메뉴 건너뛰기




Volumn 51, Issue 3, 2015, Pages 1249-1262

Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases

Author keywords

Alzheimer s disease; Amyotrophic lateral sclerosis; Huntington s disease; MicroRNA; Parkinson s disease

Indexed keywords

BIOLOGICAL MARKER; MICRORNA;

EID: 84939893709     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8803-9     Document Type: Review
Times cited : (102)

References (127)
  • 1
    • 84878777552 scopus 로고    scopus 로고
    • An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome
    • PID: 2357
    • De Jager PL, Bennett DA (2013) An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome. JAMA Neurol 70(6):719–726. doi:10.1001/jamaneurol.2013.275
    • (2013) JAMA Neurol , vol.70 , Issue.6 , pp. 719-726
    • De Jager, P.L.1    Bennett, D.A.2
  • 2
    • 84866062627 scopus 로고    scopus 로고
    • Gene expression profiling in human neurodegenerative disease
    • COI: 1:CAS:528:DC%2BC38XhtlWhsL7E, PID: 2289
    • Cooper-Knock J, Kirby J, Ferraiuolo L, Heath PR, Rattray M, Shaw PJ (2012) Gene expression profiling in human neurodegenerative disease. Nat Rev Neurol 8(9):518–530. doi:10.1038/nrneurol.2012.156
    • (2012) Nat Rev Neurol , vol.8 , Issue.9 , pp. 518-530
    • Cooper-Knock, J.1    Kirby, J.2    Ferraiuolo, L.3    Heath, P.R.4    Rattray, M.5    Shaw, P.J.6
  • 3
    • 34249874344 scopus 로고    scopus 로고
    • RNA in brain disease: no longer just “the messenger in the middle
    • COI: 1:CAS:528:DC%2BD2sXnsFKmt7o%3D, PID: 1754
    • Nelson PT, Keller JN (2007) RNA in brain disease: no longer just “the messenger in the middle”. J Neuropathol Exp Neurol 66(6):461–468. doi:10.1097/01.jnen.0000240474.27791.f3
    • (2007) J Neuropathol Exp Neurol , vol.66 , Issue.6 , pp. 461-468
    • Nelson, P.T.1    Keller, J.N.2
  • 4
    • 33745314092 scopus 로고    scopus 로고
    • Genetics: what is a gene?
    • COI: 1:CAS:528:DC%2BD28XkvVykt7s%3D, PID: 1672
    • Pearson H (2006) Genetics: what is a gene? Nature 441(7092):398–401. doi:10.1038/441398a
    • (2006) Nature , vol.441 , Issue.7092 , pp. 398-401
    • Pearson, H.1
  • 5
    • 38349186896 scopus 로고    scopus 로고
    • MicroRNAs (miRNAs) in neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BD1cXjtFKru7c%3D, PID: 1822
    • Nelson PT, Wang WX, Rajeev BW (2008) MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol 18(1):130–138. doi:10.1111/j.1750-3639.2007.00120.x
    • (2008) Brain Pathol , vol.18 , Issue.1 , pp. 130-138
    • Nelson, P.T.1    Wang, W.X.2    Rajeev, B.W.3
  • 6
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • COI: 1:CAS:528:DyaK2cXpslGqtA%3D%3D, PID: 825
    • Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75(5):843–854
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 7
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • COI: 1:CAS:528:DC%2BD3MXotVChtb8%3D, PID: 1167
    • Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294(5543):853–858. doi:10.1126/science.1064921
    • (2001) Science , vol.294 , Issue.5543 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 8
    • 38349114827 scopus 로고    scopus 로고
    • MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system
    • PID: 1771
    • Kapsimali M, Kloosterman WP, de Bruijn E, Rosa F, Plasterk RH, Wilson SW (2007) MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol 8(8):R173. doi:10.1186/gb-2007-8-8-r173
    • (2007) Genome Biol , vol.8 , Issue.8 , pp. 173
    • Kapsimali, M.1    Kloosterman, W.P.2    de Bruijn, E.3    Rosa, F.4    Plasterk, R.H.5    Wilson, S.W.6
  • 10
    • 52949109849 scopus 로고    scopus 로고
    • A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex
    • COI: 1:CAS:528:DC%2BD1cXhtFCisLrO, PID: 1863
    • Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S (2008) A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet 17(19):3030–3042. doi:10.1093/hmg/ddn201
    • (2008) Hum Mol Genet , vol.17 , Issue.19 , pp. 3030-3042
    • Mellios, N.1    Huang, H.S.2    Grigorenko, A.3    Rogaev, E.4    Akbarian, S.5
  • 13
    • 84860369464 scopus 로고    scopus 로고
    • Blood serum miRNA: non-invasive biomarkers for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XmtlGqsrg%3D, PID: 2215
    • Geekiyanage H, Jicha GA, Nelson PT, Chan C (2012) Blood serum miRNA: non-invasive biomarkers for Alzheimer’s disease. Exp Neurol 235(2):491–496. doi:10.1016/j.expneurol.2011.11.026
    • (2012) Exp Neurol , vol.235 , Issue.2 , pp. 491-496
    • Geekiyanage, H.1    Jicha, G.A.2    Nelson, P.T.3    Chan, C.4
  • 14
    • 84891391234 scopus 로고    scopus 로고
    • Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls
    • PID: 2354
    • Cardo LF, Coto E, de Mena L, Ribacoba R, Moris G, Menendez M, Alvarez V (2013) Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls. J Neurol 260(5):1420–1422. doi:10.1007/s00415-013-6900-8
    • (2013) J Neurol , vol.260 , Issue.5 , pp. 1420-1422
    • Cardo, L.F.1    Coto, E.2    de Mena, L.3    Ribacoba, R.4    Moris, G.5    Menendez, M.6    Alvarez, V.7
  • 16
    • 84872501669 scopus 로고    scopus 로고
    • Non-coding RNAs in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXjvVGiuw%3D%3D, PID: 2305
    • Tan L, Yu JT, Hu N (2013) Non-coding RNAs in Alzheimer’s disease. Mol Neurobiol 47(1):382–393. doi:10.1007/s12035-012-8359-5
    • (2013) Mol Neurobiol , vol.47 , Issue.1 , pp. 382-393
    • Tan, L.1    Yu, J.T.2    Hu, N.3
  • 17
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • COI: 1:CAS:528:DC%2BD2cXotlCrsrs%3D, PID: 1537
    • Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23(20):4051–4060. doi:10.1038/sj.emboj.7600385
    • (2004) EMBO J , vol.23 , Issue.20 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3    Yeom, K.H.4    Lee, S.5    Baek, S.H.6    Kim, V.N.7
  • 18
    • 33845370280 scopus 로고    scopus 로고
    • RNA polymerase III transcribes human microRNAs
    • COI: 1:CAS:528:DC%2BD28Xht1KrurnO, PID: 1709
    • Borchert GM, Lanier W, Davidson BL (2006) RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol 13(12):1097–1101. doi:10.1038/nsmb1167
    • (2006) Nat Struct Mol Biol , vol.13 , Issue.12 , pp. 1097-1101
    • Borchert, G.M.1    Lanier, W.2    Davidson, B.L.3
  • 19
    • 9144225636 scopus 로고    scopus 로고
    • The microprocessor complex mediates the genesis of microRNAs
    • COI: 1:CAS:528:DC%2BD2cXpsF2gt7g%3D, PID: 1553
    • Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R (2004) The microprocessor complex mediates the genesis of microRNAs. Nature 432(7014):235–240. doi:10.1038/nature03120
    • (2004) Nature , vol.432 , Issue.7014 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3    Chendrimada, T.4    Doratotaj, B.5    Cooch, N.6    Shiekhattar, R.7
  • 20
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • COI: 1:CAS:528:DC%2BD3MXlvVKksb4%3D, PID: 1145
    • Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, Zamore PD (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293(5531):834–838. doi:10.1126/science.1062961
    • (2001) Science , vol.293 , Issue.5531 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 21
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • COI: 1:CAS:528:DC%2BD2cXhtVals7o%3D, PID: 1474
    • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281–297
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 22
    • 34249810892 scopus 로고    scopus 로고
    • Argonaute proteins: mediators of RNA silencing
    • COI: 1:CAS:528:DC%2BD2sXnt1Cqtbo%3D, PID: 1756
    • Peters L, Meister G (2007) Argonaute proteins: mediators of RNA silencing. Mol Cell 26(5):611–623. doi:10.1016/j.molcel.2007.05.001
    • (2007) Mol Cell , vol.26 , Issue.5 , pp. 611-623
    • Peters, L.1    Meister, G.2
  • 23
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • COI: 1:CAS:528:DC%2BD3cXit1agtrw%3D, PID: 1074
    • Hammond SM, Bernstein E, Beach D, Hannon GJ (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404(6775):293–296. doi:10.1038/35005107
    • (2000) Nature , vol.404 , Issue.6775 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 24
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • COI: 1:CAS:528:DC%2BD3MXhvVOjtbg%3D, PID: 1115
    • Elbashir SM, Lendeckel W, Tuschl T (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15(2):188–200
    • (2001) Genes Dev , vol.15 , Issue.2 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 25
    • 85027951676 scopus 로고    scopus 로고
    • Functions of noncoding RNAs in neural development and neurological diseases
    • COI: 1:CAS:528:DC%2BC3MXhsFOjt7bI, PID: 2196
    • Bian S, Sun T (2011) Functions of noncoding RNAs in neural development and neurological diseases. Mol Neurobiol 44(3):359–373. doi:10.1007/s12035-011-8211-3
    • (2011) Mol Neurobiol , vol.44 , Issue.3 , pp. 359-373
    • Bian, S.1    Sun, T.2
  • 26
    • 63349094897 scopus 로고    scopus 로고
    • Alterations of the microRNA network cause neurodegenerative disease
    • COI: 1:CAS:528:DC%2BD1MXkt1Skt7k%3D, PID: 1926
    • Hebert SS, De Strooper B (2009) Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci 32(4):199–206. doi:10.1016/j.tins.2008.12.003
    • (2009) Trends Neurosci , vol.32 , Issue.4 , pp. 199-206
    • Hebert, S.S.1    De Strooper, B.2
  • 28
    • 1942494040 scopus 로고    scopus 로고
    • Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    • PID: 1500
    • Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V (2004) Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol 5(3):R13. doi:10.1186/gb-2004-5-3-r13
    • (2004) Genome Biol , vol.5 , Issue.3 , pp. 13
    • Sempere, L.F.1    Freemantle, S.2    Pitha-Rowe, I.3    Moss, E.4    Dmitrovsky, E.5    Ambros, V.6
  • 29
    • 38049062478 scopus 로고    scopus 로고
    • Posttranscriptional control of neuronal development by microRNA networks
    • PID: 1805
    • Gao FB (2008) Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci 31(1):20–26. doi:10.1016/j.tins.2007.10.004
    • (2008) Trends Neurosci , vol.31 , Issue.1 , pp. 20-26
    • Gao, F.B.1
  • 30
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • COI: 1:CAS:528:DC%2BD3MXms12ksA%3D%3D, PID: 1120
    • Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409(6818):363–366. doi:10.1038/35053110
    • (2001) Nature , vol.409 , Issue.6818 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 31
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • COI: 1:CAS:528:DC%2BD3MXlsVCqtrw%3D, PID: 1146
    • Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106(1):23–34
    • (2001) Cell , vol.106 , Issue.1 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6    Baillie, D.L.7    Fire, A.8    Ruvkun, G.9    Mello, C.C.10
  • 32
    • 34548537573 scopus 로고    scopus 로고
    • A microRNA feedback circuit in midbrain dopamine neurons
    • COI: 1:CAS:528:DC%2BD2sXps12ms7Y%3D, PID: 1776
    • Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A (2007) A microRNA feedback circuit in midbrain dopamine neurons. Science 317(5842):1220–1224. doi:10.1126/science.1140481
    • (2007) Science , vol.317 , Issue.5842 , pp. 1220-1224
    • Kim, J.1    Inoue, K.2    Ishii, J.3    Vanti, W.B.4    Voronov, S.V.5    Murchison, E.6    Hannon, G.7    Abeliovich, A.8
  • 33
    • 34547212309 scopus 로고    scopus 로고
    • The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
    • COI: 1:CAS:528:DC%2BD2sXptlymsrk%3D, PID: 1767
    • Makeyev EV, Zhang J, Carrasco MA, Maniatis T (2007) The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 27(3):435–448. doi:10.1016/j.molcel.2007.07.015
    • (2007) Mol Cell , vol.27 , Issue.3 , pp. 435-448
    • Makeyev, E.V.1    Zhang, J.2    Carrasco, M.A.3    Maniatis, T.4
  • 34
    • 65349085532 scopus 로고    scopus 로고
    • MicroRNA-124: micromanager of neurogenesis
    • COI: 1:CAS:528:DC%2BD1MXlvVGjt7c%3D, PID: 1942
    • Papagiannakopoulos T, Kosik KS (2009) MicroRNA-124: micromanager of neurogenesis. Cell Stem Cell 4(5):375–376. doi:10.1016/j.stem.2009.04.007
    • (2009) Cell Stem Cell , vol.4 , Issue.5 , pp. 375-376
    • Papagiannakopoulos, T.1    Kosik, K.S.2
  • 35
    • 78650692019 scopus 로고    scopus 로고
    • In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
    • COI: 1:CAS:528:DC%2BC3MXhtFGqtbo%3D, PID: 2106
    • Smith P, Al Hashimi A, Girard J, Delay C, Hebert SS (2011) In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem 116(2):240–247. doi:10.1111/j.1471-4159.2010.07097.x
    • (2011) J Neurochem , vol.116 , Issue.2 , pp. 240-247
    • Smith, P.1    Al Hashimi, A.2    Girard, J.3    Delay, C.4    Hebert, S.S.5
  • 36
    • 33749078547 scopus 로고    scopus 로고
    • MicroRNA pathways modulate polyglutamine-induced neurodegeneration
    • COI: 1:CAS:528:DC%2BD28XhtFegtbnL, PID: 1701
    • Bilen J, Liu N, Burnett BG, Pittman RN, Bonini NM (2006) MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Mol Cell 24(1):157–163. doi:10.1016/j.molcel.2006.07.030
    • (2006) Mol Cell , vol.24 , Issue.1 , pp. 157-163
    • Bilen, J.1    Liu, N.2    Burnett, B.G.3    Pittman, R.N.4    Bonini, N.M.5
  • 37
    • 34447261382 scopus 로고    scopus 로고
    • Cerebellar neurodegeneration in the absence of microRNAs
    • COI: 1:CAS:528:DC%2BD2sXnslylsr8%3D, PID: 1760
    • Schaefer A, O’Carroll D, Tan CL, Hillman D, Sugimori M, Llinas R, Greengard P (2007) Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med 204(7):1553–1558. doi:10.1084/jem.20070823
    • (2007) J Exp Med , vol.204 , Issue.7 , pp. 1553-1558
    • Schaefer, A.1    O’Carroll, D.2    Tan, C.L.3    Hillman, D.4    Sugimori, M.5    Llinas, R.6    Greengard, P.7
  • 38
    • 34848927455 scopus 로고    scopus 로고
    • The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila
    • COI: 1:CAS:528:DC%2BD2sXht1CntLnL, PID: 1792
    • Karres JS, Hilgers V, Carrera I, Treisman J, Cohen SM (2007) The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell 131(1):136–145. doi:10.1016/j.cell.2007.09.020
    • (2007) Cell , vol.131 , Issue.1 , pp. 136-145
    • Karres, J.S.1    Hilgers, V.2    Carrera, I.3    Treisman, J.4    Cohen, S.M.5
  • 39
    • 23844501276 scopus 로고    scopus 로고
    • Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner
    • COI: 1:CAS:528:DC%2BD2MXpsFClsbY%3D, PID: 1609
    • Lugli G, Larson J, Martone ME, Jones Y, Smalheiser NR (2005) Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner. J Neurochem 94(4):896–905. doi:10.1111/j.1471-4159.2005.03224.x
    • (2005) J Neurochem , vol.94 , Issue.4 , pp. 896-905
    • Lugli, G.1    Larson, J.2    Martone, M.E.3    Jones, Y.4    Smalheiser, N.R.5
  • 40
    • 34447107760 scopus 로고    scopus 로고
    • The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila
    • COI: 1:CAS:528:DC%2BD2sXotlGmtrY%3D, PID: 1759
    • Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC (2007) The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 130(1):89–100. doi:10.1016/j.cell.2007.06.028
    • (2007) Cell , vol.130 , Issue.1 , pp. 89-100
    • Okamura, K.1    Hagen, J.W.2    Duan, H.3    Tyler, D.M.4    Lai, E.C.5
  • 41
    • 34249317118 scopus 로고    scopus 로고
    • RNAi-mediated heterochromatin assembly in fission yeast
    • COI: 1:CAS:528:DC%2BD2sXls1yrtbw%3D, PID: 1738
    • Zofall M, Grewal SI (2006) RNAi-mediated heterochromatin assembly in fission yeast. Cold Spring Harb Symp Quant Biol 71:487–496. doi:10.1101/sqb.2006.71.059
    • (2006) Cold Spring Harb Symp Quant Biol , vol.71 , pp. 487-496
    • Zofall, M.1    Grewal, S.I.2
  • 42
    • 77955784599 scopus 로고    scopus 로고
    • ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
    • COI: 1:CAS:528:DC%2BC3cXht1GrurjJ, PID: 2062
    • Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW (2010) ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A 107(30):13318–13323. doi:10.1073/pnas.1008227107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.30 , pp. 13318-13323
    • Ling, S.C.1    Albuquerque, C.P.2    Han, J.S.3    Lagier-Tourenne, C.4    Tokunaga, S.5    Zhou, H.6    Cleveland, D.W.7
  • 43
    • 77955152366 scopus 로고    scopus 로고
    • Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    • COI: 1:CAS:528:DC%2BC3cXpsFWksbw%3D, PID: 2067
    • Gehrke S, Imai Y, Sokol N, Lu B (2010) Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466(7306):637–641. doi:10.1038/nature09191
    • (2010) Nature , vol.466 , Issue.7306 , pp. 637-641
    • Gehrke, S.1    Imai, Y.2    Sokol, N.3    Lu, B.4
  • 44
    • 49449091708 scopus 로고    scopus 로고
    • Huntington’s disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies
    • COI: 1:CAS:528:DC%2BD1cXpvFOju70%3D, PID: 1866
    • Savas JN, Makusky A, Ottosen S, Baillat D, Then F, Krainc D, Shiekhattar R, Markey SP, Tanese N (2008) Huntington’s disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proc Natl Acad Sci U S A 105(31):10820–10825. doi:10.1073/pnas.0800658105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.31 , pp. 10820-10825
    • Savas, J.N.1    Makusky, A.2    Ottosen, S.3    Baillat, D.4    Then, F.5    Krainc, D.6    Shiekhattar, R.7    Markey, S.P.8    Tanese, N.9
  • 45
    • 69549103145 scopus 로고    scopus 로고
    • Recent advances in our understanding of neurodegeneration
    • COI: 1:CAS:528:DC%2BD1MXhtVeqs7jM, PID: 1970
    • Jellinger KA (2009) Recent advances in our understanding of neurodegeneration. J Neural Transm 116(9):1111–1162. doi:10.1007/s00702-009-0240-y
    • (2009) J Neural Transm , vol.116 , Issue.9 , pp. 1111-1162
    • Jellinger, K.A.1
  • 46
    • 77952675535 scopus 로고    scopus 로고
    • MicroRNAs and deregulated gene expression networks in neurodegeneration
    • COI: 1:CAS:528:DC%2BC3cXmslShsrg%3D, PID: 2038
    • Sonntag KC (2010) MicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Res 1338:48–57. doi:10.1016/j.brainres.2010.03.106
    • (2010) Brain Res , vol.1338 , pp. 48-57
    • Sonntag, K.C.1
  • 49
    • 59049087888 scopus 로고    scopus 로고
    • MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1
    • COI: 1:CAS:528:DC%2BD1MXlvFaksw%3D%3D, PID: 1898
    • Boissonneault V, Plante I, Rivest S, Provost P (2009) MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 284(4):1971–1981. doi:10.1074/jbc.M807530200
    • (2009) J Biol Chem , vol.284 , Issue.4 , pp. 1971-1981
    • Boissonneault, V.1    Plante, I.2    Rivest, S.3    Provost, P.4
  • 50
    • 70349558133 scopus 로고    scopus 로고
    • miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer’s disease, inhibits bcl2 translation
    • COI: 1:CAS:528:DC%2BD1MXht1WqtbfE, PID: 1968
    • Wang X, Liu P, Zhu H, Xu Y, Ma C, Dai X, Huang L, Liu Y, Zhang L, Qin C (2009) miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer’s disease, inhibits bcl2 translation. Brain Res Bull 80(4–5):268–273. doi:10.1016/j.brainresbull.2009.08.006
    • (2009) Brain Res Bull , vol.80 , Issue.4-5 , pp. 268-273
    • Wang, X.1    Liu, P.2    Zhu, H.3    Xu, Y.4    Ma, C.5    Dai, X.6    Huang, L.7    Liu, Y.8    Zhang, L.9    Qin, C.10
  • 51
    • 24644453571 scopus 로고    scopus 로고
    • The role of apoptotic pathways in Alzheimer’s disease neurodegeneration and cell death
    • COI: 1:CAS:528:DC%2BD2MXhtVWksLnF, PID: 1624
    • LeBlanc AC (2005) The role of apoptotic pathways in Alzheimer’s disease neurodegeneration and cell death. Curr Alzheimer Res 2(4):389–402
    • (2005) Curr Alzheimer Res , vol.2 , Issue.4 , pp. 389-402
    • LeBlanc, A.C.1
  • 52
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • PID: 1823
    • Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT (2008) The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28(5):1213–1223. doi:10.1523/JNEUROSCI.5065-07.2008
    • (2008) J Neurosci , vol.28 , Issue.5 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 53
    • 80054025163 scopus 로고    scopus 로고
    • MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXhtlCgtrvL, PID: 2199
    • Geekiyanage H, Chan C (2011) MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer’s disease. J Neurosci 31(41):14820–14830. doi:10.1523/JNEUROSCI.3883-11.2011
    • (2011) J Neurosci , vol.31 , Issue.41 , pp. 14820-14830
    • Geekiyanage, H.1    Chan, C.2
  • 54
    • 56349116391 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer’s disease: an update
    • COI: 1:CAS:528:DC%2BD1cXhsVegtrjO, PID: 1860
    • Brouwers N, Sleegers K, Van Broeckhoven C (2008) Molecular genetics of Alzheimer’s disease: an update. Ann Med 40(8):562–583. doi:10.1080/07853890802186905
    • (2008) Ann Med , vol.40 , Issue.8 , pp. 562-583
    • Brouwers, N.1    Sleegers, K.2    Van Broeckhoven, C.3
  • 56
    • 84890121012 scopus 로고    scopus 로고
    • Alternative polyadenylation and miR-34 family members regulate tau expression
    • COI: 1:CAS:528:DC%2BC3sXhvVKhu7nJ, PID: 2403
    • Dickson JR, Kruse C, Montagna DR, Finsen B, Wolfe MS (2013) Alternative polyadenylation and miR-34 family members regulate tau expression. J Neurochem 127(6):739–749. doi:10.1111/jnc.12437
    • (2013) J Neurochem , vol.127 , Issue.6 , pp. 739-749
    • Dickson, J.R.1    Kruse, C.2    Montagna, D.R.3    Finsen, B.4    Wolfe, M.S.5
  • 57
    • 84883732254 scopus 로고    scopus 로고
    • MiR-26b, upregulated in Alzheimer’s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons
    • COI: 1:CAS:528:DC%2BC3sXhsVOltrjE, PID: 2402
    • Absalon S, Kochanek DM, Raghavan V, Krichevsky AM (2013) MiR-26b, upregulated in Alzheimer’s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 33(37):14645–14659. doi:10.1523/JNEUROSCI.1327-13.2013
    • (2013) J Neurosci , vol.33 , Issue.37 , pp. 14645-14659
    • Absalon, S.1    Kochanek, D.M.2    Raghavan, V.3    Krichevsky, A.M.4
  • 58
    • 71149102204 scopus 로고    scopus 로고
    • Interaction map and selection of microRNA targets in Parkinson’s disease-related genes
    • Santosh PS, Arora N, Sarma P, Pal-Bhadra M, Bhadra U (2009) Interaction map and selection of microRNA targets in Parkinson’s disease-related genes. J Biomed Biotechnol 2009:363145. doi:10.1155/2009/363145
    • (2009) J Biomed Biotechnol , vol.2009 , pp. 363145
    • Santosh, P.S.1    Arora, N.2    Sarma, P.3    Pal-Bhadra, M.4    Bhadra, U.5
  • 59
    • 69149102628 scopus 로고    scopus 로고
    • Repression of alpha-synuclein expression and toxicity by microRNA-7
    • COI: 1:CAS:528:DC%2BD1MXhtVKru7%2FL, PID: 1962
    • Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM (2009) Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci U S A 106(31):13052–13057. doi:10.1073/pnas.0906277106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.31 , pp. 13052-13057
    • Junn, E.1    Lee, K.W.2    Jeong, B.S.3    Chan, T.W.4    Im, J.Y.5    Mouradian, M.M.6
  • 60
    • 77951249562 scopus 로고    scopus 로고
    • Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153
    • COI: 1:CAS:528:DC%2BC3cXkvVGjurs%3D, PID: 2010
    • Doxakis E (2010) Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. J Biol Chem 285(17):12726–12734. doi:10.1074/jbc.M109.086827
    • (2010) J Biol Chem , vol.285 , Issue.17 , pp. 12726-12734
    • Doxakis, E.1
  • 61
    • 84878318898 scopus 로고    scopus 로고
    • Roles of FGF20 in dopaminergic neurons and Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC3sXht1Gks7%2FO, PID: 2375
    • Itoh N, Ohta H (2013) Roles of FGF20 in dopaminergic neurons and Parkinson’s disease. Front Mol Neurosci 6:15. doi:10.3389/fnmol.2013.00015
    • (2013) Front Mol Neurosci , vol.6 , pp. 15
    • Itoh, N.1    Ohta, H.2
  • 62
    • 40749145370 scopus 로고    scopus 로고
    • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
    • COI: 1:CAS:528:DC%2BD1cXit1SjurY%3D, PID: 1825
    • Wang G, van der Walt JM, Mayhew G, Li YJ, Zuchner S, Scott WK, Martin ER, Vance JM (2008) Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet 82(2):283–289. doi:10.1016/j.ajhg.2007.09.021
    • (2008) Am J Hum Genet , vol.82 , Issue.2 , pp. 283-289
    • Wang, G.1    van der Walt, J.M.2    Mayhew, G.3    Li, Y.J.4    Zuchner, S.5    Scott, W.K.6    Martin, E.R.7    Vance, J.M.8
  • 64
    • 70349782485 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons
    • COI: 1:CAS:528:DC%2BC3cXhtlWjtrzI, PID: 1973
    • Ang SL (2009) Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons. Adv Exp Med Biol 651:58–65
    • (2009) Adv Exp Med Biol , vol.651 , pp. 58-65
    • Ang, S.L.1
  • 65
    • 69049108564 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development
    • COI: 1:CAS:528:DC%2BD1MXhtVKlsL%2FN, PID: 1960
    • Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL (2009) Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol 333(2):386–396. doi:10.1016/j.ydbio.2009.07.006
    • (2009) Dev Biol , vol.333 , Issue.2 , pp. 386-396
    • Lin, W.1    Metzakopian, E.2    Mavromatakis, Y.E.3    Gao, N.4    Balaskas, N.5    Sasaki, H.6    Briscoe, J.7    Whitsett, J.A.8    Goulding, M.9    Kaestner, K.H.10    Ang, S.L.11
  • 66
    • 38549159511 scopus 로고    scopus 로고
    • The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
    • PID: 1807
    • Kittappa R, Chang WW, Awatramani RB, McKay RD (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5(12):e325. doi:10.1371/journal.pbio.0050325
    • (2007) PLoS Biol , vol.5 , Issue.12 , pp. 325
    • Kittappa, R.1    Chang, W.W.2    Awatramani, R.B.3    McKay, R.D.4
  • 68
    • 58149375393 scopus 로고    scopus 로고
    • The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s disease
    • COI: 1:CAS:528:DC%2BD1MXnsF2huw%3D%3D, PID: 1911
    • Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL (2008) The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s disease. J Neurosci 28(53):14341–14346. doi:10.1523/JNEUROSCI.2390-08.2008
    • (2008) J Neurosci , vol.28 , Issue.53 , pp. 14341-14346
    • Packer, A.N.1    Xing, Y.2    Harper, S.Q.3    Jones, L.4    Davidson, B.L.5
  • 69
    • 77958471215 scopus 로고    scopus 로고
    • A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing
    • COI: 1:CAS:528:DC%2BC3cXhsVektr7L, PID: 2059
    • Marti E, Pantano L, Banez-Coronel M, Llorens F, Minones-Moyano E, Porta S, Sumoy L, Ferrer I, Estivill X (2010) A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing. Nucleic Acids Res 38(20):7219–7235. doi:10.1093/nar/gkq575
    • (2010) Nucleic Acids Res , vol.38 , Issue.20 , pp. 7219-7235
    • Marti, E.1    Pantano, L.2    Banez-Coronel, M.3    Llorens, F.4    Minones-Moyano, E.5    Porta, S.6    Sumoy, L.7    Ferrer, I.8    Estivill, X.9
  • 70
    • 84870483497 scopus 로고    scopus 로고
    • Mechanism(s) of alteration of micro RNA expressions in Huntington’s disease and their possible contributions to the observed cellular and molecular dysfunctions in the disease
    • COI: 1:CAS:528:DC%2BC38Xhsleltr3F, PID: 2258
    • Sinha M, Mukhopadhyay S, Bhattacharyya NP (2012) Mechanism(s) of alteration of micro RNA expressions in Huntington’s disease and their possible contributions to the observed cellular and molecular dysfunctions in the disease. Neuromolecular Med 14(4):221–243. doi:10.1007/s12017-012-8183-0
    • (2012) Neuromolecular Med , vol.14 , Issue.4 , pp. 221-243
    • Sinha, M.1    Mukhopadhyay, S.2    Bhattacharyya, N.P.3
  • 72
    • 31744432337 scopus 로고    scopus 로고
    • The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    • COI: 1:CAS:528:DC%2BD28XotlGktg%3D%3D, PID: 1638
    • Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ (2006) The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 38(2):228–233. doi:10.1038/ng1725
    • (2006) Nat Genet , vol.38 , Issue.2 , pp. 228-233
    • Chen, J.F.1    Mandel, E.M.2    Thomson, J.M.3    Wu, Q.4    Callis, T.E.5    Hammond, S.M.6    Conlon, F.L.7    Wang, D.Z.8
  • 75
    • 68149183508 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of aging
    • COI: 1:CAS:528:DC%2BD1MXps1CgtrY%3D, PID: 1950
    • Fraga MF (2009) Genetic and epigenetic regulation of aging. Curr Opin Immunol 21(4):446–453. doi:10.1016/j.coi.2009.04.003
    • (2009) Curr Opin Immunol , vol.21 , Issue.4 , pp. 446-453
    • Fraga, M.F.1
  • 76
    • 34247540446 scopus 로고    scopus 로고
    • Epigenetics and microRNAs
    • COI: 1:CAS:528:DC%2BD2sXksFSjt7g%3D, PID: 1741
    • Chuang JC, Jones PA (2007) Epigenetics and microRNAs. Pediatr Res 61(5 Pt 2):24R–29R. doi:10.1203/pdr.0b013e3180457684
    • (2007) Pediatr Res , vol.61 , Issue.5 Pt 2 , pp. 24-29
    • Chuang, J.C.1    Jones, P.A.2
  • 77
    • 84888197384 scopus 로고    scopus 로고
    • Epigenetic mechanisms in Alzheimer’s disease: implications for pathogenesis and therapy
    • COI: 1:CAS:528:DC%2BC3sXpt1Cru7k%3D, PID: 2368
    • Wang J, Yu JT, Tan MS, Jiang T, Tan L (2013) Epigenetic mechanisms in Alzheimer’s disease: implications for pathogenesis and therapy. Ageing Res Rev 12(4):1024–1041. doi:10.1016/j.arr.2013.05.003
    • (2013) Ageing Res Rev , vol.12 , Issue.4 , pp. 1024-1041
    • Wang, J.1    Yu, J.T.2    Tan, M.S.3    Jiang, T.4    Tan, L.5
  • 78
    • 81255143014 scopus 로고    scopus 로고
    • Epigenetic regulation of motor neuron cell death through DNA methylation
    • COI: 1:CAS:528:DC%2BC3MXhsFaksLzO, PID: 2209
    • Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, Martin LJ (2011) Epigenetic regulation of motor neuron cell death through DNA methylation. J Neurosci 31(46):16619–16636. doi:10.1523/JNEUROSCI.1639-11.2011
    • (2011) J Neurosci , vol.31 , Issue.46 , pp. 16619-16636
    • Chestnut, B.A.1    Chang, Q.2    Price, A.3    Lesuisse, C.4    Wong, M.5    Martin, L.J.6
  • 80
    • 84869087636 scopus 로고    scopus 로고
    • The dynamics of DNA methylation in schizophrenia and related psychiatric disorders
    • COI: 1:CAS:528:DC%2BC38Xhs1ynurjF, PID: 2294
    • Grayson DR, Guidotti A (2013) The dynamics of DNA methylation in schizophrenia and related psychiatric disorders. Neuropsychopharmacology 38(1):138–166. doi:10.1038/npp.2012.125
    • (2013) Neuropsychopharmacology , vol.38 , Issue.1 , pp. 138-166
    • Grayson, D.R.1    Guidotti, A.2
  • 81
    • 33847748913 scopus 로고    scopus 로고
    • The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function
    • COI: 1:CAS:528:DC%2BD2sXhvVWruro%3D, PID: 1730
    • Brueckner B, Stresemann C, Kuner R, Mund C, Musch T, Meister M, Sultmann H, Lyko F (2007) The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res 67(4):1419–1423. doi:10.1158/0008-5472.CAN-06-4074
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1419-1423
    • Brueckner, B.1    Stresemann, C.2    Kuner, R.3    Mund, C.4    Musch, T.5    Meister, M.6    Sultmann, H.7    Lyko, F.8
  • 85
    • 84875420225 scopus 로고    scopus 로고
    • MicroRNAs in cancers and neurodegenerative disorders
    • COI: 1:CAS:528:DC%2BC3sXhtFSltLzF, PID: 2305
    • Saito Y, Saito H (2012) MicroRNAs in cancers and neurodegenerative disorders. Front Genet 3:194. doi:10.3389/fgene.2012.00194
    • (2012) Front Genet , vol.3 , pp. 194
    • Saito, Y.1    Saito, H.2
  • 86
    • 32944462300 scopus 로고    scopus 로고
    • Rapid alteration of microRNA levels by histone deacetylase inhibition
    • COI: 1:CAS:528:DC%2BD28XpsVejtQ%3D%3D, PID: 1645
    • Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC (2006) Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res 66(3):1277–1281. doi:10.1158/0008-5472.CAN-05-3632
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1277-1281
    • Scott, G.K.1    Mattie, M.D.2    Berger, C.E.3    Benz, S.C.4    Benz, C.C.5
  • 87
    • 77956099873 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation
    • COI: 1:CAS:528:DC%2BC3cXms1alt78%3D, PID: 2045
    • Liu C, Teng ZQ, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X (2010) Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell 6(5):433–444. doi:10.1016/j.stem.2010.02.017
    • (2010) Cell Stem Cell , vol.6 , Issue.5 , pp. 433-444
    • Liu, C.1    Teng, Z.Q.2    Santistevan, N.J.3    Szulwach, K.E.4    Guo, W.5    Jin, P.6    Zhao, X.7
  • 88
    • 77950565107 scopus 로고    scopus 로고
    • Cross talk between microRNA and epigenetic regulation in adult neurogenesis
    • COI: 1:CAS:528:DC%2BC3cXks1CntLw%3D, PID: 2036
    • Szulwach KE, Li X, Smrt RD, Li Y, Luo Y, Lin L, Santistevan NJ, Li W, Zhao X, Jin P (2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 189(1):127–141. doi:10.1083/jcb.200908151
    • (2010) J Cell Biol , vol.189 , Issue.1 , pp. 127-141
    • Szulwach, K.E.1    Li, X.2    Smrt, R.D.3    Li, Y.4    Luo, Y.5    Lin, L.6    Santistevan, N.J.7    Li, W.8    Zhao, X.9    Jin, P.10
  • 89
    • 77649251655 scopus 로고    scopus 로고
    • Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells
    • PID: 2008
    • Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW (2010) Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. PLoS One 5(1):e8697. doi:10.1371/journal.pone.0008697
    • (2010) PLoS One , vol.5 , Issue.1 , pp. 8697
    • Vrba, L.1    Jensen, T.J.2    Garbe, J.C.3    Heimark, R.L.4    Cress, A.E.5    Dickinson, S.6    Stampfer, M.R.7    Futscher, B.W.8
  • 90
    • 78650437816 scopus 로고    scopus 로고
    • Epigenetic architecture and miRNA: reciprocal regulators
    • COI: 1:CAS:528:DC%2BC3cXhsFOjsrjN, PID: 2212
    • Wiklund ED, Kjems J, Clark SJ (2010) Epigenetic architecture and miRNA: reciprocal regulators. Epigenomics 2(6):823–840. doi:10.2217/epi.10.51
    • (2010) Epigenomics , vol.2 , Issue.6 , pp. 823-840
    • Wiklund, E.D.1    Kjems, J.2    Clark, S.J.3
  • 91
    • 79954469878 scopus 로고    scopus 로고
    • Cancer epigenetics: above and beyond
    • COI: 1:CAS:528:DC%2BC3MXkvVWjt74%3D, PID: 2149
    • Brait M, Sidransky D (2011) Cancer epigenetics: above and beyond. Toxicol Mech Methods 21(4):275–288. doi:10.3109/15376516.2011.562671
    • (2011) Toxicol Mech Methods , vol.21 , Issue.4 , pp. 275-288
    • Brait, M.1    Sidransky, D.2
  • 93
    • 84863262723 scopus 로고    scopus 로고
    • Regulation of let-7 and its target oncogenes (Review)
    • COI: 1:CAS:528:DC%2BC38XntlyhtLc%3D, PID: 2278
    • Wang X, Cao L, Wang Y, Liu N, You Y (2012) Regulation of let-7 and its target oncogenes (Review). Oncol Lett 3(5):955–960. doi:10.3892/ol.2012.609
    • (2012) Oncol Lett , vol.3 , Issue.5 , pp. 955-960
    • Wang, X.1    Cao, L.2    Wang, Y.3    Liu, N.4    You, Y.5
  • 94
    • 54449097149 scopus 로고    scopus 로고
    • A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence
    • COI: 1:CAS:528:DC%2BD1cXht1aqur7J, PID: 1881
    • Forman JJ, Legesse-Miller A, Coller HA (2008) A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A 105(39):14879–14884. doi:10.1073/pnas.0803230105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.39 , pp. 14879-14884
    • Forman, J.J.1    Legesse-Miller, A.2    Coller, H.A.3
  • 95
    • 47949103491 scopus 로고    scopus 로고
    • Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma
    • COI: 1:CAS:528:DC%2BD1cXhtFWhs7bJ, PID: 1853
    • Omura N, Li CP, Li A, Hong SM, Walter K, Jimeno A, Hidalgo M, Goggins M (2008) Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma. Cancer Biol Ther 7(7):1146–1156
    • (2008) Cancer Biol Ther , vol.7 , Issue.7 , pp. 1146-1156
    • Omura, N.1    Li, C.P.2    Li, A.3    Hong, S.M.4    Walter, K.5    Jimeno, A.6    Hidalgo, M.7    Goggins, M.8
  • 96
    • 79954455860 scopus 로고    scopus 로고
    • Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
    • PID: 2122
    • Vogt M, Munding J, Gruner M, Liffers ST, Verdoodt B, Hauk J, Steinstraesser L, Tannapfel A, Hermeking H (2011) Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Arch 458(3):313–322. doi:10.1007/s00428-010-1030-5
    • (2011) Virchows Arch , vol.458 , Issue.3 , pp. 313-322
    • Vogt, M.1    Munding, J.2    Gruner, M.3    Liffers, S.T.4    Verdoodt, B.5    Hauk, J.6    Steinstraesser, L.7    Tannapfel, A.8    Hermeking, H.9
  • 97
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer’s disease brain neocortex: validation study
    • COI: 1:CAS:528:DC%2BC3cXptFGlt7o%3D, PID: 2041
    • Nelson PT, Wang WX (2010) MiR-107 is reduced in Alzheimer’s disease brain neocortex: validation study. J Alzheimers Dis 21(1):75–79. doi:10.3233/JAD-2010-091603
    • (2010) J Alzheimers Dis , vol.21 , Issue.1 , pp. 75-79
    • Nelson, P.T.1    Wang, W.X.2
  • 98
    • 65449166892 scopus 로고    scopus 로고
    • Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer
    • COI: 1:CAS:528:DC%2BD1MXmtFCisL8%3D, PID: 1940
    • Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins MG, Mendell JT, Maitra A (2009) Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology 9(3):293–301. doi:10.1159/000186051
    • (2009) Pancreatology , vol.9 , Issue.3 , pp. 293-301
    • Lee, K.H.1    Lotterman, C.2    Karikari, C.3    Omura, N.4    Feldmann, G.5    Habbe, N.6    Goggins, M.G.7    Mendell, J.T.8    Maitra, A.9
  • 99
    • 79956150179 scopus 로고    scopus 로고
    • miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer
    • COI: 1:CAS:528:DC%2BC3MXmtVGlt7g%3D, PID: 2144
    • Zhang Y, Yan LX, Wu QN, Du ZM, Chen J, Liao DZ, Huang MY, Hou JH, Wu QL, Zeng MS, Huang WL, Zeng YX, Shao JY (2011) miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res 71(10):3552–3562. doi:10.1158/0008-5472.CAN-10-2435
    • (2011) Cancer Res , vol.71 , Issue.10 , pp. 3552-3562
    • Zhang, Y.1    Yan, L.X.2    Wu, Q.N.3    Du, Z.M.4    Chen, J.5    Liao, D.Z.6    Huang, M.Y.7    Hou, J.H.8    Wu, Q.L.9    Zeng, M.S.10    Huang, W.L.11    Zeng, Y.X.12    Shao, J.Y.13
  • 100
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer’s disease hippocampus
    • COI: 1:CAS:528:DC%2BD2sXhvFWrtLw%3D, PID: 1731
    • Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer’s disease hippocampus. Neuroreport 18(3):297–300. doi:10.1097/WNR.0b013e3280148e8b
    • (2007) Neuroreport , vol.18 , Issue.3 , pp. 297-300
    • Lukiw, W.J.1
  • 101
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways
    • COI: 1:CAS:528:DC%2BD1cXmtlygt78%3D, PID: 1852
    • Cogswell JPWJ, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C et al (2008) Identification of miRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14:27–41
    • (2008) J Alzheimers Dis , vol.14 , pp. 27-41
    • Cogswell, J.P.W.J.1    Taylor, I.A.2    Waters, M.3    Shi, Y.4    Cannon, B.5    Kelnar, K.6    Kemppainen, J.7    Brown, D.8    Chen, C.9
  • 102
    • 77952745811 scopus 로고    scopus 로고
    • Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation
    • COI: 1:CAS:528:DC%2BC3cXlvVejsLo%3D, PID: 2034
    • Pogue AI, Cui JG, Li YY, Zhao Y, Culicchia F, Lukiw WJ (2010) Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neurosci Lett 476(1):18–22. doi:10.1016/j.neulet.2010.03.054
    • (2010) Neurosci Lett , vol.476 , Issue.1 , pp. 18-22
    • Pogue, A.I.1    Cui, J.G.2    Li, Y.Y.3    Zhao, Y.4    Culicchia, F.5    Lukiw, W.J.6
  • 103
    • 70350436694 scopus 로고    scopus 로고
    • MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1
    • COI: 1:CAS:528:DC%2BD1MXhsValsLrP, PID: 1981
    • Strum JC, Johnson JH, Ward J, Xie H, Feild J, Hester A, Alford A, Waters KM (2009) MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol 23(11):1876–1884. doi:10.1210/me.2009-0117
    • (2009) Mol Endocrinol , vol.23 , Issue.11 , pp. 1876-1884
    • Strum, J.C.1    Johnson, J.H.2    Ward, J.3    Xie, H.4    Feild, J.5    Hester, A.6    Alford, A.7    Waters, K.M.8
  • 104
    • 80053563273 scopus 로고    scopus 로고
    • NeurimmiRs: microRNAs in the neuroimmune interface
    • COI: 1:CAS:528:DC%2BC3MXht1ymtr7L, PID: 2181
    • Soreq H, Wolf Y (2011) NeurimmiRs: microRNAs in the neuroimmune interface. Trends Mol Med 17(10):548–555. doi:10.1016/j.molmed.2011.06.009
    • (2011) Trends Mol Med , vol.17 , Issue.10 , pp. 548-555
    • Soreq, H.1    Wolf, Y.2
  • 105
    • 41849119117 scopus 로고    scopus 로고
    • MeCP2-dependent repression of an imprinted miR-184 released by depolarization
    • COI: 1:CAS:528:DC%2BD1cXktlSktbk%3D, PID: 1820
    • Nomura T, Kimura M, Horii T, Morita S, Soejima H, Kudo S, Hatada I (2008) MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum Mol Genet 17(8):1192–1199. doi:10.1093/hmg/ddn011
    • (2008) Hum Mol Genet , vol.17 , Issue.8 , pp. 1192-1199
    • Nomura, T.1    Kimura, M.2    Horii, T.3    Morita, S.4    Soejima, H.5    Kudo, S.6    Hatada, I.7
  • 106
    • 0034234237 scopus 로고    scopus 로고
    • CBP/p300 in cell growth, transformation, and development
    • COI: 1:CAS:528:DC%2BD3cXkvFCkurc%3D, PID: 1088
    • Goodman RH, Smolik S (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev 14(13):1553–1577
    • (2000) Genes Dev , vol.14 , Issue.13 , pp. 1553-1577
    • Goodman, R.H.1    Smolik, S.2
  • 108
    • 70350142444 scopus 로고    scopus 로고
    • Gene dysregulation in Huntington’s disease: REST, microRNAs and beyond
    • COI: 1:CAS:528:DC%2BD1MXhtF2js77M, PID: 1945
    • Johnson R, Buckley NJ (2009) Gene dysregulation in Huntington’s disease: REST, microRNAs and beyond. Neuromolecular Med 11(3):183–199. doi:10.1007/s12017-009-8063-4
    • (2009) Neuromolecular Med , vol.11 , Issue.3 , pp. 183-199
    • Johnson, R.1    Buckley, N.J.2
  • 109
    • 84878005741 scopus 로고    scopus 로고
    • Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels
    • COI: 1:CAS:528:DC%2BC3sXhtVSkur%2FO, PID: 2370
    • Campos-Melo D, Droppelmann CA, He Z, Volkening K, Strong MJ (2013) Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels. Mol Brain 6:26. doi:10.1186/1756-6606-6-26
    • (2013) Mol Brain , vol.6 , pp. 26
    • Campos-Melo, D.1    Droppelmann, C.A.2    He, Z.3    Volkening, K.4    Strong, M.J.5
  • 110
    • 84855859453 scopus 로고    scopus 로고
    • Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages
    • COI: 1:CAS:528:DC%2BC38XitVensLc%3D, PID: 2198
    • Jiang M, Xiang Y, Wang D, Gao J, Liu D, Liu Y, Liu S, Zheng D (2012) Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell 11(1):29–40. doi:10.1111/j.1474-9726.2011.00757.x
    • (2012) Aging Cell , vol.11 , Issue.1 , pp. 29-40
    • Jiang, M.1    Xiang, Y.2    Wang, D.3    Gao, J.4    Liu, D.5    Liu, Y.6    Liu, S.7    Zheng, D.8
  • 111
    • 84886423682 scopus 로고    scopus 로고
    • Genome-wide microRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation identifies modulators of neuronal apoptosis
    • COI: 1:CAS:528:DC%2BC3sXhslWksL7P, PID: 2420
    • Sun Z, Yu JT, Jiang T, Li MM, Tan L, Zhang Q (2013) Genome-wide microRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation identifies modulators of neuronal apoptosis. PLoS One 8(10):e78375. doi:10.1371/journal.pone.0078375
    • (2013) PLoS One , vol.8 , Issue.10 , pp. 78375
    • Sun, Z.1    Yu, J.T.2    Jiang, T.3    Li, M.M.4    Tan, L.5    Zhang, Q.6
  • 112
    • 84899115417 scopus 로고    scopus 로고
    • Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy
    • PID: 2475
    • Li MM, Jiang T, Sun Z, Zhang Q, Tan CC, Yu JT, Tan L (2014) Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy. Sci Rep 4:4734. doi:10.1038/srep04734
    • (2014) Sci Rep , vol.4 , pp. 4734
    • Li, M.M.1    Jiang, T.2    Sun, Z.3    Zhang, Q.4    Tan, C.C.5    Yu, J.T.6    Tan, L.7
  • 114
    • 84901767463 scopus 로고    scopus 로고
    • Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXotFSktr0%3D, PID: 2457
    • Tan L, Yu JT, Tan MS, Liu QY, Wang HF, Zhang W, Jiang T (2014) Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer’s disease. J Alzheimers Dis 40(4):1017–1027. doi:10.3233/JAD-132144
    • (2014) J Alzheimers Dis. , vol.40 , Issue.4 , pp. 1017-1027
    • Tan, L.1    Yu, J.T.2    Tan, M.S.3    Liu, Q.Y.4    Wang, H.F.5    Zhang, W.6    Jiang, T.7
  • 115
    • 84891525727 scopus 로고    scopus 로고
    • Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study
    • COI: 1:CAS:528:DC%2BC2cXhtleru7
    • Sheinerman KS, Tsivinsky VG, Abdullah L, Crawford F, Umansky SR (2013) Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. Aging (Albany NY) 5(12):925–938
    • (2013) Aging (Albany NY) , vol.5 , Issue.12 , pp. 925-938
    • Sheinerman, K.S.1    Tsivinsky, V.G.2    Abdullah, L.3    Crawford, F.4    Umansky, S.R.5
  • 117
    • 84893946623 scopus 로고    scopus 로고
    • MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXhtFKls74%3D, PID: 2415
    • Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T (2014) MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer’s disease. J Alzheimers Dis 39(2):253–259. doi:10.3233/JAD-130932
    • (2014) J Alzheimers Dis , vol.39 , Issue.2 , pp. 253-259
    • Kiko, T.1    Nakagawa, K.2    Tsuduki, T.3    Furukawa, K.4    Arai, H.5    Miyazawa, T.6
  • 118
    • 79952898846 scopus 로고    scopus 로고
    • Identification of blood microRNAs associated to Parkinsons disease
    • COI: 1:CAS:528:DC%2BC3MXjvV2ktLk%3D, PID: 2129
    • Margis R, Rieder CR (2011) Identification of blood microRNAs associated to Parkinsons disease. J Biotechnol 152(3):96–101. doi:10.1016/j.jbiotec.2011.01.023
    • (2011) J Biotechnol , vol.152 , Issue.3 , pp. 96-101
    • Margis, R.1    Rieder, C.R.2
  • 119
    • 84876435649 scopus 로고    scopus 로고
    • Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes
    • COI: 1:CAS:528:DC%2BC3sXht1Gks7%2FK, PID: 2371
    • Soreq L, Salomonis N, Bronstein M, Greenberg DS, Israel Z, Bergman H, Soreq H (2013) Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes. Front Mol Neurosci 6:10. doi:10.3389/fnmol.2013.00010
    • (2013) Front Mol Neurosci , vol.6 , pp. 10
    • Soreq, L.1    Salomonis, N.2    Bronstein, M.3    Greenberg, D.S.4    Israel, Z.5    Bergman, H.6    Soreq, H.7
  • 121
    • 79956032718 scopus 로고    scopus 로고
    • Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington’s disease
    • COI: 1:CAS:528:DC%2BC3MXmtVyqt7g%3D, PID: 2142
    • Gaughwin PM, Ciesla M, Lahiri N, Tabrizi SJ, Brundin P, Bjorkqvist M (2011) Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington’s disease. Hum Mol Genet 20(11):2225–2237. doi:10.1093/hmg/ddr111
    • (2011) Hum Mol Genet , vol.20 , Issue.11 , pp. 2225-2237
    • Gaughwin, P.M.1    Ciesla, M.2    Lahiri, N.3    Tabrizi, S.J.4    Brundin, P.5    Bjorkqvist, M.6
  • 122
    • 84865536102 scopus 로고    scopus 로고
    • A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
    • PID: 2290
    • De Felice B, Guida M, Coppola C, De Mieri G, Cotrufo R (2012) A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis. Gene 508(1):35–40. doi:10.1016/j.gene.2012.07.058
    • (2012) Gene , vol.508 , Issue.1 , pp. 35-40
    • De Felice, B.1    Guida, M.2    Coppola, C.3    De Mieri, G.4    Cotrufo, R.5
  • 123
    • 84895875610 scopus 로고    scopus 로고
    • MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis
    • PID: 2458
    • Toivonen JM, Manzano R, Olivan S, Zaragoza P, Garcia-Redondo A, Osta R (2014) MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis. PLoS One 9(2):e89065. doi:10.1371/journal.pone.0089065
    • (2014) PLoS One , vol.9 , Issue.2 , pp. 89065
    • Toivonen, J.M.1    Manzano, R.2    Olivan, S.3    Zaragoza, P.4    Garcia-Redondo, A.5    Osta, R.6
  • 124
    • 83255177161 scopus 로고    scopus 로고
    • Using non-coding small RNAs to develop therapies for Huntington’s disease
    • COI: 1:CAS:528:DC%2BC3MXhsF2jt7nM, PID: 2215
    • Zhang Y, Friedlander RM (2011) Using non-coding small RNAs to develop therapies for Huntington’s disease. Gene Ther 18(12):1139–1149. doi:10.1038/gt.2011.170
    • (2011) Gene Ther , vol.18 , Issue.12 , pp. 1139-1149
    • Zhang, Y.1    Friedlander, R.M.2
  • 126
    • 84900430088 scopus 로고    scopus 로고
    • Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer’s and Parkinson’s diseases correlate with disease status and features of pathology
    • PID: 2479
    • Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T, Shill H, Adler C, Sabbagh M, Villa S, Tembe W, Craig D, Van Keuren-Jensen K (2014) Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer’s and Parkinson’s diseases correlate with disease status and features of pathology. PLoS One 9(5):e94839. doi:10.1371/journal.pone.0094839
    • (2014) PLoS One , vol.9 , Issue.5 , pp. 94839
    • Burgos, K.1    Malenica, I.2    Metpally, R.3    Courtright, A.4    Rakela, B.5    Beach, T.6    Shill, H.7    Adler, C.8    Sabbagh, M.9    Villa, S.10    Tembe, W.11    Craig, D.12    Van Keuren-Jensen, K.13
  • 127
    • 84898606538 scopus 로고    scopus 로고
    • Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis
    • PID: 2445
    • Ishtiaq M, Campos-Melo D, Volkening K, Strong MJ (2014) Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis. PLoS One 9(1):e85653. doi:10.1371/journal.pone.0085653
    • (2014) PLoS One , vol.9 , Issue.1 , pp. 85653
    • Ishtiaq, M.1    Campos-Melo, D.2    Volkening, K.3    Strong, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.