CAMP-mediated regulation of HNF-4α depends on the level of coactivator PGC-1α

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1803, Issue 9, 2010, Pages 1013-1019

  Dankel, Simon Nitter ^a   Hoang, Tuyen ^a   Flågeng, Marianne Hauglid ^a   Sagen, Jørn Vegard ^a   Mellgren, Gunnar ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Coactivator; CREB; HNF 4 ; Nuclear receptor; PGC 1 ; PKA

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE 6 PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; HEAT SHOCK PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, HUMAN; PPARGC1A PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; GENE INDUCTION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEPG2 CELL LINE; METABOLISM; PHYSIOLOGY; TRANSCRIPTION INITIATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 77954952689     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2010.05.008     Document Type: Article

References (40)

1. Sands W.A., Palmer T.M. Regulating gene transcription in response to cyclic AMP elevation. Cell. Signal. 2008, 20:460-466.
2. Mayr B., Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2001, 2:599-609.
3. Robinson-Rechavi M., Escriva Garcia H., Laudet V. The nuclear receptor superfamily. J. Cell Sci. 2003, 116:585-586.
4. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
5. Sladek F.M., Zhong W.M., Lai E., Darnell J.E. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 1990, 4:2353-2365.
6. Costa R.H., Grayson D.R., Darnell J.E. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol. Cell. Biol. 1989, 9:1415-1425.
7. Miquerol L., Lopez S., Cartier N., Tulliez M., Raymondjean M., Kahn A. Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas. J. Biol. Chem. 1994, 269:8944-8951.
8. Odom D.T., Zizlsperger N., Gordon D.B., Bell G.W., Rinaldi N.J., Murray H.L., Volkert T.L., Schreiber J., Rolfe P.A., Gifford D.K., Fraenkel E., Bell G.I., Young R.A. Control of pancreas and liver gene expression by HNF transcription factors. Science 2004, 303:1378-1381.
9. Watt A.J., Garrison W.D., Duncan S.A. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 2003, 37:1249-1253.
10. Rhee J., Inoue Y., Yoon J.C., Puigserver P., Fan M., Gonzalez F.J., Spiegelman B.M. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:4012-4017.
11. Rhee J., Ge H., Yang W., Fan M., Handschin C., Cooper M., Lin J., Li C., Spiegelman B.M. Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J. Biol. Chem. 2006, 281:14683-14690.
12. Hayhurst G.P., Lee Y.H., Lambert G., Ward J.M., Gonzalez F.J. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 2001, 21:1393-1403.
13. Yamagata K., Furuta H., Oda N., Kaisaki P.J., Menzel S., Cox N.J., Fajans S.S., Signorini S., Stoffel M., Bell G.I. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 1996, 384:458-460.
14. Gonzalez F.J. Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metab. Pharmacokinet. 2008, 23:2-7.
15. Jiang G., Nepomuceno L., Yang Q., Sladek F.M. Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4. Arch. Biochem. Biophys. 1997, 340:1-9.
16. Viollet B., Kahn A., Raymondjean M. Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4. Mol. Cell. Biol. 1997, 17:4208-4219.
17. Guo H., Gao C., Mi Z., Wai P.Y., Kuo P.C. Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochem. J. 2006, 394:379-387.
18. Lonard D.M., O'Malley B.W. The expanding cosmos of nuclear receptor coactivators. Cell 2006, 125:411-414.
19. O'Malley B.W. Molecular biology. Little molecules with big goals. Science 2006, 313:1749-1750.
20. Rochette-Egly C. Dynamic combinatorial networks in nuclear receptor-mediated transcription. J. Biol. Chem. 2005, 280:32565-32568.
21. Iordanidou P., Aggelidou E., Demetriades C., Hadzopoulou-Cladaras M. Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha. J. Biol. Chem. 2005, 280:21810-21819.
22. Dell H., Hadzopoulou-Cladaras M. CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. J. Biol. Chem. 1999, 274:9013-9021.
23. Wang J.C., Stafford J.M., Granner D.K. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J. Biol. Chem. 1998, 273:30847-30850.
24. Wu R.C., Smith C.L., O'Malley B.W. Transcriptional regulation by steroid receptor coactivator phosphorylation. Endocr. Rev. 2005, 26:393-399.
25. Yan F., Gao X., Lonard D.M., Nawaz Z. Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators. Mol. Endocrinol. 2003, 17:1315-1331.
26. Chen J.D., Li H. Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors. Crit. Rev. Eukaryot. Gene Expr. 1998, 8:169-190.
27. Lin J., Handschin C., Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005, 1:361-370.
28. Yoon J.C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C.R., Granner D.K., Newgard C.B., Spiegelman B.M. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001, 413:131-138.
29. Herzig S., Long F., Jhala U.S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., Spiegelman B., Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001, 413:179-183.
30. Dietrich C.G., Martin I.V., Porn A.C., Voigt S., Gartung C., Trautwein C., Geier A. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293:G585-590.
31. Boustead J.N., Stadelmaier B.T., Eeds A.M., Wiebe P.O., Svitek C.A., Oeser J.K., O'Brien R.M. Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells. Biochem. J. 2003, 369:17-22.
32. Martinez-Jimenez C.P., Gomez-Lechon M.J., Castell J.V., Jover R. Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells. J. Biol. Chem. 2006, 281:29840-29849.
33. Miao J., Fang S., Bae Y., Kemper J.K. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. J. Biol. Chem. 2006, 281:14537-14546.
34. Ponugoti B., Fang S., Kemper J.K. Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol. Endocrinol. 2007, 21:2698-2712.
35. Song K.H., Chiang J.Y. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology 2006, 43:117-125.
36. Lee Y.H., Koh S.S., Zhang X., Cheng X., Stallcup M.R. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol. Cell. Biol. 2002, 22:3621-3632.
37. Arpiainen S., Jarvenpaa S.M., Manninen A., Viitala P., Lang M.A., Pelkonen O., Hakkola J. Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes. Toxicol. Appl. Pharmacol. 2008, 232:135-141.
38. Rohas L.M., St-Pierre J., Uldry M., Jager S., Handschin C., Spiegelman B.M. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:7933-7938.
39. Hoang T., Fenne I.S., Cook C., Borud B., Bakke M., Lien E.A., Mellgren G. cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. J. Biol. Chem. 2004, 279:49120-49130.
40. Borud B., Hoang T., Bakke M., Jacob A.L., Lund J., Mellgren G. The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1. Mol. Endocrinol. 2002, 16:757-773.