Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

Journal of Bioscience and Bioengineering

Volumn 111, Issue 1, 2011, Pages 78-84

  Nakamura, Kazuaki ^a   Mizutani, Reiko ^a   Sanbe, Atsushi ^a   Enosawa, Shin ^a   Kasahara, Mureo ^b   Nakagawa, Atsuko ^b   Ejiri, Yoko ^a,c   Murayama, Norie ^d   Miyamoto, Yuki ^a   Torii, Tomohiro ^a   Kusakawa, Shinji ^a   Yamauchi, Junji ^a   Fukuda, Motohiro ^c   Yamazaki, Hiroshi ^d   Tanoue, Akito ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c KURARAY CO LTD   (Japan)

^d SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Drug toxicity; Hepatocyte; Hepatocyte specific function; HepG2 cells; Micro space cell culture; Three dimension culture

Indexed keywords

DRUG TOXICITY; HEPATOCYTES; HEPG2 CELLS; MICRO-SPACE CELL CULTURE; THREE-DIMENSION;

ANIMAL CELL CULTURE; CELLS; ENZYMES; FUNCTION EVALUATION; MONOLAYERS; THREE DIMENSIONAL; TISSUE CULTURE; TOXICITY;

CELL CULTURE;

ALBUMIN; CYTOCHROME P450; MESSENGER RNA; PARACETAMOL;

ARTICLE; CELL CULTURE; CELL DAMAGE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; LIVER FUNCTION; MONOLAYER CULTURE; TOXICITY TESTING;

ACETAMINOPHEN; ALBUMINS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; HEP G2 CELLS; HEPATOCYTES; HUMANS; TOXICITY TESTS;

EID: 78650969052     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2010.08.008     Document Type: Article

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