Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

Xenobiotica

Volumn 45, Issue 1, 2015, Pages 29-44

  Vivares, Aurelie ^a   Salle Lefort, Sandrine ^a   Arabeyre Fabre, Catherine ^a   Ngo, Robert ^a   Penarier, Geraldine ^a   Bremond, Michele ^a   Moliner, Patricia ^a   Gallas, Jean François ^a   Fabre, Gerard ^a   Klieber, Sylvie ^a  

^a SANOFI   (France)

Author keywords

Drug metabolism; Dynamic culture; LiverChip device

Indexed keywords

AMFEBUTAMONE; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; DEXTROMETHORPHAN; ENZYME; GLYCOGEN; MESSENGER RNA; MIDAZOLAM; PHENACETIN; TOLBUTAMIDE; CELL RECEPTOR; CYTOCHROME P450;

ARTICLE; BIOREACTOR; CELL FUNCTION; CELL JUNCTION; CELL STRUCTURE; CRYOPRESERVATION; DRUG CLEARANCE; DRUG METABOLISM; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRAHEPATIC BILE DUCT; LIVER CELL; LIVER CELL CULTURE; MAJOR GENE; MEDICAL DEVICE; METABOLIC CAPACITY; MICROFLUIDICS; MICROSCOPY; PERFUSED MULTIWELL DEVICE; PREDICTION; PRIMARY CELL; PRIMARY HEPATOCYTE; RESERVOIR; STORAGE; TISSUE STRUCTURE; CELL CULTURE; CULTURE TECHNIQUE; DEVICES; DRUG DETOXIFICATION; EVALUATION STUDY; METABOLISM; PERFUSION; ULTRASTRUCTURE;

CELL CULTURE TECHNIQUES; CELLS, CULTURED; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; HEPATOCYTES; METABOLIC DETOXICATION, PHASE II; PERFUSION; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84916918991     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2014.944612     Document Type: Article

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