
  • 4
    • 0027361094 scopus 로고
    • Saturable transport of insulin from plasma into the central nervous system of dogs in vivoA mechanism for regulated insulin delivery to the brain
    • Baura GD, Foster DM, Porte D Jr, Kahn SE, Bergman RN, Cobelli C, Schwartz MW (1993) Saturable transport of insulin from plasma into the central nervous system of dogs in vivoA mechanism for regulated insulin delivery to the brain. J Clin Invest 92, 1824-1830
    • (1993) J Clin Invest , vol.92 , pp. 1824-1830
    • Baura, G.D.1    Foster, D.M.2    Porte Jr., D.3    Kahn, S.E.4    Bergman, R.N.5    Cobelli, C.6    Schwartz, M.W.7
  • 5
    • 0033197996 scopus 로고    scopus 로고
    • The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
    • Abbott MA,Wells DG, Fallon JR (1999) The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci 19, 7300-7308
    • (1999) J Neurosci , vol.19 , pp. 7300-7308
    • Abbott, M.A.1    Wells, D.G.2    Fallon, J.R.3
  • 6
    • 44649198605 scopus 로고    scopus 로고
    • Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo
    • Chiu SL, Chen CM, Cline HT (2008) Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58, 708-719
    • (2008) Neuron , vol.58 , pp. 708-719
    • Chiu, S.L.1    Chen, C.M.2    Cline, H.T.3
  • 7
    • 64249129005 scopus 로고    scopus 로고
    • Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    • Zhao WQ, Townsend M (2009) Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta 1792, 482-496
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 482-496
    • Zhao, W.Q.1    Townsend, M.2
  • 8
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • Havrankova J, Roth J, Brownstein M (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272, 827-829
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 10
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
    • Unger JW, Livingston JN, Moss AM (1991) Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects. Prog Neurobiol 36, 343-362
    • (1991) Prog Neurobiol , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 11
    • 70349285955 scopus 로고    scopus 로고
    • Insulin-Stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent
    • Grillo CA, Piroli GG, Hendry RM, Reagan LP (2009) Insulin-Stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain Res 1296, 35-45
    • (2009) Brain Res , vol.1296 , pp. 35-45
    • Grillo, C.A.1    Piroli, G.G.2    Hendry, R.M.3    Reagan, L.P.4
  • 12
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao WQ, Alkon DL (2001) Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 177, 125-134
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 13
    • 0035853124 scopus 로고    scopus 로고
    • Insulin promotes rapid delivery of N-Methyl-Daspartate receptors to the cell surface by exocytosis
    • Skeberdis VA, Lan J, Zheng X, Zukin RS, Bennett MV (2001) Insulin promotes rapid delivery of N-Methyl-Daspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A 98, 3561-3566
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3561-3566
    • Skeberdis, V.A.1    Lan, J.2    Zheng, X.3    Zukin, R.S.4    Bennett, M.V.5
  • 14
    • 0027400795 scopus 로고
    • Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus
    • Figlewicz DP, Szot P, Israel PA, Payne C, Dorsa DM (1993) Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus. Brain Res 602, 161-164
    • (1993) Brain Res , vol.602 , pp. 161-164
    • Figlewicz, D.P.1    Szot, P.2    Israel, P.A.3    Payne, C.4    Dorsa, D.M.5
  • 15
    • 0032863618 scopus 로고    scopus 로고
    • Effects of posttraining administration of insulin on retention of a habituation response in mice: Participation of a central cholinergic mechanism
    • Kopf SR, Baratti CM (1999) Effects of posttraining administration of insulin on retention of a habituation response in mice: Participation of a central cholinergic mechanism. Neurobiol Learn Mem 71, 50-61
    • (1999) Neurobiol Learn Mem , vol.71 , pp. 50-61
    • Kopf, S.R.1    Baratti, C.M.2
  • 16
    • 78650054323 scopus 로고    scopus 로고
    • Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory
    • Krug R, Benedict C, Born J, Hallschmid M (2010) Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory. J Clin Endocrinol Metab 95, E468-472
    • (2010) J Clin Endocrinol Metab , vol.95
    • Krug, R.1    Benedict, C.2    Born, J.3    Hallschmid, M.4
  • 18
    • 0031907459 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype
    • Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D Jr (1998) Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype. Neurology 50, 164-168
    • (1998) Neurology , vol.50 , pp. 164-168
    • Craft, S.1    Peskind, E.2    Schwartz, M.W.3    Schellenberg, G.D.4    Raskind, M.5    Porte Jr., D.6
  • 20
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-Like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine
    • Rivera E, Goldin A, Fulmer N, Tavares R, Wands J, de la Monte S (2005) Insulin and insulin-Like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine. J Alzheimers Dis 8, 247-268
    • (2005) J Alzheimers Dis , vol.8 , pp. 247-268
    • Rivera, E.1    Goldin, A.2    Fulmer, N.3    Tavares, R.4    Wands, J.5    De La Monte, S.6
  • 21
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid betaprotein impair synaptic plasticity and behavior
    • Selkoe DJ (2008) Soluble oligomers of the amyloid betaprotein impair synaptic plasticity and behavior. Behav Brain Res 192, 106-113
    • (2008) Behav Brain Res , vol.192 , pp. 106-113
    • Selkoe, D.J.1
  • 23
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of beta-Amyloid precursor protein trafficking by insulin reduces intraneuronal beta-Amyloid and requires mitogen-Activated protein kinase signaling
    • Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H (2001) Stimulation of beta-Amyloid precursor protein trafficking by insulin reduces intraneuronal beta-Amyloid and requires mitogen-Activated protein kinase signaling. J Neurosci 21, 2561-2570
    • (2001) J Neurosci , vol.21 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3    Gross, R.S.4    Beal, M.F.5    Greengard, P.6    Xu, H.7
  • 24
    • 58549102356 scopus 로고    scopus 로고
    • Insulin rescues amyloid beta-induced impairment of hippocampal long-Term potentiation
    • Lee CC, Kuo YM, Huang CC, Hsu KS (2009) Insulin rescues amyloid beta-induced impairment of hippocampal long-Term potentiation. Neurobiol Aging 30, 377-387
    • (2009) Neurobiol Aging , vol.30 , pp. 377-387
    • Lee, C.C.1    Kuo, Y.M.2    Huang, C.C.3    Hsu, K.S.4
  • 25
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M, Mehta T, Selkoe DJ (2007) Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 282, 33305-33312
    • (2007) J Biol Chem , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 26
  • 27
    • 37549035051 scopus 로고    scopus 로고
    • Intake of sucrosesweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
    • Cao D, Lu H, Lewis TL, Li L (2007) Intake of sucrosesweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J BiolChem282, 36275-36282
    • (2007) J BiolChem , vol.282 , pp. 36275-36282
    • Cao, D.1    Lu, H.2    Lewis, T.L.3    Li, L.4
  • 30
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-Like growth factor-1 regulate tau phosphorylation in cultured human neurons
    • Hong M, Lee V (1997) Insulin and insulin-Like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 272, 19547-19553
    • (1997) J Biol Chem , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.2
  • 31
    • 78651274000 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer-Like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    • Baker LD, Cross DJ, Minoshima S, Belongia D,Watson GS, Craft S (2011) Insulin resistance and Alzheimer-Like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol 68, 51-57
    • (2011) Arch Neurol , vol.68 , pp. 51-57
    • Baker, L.D.1    Cross, D.J.2    Minoshima, S.3    Belongia, D.4    Watson, G.S.5    Craft, S.6
  • 33
    • 33244483359 scopus 로고    scopus 로고
    • The precuneus: A review of its functional anatomy and behavioural correlates
    • Cavanna AE, Trimble MR (2006) The precuneus: A review of its functional anatomy and behavioural correlates. Brain 129, 564-583
    • (2006) Brain , vol.129 , pp. 564-583
    • Cavanna, A.E.1    Trimble, M.R.2
  • 34
    • 33745948085 scopus 로고    scopus 로고
    • Insulin resistance and endothelial dysfunction: The road map to cardiovascular diseases
    • Cersosimo E, DeFronzo RA (2006) Insulin resistance and endothelial dysfunction: The road map to cardiovascular diseases. Diabetes Metab Res Rev 22, 423-436
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 423-436
    • Cersosimo, E.1    DeFronzo, R.A.2
  • 35
    • 48649110601 scopus 로고    scopus 로고
    • Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-Analysis
    • Anstey KJ, Lipnicki DM, Low LF (2008) Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-Analysis. Am J Geriatr Psychiatry 16, 343-354
    • (2008) Am J Geriatr Psychiatry , vol.16 , pp. 343-354
    • Anstey, K.J.1    Lipnicki, D.M.2    Low, L.F.3
  • 37
    • 0032708963 scopus 로고    scopus 로고
    • Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity
    • Sechi LA (1999) Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity. J Hypertens 17, 1229-1237
    • (1999) J Hypertens , vol.17 , pp. 1229-1237
    • Sechi, L.A.1
  • 39
    • 0034507950 scopus 로고    scopus 로고
    • A perspective on inflammation in Alzheimer's disease
    • Rogers J, Shen Y (2000) A perspective on inflammation in Alzheimer's disease. Ann N Y Acad Sci 924, 132-135
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 132-135
    • Rogers, J.1    Shen, Y.2
  • 40
    • 0030014561 scopus 로고    scopus 로고
    • The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease
    • Hull M, Strauss S, Berger M, Volk B, Bauer J (1996) The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease. Behav Brain Res 78, 37-41
    • (1996) Behav Brain Res , vol.78 , pp. 37-41
    • Hull, M.1    Strauss, S.2    Berger, M.3    Volk, B.4    Bauer, J.5
  • 41
    • 0034745018 scopus 로고    scopus 로고
    • Cerebrospinal fluid abeta42, tau, and f2-isoprostane concentrations in patients with Alzheimer disease, other dementias, and in age-Matched controls
    • Montine TJ, Kaye JA, Montine KS, McFarland L, Morrow JD, Quinn JF (2001) Cerebrospinal fluid abeta42, tau, and f2-isoprostane concentrations in patients with Alzheimer disease, other dementias, and in age-Matched controls. Arch Pathol Lab Med 125, 510-512
    • (2001) Arch Pathol Lab Med , vol.125 , pp. 510-512
    • Montine, T.J.1    Kaye, J.A.2    Montine, K.S.3    McFarland, L.4    Morrow, J.D.5    Quinn, J.F.6
  • 42
    • 0035150373 scopus 로고    scopus 로고
    • Intra vitam lumbar and post mortem ventricular cerebrospinal fluid immunoreactive interleukin-6 in Alzheimer's disease patients
    • Rosler N,Wichart I, Jellinger KA (2001) Intra vitam lumbar and post mortem ventricular cerebrospinal fluid immunoreactive interleukin-6 in Alzheimer's disease patients. Acta Neurol Scand 103, 126-130
    • (2001) Acta Neurol Scand , vol.103 , pp. 126-130
    • Rosler, N.1    Wichart, I.2    Jellinger, K.A.3
  • 43
    • 0042835437 scopus 로고    scopus 로고
    • Lipopolysaccharide-inducedneuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice
    • Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE (2003) Lipopolysaccharide-inducedneuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis 14, 133-145
    • (2003) Neurobiol Dis , vol.14 , pp. 133-145
    • Sheng, J.G.1    Bora, S.H.2    Xu, G.3    Borchelt, D.R.4    Price, D.L.5    Koliatsos, V.E.6
  • 44
    • 0036706725 scopus 로고    scopus 로고
    • Endothelium, inflammation, and diabetes
    • Dandona P (2002) Endothelium, inflammation, and diabetes. Curr Diab Rep 2, 311-315
    • (2002) Curr Diab Rep , vol.2 , pp. 311-315
    • Dandona, P.1
  • 46
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-Activated receptor gamma agonists
    • Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-Activated receptor gamma agonists. J Clin Invest 106, 467-472
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 47
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Inhibition of beta-Amyloid-Stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE (2000) Inflammatory mechanisms in Alzheimer's disease: Inhibition of beta-Amyloid-Stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci 20, 558-567
    • (2000) J Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 48
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptors in inflammation control
    • Delerive P, Fruchart JC, Staels B (2001) Peroxisome proliferator- Activated receptors in inflammation control. J Endocrinol 169, 453-459
    • (2001) J Endocrinol , vol.169 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 49
    • 0034623141 scopus 로고    scopus 로고
    • Two opposing effects of non-Steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways
    • Paik JH, Ju JH, Lee JY, Boudreau MD, Hwang DH (2000) Two opposing effects of non-Steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J Biol Chem 275, 28173-28179
    • (2000) J Biol Chem , vol.275 , pp. 28173-28179
    • Paik, J.H.1    Ju, J.H.2    Lee, J.Y.3    Boudreau, M.D.4    Hwang, D.H.5
  • 51
    • 1542313910 scopus 로고    scopus 로고
    • Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients
    • Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, Heneka MT (2004) Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. J Leukoc Biol 75, 478-485
    • (2004) J Leukoc Biol , vol.75 , pp. 478-485
    • Schmidt, S.1    Moric, E.2    Schmidt, M.3    Sastre, M.4    Feinstein, D.L.5    Heneka, M.T.6
  • 52
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-Activated receptor gamma (PPAR gamma
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-Activated receptor gamma (PPAR gamma). J Biol Chem 270, 12953-12956
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 58
    • 58149265311 scopus 로고    scopus 로고
    • Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus
    • Hanyu H, Sato T, Kiuchi A, Sakurai H, Iwamoto T (2009) Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus. J Am Geriatr Soc 57, 177-179
    • (2009) J Am Geriatr Soc , vol.57 , pp. 177-179
    • Hanyu, H.1    Sato, T.2    Kiuchi, A.3    Sakurai, H.4    Iwamoto, T.5
  • 59
    • 77952130974 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-Alpha in cognitive improvement after peroxisome proliferator-Activator receptor gamma agonist pioglitazone treatment in Alzheimer's disease
    • Hanyu H, Sato T, Sakurai H, Iwamoto T (2010) The role of tumor necrosis factor-Alpha in cognitive improvement after peroxisome proliferator-Activator receptor gamma agonist pioglitazone treatment in Alzheimer's disease. J Am Geriatr Soc 58, 1000-1001
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1000-1001
    • Hanyu, H.1    Sato, T.2    Sakurai, H.3    Iwamoto, T.4
  • 60
    • 78651322583 scopus 로고    scopus 로고
    • A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
    • Geldmacher DS, Fritsch T, McClendon MJ, Landreth G (2011) A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. Arch Neurol 68, 45-50
    • (2011) Arch Neurol , vol.68 , pp. 45-50
    • Geldmacher, D.S.1    Fritsch, T.2    McClendon, M.J.3    Landreth, G.4
  • 62
    • 84856492410 scopus 로고    scopus 로고
    • The effect of rosiglitazone on LRP1 expression and amyloid beta uptake in human brain microvascular endothelial cells: A possible role of a low-Dose thiazolidinedione for dementia treatment
    • Moon JH, Kim HJ, Yang AH, Kim HM, Lee BW, Kang ES, Lee HC, Cha BS (2011) The effect of rosiglitazone on LRP1 expression and amyloid beta uptake in human brain microvascular endothelial cells: A possible role of a low-Dose thiazolidinedione for dementia treatment. Int J Neuropsychopharmacol 15, 135-142
    • (2011) Int J Neuropsychopharmacol , vol.15 , pp. 135-142
    • Moon, J.H.1    Kim, H.J.2    Yang, A.H.3    Kim, H.M.4    Lee, B.W.5    Kang, E.S.6    Lee, H.C.7    Cha, B.S.8
  • 63
    • 78649385516 scopus 로고    scopus 로고
    • The role of GLP-1 in neuronal activity and neurodegeneration
    • Holscher C (2010) The role of GLP-1 in neuronal activity and neurodegeneration. Vitam Horm 84, 331-354
    • (2010) Vitam Horm , vol.84 , pp. 331-354
    • Holscher, C.1
  • 69
    • 0034012731 scopus 로고    scopus 로고
    • Intracerebroventricular insulin enhances memory in a passive-Avoidance task
    • Park CR, Seeley RJ, Craft S, Woods SC (2000) Intracerebroventricular insulin enhances memory in a passive-Avoidance task. Physiol Behav 68, 509-514
    • (2000) Physiol Behav , vol.68 , pp. 509-514
    • Park, C.R.1    Seeley, R.J.2    Craft, S.3    Woods, S.C.4
  • 71
    • 0037802511 scopus 로고    scopus 로고
    • Intranasal delivery: Bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord
    • Frey WH 2nd (2002) Intranasal delivery: Bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord. Drug Deliv Technol 2, 46-49
    • (2002) Drug Deliv Technol , vol.2 , pp. 46-49
    • Frey II, W.H.1
  • 72
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-Like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH, 2nd (2004) Delivery of insulin-Like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127, 481-496
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey II, W.H.4
  • 73
    • 0022477568 scopus 로고
    • Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat
    • Baker H, Spencer RF (1986) Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat. Exp Brain Res 63, 461-473
    • (1986) Exp Brain Res , vol.63 , pp. 461-473
    • Baker, H.1    Spencer, R.F.2
  • 74
    • 0022552302 scopus 로고
    • Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey
    • Balin BJ, Broadwell RD, Salcman M, el-Kalliny M (1986) Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251, 260-280
    • (1986) J Comp Neurol , vol.251 , pp. 260-280
    • Balin, B.J.1    Broadwell, R.D.2    Salcman, M.3    El-Kalliny, M.4
  • 75
    • 0022384030 scopus 로고
    • Endocytic and exocytic pathways of the neuronal secretory process and transsynaptic transfer of wheat germ agglutinin-horseradish peroxidase in vivo
    • Broadwell RD, Balin BJ (1985) Endocytic and exocytic pathways of the neuronal secretory process and transsynaptic transfer of wheat germ agglutinin-horseradish peroxidase in vivo. J Comp Neurol 242, 632-650
    • (1985) J Comp Neurol , vol.242 , pp. 632-650
    • Broadwell, R.D.1    Balin, B.J.2
  • 76
    • 0022253549 scopus 로고
    • Transport of molecules from nose to brain: Transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutininhorseradish peroxidase applied to the nasal epithelium
    • Shipley MT (1985) Transport of molecules from nose to brain: Transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutininhorseradish peroxidase applied to the nasal epithelium. Brain Res Bull 15, 129-142
    • (1985) Brain Res Bull , vol.15 , pp. 129-142
    • Shipley, M.T.1
  • 77
    • 0033014163 scopus 로고    scopus 로고
    • Central nervous system effects of intranasally administered insulin during euglycemia in men
    • Kern W, Born J, Schreiber H, Fehm HL (1999) Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes 48, 557-563
    • (1999) Diabetes , vol.48 , pp. 557-563
    • Kern, W.1    Born, J.2    Schreiber, H.3    Fehm, H.L.4
  • 80
    • 42049089751 scopus 로고    scopus 로고
    • Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    • Benedict C, Kern W, Schultes B, Born J, Hallschmid M (2008) Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab 93, 1339-1344
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1339-1344
    • Benedict, C.1    Kern, W.2    Schultes, B.3    Born, J.4    Hallschmid, M.5
  • 81
    • 39449093463 scopus 로고    scopus 로고
    • Obese men respond to cognitive but not to catabolic brain insulin signaling
    • Hallschmid M, Benedict C, Schultes B, Born J, Kern W (2008) Obese men respond to cognitive but not to catabolic brain insulin signaling. Int J Obes (Lond) 32, 275-282
    • (2008) Int J Obes (Lond , vol.32 , pp. 275-282
    • Hallschmid, M.1    Benedict, C.2    Schultes, B.3    Born, J.4    Kern, W.5
  • 82
    • 6344250713 scopus 로고    scopus 로고
    • Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
    • Stockhorst U, de Fries D, Steingrueber HJ, Scherbaum WA (2004) Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav 83, 47-54
    • (2004) Physiol Behav , vol.83 , pp. 47-54
    • Stockhorst, U.1    De Fries, D.2    Steingrueber, H.J.3    Scherbaum, W.A.4
  • 87
    • 0037423144 scopus 로고    scopus 로고
    • Obesity and the environment: Where do we go from here?
    • Hill JO,Wyatt HR, ReedGW, Peters JC (2003) Obesity and the Environment: Where do we go from here? Science 299, 853-855
    • (2003) Science , vol.299 , pp. 853-855
    • Hill, J.O.1    Wyatt, H.R.2    Reed, G.W.3    Peters, J.C.4
  • 88
  • 90
    • 79952483902 scopus 로고    scopus 로고
    • Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
    • Kanoski SE, Davidson TL (2011)Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity. Physiol Behav 103, 59-68
    • (2011) Physiol Behav , vol.103 , pp. 59-68
    • Kanoski, S.E.1    Davidson, T.L.2
  • 94
    • 0035372336 scopus 로고    scopus 로고
    • Effects of apolipoprotein E (apoE) isoforms, beta-Amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-Alpha (PKC-Alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
    • Cedazo-Minguez A, Wiehager B, Winblad B, Huttinger M, Cowburn RF (2001) Effects of apolipoprotein E (apoE) isoforms, beta-Amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-Alpha (PKC-Alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Neurochem Int 38, 615-625
    • (2001) Neurochem Int , vol.38 , pp. 615-625
    • Cedazo-Minguez, A.1    Wiehager, B.2    Winblad, B.3    Huttinger, M.4    Cowburn, R.F.5
  • 96
    • 77956026310 scopus 로고    scopus 로고
    • Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases
    • Schroeder JE, Richardson JC, Virley DJ (2010) Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases. Biochim Biophys Acta 1802, 840-846
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 840-846
    • Schroeder, J.E.1    Richardson, J.C.2    Virley, D.J.3
  • 97
    • 77953736212 scopus 로고    scopus 로고
    • Diet and neurocognition: Review of evidence and methodological considerations
    • Smith PJ, Blumenthal JA (2010) Diet and neurocognition: Review of evidence and methodological considerations. Curr Aging Sci 3, 57-66
    • (2010) Curr Aging Sci , vol.3 , pp. 57-66
    • Smith, P.J.1    Blumenthal, J.A.2
  • 104
    • 79251551381 scopus 로고    scopus 로고
    • Regular physical exercise training assists in preventing type 2 diabetes development: Focus on its antioxidant and antiinflammatory properties
    • Teixeira-Lemos E, Nunes S, Teixeira F, Reis F (2011) Regular physical exercise training assists in preventing type 2 diabetes development: Focus on its antioxidant and antiinflammatory properties. Cardiovasc Diabetol 10, 12
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 12
    • Teixeira-Lemos, E.1    Nunes, S.2    Teixeira, F.3    Reis, F.4
  • 105
    • 79952093796 scopus 로고    scopus 로고
    • Physical exercise alleviates debilities of normal aging and Alzheimer's disease
    • Archer T (2011) Physical exercise alleviates debilities of normal aging and Alzheimer's disease. Acta Neurol Scand 123, 221-238
    • (2011) Acta Neurol Scand , vol.123 , pp. 221-238
    • Archer, T.1
  • 107
    • 57349148171 scopus 로고    scopus 로고
    • Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: Independence from changes in dynamic autoregulation and reactivity
    • Ainslie PN, Hamlin M, Hellemans J, Rasmussen P, Ogoh S (2008) Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: Independence from changes in dynamic autoregulation and reactivity. Am J Physiol Regul Integr Comp Physiol 295, R1613-1622
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Ainslie, P.N.1    Hamlin, M.2    Hellemans, J.3    Rasmussen, P.4    Ogoh, S.5
  • 109
    • 42649110683 scopus 로고    scopus 로고
    • Association between arterial elasticity, C-reactive protein and maximal oxygen consumption in well-Trained cadets during three days extreme physical load: A pilot study
    • Kampus P, Kals J, Unt E, Zilmer K, Eha J, Teesalu R, Normak A, Zilmer M (2008) Association between arterial elasticity, C-reactive protein and maximal oxygen consumption in well-Trained cadets during three days extreme physical load: A pilot study. Physiol Meas 29, 429-437
    • (2008) Physiol Meas , vol.29 , pp. 429-437
    • Kampus, P.1    Kals, J.2    Unt, E.3    Zilmer, K.4    Eha, J.5    Teesalu, R.6    Normak, A.7    Zilmer, M.8
  • 110
    • 56749180855 scopus 로고    scopus 로고
    • Brain-Derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
    • Gomez-Pinilla F, Vaynman S, Ying Z (2008) Brain-Derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 28, 2278-2287
    • (2008) Eur J Neurosci , vol.28 , pp. 2278-2287
    • Gomez-Pinilla, F.1    Vaynman, S.2    Ying, Z.3
  • 112
  • 114
    • 80054948772 scopus 로고    scopus 로고
    • Non-Pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI
    • TeixeiraCV, GobbiLT, Corazza DI, Stella F, Costa JL, Gobbi S (2012) Non-Pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI). Arch Gerontol Geriatr 54, 175-180
    • (2012) Arch Gerontol Geriatr , vol.54 , pp. 175-180
    • Teixeira, C.V.1    Gobbi, L.T.2    Corazza, D.I.3    Stella, F.4    Costa, J.L.5    Gobbi, S.6
  • 115
    • 21444458336 scopus 로고    scopus 로고
    • Mild cognitive impairment (MCI) represents early-Stage Alzheimer's disease
    • 235-239; discussion
    • Morris JC, Cummings J (2005) Mild cognitive impairment (MCI) represents early-Stage Alzheimer's disease. J Alzheimers Dis 7, 235-239; discussion 255-262
    • (2005) J Alzheimers Dis , vol.7 , pp. 255-262
    • Morris, J.C.1    Cummings, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.