메뉴 건너뛰기




Volumn 29, Issue 12, 2016, Pages 1936-1955

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHIP; BIOPRINTING; COCULTURE; HEP-G2 CELL LINE; HOLLOW FIBER REACTOR; HUMAN; HUMAN CELL CULTURE; LIVER CELL; LIVER FUNCTION; MICROFLUIDICS; NONHUMAN; PHENOTYPE; PRIMARY CELL CULTURE; REVIEW; SPHEROID CELL; STEM CELL; THREE DIMENSIONAL IMAGING; TOXIC HEPATITIS; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; LIVER FUNCTION TEST; METABOLISM;

EID: 84992503017     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.6b00150     Document Type: Review
Times cited : (201)

References (168)
  • 1
    • 84874053088 scopus 로고    scopus 로고
    • The burden of liver disease in Europe: A review of available epidemiological data
    • Blachier, M., Leleu, H., Peck-Radosavljevic, M., Valla, D.-C., and Roudot-Thoraval, F. (2013) The burden of liver disease in Europe: A review of available epidemiological data J. Hepatol. 58, 593-608 10.1016/j.jhep.2012.12.005
    • (2013) J. Hepatol. , vol.58 , pp. 593-608
    • Blachier, M.1    Leleu, H.2    Peck-Radosavljevic, M.3    Valla, D.-C.4    Roudot-Thoraval, F.5
  • 2
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • Guidotti, L. G. and Chisari, F. V. (2006) Immunobiology and pathogenesis of viral hepatitis Annu. Rev. Pathol.: Mech. Dis. 1, 23-61 10.1146/annurev.pathol.1.110304.100230
    • (2006) Annu. Rev. Pathol.: Mech. Dis. , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 3
    • 84926420371 scopus 로고    scopus 로고
    • Alcoholic liver disease: Mechanisms of injury and targeted treatment
    • Louvet, A. and Mathurin, P. (2015) Alcoholic liver disease: mechanisms of injury and targeted treatment Nat. Rev. Gastroenterol. Hepatol. 12, 231-242 10.1038/nrgastro.2015.35
    • (2015) Nat. Rev. Gastroenterol. Hepatol. , vol.12 , pp. 231-242
    • Louvet, A.1    Mathurin, P.2
  • 4
    • 84930788424 scopus 로고    scopus 로고
    • Nonalcoholic Fatty Liver Disease
    • Rinella, M. E. (2015) Nonalcoholic Fatty Liver Disease JAMA 313, 2263 10.1001/jama.2015.5370
    • (2015) JAMA , vol.313 , pp. 2263
    • Rinella, M.E.1
  • 5
    • 84900806395 scopus 로고    scopus 로고
    • Liver cirrhosis
    • Tsochatzis, E. A., Bosch, J., and Burroughs, A. K. (2014) Liver cirrhosis Lancet 383, 1749-1761 10.1016/S0140-6736(14)60121-5
    • (2014) Lancet , vol.383 , pp. 1749-1761
    • Tsochatzis, E.A.1    Bosch, J.2    Burroughs, A.K.3
  • 6
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag, H. B. (2011) Hepatocellular carcinoma N. Engl. J. Med. 365, 1118-1127 10.1056/NEJMra1001683
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 7
    • 84947340401 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • Carey, E. J., Ali, A. H., and Lindor, K. D. (2015) Primary biliary cirrhosis Lancet 386, 1565-1575 10.1016/S0140-6736(15)00154-3
    • (2015) Lancet , vol.386 , pp. 1565-1575
    • Carey, E.J.1    Ali, A.H.2    Lindor, K.D.3
  • 8
    • 84882846687 scopus 로고    scopus 로고
    • Update on primary sclerosing cholangitis
    • Karlsen, T. H. and Boberg, K. M. (2013) Update on primary sclerosing cholangitis J. Hepatol. 59, 571-582 10.1016/j.jhep.2013.03.015
    • (2013) J. Hepatol. , vol.59 , pp. 571-582
    • Karlsen, T.H.1    Boberg, K.M.2
  • 9
    • 3042723720 scopus 로고    scopus 로고
    • Adverse drug reactions as cause of admission to hospital: Prospective analysis of 18 820 patients
    • Pirmohamed, M. (2004) Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients BMJ. 329, 15-19 10.1136/bmj.329.7456.15
    • (2004) BMJ. , vol.329 , pp. 15-19
    • Pirmohamed, M.1
  • 10
    • 84861305959 scopus 로고    scopus 로고
    • Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes
    • Davies, E. C., Green, C. F., Taylor, S., Williamson, P. R., Mottram, D. R., and Pirmohamed, M. (2009) Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes PLoS One 4, e4439 10.1371/journal.pone.0004439
    • (2009) PLoS One , vol.4 , pp. e4439
    • Davies, E.C.1    Green, C.F.2    Taylor, S.3    Williamson, P.R.4    Mottram, D.R.5    Pirmohamed, M.6
  • 11
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of Adverse Drug Reactions in Hospitalized Patients
    • Lazarou, J., Pomeranz, B. H., and Corey, P. N. (1998) Incidence of Adverse Drug Reactions in Hospitalized Patients JAMA 279, 1200 10.1001/jama.279.15.1200
    • (1998) JAMA , vol.279 , pp. 1200
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 12
    • 32944454759 scopus 로고    scopus 로고
    • Pharmacogenomics and Individualized Drug Therapy
    • Eichelbaum, M., Ingelman-Sundberg, M., and Evans, W. E. (2006) Pharmacogenomics and Individualized Drug Therapy Annu. Rev. Med. 57, 119-137 10.1146/annurev.med.56.082103.104724
    • (2006) Annu. Rev. Med. , vol.57 , pp. 119-137
    • Eichelbaum, M.1    Ingelman-Sundberg, M.2    Evans, W.E.3
  • 13
    • 38949188630 scopus 로고    scopus 로고
    • Pharmacogenomic Biomarkers for Prediction of Severe Adverse Drug Reactions
    • Ingelman-Sundberg, M. (2008) Pharmacogenomic Biomarkers for Prediction of Severe Adverse Drug Reactions N. Engl. J. Med. 358, 637-639 10.1056/NEJMe0708842
    • (2008) N. Engl. J. Med. , vol.358 , pp. 637-639
    • Ingelman-Sundberg, M.1
  • 14
    • 84946707237 scopus 로고    scopus 로고
    • Genetic variation in the human cytochrome P450 supergene family
    • Fujikura, K., Ingelman-Sundberg, M., and Lauschke, V. M. (2015) Genetic variation in the human cytochrome P450 supergene family Pharmacogenet. Genomics 25, 584-594 10.1097/FPC.0000000000000172
    • (2015) Pharmacogenet. Genomics , vol.25 , pp. 584-594
    • Fujikura, K.1    Ingelman-Sundberg, M.2    Lauschke, V.M.3
  • 15
    • 85009205080 scopus 로고    scopus 로고
    • Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response
    • Kozyra, M., Ingelman-Sundberg, M., and Lauschke, V. M. (2016) Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response Genet. Med. 10.1038/gim.2016.33
    • (2016) Genet. Med.
    • Kozyra, M.1    Ingelman-Sundberg, M.2    Lauschke, V.M.3
  • 16
    • 84872899545 scopus 로고    scopus 로고
    • Pharmacogenomics of drug-metabolizing enzymes: A recent update on clinical implications and endogenous effects
    • Sim, S. C., Kacevska, M., and Ingelman-Sundberg, M. (2013) Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects Pharmacogenomics J. 13, 1-11 10.1038/tpj.2012.45
    • (2013) Pharmacogenomics J. , vol.13 , pp. 1-11
    • Sim, S.C.1    Kacevska, M.2    Ingelman-Sundberg, M.3
  • 17
    • 84955677862 scopus 로고    scopus 로고
    • Precision Medicine and Rare Genetic Variants
    • Lauschke, V. M. and Ingelman-Sundberg, M. (2016) Precision Medicine and Rare Genetic Variants Trends Pharmacol. Sci. 37, 85-86 10.1016/j.tips.2015.10.006
    • (2016) Trends Pharmacol. Sci. , vol.37 , pp. 85-86
    • Lauschke, V.M.1    Ingelman-Sundberg, M.2
  • 19
    • 51049109692 scopus 로고    scopus 로고
    • Industry concern over EU hepatotoxicity guidance
    • Hughes, B. (2008) Industry concern over EU hepatotoxicity guidance Nat. Rev. Drug Discovery 7, 719-719 10.1038/nrd2677
    • (2008) Nat. Rev. Drug Discovery , vol.7 , pp. 719
    • Hughes, B.1
  • 20
    • 85006717272 scopus 로고    scopus 로고
    • Tufts Center for the Study of Drug Development () How the Tufts Center for the Study of Drug Development Pegged the Cost of a New Drug at $2.6 Billion, 18 Nov, 2014
    • Tufts Center for the Study of Drug Development (2014) How the Tufts Center for the Study of Drug Development Pegged the Cost of a New Drug at $2.6 Billion, 18 Nov, 2014. http://csdd.tufts.edu/files/uploads/cost-study-backgrounder.pdf.
    • (2014)
  • 21
    • 84884989156 scopus 로고    scopus 로고
    • Mechanisms of Drug-induced Liver Injury
    • Yuan, L. and Kaplowitz, N. (2013) Mechanisms of Drug-induced Liver Injury Clin. Liver Dis. 17, 507-518 10.1016/j.cld.2013.07.002
    • (2013) Clin. Liver Dis. , vol.17 , pp. 507-518
    • Yuan, L.1    Kaplowitz, N.2
  • 22
    • 84907014643 scopus 로고    scopus 로고
    • The relevance and potential roles of microphysiological systems in biology and medicine
    • Wikswo, J. P. (2014) The relevance and potential roles of microphysiological systems in biology and medicine Exp. Biol. Med. 239, 1061-1072 10.1177/1535370214542068
    • (2014) Exp. Biol. Med. , vol.239 , pp. 1061-1072
    • Wikswo, J.P.1
  • 24
    • 85006787728 scopus 로고    scopus 로고
    • Project website of the Innovative Medicines Initiative project MIP-DILI
    • Project website of the Innovative Medicines Initiative project MIP-DILI (http://www.mip-dili.eu/).
  • 26
    • 84879441471 scopus 로고    scopus 로고
    • Hepatocyte polarity
    • Treyer, A. and Müsch, A. (2013) Hepatocyte polarity Compr. Physiol. 3, 243-287 10.1002/cphy.c120009
    • (2013) Compr. Physiol. , vol.3 , pp. 243-287
    • Treyer, A.1    Müsch, A.2
  • 27
    • 33747152561 scopus 로고    scopus 로고
    • Matrix Elasticity Directs Stem Cell Lineage Specification
    • Engler, A. J., Sen, S., Sweeney, H. L., and Discher, D. E. (2006) Matrix Elasticity Directs Stem Cell Lineage Specification Cell 126, 677-689 10.1016/j.cell.2006.06.044
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 30
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni, F., Reynaud, E. G., and Stelzer, E. H. K. (2007) The third dimension bridges the gap between cell culture and live tissue Nat. Rev. Mol. Cell Biol. 8, 839-845 10.1038/nrm2236
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.K.3
  • 31
    • 84875101870 scopus 로고    scopus 로고
    • Ed., Humana Press, Totowa, NJ
    • Haycock, J. W., Ed. (2011) 3D Cell Culture, Vol. 695, Humana Press, Totowa, NJ.
    • (2011) 3D Cell Culture , vol.695
    • Haycock, J.W.1
  • 32
    • 0029852524 scopus 로고    scopus 로고
    • Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: Hepatocytes cultured in a sandwich configuration
    • Berthiaume, F., Moghe, P. V., Toner, M., and Yarmush, M. L. (1996) Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration FASEB J. 10, 1471-1484
    • (1996) FASEB J. , vol.10 , pp. 1471-1484
    • Berthiaume, F.1    Moghe, P.V.2    Toner, M.3    Yarmush, M.L.4
  • 33
    • 33747841593 scopus 로고    scopus 로고
    • Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport
    • Bi, Y.-a., Kazolias, D., and Duignan, D. B. (2006) Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport Drug Metab. Dispos. 34, 1658-1665 10.1124/dmd.105.009118
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1658-1665
    • Bi, Y.-A.1    Kazolias, D.2    Duignan, D.B.3
  • 34
    • 77954362516 scopus 로고    scopus 로고
    • Sandwich-cultured hepatocytes: An in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity
    • Swift, B., Pfeifer, N. D., and Brouwer, K. L. R. (2010) Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity Drug Metab. Rev. 42, 446-471 10.3109/03602530903491881
    • (2010) Drug Metab. Rev. , vol.42 , pp. 446-471
    • Swift, B.1    Pfeifer, N.D.2    Brouwer, K.L.R.3
  • 35
    • 84876350292 scopus 로고    scopus 로고
    • Sandwich-cultured hepatocytes: Utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity
    • De Bruyn, T., Chatterjee, S., Fattah, S., Keemink, J., Nicolaï, J., Augustijns, P., and Annaert, P. (2013) Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity Expert Opin. Drug Metab. Toxicol. 9, 589-616 10.1517/17425255.2013.773973
    • (2013) Expert Opin. Drug Metab. Toxicol. , vol.9 , pp. 589-616
    • De Bruyn, T.1    Chatterjee, S.2    Fattah, S.3    Keemink, J.4    Nicolaï, J.5    Augustijns, P.6    Annaert, P.7
  • 36
    • 84889603695 scopus 로고    scopus 로고
    • Hepatocyte-based in vitro model for assessment of drug-induced cholestasis
    • Chatterjee, S., Richert, L., Augustijns, P., and Annaert, P. (2014) Hepatocyte-based in vitro model for assessment of drug-induced cholestasis Toxicol. Appl. Pharmacol. 274, 124-136 10.1016/j.taap.2013.10.032
    • (2014) Toxicol. Appl. Pharmacol. , vol.274 , pp. 124-136
    • Chatterjee, S.1    Richert, L.2    Augustijns, P.3    Annaert, P.4
  • 37
  • 38
    • 0036381159 scopus 로고    scopus 로고
    • Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes
    • Weiss, T. S., Jahn, B., Cetto, M., Jauch, K.-W., and Thasler, W. E. (2002) Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes Cell Proliferation 35, 257-267 10.1046/j.1365-2184.2002.00248.x
    • (2002) Cell Proliferation , vol.35 , pp. 257-267
    • Weiss, T.S.1    Jahn, B.2    Cetto, M.3    Jauch, K.-W.4    Thasler, W.E.5
  • 39
    • 84862934885 scopus 로고    scopus 로고
    • Differential Modulation of Cytochrome P450 Activity and the Effect of 1-Aminobenzotriazole on Hepatic Transport in Sandwich-Cultured Human Hepatocytes
    • Kimoto, E., Walsky, R., Zhang, H., Bi, Y. a., Whalen, K. M., Yang, Y. S., Linder, C., Xiao, Y., Iseki, K., Fenner, K. S., El-Kattan, A. F., and Lai, Y. (2012) Differential Modulation of Cytochrome P450 Activity and the Effect of 1-Aminobenzotriazole on Hepatic Transport in Sandwich-Cultured Human Hepatocytes Drug Metab. Dispos. 40, 407-411 10.1124/dmd.111.039297
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 407-411
    • Kimoto, E.1    Walsky, R.2    Zhang, H.3    Bi, A.Y.4    Whalen, K.M.5    Yang, Y.S.6    Linder, C.7    Xiao, Y.8    Iseki, K.9    Fenner, K.S.10    El-Kattan, A.F.11    Lai, Y.12
  • 40
    • 49249103327 scopus 로고    scopus 로고
    • Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury
    • Xu, J. J., Henstock, P. V., Dunn, M. C., Smith, A. R., Chabot, J. R., and de Graaf, D. (2008) Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury Toxicol. Sci. 105, 97-105 10.1093/toxsci/kfn109
    • (2008) Toxicol. Sci. , vol.105 , pp. 97-105
    • Xu, J.J.1    Henstock, P.V.2    Dunn, M.C.3    Smith, A.R.4    Chabot, J.R.5    De Graaf, D.6
  • 41
    • 1842484779 scopus 로고    scopus 로고
    • Designing materials for biology and medicine
    • Langer, R. and Tirrell, D. A. (2004) Designing materials for biology and medicine Nature 428, 487-492 10.1038/nature02388
    • (2004) Nature , vol.428 , pp. 487-492
    • Langer, R.1    Tirrell, D.A.2
  • 42
    • 0042904900 scopus 로고    scopus 로고
    • Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties
    • Wilkening, S., Stahl, F., and Bader, A. (2003) Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties Drug Metab. Dispos. 31, 1035-1042 10.1124/dmd.31.8.1035
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 1035-1042
    • Wilkening, S.1    Stahl, F.2    Bader, A.3
  • 43
    • 38749154690 scopus 로고    scopus 로고
    • Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells
    • Liguori, M. J., Blomme, E. A. G., and Waring, J. F. (2008) Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells Drug Metab. Dispos. 36, 223-233 10.1124/dmd.107.017608
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 223-233
    • Liguori, M.J.1    Blomme, E.A.G.2    Waring, J.F.3
  • 44
    • 84859163249 scopus 로고    scopus 로고
    • Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
    • Gerets, H. H. J., Tilmant, K., Gerin, B., Chanteux, H., Depelchin, B. O., Dhalluin, S., and Atienzar, F. A. (2012) Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins Cell Biol. Toxicol. 28, 69-87 10.1007/s10565-011-9208-4
    • (2012) Cell Biol. Toxicol. , vol.28 , pp. 69-87
    • Gerets, H.H.J.1    Tilmant, K.2    Gerin, B.3    Chanteux, H.4    Depelchin, B.O.5    Dhalluin, S.6    Atienzar, F.A.7
  • 45
    • 84901339650 scopus 로고    scopus 로고
    • A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies
    • Ramaiahgari, S. C., den Braver, M. W., Herpers, B., Terpstra, V., Commandeur, J. N. M., van de Water, B., and Price, L. S. (2014) A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies Arch. Toxicol. 88, 1083-1095 10.1007/s00204-014-1215-9
    • (2014) Arch. Toxicol. , vol.88 , pp. 1083-1095
    • Ramaiahgari, S.C.1    Den Braver, M.W.2    Herpers, B.3    Terpstra, V.4    Commandeur, J.N.M.5    Van De Water, B.6    Price, L.S.7
  • 46
    • 0037701271 scopus 로고    scopus 로고
    • Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
    • Kelm, J. M., Timmins, N. E., Brown, C. J., Fussenegger, M., and Nielsen, L. K. (2003) Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types Biotechnol. Bioeng. 83, 173-180 10.1002/bit.10655
    • (2003) Biotechnol. Bioeng. , vol.83 , pp. 173-180
    • Kelm, J.M.1    Timmins, N.E.2    Brown, C.J.3    Fussenegger, M.4    Nielsen, L.K.5
  • 47
    • 84872269827 scopus 로고    scopus 로고
    • Organotypic Cultures of Hepg2 Cells for in Vitro Toxicity Studies
    • Mueller, D., Koetemann, A., and Noor, F. (2011) Organotypic Cultures of Hepg2 Cells for In Vitro Toxicity Studies J. Bioeng. Biomed. Sci. 1, 1-10 10.4172/2155-9538.S2-002
    • (2011) J. Bioeng. Biomed. Sci. , vol.1 , pp. 1-10
    • Mueller, D.1    Koetemann, A.2    Noor, F.3
  • 49
    • 84934934954 scopus 로고    scopus 로고
    • Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells
    • Takahashi, Y., Hori, Y., Yamamoto, T., Urashima, T., Ohara, Y., and Tanaka, H. (2015) Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells Biosci. Rep. 1-7 10.1042/BSR20150034
    • (2015) Biosci. Rep. , pp. 1-7
    • Takahashi, Y.1    Hori, Y.2    Yamamoto, T.3    Urashima, T.4    Ohara, Y.5    Tanaka, H.6
  • 50
    • 84861464199 scopus 로고    scopus 로고
    • Determination of Drug Toxicity Using 3D Spheroids Constructed from an Immortal Human Hepatocyte Cell Line
    • Fey, S. J. and Wrzesinski, K. (2012) Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line Toxicol. Sci. 127, 403-411 10.1093/toxsci/kfs122
    • (2012) Toxicol. Sci. , vol.127 , pp. 403-411
    • Fey, S.J.1    Wrzesinski, K.2
  • 51
    • 77952300660 scopus 로고    scopus 로고
    • A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues
    • Hart, S. N., Li, Y., Nakamoto, K., Subileau, E. A., Steen, D., and Zhong, X. B. (2010) A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues Drug Metab. Dispos. 38, 988-994 10.1124/dmd.109.031831
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 988-994
    • Hart, S.N.1    Li, Y.2    Nakamoto, K.3    Subileau, E.A.4    Steen, D.5    Zhong, X.B.6
  • 52
    • 79551687759 scopus 로고    scopus 로고
    • Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification
    • Jennen, D. G. J., Magkoufopoulou, C., Ketelslegers, H. B., van Herwijnen, M. H. M., Kleinjans, J. C. S., and van Delft, J. H. M. (2010) Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification Toxicol. Sci. 115, 66-79 10.1093/toxsci/kfq026
    • (2010) Toxicol. Sci. , vol.115 , pp. 66-79
    • Jennen, D.G.J.1    Magkoufopoulou, C.2    Ketelslegers, H.B.3    Van Herwijnen, M.H.M.4    Kleinjans, J.C.S.5    Van Delft, J.H.M.6
  • 55
    • 84876802415 scopus 로고    scopus 로고
    • 3D Organotypic Cultures of Human HepaRG Cells: A Tool for in Vitro Toxicity Studies
    • Gunness, P., Mueller, D., Shevchenko, V., Heinzle, E., Ingelman-Sundberg, M., and Noor, F. (2013) 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies Toxicol. Sci. 133, 67-78 10.1093/toxsci/kft021
    • (2013) Toxicol. Sci. , vol.133 , pp. 67-78
    • Gunness, P.1    Mueller, D.2    Shevchenko, V.3    Heinzle, E.4    Ingelman-Sundberg, M.5    Noor, F.6
  • 56
    • 33644919674 scopus 로고    scopus 로고
    • Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
    • Le Vee, M., Jigorel, E., Glaise, D., Gripon, P., Guguen-Guillouzo, C., and Fardel, O. (2006) Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line Eur. J. Pharm. Sci. 28, 109-117 10.1016/j.ejps.2006.01.004
    • (2006) Eur. J. Pharm. Sci. , vol.28 , pp. 109-117
    • Le Vee, M.1    Jigorel, E.2    Glaise, D.3    Gripon, P.4    Guguen-Guillouzo, C.5    Fardel, O.6
  • 58
    • 84934761586 scopus 로고    scopus 로고
    • Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays
    • Murayama, N., Usui, T., Slawny, N., Chesne, C., and Yamazaki, H. (2015) Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays Drug Metab. Lett. 9, 3-7 10.2174/1872312809666150119104806
    • (2015) Drug Metab. Lett. , vol.9 , pp. 3-7
    • Murayama, N.1    Usui, T.2    Slawny, N.3    Chesne, C.4    Yamazaki, H.5
  • 59
    • 84985945921 scopus 로고    scopus 로고
    • Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes
    • Higuchi, Y., Kawai, K., Kanaki, T., Yamazaki, H., Chesne, C., Guguen-Guillouzo, C., and Suemizu, H. (2016) Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes Hepatol. Res. 46, 1045 10.1111/hepr.12644
    • (2016) Hepatol. Res. , vol.46 , pp. 1045
    • Higuchi, Y.1    Kawai, K.2    Kanaki, T.3    Yamazaki, H.4    Chesne, C.5    Guguen-Guillouzo, C.6    Suemizu, H.7
  • 60
    • 84888290491 scopus 로고    scopus 로고
    • 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
    • Mueller, D., Krämer, L., Hoffmann, E., Klein, S., and Noor, F. (2014) 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies Toxicol. In Vitro 28, 104-112 10.1016/j.tiv.2013.06.024
    • (2014) Toxicol. in Vitro , vol.28 , pp. 104-112
    • Mueller, D.1    Krämer, L.2    Hoffmann, E.3    Klein, S.4    Noor, F.5
  • 62
    • 84865845140 scopus 로고    scopus 로고
    • Generation of proliferating human hepatocytes using upcyte ®technology: Characterisation and applications in induction and cytotoxicity assays
    • Burkard, A., Dähn, C., Heinz, S., Zutavern, A., Sonntag-Buck, V., Maltman, D., Przyborski, S., Hewitt, N. J., and Braspenning, J. (2012) Generation of proliferating human hepatocytes using upcyte ®technology: characterisation and applications in induction and cytotoxicity assays Xenobiotica 42, 939-956 10.3109/00498254.2012.675093
    • (2012) Xenobiotica , vol.42 , pp. 939-956
    • Burkard, A.1    Dähn, C.2    Heinz, S.3    Zutavern, A.4    Sonntag-Buck, V.5    Maltman, D.6    Przyborski, S.7    Hewitt, N.J.8    Braspenning, J.9
  • 63
    • 77954955259 scopus 로고    scopus 로고
    • Human papillomavirus oncoproteins: Pathways to transformation
    • Moody, C. A. and Laimins, L. A. (2010) Human papillomavirus oncoproteins: pathways to transformation Nat. Rev. Cancer 10, 550-560 10.1038/nrc2886
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 550-560
    • Moody, C.A.1    Laimins, L.A.2
  • 66
  • 67
    • 84859119473 scopus 로고    scopus 로고
    • Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
    • Tostões, R. M., Leite, S. B., Serra, M., Jensen, J., Björquist, P., Carrondo, M. J. T., Brito, C., and Alves, P. M. (2012) Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing Hepatology 55, 1227-1236 10.1002/hep.24760
    • (2012) Hepatology , vol.55 , pp. 1227-1236
    • Tostões, R.M.1    Leite, S.B.2    Serra, M.3    Jensen, J.4    Björquist, P.5    Carrondo, M.J.T.6    Brito, C.7    Alves, P.M.8
  • 68
    • 84872301011 scopus 로고    scopus 로고
    • Multi-cell type human liver microtissues for hepatotoxicity testing
    • Messner, S., Agarkova, I., Moritz, W., and Kelm, J. M. (2013) Multi-cell type human liver microtissues for hepatotoxicity testing Arch. Toxicol. 87, 209-213 10.1007/s00204-012-0968-2
    • (2013) Arch. Toxicol. , vol.87 , pp. 209-213
    • Messner, S.1    Agarkova, I.2    Moritz, W.3    Kelm, J.M.4
  • 70
    • 84964697470 scopus 로고    scopus 로고
    • Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
    • Kermanizadeh, A., L hr, M., Roursgaard, M., Messner, S., Gunness, P., Kelm, J. M., Møller, P., Stone, V., and Loft, S. (2014) Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model Part. Fibre Toxicol. 11, 267-215 10.1186/s12989-014-0056-2
    • (2014) Part. Fibre Toxicol. , vol.11 , pp. 215-267
    • Kermanizadeh, A.1    Hr M, L.2    Roursgaard, M.3    Messner, S.4    Gunness, P.5    Kelm, J.M.6    Møller, P.7    Stone, V.8    Loft, S.9
  • 72
    • 1542327565 scopus 로고    scopus 로고
    • Drug-induced liver injury
    • Kaplowitz, N. (2004) Drug-induced liver injury Clin. Infect. Dis. 38 (Suppl. 2) S44-48 10.1086/381446
    • (2004) Clin. Infect. Dis. , vol.38 , pp. S44-48
    • Kaplowitz, N.1
  • 76
    • 84870954967 scopus 로고    scopus 로고
    • Functional 3D Human Primary Hepatocyte Spheroids Made by Co-Culturing Hepatocytes from Partial Hepatectomy Specimens and Human Adipose-Derived Stem Cells
    • No, D. Y., Lee, S.-A., Choi, Y. Y., Park, D., Jang, J. Y., Kim, D.-S., and Lee, S.-H. (2012) Functional 3D Human Primary Hepatocyte Spheroids Made by Co-Culturing Hepatocytes from Partial Hepatectomy Specimens and Human Adipose-Derived Stem Cells PLoS One 7, e50723-50728 10.1371/journal.pone.0050723
    • (2012) PLoS One , vol.7 , pp. e50723-50728
    • No, D.Y.1    Lee, S.-A.2    Choi, Y.Y.3    Park, D.4    Jang, J.Y.5    Kim, D.-S.6    Lee, S.-H.7
  • 77
    • 84949293968 scopus 로고    scopus 로고
    • Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: Improved functionality in long-term bioreactor cultures
    • Rebelo, S. P., Costa, R., Silva, M. M., Marcelino, P., Brito, C., and Alves, P. M. (2015) Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures. J. Tissue Eng. Regener. Med., DOI: 10.1002/term.2099.
    • (2015) J. Tissue Eng. Regener. Med.
    • Rebelo, S.P.1    Costa, R.2    Silva, M.M.3    Marcelino, P.4    Brito, C.5    Alves, P.M.6
  • 78
    • 84876091618 scopus 로고    scopus 로고
    • Liver tissue engineering and cell sources: Issues and challenges
    • Palakkan, A. A., Hay, D. C., PR, A. K., Tv, K., and Ross, J. A. (2013) Liver tissue engineering and cell sources: issues and challenges Liver Int. 33, 666-676 10.1111/liv.12134
    • (2013) Liver Int. , vol.33 , pp. 666-676
    • Palakkan, A.A.1    Hay, D.C.2    Pr, K.A.3    Tv, K.4    Ross, J.A.5
  • 79
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Cell 131, 861-872 10.1016/j.cell.2007.11.019
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 85
    • 79959992876 scopus 로고    scopus 로고
    • Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells
    • Bar-Nur, O., Russ, H. A., Efrat, S., and Benvenisty, N. (2011) Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells Cell Stem Cell 9, 17-23 10.1016/j.stem.2011.06.007
    • (2011) Cell Stem Cell , vol.9 , pp. 17-23
    • Bar-Nur, O.1    Russ, H.A.2    Efrat, S.3    Benvenisty, N.4
  • 90
    • 77749279749 scopus 로고    scopus 로고
    • Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    • Hu, B. Y., Weick, J. P., Yu, J., Ma, L. X., Zhang, X. Q., Thomson, J. A., and Zhang, S. C. (2010) Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency Proc. Natl. Acad. Sci. U. S. A. 107, 4335-4340 10.1073/pnas.0910012107
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 4335-4340
    • Hu, B.Y.1    Weick, J.P.2    Yu, J.3    Ma, L.X.4    Zhang, X.Q.5    Thomson, J.A.6    Zhang, S.C.7
  • 91
    • 77950995392 scopus 로고    scopus 로고
    • Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence
    • Feng, Q., Lu, S.-J., Klimanskaya, I., Gomes, I., Kim, D., Chung, Y., Honig, G. R., Kim, K.-S., and Lanza, R. (2010) Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence Stem Cells 28, 704-712 10.1002/stem.321
    • (2010) Stem Cells , vol.28 , pp. 704-712
    • Feng, Q.1    Lu, S.-J.2    Klimanskaya, I.3    Gomes, I.4    Kim, D.5    Chung, Y.6    Honig, G.R.7    Kim, K.-S.8    Lanza, R.9
  • 94
  • 96
    • 84872024484 scopus 로고    scopus 로고
    • Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects
    • Zhao, D., Chen, S., Duo, S., Xiang, C., Jia, J., Guo, M., Lai, W., Lu, S., and Deng, H. (2013) Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects Cell Res. 23, 157-161 10.1038/cr.2012.144
    • (2013) Cell Res. , vol.23 , pp. 157-161
    • Zhao, D.1    Chen, S.2    Duo, S.3    Xiang, C.4    Jia, J.5    Guo, M.6    Lai, W.7    Lu, S.8    Deng, H.9
  • 97
    • 84895469494 scopus 로고    scopus 로고
    • Pluripotent stem cell-derived hepatocyte-like cells
    • Schwartz, R. E., Fleming, H. E., Khetani, S. R., and Bhatia, S. N. (2014) Pluripotent stem cell-derived hepatocyte-like cells Biotechnol. Adv. 32, 504-513 10.1016/j.biotechadv.2014.01.003
    • (2014) Biotechnol. Adv. , vol.32 , pp. 504-513
    • Schwartz, R.E.1    Fleming, H.E.2    Khetani, S.R.3    Bhatia, S.N.4
  • 100
    • 84940652333 scopus 로고    scopus 로고
    • Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics
    • Kim, J. H., Jang, Y. J., An, S. Y., Son, J., Lee, J., Lee, G., Park, J. Y., Park, H.-J., Hwang, D.-Y., Kim, J.-H., and Han, J. (2015) Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics Toxicol. Sci. 147, 190-206 10.1093/toxsci/kfv121
    • (2015) Toxicol. Sci. , vol.147 , pp. 190-206
    • Kim, J.H.1    Jang, Y.J.2    An, S.Y.3    Son, J.4    Lee, J.5    Lee, G.6    Park, J.Y.7    Park, H.-J.8    Hwang, D.-Y.9    Kim, J.-H.10    Han, J.11
  • 102
    • 84873326803 scopus 로고    scopus 로고
    • Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor
    • Sivertsson, L., Synnergren, J., Jensen, J., Björquist, P., and Ingelman-Sundberg, M. (2013) Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor Stem Cells Dev. 22, 581-594 10.1089/scd.2012.0202
    • (2013) Stem Cells Dev. , vol.22 , pp. 581-594
    • Sivertsson, L.1    Synnergren, J.2    Jensen, J.3    Björquist, P.4    Ingelman-Sundberg, M.5
  • 103
    • 84925307610 scopus 로고    scopus 로고
    • Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro
    • Berger, D. R., Ware, B. R., Davidson, M. D., Allsup, S. R., and Khetani, S. R. (2015) Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro Hepatology 61, 1370-1381 10.1002/hep.27621
    • (2015) Hepatology , vol.61 , pp. 1370-1381
    • Berger, D.R.1    Ware, B.R.2    Davidson, M.D.3    Allsup, S.R.4    Khetani, S.R.5
  • 105
    • 77954952689 scopus 로고    scopus 로고
    • CAMP-mediated regulation of HNF-4alpha depends on the level of coactivator PGC-1alpha
    • Dankel, S. N., Hoang, T., Flågeng, M. H., Sagen, J. V., and Mellgren, G. (2010) cAMP-mediated regulation of HNF-4alpha depends on the level of coactivator PGC-1alpha Biochim. Biophys. Acta, Mol. Cell Res. 1803, 1013-1019 10.1016/j.bbamcr.2010.05.008
    • (2010) Biochim. Biophys. Acta, Mol. Cell Res. , vol.1803 , pp. 1013-1019
    • Dankel, S.N.1    Hoang, T.2    Flågeng, M.H.3    Sagen, J.V.4    Mellgren, G.5
  • 106
    • 84891848152 scopus 로고    scopus 로고
    • Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells
    • Subramanian, K., Owens, D. J., Raju, R., Firpo, M., O'Brien, T. D., Verfaillie, C. M., and Hu, W.-S. (2014) Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells Stem Cells Dev. 23, 124-131 10.1089/scd.2013.0097
    • (2014) Stem Cells Dev. , vol.23 , pp. 124-131
    • Subramanian, K.1    Owens, D.J.2    Raju, R.3    Firpo, M.4    O'Brien, T.D.5    Verfaillie, C.M.6    Hu, W.-S.7
  • 107
    • 84903840046 scopus 로고    scopus 로고
    • Aggregate Culture of Human Embryonic Stem Cell-Derived Hepatocytes in Suspension Are an Improved in Vitro Model for Drug Metabolism and Toxicity Testing
    • Sengupta, S., Johnson, B. P., Swanson, S. A., Stewart, R., Bradfield, C. A., and Thomson, J. A. (2014) Aggregate Culture of Human Embryonic Stem Cell-Derived Hepatocytes in Suspension Are an Improved In Vitro Model for Drug Metabolism and Toxicity Testing Toxicol. Sci. 140, 236-245 10.1093/toxsci/kfu069
    • (2014) Toxicol. Sci. , vol.140 , pp. 236-245
    • Sengupta, S.1    Johnson, B.P.2    Swanson, S.A.3    Stewart, R.4    Bradfield, C.A.5    Thomson, J.A.6
  • 108
    • 0021718718 scopus 로고
    • Urinary excretion of acetaminophen and its metabolites as studied by proton NMR spectroscopy
    • Bales, J. R., Sadler, P. J., Nicholson, J. K., and Timbrell, J. A. (1984) Urinary excretion of acetaminophen and its metabolites as studied by proton NMR spectroscopy Clin. Chem. 30, 1631-1636
    • (1984) Clin. Chem. , vol.30 , pp. 1631-1636
    • Bales, J.R.1    Sadler, P.J.2    Nicholson, J.K.3    Timbrell, J.A.4
  • 109
    • 33744500475 scopus 로고    scopus 로고
    • Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen-Induced Hepatotoxicity
    • Mutlib, A. E., Goosen, T. C., Bauman, J. N., Williams, J. A., Kulkarni, S., and Kostrubsky, S. (2006) Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen-Induced Hepatotoxicity Chem. Res. Toxicol. 19, 701-709 10.1021/tx050317i
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 701-709
    • Mutlib, A.E.1    Goosen, T.C.2    Bauman, J.N.3    Williams, J.A.4    Kulkarni, S.5    Kostrubsky, S.6
  • 112
    • 84881094106 scopus 로고    scopus 로고
    • Engraftment Potential of Spheroid-Forming Hepatic Endoderm Derived from Human Embryonic Stem Cells
    • Kim, S.-E., An, S. Y., Woo, D.-H., Han, J., Kim, J. H., Jang, Y. J., Son, J. S., Yang, H., Cheon, Y. P., and Kim, J.-H. (2013) Engraftment Potential of Spheroid-Forming Hepatic Endoderm Derived from Human Embryonic Stem Cells Stem Cells Dev. 22, 1818-1829 10.1089/scd.2012.0401
    • (2013) Stem Cells Dev. , vol.22 , pp. 1818-1829
    • Kim, S.-E.1    An, S.Y.2    Woo, D.-H.3    Han, J.4    Kim, J.H.5    Jang, Y.J.6    Son, J.S.7    Yang, H.8    Cheon, Y.P.9    Kim, J.-H.10
  • 115
    • 84961150998 scopus 로고    scopus 로고
    • Fluid shear stress modulation of hepatocyte-like cell function
    • Rashidi, H., Alhaque, S., Szkolnicka, D., Flint, O., and Hay, D. C. (2016) Fluid shear stress modulation of hepatocyte-like cell function Arch. Toxicol. 90, 1757-1761 10.1007/s00204-016-1689-8
    • (2016) Arch. Toxicol. , vol.90 , pp. 1757-1761
    • Rashidi, H.1    Alhaque, S.2    Szkolnicka, D.3    Flint, O.4    Hay, D.C.5
  • 116
    • 0141478911 scopus 로고    scopus 로고
    • Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: A morphologic study
    • Gerlach, J. r. C., Mutig, K., Sauer, I. M., Schrade, P., Efimova, E., Mieder, T., Naumann, G. t., Grunwald, A., Pless, G., Mas, A., Bachmann, S., Neuhaus, P., and Zeilinger, K. (2003) Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study Transplantation 76, 781-786 10.1097/01.TP.0000083319.36931.32
    • (2003) Transplantation , vol.76 , pp. 781-786
    • Gerlach, R.J.C.1    Mutig, K.2    Sauer, I.M.3    Schrade, P.4    Efimova, E.5    Mieder, T.6    Naumann, T.G.7    Grunwald, A.8    Pless, G.9    Mas, A.10    Bachmann, S.11    Neuhaus, P.12    Zeilinger, K.13
  • 117
    • 79955441221 scopus 로고    scopus 로고
    • Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological in VitroStudies
    • Zeilinger, K., Schreiter, T., Darnell, M., Söderdahl, T., Lübberstedt, M., Dillner, B., Knobeloch, D., Nüssler, A. K., Gerlach, J. C., and Andersson, T. B. (2011) Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In VitroStudies Tissue Eng., Part C 17, 549-556 10.1089/ten.tec.2010.0580
    • (2011) Tissue Eng., Part C , vol.17 , pp. 549-556
    • Zeilinger, K.1    Schreiter, T.2    Darnell, M.3    Söderdahl, T.4    Lübberstedt, M.5    Dillner, B.6    Knobeloch, D.7    Nüssler, A.K.8    Gerlach, J.C.9    Andersson, T.B.10
  • 119
    • 84866315126 scopus 로고    scopus 로고
    • Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system
    • Ulvestad, M., Darnell, M., Molden, E., Ellis, E., Åsberg, A., and Andersson, T. B. (2012) Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system J. Pharmacol. Exp. Ther. 343, 145-156 10.1124/jpet.112.195750
    • (2012) J. Pharmacol. Exp. Ther. , vol.343 , pp. 145-156
    • Ulvestad, M.1    Darnell, M.2    Molden, E.3    Ellis, E.4    Åsberg, A.5    Andersson, T.B.6
  • 120
    • 84866331511 scopus 로고    scopus 로고
    • In Vitro Evaluation of Major in Vivo Drug Metabolic Pathways Using Primary Human Hepatocytes and HepaRG Cells in Suspension and a Dynamic Three-Dimensional Bioreactor System
    • Darnell, M., Ulvestad, M., Ellis, E., Weidolf, L., and Andersson, T. B. (2012) In Vitro Evaluation of Major In Vivo Drug Metabolic Pathways Using Primary Human Hepatocytes and HepaRG Cells in Suspension and a Dynamic Three-Dimensional Bioreactor System J. Pharmacol. Exp. Ther. 343, 134-144 10.1124/jpet.112.195834
    • (2012) J. Pharmacol. Exp. Ther. , vol.343 , pp. 134-144
    • Darnell, M.1    Ulvestad, M.2    Ellis, E.3    Weidolf, L.4    Andersson, T.B.5
  • 121
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • Khetani, S. R. and Bhatia, S. N. (2007) Microscale culture of human liver cells for drug development Nat. Biotechnol. 26, 120-126 10.1038/nbt1361
    • (2007) Nat. Biotechnol. , vol.26 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 122
    • 84876475743 scopus 로고    scopus 로고
    • Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans
    • Khetani, S. R., Kanchagar, C., Ukairo, O., Krzyzewski, S., Moore, A., Shi, J., Aoyama, S., Aleo, M., and Will, Y. (2013) Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans Toxicol. Sci. 132, 107-117 10.1093/toxsci/kfs326
    • (2013) Toxicol. Sci. , vol.132 , pp. 107-117
    • Khetani, S.R.1    Kanchagar, C.2    Ukairo, O.3    Krzyzewski, S.4    Moore, A.5    Shi, J.6    Aoyama, S.7    Aleo, M.8    Will, Y.9
  • 124
    • 84889586629 scopus 로고    scopus 로고
    • Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes
    • Garside, H., Marcoe, K. F., Chesnut-Speelman, J., Foster, A. J., Muthas, D., Kenna, J. G., Warrior, U., Bowes, J., and Baumgartner, J. (2014) Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes Toxicol. In Vitro 28, 171-181 10.1016/j.tiv.2013.10.015
    • (2014) Toxicol. in Vitro , vol.28 , pp. 171-181
    • Garside, H.1    Marcoe, K.F.2    Chesnut-Speelman, J.3    Foster, A.J.4    Muthas, D.5    Kenna, J.G.6    Warrior, U.7    Bowes, J.8    Baumgartner, J.9
  • 125
    • 84958186127 scopus 로고    scopus 로고
    • Application of a Micropatterned Cocultured Hepatocyte System to Predict Preclinical and Human-Specific Drug Metabolism
    • Ballard, T. E., Wang, S., Cox, L. M., Moen, M. A., Krzyzewski, S., Ukairo, O., and Obach, R. S. (2016) Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism Drug Metab. Dispos. 44, 172-179 10.1124/dmd.115.066688
    • (2016) Drug Metab. Dispos. , vol.44 , pp. 172-179
    • Ballard, T.E.1    Wang, S.2    Cox, L.M.3    Moen, M.A.4    Krzyzewski, S.5    Ukairo, O.6    Obach, R.S.7
  • 126
    • 84888599070 scopus 로고    scopus 로고
    • Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
    • Chan, T. S., Yu, H., Moore, A., Khetani, S. R., and Tweedie, D. (2013) Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac Drug Metab. Dispos. 41, 2024-2032 10.1124/dmd.113.053397
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 2024-2032
    • Chan, T.S.1    Yu, H.2    Moore, A.3    Khetani, S.R.4    Tweedie, D.5
  • 127
    • 77957118925 scopus 로고    scopus 로고
    • Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
    • Wang, W. W., Khetani, S. R., Krzyzewski, S., Duignan, D. B., and Obach, R. S. (2010) Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites Drug Metab. Dispos. 38, 1900-1905 10.1124/dmd.110.034876
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1900-1905
    • Wang, W.W.1    Khetani, S.R.2    Krzyzewski, S.3    Duignan, D.B.4    Obach, R.S.5
  • 128
    • 84928328255 scopus 로고    scopus 로고
    • Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes
    • Ware, B. R., Berger, D. R., and Khetani, S. R. (2015) Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes Toxicol. Sci. 145, 252-262 10.1093/toxsci/kfv048
    • (2015) Toxicol. Sci. , vol.145 , pp. 252-262
    • Ware, B.R.1    Berger, D.R.2    Khetani, S.R.3
  • 129
    • 84928345304 scopus 로고    scopus 로고
    • Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
    • Nguyen, T. V., Ukairo, O., Khetani, S. R., McVay, M., Kanchagar, C., Seghezzi, W., Ayanoglu, G., Irrechukwu, O., and Evers, R. (2015) Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters Drug Metab. Dispos. 43, 774-785 10.1124/dmd.114.061317
    • (2015) Drug Metab. Dispos. , vol.43 , pp. 774-785
    • Nguyen, T.V.1    Ukairo, O.2    Khetani, S.R.3    McVay, M.4    Kanchagar, C.5    Seghezzi, W.6    Ayanoglu, G.7    Irrechukwu, O.8    Evers, R.9
  • 130
    • 4544247564 scopus 로고    scopus 로고
    • Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
    • Khetani, S. R., Szulgit, G., Del Rio, J. A., Barlow, C., and Bhatia, S. N. (2004) Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling Hepatology 40, 545-554 10.1002/hep.20351
    • (2004) Hepatology , vol.40 , pp. 545-554
    • Khetani, S.R.1    Szulgit, G.2    Del Rio, J.A.3    Barlow, C.4    Bhatia, S.N.5
  • 131
    • 55549087204 scopus 로고    scopus 로고
    • T-cadherin modulates hepatocyte functions in vitro
    • Khetani, S. R., Chen, A. A., Ranscht, B., and Bhatia, S. N. (2008) T-cadherin modulates hepatocyte functions in vitro FASEB J. 22, 3768-3775 10.1096/fj.07-105155
    • (2008) FASEB J. , vol.22 , pp. 3768-3775
    • Khetani, S.R.1    Chen, A.A.2    Ranscht, B.3    Bhatia, S.N.4
  • 132
    • 77952528235 scopus 로고    scopus 로고
    • Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity
    • Meng, Q. (2010) Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity Expert Opin. Drug Metab. Toxicol. 6, 733-746 10.1517/17425251003674356
    • (2010) Expert Opin. Drug Metab. Toxicol. , vol.6 , pp. 733-746
    • Meng, Q.1
  • 133
  • 136
    • 84901375338 scopus 로고    scopus 로고
    • Investigation of the hepatotoxicity of flutamide: Pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips
    • Legendre, A., Jacques, S., Dumont, F., Cotton, J., Paullier, P., Fleury, M. J., and Leclerc, E. (2014) Investigation of the hepatotoxicity of flutamide: Pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips Toxicol. In Vitro 28, 1075-1087 10.1016/j.tiv.2014.04.008
    • (2014) Toxicol. in Vitro , vol.28 , pp. 1075-1087
    • Legendre, A.1    Jacques, S.2    Dumont, F.3    Cotton, J.4    Paullier, P.5    Fleury, M.J.6    Leclerc, E.7
  • 137
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • Toh, Y.-C., Lim, T. C., Tai, D., Xiao, G., van Noort, D., and Yu, H. (2009) A microfluidic 3D hepatocyte chip for drug toxicity testing Lab Chip 9, 2026-2010 10.1039/b900912d
    • (2009) Lab Chip , vol.9 , pp. 2010-2026
    • Toh, Y.-C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    Van Noort, D.5    Yu, H.6
  • 138
    • 67650802351 scopus 로고    scopus 로고
    • Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
    • James, L. P., Letzig, L., Simpson, P. M., Capparelli, E., Roberts, D. W., Hinson, J. A., Davern, T. J., and Lee, W. M. (2009) Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure Drug Metab. Dispos. 37, 1779-1784 10.1124/dmd.108.026195
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 1779-1784
    • James, L.P.1    Letzig, L.2    Simpson, P.M.3    Capparelli, E.4    Roberts, D.W.5    Hinson, J.A.6    Davern, T.J.7    Lee, W.M.8
  • 139
    • 84964343834 scopus 로고    scopus 로고
    • Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction
    • Bavli, D., Prill, S., Ezra, E., Levy, G., Cohen, M., Vinken, M., Vanfleteren, J., Jaeger, M., and Nahmias, Y. (2016) Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction Proc. Natl. Acad. Sci. U. S. A. 113, E2231-E2240 10.1073/pnas.1522556113
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. E2231-E2240
    • Bavli, D.1    Prill, S.2    Ezra, E.3    Levy, G.4    Cohen, M.5    Vinken, M.6    Vanfleteren, J.7    Jaeger, M.8    Nahmias, Y.9
  • 141
    • 77957671875 scopus 로고    scopus 로고
    • A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
    • van Midwoud, P. M., Merema, M. T., Verpoorte, E., and Groothuis, G. M. M. (2010) A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices Lab Chip 10, 2778-2779 10.1039/c0lc00043d
    • (2010) Lab Chip , vol.10 , pp. 2778-2779
    • Van Midwoud, P.M.1    Merema, M.T.2    Verpoorte, E.3    Groothuis, G.M.M.4
  • 142
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang, J. Y. L. (2009) Bile acids: regulation of synthesis J. Lipid Res. 50, 1955-1966 10.1194/jlr.R900010-JLR200
    • (2009) J. Lipid Res. , vol.50 , pp. 1955-1966
    • Chiang, J.Y.L.1
  • 146
    • 84983741937 scopus 로고    scopus 로고
    • Design and demonstration of a pumpless 14 compartment microphysiological system
    • Miller, P. G. and Shuler, M. L. (2016) Design and demonstration of a pumpless 14 compartment microphysiological system Biotechnol. Bioeng. 113, 2213-2227 10.1002/bit.25989
    • (2016) Biotechnol. Bioeng. , vol.113 , pp. 2213-2227
    • Miller, P.G.1    Shuler, M.L.2
  • 148
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (μCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
    • Sung, J. H. and Shuler, M. L. (2009) A micro cell culture analog (μCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs Lab Chip 9, 1385-1310 10.1039/b901377f
    • (2009) Lab Chip , vol.9 , pp. 1310-1385
    • Sung, J.H.1    Shuler, M.L.2
  • 149
    • 84862811634 scopus 로고    scopus 로고
    • Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system
    • Ma, L., Barker, J., Zhou, C., Li, W., Zhang, J., Lin, B., Foltz, G., Küblbeck, J., and Honkakoski, P. (2012) Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system Biomaterials 33, 4353-4361 10.1016/j.biomaterials.2012.02.054
    • (2012) Biomaterials , vol.33 , pp. 4353-4361
    • Ma, L.1    Barker, J.2    Zhou, C.3    Li, W.4    Zhang, J.5    Lin, B.6    Foltz, G.7    Küblbeck, J.8    Honkakoski, P.9
  • 150
    • 78650330307 scopus 로고    scopus 로고
    • Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity
    • Imura, Y., Sato, K., and Yoshimura, E. (2010) Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity Anal. Chem. 82, 9983-9988 10.1021/ac100806x
    • (2010) Anal. Chem. , vol.82 , pp. 9983-9988
    • Imura, Y.1    Sato, K.2    Yoshimura, E.3
  • 151
    • 84862247532 scopus 로고    scopus 로고
    • Micro total bioassay system for oral drugs: Evaluation of gastrointestinal degradation, intestinal absorption, hepatic metabolism, and bioactivity
    • Imura, Y., Yoshimura, E., and Sato, K. (2012) Micro total bioassay system for oral drugs: evaluation of gastrointestinal degradation, intestinal absorption, hepatic metabolism, and bioactivity Anal. Sci. 28, 197-199 10.2116/analsci.28.197
    • (2012) Anal. Sci. , vol.28 , pp. 197-199
    • Imura, Y.1    Yoshimura, E.2    Sato, K.3
  • 152
    • 84962210462 scopus 로고    scopus 로고
    • 3D printing of functional biomaterials for tissue engineering
    • Zhu, W., Ma, X., Gou, M., Mei, D., Zhang, K., and Chen, S. (2016) 3D printing of functional biomaterials for tissue engineering Curr. Opin. Biotechnol. 40, 103-112 10.1016/j.copbio.2016.03.014
    • (2016) Curr. Opin. Biotechnol. , vol.40 , pp. 103-112
    • Zhu, W.1    Ma, X.2    Gou, M.3    Mei, D.4    Zhang, K.5    Chen, S.6
  • 154
    • 69249208450 scopus 로고    scopus 로고
    • Scaffold-free vascular tissue engineering using bioprinting
    • Norotte, C., Marga, F. S., Niklason, L. E., and Forgacs, G. (2009) Scaffold-free vascular tissue engineering using bioprinting Biomaterials 30, 5910-5917 10.1016/j.biomaterials.2009.06.034
    • (2009) Biomaterials , vol.30 , pp. 5910-5917
    • Norotte, C.1    Marga, F.S.2    Niklason, L.E.3    Forgacs, G.4
  • 155
    • 84978640780 scopus 로고    scopus 로고
    • Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity in Vitro
    • Nguyen, D. G., Funk, J., Robbins, J. B., Crogan-Grundy, C., Presnell, S. C., Singer, T., and Roth, A. B. (2016) Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro PLoS One 11, e0158674-17 10.1371/journal.pone.0158674
    • (2016) PLoS One , vol.11 , pp. e0158674-e0158717
    • Nguyen, D.G.1    Funk, J.2    Robbins, J.B.3    Crogan-Grundy, C.4    Presnell, S.C.5    Singer, T.6    Roth, A.B.7
  • 156
    • 0025913258 scopus 로고
    • Endotoxin-inducible cytotoxicity in liver cell cultures - I
    • Hartung, T. and Wendel, A. (1991) Endotoxin-inducible cytotoxicity in liver cell cultures - I Biochem. Pharmacol. 42, 1129-1135 10.1016/0006-2952(91)90298-J
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 1129-1135
    • Hartung, T.1    Wendel, A.2
  • 164
    • 84862181007 scopus 로고    scopus 로고
    • Organotypic liver culture models: Meeting current challenges in toxicity testing
    • LeCluyse, E. L., Witek, R. P., Andersen, M. E., and Powers, M. J. (2012) Organotypic liver culture models: Meeting current challenges in toxicity testing Crit. Rev. Toxicol. 42, 501-548 10.3109/10408444.2012.682115
    • (2012) Crit. Rev. Toxicol. , vol.42 , pp. 501-548
    • LeCluyse, E.L.1    Witek, R.P.2    Andersen, M.E.3    Powers, M.J.4
  • 165
    • 84899916765 scopus 로고    scopus 로고
    • The application of 3D cell models to support drug safety assessment: Opportunities & challenges
    • Roth, A. and Singer, T. (2014) The application of 3D cell models to support drug safety assessment: Opportunities & challenges Adv. Drug Delivery Rev. 69-70, 179-189 10.1016/j.addr.2013.12.005
    • (2014) Adv. Drug Delivery Rev. , vol.6970 , pp. 179-189
    • Roth, A.1    Singer, T.2
  • 166
    • 85006707570 scopus 로고    scopus 로고
    • OECD guidelines for the in vitro testing of chemicals for skin corrosion
    • OECD guidelines for the in vitro testing of chemicals for skin corrosion (http://www.oecd-ilibrary.org/environment/test-no-431-in-vitro-skin-corrosion-human-skin-model-test-9789264071148-en).
  • 167
    • 85006787249 scopus 로고    scopus 로고
    • OECD guidelines for the in vitro testing of chemicals for skin irritation
    • OECD guidelines for the in vitro testing of chemicals for skin irritation (http://www.oecd.org/env/test-no-439-in-vitro-skin-irritation-reconstructed-human-epidermis-test-method-9789264242845-en.htm).
  • 168
    • 85006736027 scopus 로고    scopus 로고
    • The internet pathology laboratory for medical education
    • The internet pathology laboratory for medical education (http://library.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.