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Volumn 12, Issue 4, 2015, Pages 231-242

Alcoholic liver disease: Mechanisms of injury and targeted treatment

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIOXIDANT; BASILIXIMAB; BETAINE; CIPROFLOXACIN; CORTICOSTEROID; EMRICASAN; ETANERCEPT; GARLIC ACID; INFLIXIMAB; METADOXIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OBETICHOLIC ACID; PENTOXIFYLLINE; PLACEBO; PREDNISOLONE; PROBIOTIC AGENT; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RIFAXIMIN; RILONACEPT; S ADENOSYLMETHIONINE; TUMOR NECROSIS FACTOR ANTIBODY; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG; ZINC; CENTRAL DEPRESSANT AGENT;

EID: 84926420371     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2015.35     Document Type: Review
Times cited : (713)

References (200)
  • 1
    • 84863967084 scopus 로고    scopus 로고
    • Easl clinical practical guidelines: Management of alcoholic liver disease
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver. EASL clinical practical guidelines: management of alcoholic liver disease. J. Hepatol. 57, 399-420 (2012
    • (2012) J. Hepatol , vol.57 , pp. 399-420
  • 2
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: Pathogenesis and new therapeutic targets
    • Gao B. & Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141, 1572-1585 (2011
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 4
    • 34247163136 scopus 로고    scopus 로고
    • Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features
    • Mathurin P., et al. Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features. Aliment. Pharmacol. Ther. 25, 1047-1054 (2007
    • (2007) Aliment. Pharmacol. Ther , vol.25 , pp. 1047-1054
    • Mathurin, P.1
  • 5
    • 0037532347 scopus 로고    scopus 로고
    • Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis effect of alcoholic hepatitis smoking and abstinence
    • Pessione F., et al. Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic hepatitis smoking and abstinence. Liver Int. 23, 45-53 (2003
    • (2003) Liver Int , vol.23 , pp. 45-53
    • Pessione, F.1
  • 6
    • 64149084811 scopus 로고    scopus 로고
    • Alcohol-related cirrhosis-early abstinence is a key factor in prognosis even in the most severe cases
    • Verrill C., Markham H., Templeton A., Carr N. J. & Sheron N. Alcohol-related cirrhosis-early abstinence is a key factor in prognosis even in the most severe cases. Addiction 104, 768-774 (2009
    • (2009) Addiction , vol.104 , pp. 768-774
    • Verrill, C.1    Markham, H.2    Templeton, A.3    Carr, N.J.4    Sheron, N.5
  • 7
    • 0014336420 scopus 로고
    • Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis
    • Mendenhall C. L. Anabolic steroid therapy as an adjunct to diet in alcoholic hepatic steatosis. Am. J. Dig. Dis. 13, 783-791 (1968
    • (1968) Am. J. Dig. Dis , vol.13 , pp. 783-791
    • Mendenhall, C.L.1
  • 8
    • 0015450369 scopus 로고
    • Natural history of alcoholic hepatitis 3 histological changes
    • Galambos J. T. Natural history of alcoholic hepatitis. 3. Histological changes. Gastroenterology 63, 1026-1035 (1972
    • (1972) Gastroenterology , vol.63 , pp. 1026-1035
    • Galambos, J.T.1
  • 9
    • 0022657973 scopus 로고
    • Histological course of alcoholic hepatitis influence of abstinence sex and extent of hepatic damage
    • Pares A., Caballeria J., Bruguera M., Torres M. & Rodes J. Histological course of alcoholic hepatitis. Influence of abstinence sex and extent of hepatic damage. J. Hepatol. 2, 33-42 (1986
    • (1986) J. Hepatol , vol.2 , pp. 33-42
    • Pares, A.1    Caballeria, J.2    Bruguera, M.3    Torres, M.4    Rodes, J.5
  • 10
    • 0037227494 scopus 로고    scopus 로고
    • Role of variability in explaining ethanol pharmacokinetics: Research and forensic applications
    • Norberg A., Jones A. W., Hahn R. G. & Gabrielsson J. L. Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. Clin. Pharmacokinet. 42, 1-31 (2003
    • (2003) Clin. Pharmacokinet , vol.42 , pp. 1-31
    • Norberg, A.1    Jones, A.W.2    Hahn, R.G.3    Gabrielsson, J.L.4
  • 11
    • 84867921274 scopus 로고    scopus 로고
    • Alcohol metabolism
    • Cederbaum A. I. Alcohol metabolism. Clin. Liver Dis. 16, 667-685 (2012
    • (2012) Clin. Liver Dis , vol.16 , pp. 667-685
    • Cederbaum, A.I.1
  • 12
    • 0033835308 scopus 로고    scopus 로고
    • Alcohol: Its metabolism and interaction with nutrients
    • Lieber C. S. ALCOHOL: its metabolism and interaction with nutrients. Ann. Rev. Nutr. 20, 395-430 (2000
    • (2000) Ann. Rev. Nutr , vol.20 , pp. 395-430
    • Lieber, C.S.1
  • 13
    • 12844288099 scopus 로고    scopus 로고
    • Alcoholic fatty liver: Its pathogenesis and mechanism of progression to inflammation and fibrosis
    • Lieber C. S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 34, 9-19 (2004
    • (2004) Alcohol , vol.34 , pp. 9-19
    • Lieber, C.S.1
  • 14
    • 39149123560 scopus 로고    scopus 로고
    • Cyp2e1 and oxidative liver injury by alcohol
    • Lu Y. & Cederbaum A. I. CYP2E1 and oxidative liver injury by alcohol. Free Radic. Biol. Med. 44, 723-738 (2008
    • (2008) Free Radic. Biol. Med , vol.44 , pp. 723-738
    • Lu, Y.1    Cederbaum, A.I.2
  • 15
    • 0033053587 scopus 로고    scopus 로고
    • Microsomal ethanol-oxidizing system (meos): The first 30 years 1968-1998)-a review
    • Lieber C. S. Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)-a review. Alcohol. Clin. Exp. Res. 23, 991-1007 (1999
    • (1999) Alcohol. Clin. Exp. Res , vol.23 , pp. 991-1007
    • Lieber, C.S.1
  • 16
    • 33747605553 scopus 로고    scopus 로고
    • Cytochrome p450 2e1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells
    • Cederbaum A. I. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J. Gastroenterol. Hepatol. 21 (Suppl. 3), S22-S25 (2006
    • (2006) J. Gastroenterol. Hepatol , vol.21 , pp. S22-S25
    • Cederbaum, A.I.1
  • 17
    • 0035893937 scopus 로고    scopus 로고
    • The role of Kupffer cell oxidant production in early ethanol-induced liver disease
    • Wheeler M. D., et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic. Biol. Med. 31, 1544-1549 (2001
    • (2001) Free Radic. Biol. Med , vol.31 , pp. 1544-1549
    • Wheeler, M.D.1
  • 18
    • 34648830569 scopus 로고    scopus 로고
    • Role of iron in hepatic fibrosis: One piece in the puzzle
    • Philippe M. A., Ruddell R. G. & Ramm G. A. Role of iron in hepatic fibrosis: one piece in the puzzle. World J. Gastroenterol. 13, 4746-4754 (2007
    • (2007) World J. Gastroenterol , vol.13 , pp. 4746-4754
    • Philippe, M.A.1    Ruddell, R.G.2    Ramm, G.A.3
  • 19
    • 0029160569 scopus 로고
    • Experimental liver cirrhosis induced by alcohol and iron
    • Tsukamoto H., et al. Experimental liver cirrhosis induced by alcohol and iron. J. Clin. Invest. 96, 620-630 (1995
    • (1995) J. Clin. Invest , vol.96 , pp. 620-630
    • Tsukamoto, H.1
  • 20
    • 84919465499 scopus 로고    scopus 로고
    • Cell death and cell death responses in liver disease: Mechanisms and clinical relevance
    • Luedde T., Kaplowitz N. & Schwabe R. F. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 147, 765-783 (2014
    • (2014) Gastroenterology , vol.147 , pp. 765-783
    • Luedde, T.1    Kaplowitz, N.2    Schwabe, R.F.3
  • 21
    • 84882827495 scopus 로고    scopus 로고
    • Decoding cell death signals in liver inflammation
    • Brenner C., Galluzzi L., Kepp O. & Kroemer G. Decoding cell death signals in liver inflammation. J. Hepatol. 59, 583-594 (2013
    • (2013) J. Hepatol , vol.59 , pp. 583-594
    • Brenner, C.1    Galluzzi, L.2    Kepp, O.3    Kroemer, G.4
  • 23
    • 0025979356 scopus 로고
    • Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress
    • Fernandez-Checa J. C., Garcia-Ruiz C., Ookhtens M. & Kaplowitz N. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J. Clin. Invest. 87, 397-405 (1991
    • (1991) J. Clin. Invest , vol.87 , pp. 397-405
    • Fernandez-Checa, J.C.1    Garcia-Ruiz, C.2    Ookhtens, M.3    Kaplowitz, N.4
  • 24
    • 0024604102 scopus 로고
    • Effects of chronic ethanol feeding on rat hepatocytic glutathione relationship of cytosolic glutathione to efflux and mitochondrial sequestration
    • Fernandez-Checa J. C., Ookhtens M. & Kaplowitz N. Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J. Clin. Invest. 83, 1247-1252 (1989
    • (1989) J. Clin. Invest , vol.83 , pp. 1247-1252
    • Fernandez-Checa, J.C.1    Ookhtens, M.2    Kaplowitz, N.3
  • 25
    • 0026493715 scopus 로고
    • Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats
    • Hirano T., Kaplowitz N., Tsukamoto H., Kamimura S. & Fernandez-Checa J. C. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16, 1423-1427 (1992
    • (1992) Hepatology , vol.16 , pp. 1423-1427
    • Hirano, T.1    Kaplowitz, N.2    Tsukamoto, H.3    Kamimura, S.4    Fernandez-Checa, J.C.5
  • 26
    • 0035965322 scopus 로고    scopus 로고
    • Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat
    • Wheeler M. D., et al. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J. Biol. Chem. 276, 36664-36672 (2001
    • (2001) J. Biol. Chem , vol.276 , pp. 36664-36672
    • Wheeler, M.D.1
  • 28
    • 0027739805 scopus 로고
    • Mitochondrial glutathione depletion in alcoholic liver disease
    • Fernandez-Checa J. C., Hirano T., Tsukamoto H. & Kaplowitz N. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol 10, 469-475 (1993
    • (1993) Alcohol , vol.10 , pp. 469-475
    • Fernandez-Checa, J.C.1    Hirano, T.2    Tsukamoto, H.3    Kaplowitz, N.4
  • 29
    • 1642481240 scopus 로고    scopus 로고
    • Heme oxygenase 1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity
    • Gong P., Cederbaum A. I. & Nieto N. Heme oxygenase 1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Free Radic. Biol. Med. 36, 307-318 (2004
    • (2004) Free Radic. Biol. Med , vol.36 , pp. 307-318
    • Gong, P.1    Cederbaum, A.I.2    Nieto, N.3
  • 30
    • 84867579475 scopus 로고    scopus 로고
    • Stress management: How the unfolded protein response impacts fatty liver disease
    • Imrie D. & Sadler K. C. Stress management: how the unfolded protein response impacts fatty liver disease. J. Hepatol. 57, 1147-1151 (2012
    • (2012) J. Hepatol , vol.57 , pp. 1147-1151
    • Imrie, D.1    Sadler, K.C.2
  • 31
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • Malhi H. & Kaufman R. J. Endoplasmic reticulum stress in liver disease. J. Hepatol. 54, 795-809 (2011
    • (2011) J. Hepatol , vol.54 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 32
    • 4043064391 scopus 로고    scopus 로고
    • Role of TNF-α in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury
    • Ji C., Deng Q. & Kaplowitz N. Role of TNF-α in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology 40, 442-451 (2004
    • (2004) Hepatology , vol.40 , pp. 442-451
    • Ji, C.1    Deng, Q.2    Kaplowitz, N.3
  • 33
    • 84885332714 scopus 로고    scopus 로고
    • Sting-irf3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
    • Petrasek J., et al. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc. Natl Acad. Sci. USA 110, 16544-16549 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16544-16549
    • Petrasek, J.1
  • 34
    • 21744436422 scopus 로고    scopus 로고
    • Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs
    • Esfandiari F., Villanueva J. A., Wong D. H., French S. W. & Halsted C. H. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am. J. Physiol. 289, G54-G63 (2005
    • (2005) Am. J. Physiol , vol.289 , pp. G54-G63
    • Esfandiari, F.1    Villanueva, J.A.2    Wong, D.H.3    French, S.W.4    Halsted, C.H.5
  • 35
    • 40749083206 scopus 로고    scopus 로고
    • Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
    • Ji C. Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J. Gastroenterol. Hepatol. 23 (Suppl. 1), S16-S24 (2008
    • (2008) J. Gastroenterol. Hepatol , vol.23 , pp. S16-S24
    • Ji, C.1
  • 37
    • 0037960128 scopus 로고    scopus 로고
    • Betaine decreases hyperhomocysteinemia endoplasmic reticulum stress and liver injury in alcohol-fed mice
    • Ji C. & Kaplowitz N. Betaine decreases hyperhomocysteinemia endoplasmic reticulum stress and liver injury in alcohol-fed mice. Gastroenterology 124, 1488-1499 (2003
    • (2003) Gastroenterology , vol.124 , pp. 1488-1499
    • Ji, C.1    Kaplowitz, N.2
  • 38
    • 84879160597 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy
    • Hernandez-Gea V., et al. Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J. Hepatol. 59, 98-104 (2013
    • (2013) J. Hepatol , vol.59 , pp. 98-104
    • Hernandez-Gea, V.1
  • 39
    • 0037047284 scopus 로고    scopus 로고
    • Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (srebp
    • You M., Fischer M., Deeg M. A. & Crabb D. W. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J. Biol. Chem. 277, 29342-29347 (2002
    • (2002) J. Biol. Chem , vol.277 , pp. 29342-29347
    • You, M.1    Fischer, M.2    Deeg, M.A.3    Crabb, D.W.4
  • 40
    • 34247604581 scopus 로고    scopus 로고
    • Tnf-α induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (srebp-1c
    • Endo M., Masaki T., Seike M. & Yoshimatsu H. TNF-α induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp. Biol. Med (Maywood) 232, 614-621 (2007
    • (2007) Exp. Biol. Med (Maywood , vol.232 , pp. 614-621
    • Endo, M.1    Masaki, T.2    Seike, M.3    Yoshimatsu, H.4
  • 41
    • 0032570828 scopus 로고    scopus 로고
    • Tumor necrosis factor-α stimulates the maturation of sterol regulatory element binding protein 1 in human hepatocytes through the action of neutral sphingomyelinase
    • Lawler J. F. Jr Yin M., Diehl A. M., Roberts E. & Chatterjee S. Tumor necrosis factor-α stimulates the maturation of sterol regulatory element binding protein 1 in human hepatocytes through the action of neutral sphingomyelinase. J. Biol. Chem. 273, 5053-5059 (1998
    • (1998) J. Biol. Chem , vol.273 , pp. 5053-5059
    • Lawler, J.F.1    Yin, M.2    Diehl, A.M.3    Roberts, E.4    Chatterjee, S.5
  • 42
    • 4644353364 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
    • Nakajima T., et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 40, 972-980 (2004
    • (2004) Hepatology , vol.40 , pp. 972-980
    • Nakajima, T.1
  • 43
    • 0035808410 scopus 로고    scopus 로고
    • The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism a novel mechanism for the development of ethanol-induced fatty liver
    • Galli A., Pinaire J., Fischer M., Dorris R. & Crabb D. W. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J. Biol. Chem. 276, 68-75 (2001
    • (2001) J. Biol. Chem , vol.276 , pp. 68-75
    • Galli, A.1    Pinaire, J.2    Fischer, M.3    Dorris, R.4    Crabb, D.W.5
  • 44
    • 0042847330 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (pparalpha) agonist treatment reverses pparalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
    • Fischer M., You M., Matsumoto M. & Crabb D. W. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J. Biol. Chem. 278, 27997-28004 (2003
    • (2003) J. Biol. Chem , vol.278 , pp. 27997-28004
    • Fischer, M.1    You, M.2    Matsumoto, M.3    Crabb, D.W.4
  • 45
    • 50349090249 scopus 로고    scopus 로고
    • Alcohol-intoxicating roadblocks and bottlenecks in hepatic protein and lipid metabolism
    • Molina P. E. Alcohol-intoxicating roadblocks and bottlenecks in hepatic protein and lipid metabolism. Am. J. Physiol. Endocrinol. Metab. 295, E1-E2 (2008
    • (2008) Am. J. Physiol. Endocrinol. Metab , vol.295 , pp. E1-E2
    • Molina, P.E.1
  • 46
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167-1174 (2001
    • (2001) J. Clin. Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1
  • 47
    • 38949104356 scopus 로고    scopus 로고
    • Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
    • Garcia-Villafranca J., Guillen A. & Castro J. Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver. Biochimie 90, 460-466 (2008
    • (2008) Biochimie , vol.90 , pp. 460-466
    • Garcia-Villafranca, J.1    Guillen, A.2    Castro, J.3
  • 48
    • 3042550657 scopus 로고    scopus 로고
    • Recent advances in alcoholic liver disease i minireview: Molecular mechanisms of alcoholic fatty liver
    • You M. & Crabb D. W. Recent advances in alcoholic liver disease. I. Minireview: molecular mechanisms of alcoholic fatty liver. Am. J. Physiol. 287, G1-G6 (2004
    • (2004) Am. J. Physiol , vol.287 , pp. G1-G6
    • You, M.1    Crabb, D.W.2
  • 49
    • 84894348922 scopus 로고    scopus 로고
    • Deletion of sirt1 from hepatocytes in mice disrupts lipin 1 signaling and aggravates alcoholic fatty liver
    • Yin H., et al. Deletion of SIRT1 from hepatocytes in mice disrupts lipin 1 signaling and aggravates alcoholic fatty liver. Gastroenterology 146, 801-811 (2014
    • (2014) Gastroenterology , vol.146 , pp. 801-811
    • Yin, H.1
  • 50
    • 42049113608 scopus 로고    scopus 로고
    • Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
    • You M., Liang X., Ajmo J. M. & Ness G. C. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am. J. Physiol. 294, G892-G898 (2008
    • (2008) Am. J. Physiol , vol.294 , pp. G892-G898
    • You, M.1    Liang, X.2    Ajmo, J.M.3    Ness, G.C.4
  • 51
    • 38649114788 scopus 로고    scopus 로고
    • Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    • Jeong W. I., et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell. Metab. 7, 227-235 (2008
    • (2008) Cell. Metab , vol.7 , pp. 227-235
    • Jeong, W.I.1
  • 52
    • 80053314254 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
    • Louvet A., et al. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology 54, 1217-1226 (2011
    • (2011) Hepatology , vol.54 , pp. 1217-1226
    • Louvet, A.1
  • 53
    • 34047131669 scopus 로고    scopus 로고
    • Hepatic gene expression and lipid parameters in complement C3-/- mice that do not develop ethanol-induced steatosis
    • Bykov I., et al. Hepatic gene expression and lipid parameters in complement C3-/- mice that do not develop ethanol-induced steatosis. J. Hepatol. 46, 907-914 (2007
    • (2007) J. Hepatol , vol.46 , pp. 907-914
    • Bykov, I.1
  • 54
    • 77955474503 scopus 로고    scopus 로고
    • Complement and alcoholic liver disease: Role of C1q in the pathogenesis of ethanol-induced liver injury in mice
    • Cohen J. I., Roychowdhury S., McMullen M. R., Stavitsky A. B. & Nagy L. E. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 139, 664-674. (2010
    • (2010) Gastroenterology , vol.139 , pp. 664-674
    • Cohen, J.I.1    Roychowdhury, S.2    McMullen, M.R.3    Stavitsky, A.B.4    Nagy, L.E.5
  • 55
    • 33947320624 scopus 로고    scopus 로고
    • Differential contributions of C3 C5, and decay-accelerating factor to ethanol-induced fatty liver in mice
    • Pritchard M. T., et al. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132, 1117-1126 (2007
    • (2007) Gastroenterology , vol.132 , pp. 1117-1126
    • Pritchard, M.T.1
  • 56
    • 10744221756 scopus 로고    scopus 로고
    • Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c met
    • Tomita K., et al. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c Met. Gastroenterology 126, 873-885 (2004
    • (2004) Gastroenterology , vol.126 , pp. 873-885
    • Tomita, K.1
  • 57
    • 77952549747 scopus 로고    scopus 로고
    • Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease
    • Naveau S., et al. Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease. J. Hepatol. 52, 895-902 (2010
    • (2010) J. Hepatol , vol.52 , pp. 895-902
    • Naveau, S.1
  • 58
    • 0031012322 scopus 로고    scopus 로고
    • Excess weight risk factor for alcoholic liver disease
    • Naveau S. Excess weight risk factor for alcoholic liver disease. Hepatology 25, 108-111 (1997
    • (1997) Hepatology , vol.25 , pp. 108-111
    • Naveau, S.1
  • 59
    • 0036185832 scopus 로고    scopus 로고
    • Risk factors of fibrosis in alcohol-induced liver disease
    • Raynard B., et al. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology 35, 635-638 (2002
    • (2002) Hepatology , vol.35 , pp. 635-638
    • Raynard, B.1
  • 60
    • 84863987868 scopus 로고    scopus 로고
    • Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (nafld
    • Dunn W., et al. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD). J. Hepatol. 57, 384-391 (2012
    • (2012) J. Hepatol , vol.57 , pp. 384-391
    • Dunn, W.1
  • 61
    • 34548267629 scopus 로고    scopus 로고
    • Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines
    • Kang L., et al. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol. Clin. Exp. Res. 31, 1581-1588 (2007
    • (2007) Alcohol. Clin. Exp. Res , vol.31 , pp. 1581-1588
    • Kang, L.1
  • 62
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A., et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112, 91-100 (2003
    • (2003) J. Clin. Invest , vol.112 , pp. 91-100
    • Xu, A.1
  • 63
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288-1295 (2002
    • (2002) Nat. Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1
  • 64
    • 24144496133 scopus 로고    scopus 로고
    • Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • You M., Considine R. V., Leone T. C., Kelly D. P. & Crabb D. W. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42, 568-577 (2005
    • (2005) Hepatology , vol.42 , pp. 568-577
    • You, M.1    Considine, R.V.2    Leone, T.C.3    Kelly, D.P.4    Crabb, D.W.5
  • 65
    • 40949119415 scopus 로고    scopus 로고
    • Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease
    • Song Z., Zhou Z., Deaciuc I., Chen T. & McClain C. J. Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease. Hepatology 47, 867-879 (2008
    • (2008) Hepatology , vol.47 , pp. 867-879
    • Song, Z.1    Zhou, Z.2    Deaciuc, I.3    Chen, T.4    McClain, C.J.5
  • 66
    • 0033765501 scopus 로고    scopus 로고
    • Exacerbation of alcoholic liver injury by enteral endotoxin in rats
    • Mathurin P., et al. Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32, 1008-1017 (2000
    • (2000) Hepatology , vol.32 , pp. 1008-1017
    • Mathurin, P.1
  • 67
    • 0342699553 scopus 로고    scopus 로고
    • Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
    • Parlesak A., Schafer C., Schutz T., Bode J. C. & Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J. Hepatol. 32, 742-747 (2000
    • (2000) J. Hepatol , vol.32 , pp. 742-747
    • Parlesak, A.1    Schafer, C.2    Schutz, T.3    Bode, J.C.4    Bode, C.5
  • 68
    • 0036667819 scopus 로고    scopus 로고
    • Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats
    • Suppl
    • Tamai H., Horie Y., Kato S., Yokoyama H. & Ishii H. Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats. Alcohol. Clin. Exp. Res. 26 (8 Suppl.) 75S-80S (2002
    • (2002) Alcohol. Clin. Exp. Res , vol.26 , Issue.8 , pp. 75S-80S
    • Tamai, H.1    Horie, Y.2    Kato, S.3    Yokoyama, H.4    Ishii, H.5
  • 69
    • 0034014905 scopus 로고    scopus 로고
    • Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: Relation to severity of liver disturbance
    • Suppl
    • Fujimoto M., et al. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance. Alcohol. Clin. Exp. Res. 24 (4 Suppl.) 48S-54S (2000
    • (2000) Alcohol. Clin. Exp. Res , vol.24 , Issue.4 , pp. 48S-54S
    • Fujimoto, M.1
  • 70
    • 0031769233 scopus 로고    scopus 로고
    • Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis
    • Hanck C., Rossol S., Bocker U., Tokus M., Singer M. V. Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis. Alcohol Alcohol. 33, 606-608 (1998
    • (1998) Alcohol Alcohol , vol.33 , pp. 606-608
    • Hanck, C.1    Rossol, S.2    Bocker, U.3    Tokus, M.4    Singer, M.V.5
  • 71
    • 0023222579 scopus 로고
    • Endotoxin induced hepatic necrosis in rats on an alcohol diet
    • Bhagwandeen B. S., Apte M., Manwarring L. & Dickeson J. Endotoxin induced hepatic necrosis in rats on an alcohol diet. J. Pathol. 152, 47-53 (1987
    • (1987) J. Pathol , vol.152 , pp. 47-53
    • Bhagwandeen, B.S.1    Apte, M.2    Manwarring, L.3    Dickeson, J.4
  • 72
    • 0028796860 scopus 로고
    • Antibiotics prevent liver injury in rats following long-term exposure to ethanol
    • Adachi Y., Moore L. E., Bradford B. U., Gao W. & Thurman R. G. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108, 218-224 (1995
    • (1995) Gastroenterology , vol.108 , pp. 218-224
    • Adachi, Y.1    Moore, L.E.2    Bradford, B.U.3    Gao, W.4    Thurman, R.G.5
  • 73
    • 0028220726 scopus 로고
    • Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease
    • Nanji A. A., Khettry U. & Sadrzadeh S. M. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc. Soc. Exp. Biol Med. 205, 243-247 (1994
    • (1994) Proc. Soc. Exp. Biol Med , vol.205 , pp. 243-247
    • Nanji, A.A.1    Khettry, U.2    Sadrzadeh, S.M.3
  • 74
    • 33646539166 scopus 로고    scopus 로고
    • Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver
    • Gustot T., et al. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology 43, 989-1000 (2006
    • (2006) Hepatology , vol.43 , pp. 989-1000
    • Gustot, T.1
  • 75
    • 33744901148 scopus 로고    scopus 로고
    • TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes
    • Oak S., Mandrekar P., Catalano D., Kodys K. & Szabo G. TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J. Immunol. 176, 7628-7635 (2006
    • (2006) J. Immunol , vol.176 , pp. 7628-7635
    • Oak, S.1    Mandrekar, P.2    Catalano, D.3    Kodys, K.4    Szabo, G.5
  • 76
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • Guha M. & Mackman N. LPS induction of gene expression in human monocytes. Cell. Signal. 13, 85-94 (2001
    • (2001) Cell. Signal , vol.13 , pp. 85-94
    • Guha, M.1    MacKman, N.2
  • 77
    • 0037424240 scopus 로고    scopus 로고
    • Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP 1 pathway
    • Wheeler M. D. & Thurman R. G. Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP 1 pathway. J. Biol. Chem. 278, 8435-8441 (2003
    • (2003) J. Biol. Chem , vol.278 , pp. 8435-8441
    • Wheeler, M.D.1    Thurman, R.G.2
  • 78
    • 54449092214 scopus 로고    scopus 로고
    • The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    • Hritz I., et al. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 48, 1224-1231 (2008
    • (2008) Hepatology , vol.48 , pp. 1224-1231
    • Hritz, I.1
  • 79
    • 32044457123 scopus 로고    scopus 로고
    • Oxidative stress and signal transduction pathways in alcoholic liver disease
    • Suppl
    • Zima T. & Kalousova M. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcohol. Clin. Exp. Res. 29 (11 Suppl.) 110S-115S (2005
    • (2005) Alcohol. Clin. Exp. Res , vol.29 , Issue.11 , pp. 110S-115S
    • Zima, T.1    Kalousova, M.2
  • 80
    • 40749104940 scopus 로고    scopus 로고
    • Oxidative stress in alcoholic liver disease: Role of nadph oxidase complex
    • De Minicis S. & Brenner D. A. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. J. Gastroenterol. Hepatol. 23 (Suppl. 1) S98-S103 (2008
    • (2008) J. Gastroenterol. Hepatol , vol.23 , pp. S98-S103
    • De Minicis, S.1    Brenner, D.A.2
  • 81
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • Uesugi T., Froh M., Arteel G. E., Bradford B. U. & Thurman R. G. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34, 101-108 (2001
    • (2001) Hepatology , vol.34 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Thurman, R.G.5
  • 82
    • 53449098862 scopus 로고    scopus 로고
    • Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis
    • Xiong S., et al. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Am. J. Physiol. 295, G512-G521 (2008
    • (2008) Am. J. Physiol , vol.295 , pp. G512-G521
    • Xiong, S.1
  • 83
    • 0030858597 scopus 로고    scopus 로고
    • Role of iron in NF kappa B activation and cytokine gene expression by rat hepatic macrophages
    • Lin M., Rippe R. A., Niemela O., Brittenham G. & Tsukamoto H. Role of iron in NF kappa B activation and cytokine gene expression by rat hepatic macrophages. Am. J. Physiol. 272, G1355-G1364 (1997
    • (1997) Am. J. Physiol , vol.272 , pp. G1355-G1364
    • Lin, M.1    Rippe, R.A.2    Niemela, O.3    Brittenham, G.4    Tsukamoto, H.5
  • 84
    • 0036720960 scopus 로고    scopus 로고
    • Iron activates NF kappaB in Kupffer cells
    • She H., et al. Iron activates NF kappaB in Kupffer cells. Am. J. Physiol. 283, G719-G726 (2002
    • (2002) Am. J. Physiol , vol.283 , pp. G719-G726
    • She, H.1
  • 85
    • 0033373209 scopus 로고    scopus 로고
    • Iron primes hepatic macrophages for NF kappaB activation in alcoholic liver injury
    • Tsukamoto H., et al. Iron primes hepatic macrophages for NF kappaB activation in alcoholic liver injury. Am. J. Physiol. 277, G1240-G1250 (1999
    • (1999) Am. J. Physiol , vol.277 , pp. G1240-G1250
    • Tsukamoto, H.1
  • 86
    • 0031685777 scopus 로고    scopus 로고
    • Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis
    • Afford S. C., et al. Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. J. Pathol. 186, 82-89 (1998
    • (1998) J. Pathol , vol.186 , pp. 82-89
    • Afford, S.C.1
  • 87
    • 33847039276 scopus 로고    scopus 로고
    • Hepatic expression of candidate genes in patients with alcoholic hepatitis: Correlation with disease severity
    • Colmenero J., et al. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. Gastroenterology 132, 687-697 (2007
    • (2007) Gastroenterology , vol.132 , pp. 687-697
    • Colmenero, J.1
  • 88
    • 0029957573 scopus 로고    scopus 로고
    • Chemokine levels in human liver homogenates: Associations between GRO alpha and histopathological evidence of alcoholic hepatitis
    • Maltby J., Wright S., Bird G. & Sheron N. Chemokine levels in human liver homogenates: associations between GRO alpha and histopathological evidence of alcoholic hepatitis. Hepatology 24, 1156-1160 (1996
    • (1996) Hepatology , vol.24 , pp. 1156-1160
    • Maltby, J.1    Wright, S.2    Bird, G.3    Sheron, N.4
  • 89
    • 0342368653 scopus 로고    scopus 로고
    • Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: Effect of corticosteroids
    • Taieb J., et al. Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. J. Hepatol. 32, 579-586 (2000
    • (2000) J. Hepatol , vol.32 , pp. 579-586
    • Taieb, J.1
  • 90
    • 84876707996 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury steatohepatitis and steatosis
    • Barnes M. A., et al. Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury steatohepatitis and steatosis. Hepatology 57, 1980-1991 (2013
    • (2013) Hepatology , vol.57 , pp. 1980-1991
    • Barnes, M.A.1
  • 91
    • 82455167937 scopus 로고    scopus 로고
    • An essential role for monocyte chemoattractant protein 1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice
    • Mandrekar P., Ambade A., Lim A., Szabo G. & Catalano D. An essential role for monocyte chemoattractant protein 1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology 54, 2185-2197 (2011
    • (2011) Hepatology , vol.54 , pp. 2185-2197
    • Mandrekar, P.1    Ambade, A.2    Lim, A.3    Szabo, G.4    Catalano, D.5
  • 92
    • 84894798789 scopus 로고    scopus 로고
    • M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
    • Wan J., et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 59, 130-142 (2014
    • (2014) Hepatology , vol.59 , pp. 130-142
    • Wan, J.1
  • 93
    • 84872366958 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin 10 in mice
    • Byun J. S., Suh Y. G., Yi H. S., Lee Y. S. & Jeong W. I. Activation of Toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin 10 in mice. J. Hepatol. 58, 342-349 (2013
    • (2013) J. Hepatol , vol.58 , pp. 342-349
    • Byun, J.S.1    Suh, Y.G.2    Yi, H.S.3    Lee, Y.S.4    Jeong, W.I.5
  • 94
    • 2142653007 scopus 로고    scopus 로고
    • Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption
    • Minagawa M., Deng Q., Liu Z. X., Tsukamoto H. & Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology 126, 1387-1399 (2004
    • (2004) Gastroenterology , vol.126 , pp. 1387-1399
    • Minagawa, M.1    Deng, Q.2    Liu, Z.X.3    Tsukamoto, H.4    Dennert, G.5
  • 95
    • 58849132562 scopus 로고    scopus 로고
    • A recent perspective on alcohol immunity and host defense
    • Szabo G. & Mandrekar P. A recent perspective on alcohol immunity and host defense. Alcohol. Clin. Exp. Res. 33, 220-232 (2009
    • (2009) Alcohol. Clin. Exp. Res , vol.33 , pp. 220-232
    • Szabo, G.1    Mandrekar, P.2
  • 96
    • 24044432235 scopus 로고    scopus 로고
    • Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells
    • Brun P., Castagliuolo I., Pinzani M., Palu G. & Martines D. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am. J. Physiol. 289, G571-G578 (2005
    • (2005) Am. J. Physiol , vol.289 , pp. G571-G578
    • Brun, P.1    Castagliuolo, I.2    Pinzani, M.3    Palu, G.4    Martines, D.5
  • 97
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik Y. H., et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37, 1043-1055 (2003
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1
  • 98
    • 21644434942 scopus 로고    scopus 로고
    • Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes
    • Thirunavukkarasu C., Uemura T., Wang L. F., Watkins S. C. & Gandhi C. R. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes. J. Cell. Physiol. 204, 654-665 (2005
    • (2005) J. Cell. Physiol , vol.204 , pp. 654-665
    • Thirunavukkarasu, C.1    Uemura, T.2    Wang, L.F.3    Watkins, S.C.4    Gandhi, C.R.5
  • 99
    • 78751537350 scopus 로고    scopus 로고
    • Enteric dysbiosis associated with a mouse model of alcoholic liver disease
    • Yan A. W., et al. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology 53, 96-105 (2011
    • (2011) Hepatology , vol.53 , pp. 96-105
    • Yan, A.W.1
  • 100
    • 70349335851 scopus 로고    scopus 로고
    • Intestinal dysbiosis: A possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    • Mutlu E., et al. Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol. Clin. Exp. Res. 33, 1836-1846 (2009
    • (2009) Alcohol. Clin. Exp. Res , vol.33 , pp. 1836-1846
    • Mutlu, E.1
  • 101
    • 84923468701 scopus 로고    scopus 로고
    • Dysbiosis-induced intestinal inflammation activates tumor necrosis factor i and mediates alcoholic liver disease in mice
    • Chen P., Starkel P., Turner J. R., Ho S. B. & Schnabl B. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor I and mediates alcoholic liver disease in mice. Hepatology http://dx.doi.org/10.1002/hep.27489
    • Hepatology
    • Chen, P.1    Starkel, P.2    Turner, J.R.3    Ho, S.B.4    Schnabl, B.5
  • 102
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B. & Brenner D. A. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146, 1513-1524 (2014
    • (2014) Gastroenterology , vol.146 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 103
    • 84922630906 scopus 로고    scopus 로고
    • Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice
    • Chen P., et al. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology 148, 203-214 (2014
    • (2014) Gastroenterology , vol.148 , pp. 203-214
    • Chen, P.1
  • 104
    • 84860515098 scopus 로고    scopus 로고
    • Colonic microbiome is altered in alcoholism
    • Mutlu E. A., et al. Colonic microbiome is altered in alcoholism. Am. J. Physiol. 302, G966-G978 (2012
    • (2012) Am. J. Physiol , vol.302 , pp. G966-G978
    • Mutlu, E.A.1
  • 105
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin N., et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 513, 59-64 (2014
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1
  • 106
    • 61349161828 scopus 로고    scopus 로고
    • Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress gut leakiness and liver injury in a rat model of alcoholic steatohepatitis
    • Forsyth C. B., et al. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress gut leakiness and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43, 163-172 (2009
    • (2009) Alcohol , vol.43 , pp. 163-172
    • Forsyth, C.B.1
  • 107
    • 43049181923 scopus 로고    scopus 로고
    • Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis
    • Stadlbauer V., et al. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J. Hepatol. 48, 945-951 (2008
    • (2008) J. Hepatol , vol.48 , pp. 945-951
    • Stadlbauer, V.1
  • 108
    • 56349169101 scopus 로고    scopus 로고
    • Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: A pilot study
    • Kirpich I. A., et al. Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study. Alcohol 42, 675-682 (2008
    • (2008) Alcohol , vol.42 , pp. 675-682
    • Kirpich, I.A.1
  • 109
    • 80054913827 scopus 로고    scopus 로고
    • Targeting gut microbiota in obesity: Effects of prebiotics and probiotics
    • Delzenne N. M., Neyrinck A. M., Backhed F. & Cani P. D. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639-646 (2011
    • (2011) Nat. Rev. Endocrinol , vol.7 , pp. 639-646
    • Delzenne, N.M.1    Neyrinck, A.M.2    Backhed, F.3    Cani, P.D.4
  • 111
    • 10844265570 scopus 로고    scopus 로고
    • Recent events in alcoholic liver disease v effects of ethanol on liver regeneration
    • Diehl A. M. Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration. Am. J. Physiol. 288, G1-G6 (2005
    • (2005) Am. J. Physiol , vol.288 , pp. G1-G6
    • Diehl, A.M.1
  • 112
    • 78651447817 scopus 로고    scopus 로고
    • Liver regeneration: Alternative epithelial pathways
    • Michalopoulos G. K. Liver regeneration: alternative epithelial pathways. Int. J. Biochem. Cell Biol. 43, 173-179 (2011
    • (2011) Int. J. Biochem. Cell Biol , vol.43 , pp. 173-179
    • Michalopoulos, G.K.1
  • 113
    • 47149092247 scopus 로고    scopus 로고
    • An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha
    • Cosgrove B. D., et al. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology 48, 276-288 (2008
    • (2008) Hepatology , vol.48 , pp. 276-288
    • Cosgrove, B.D.1
  • 114
    • 84887025014 scopus 로고    scopus 로고
    • Loss of caspase 8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation
    • Freimuth J., et al. Loss of caspase 8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation. Hepatology 58, 1779-1789 (2013
    • (2013) Hepatology , vol.58 , pp. 1779-1789
    • Freimuth, J.1
  • 115
    • 77950625278 scopus 로고    scopus 로고
    • Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity
    • Wang H., et al. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology 51, 1354-1362 (2010
    • (2010) Hepatology , vol.51 , pp. 1354-1362
    • Wang, H.1
  • 116
    • 0031787394 scopus 로고    scopus 로고
    • Tumor necrosis factor primes hepatocytes for DNA replication in the rat
    • Webber E. M., Bruix J., Pierce R. H. & Fausto N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 28, 1226-1234 (1998
    • (1998) Hepatology , vol.28 , pp. 1226-1234
    • Webber, E.M.1    Bruix, J.2    Pierce, R.H.3    Fausto, N.4
  • 117
    • 84921509612 scopus 로고    scopus 로고
    • Liver is the major source of elevated serum lipocalin 2 levels after bacterial infection or partial hepatectomy: A critical role for il 6/stat3
    • Xu M. J., et al. Liver is the major source of elevated serum lipocalin 2 levels after bacterial infection or partial hepatectomy: a critical role for IL 6/STAT3. Hepatology 61, 692-702 (2015
    • (2015) Hepatology , vol.61 , pp. 692-702
    • Xu, M.J.1
  • 118
    • 0042033294 scopus 로고    scopus 로고
    • Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease
    • Roskams T., et al. Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am. J. Physiol. 163, 1301-1311 (2003
    • (2003) Am. J. Physiol , vol.163 , pp. 1301-1311
    • Roskams, T.1
  • 119
    • 0037066779 scopus 로고    scopus 로고
    • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N terminal kinase and caspase 3 activation
    • Koteish A., Yang S., Lin H., Huang X. & Diehl A. M. Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N terminal kinase and caspase 3 activation. J. Biol. Chem. 277, 13037-13044 (2002
    • (2002) J. Biol. Chem , vol.277 , pp. 13037-13044
    • Koteish, A.1    Yang, S.2    Lin, H.3    Huang, X.4    Diehl, A.M.5
  • 120
    • 84872488869 scopus 로고    scopus 로고
    • Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration
    • Dippold R. P., Vadigepalli R., Gonye G. E., Patra B. & Hoek J. B. Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration. Alcohol. Clin. Exp. Res. 37 (Suppl. 1) E59-E69 (2013
    • (2013) Alcohol. Clin. Exp. Res , vol.37 , pp. E59-E69
    • Dippold, R.P.1    Vadigepalli, R.2    Gonye, G.E.3    Patra, B.4    Hoek, J.B.5
  • 121
    • 42949150926 scopus 로고    scopus 로고
    • Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans
    • Jung Y., et al. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology 134, 1532-1543 (2008
    • (2008) Gastroenterology , vol.134 , pp. 1532-1543
    • Jung, Y.1
  • 122
    • 84861576624 scopus 로고    scopus 로고
    • Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis
    • Sancho-Bru P., et al. Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis. Hepatology 55, 1931-1941 (2012
    • (2012) Hepatology , vol.55 , pp. 1931-1941
    • Sancho-Bru, P.1
  • 123
    • 84926410657 scopus 로고    scopus 로고
    • Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis
    • in press
    • Dubuquoy L., et al. Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis. Gut (in press
    • Gut
    • Dubuquoy, L.1
  • 124
    • 84863516824 scopus 로고    scopus 로고
    • Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
    • Tsuchiya M., et al. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology 56, 130-139 (2012
    • (2012) Hepatology , vol.56 , pp. 130-139
    • Tsuchiya, M.1
  • 125
    • 0000156898 scopus 로고
    • Effects of prolonged ethanol intake: Production of fatty liver despite adequate diets
    • Lieber C. S., Jones D. P. & Decarli L. M. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J. Clin. Invest. 44, 1009-1021 (1965
    • (1965) J. Clin. Invest , vol.44 , pp. 1009-1021
    • Lieber, C.S.1    Jones, D.P.2    Decarli, L.M.3
  • 126
    • 0024326007 scopus 로고
    • Experimental methods of ethanol administration
    • Lieber C. S., DeCarli L. M. & Sorrell M. F. Experimental methods of ethanol administration. Hepatology 10, 501-510 (1989
    • (1989) Hepatology , vol.10 , pp. 501-510
    • Lieber, C.S.1    De Carli, L.M.2    Sorrell, M.F.3
  • 127
    • 0021923933 scopus 로고
    • Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet
    • Tsukamoto H., et al. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5, 224-232 (1985
    • (1985) Hepatology , vol.5 , pp. 224-232
    • Tsukamoto, H.1
  • 128
    • 0011057855 scopus 로고
    • Long-term cannulation model for blood sampling and intragastric infusion in the rat
    • Tsukamoto H., Reidelberger R. D., French S. W. & Largman C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am. J. Physiol. 247, R595-R599 (1984
    • (1984) Am. J. Physiol , vol.247 , pp. R595-R599
    • Tsukamoto, H.1    Reidelberger, R.D.2    French, S.W.3    Largman, C.4
  • 129
    • 45849146525 scopus 로고    scopus 로고
    • Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice
    • von Montfort C., Beier J. I., Guo L., Kaiser J. P. & Arteel G. E. Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice. Am. J. Physiol. 294, G1227-G1234 (2008
    • (2008) Am. J. Physiol , vol.294 , pp. G1227-G1234
    • Von Montfort, C.1    Beier, J.I.2    Guo, L.3    Kaiser, J.P.4    Arteel, G.E.5
  • 130
    • 84887016336 scopus 로고    scopus 로고
    • Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for e selectin
    • Bertola A., Park O. & Gao B. Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E selectin. Hepatology 58, 1814-1823 (2013
    • (2013) Hepatology , vol.58 , pp. 1814-1823
    • Bertola, A.1    Park, O.2    Gao, B.3
  • 131
    • 84900821567 scopus 로고    scopus 로고
    • Animals models of gastrointestinal and liver diseases animal models of alcohol-induced liver disease: Pathophysiology translational relevance and challenges
    • Mathews S., Xu M., Wang H., Bertola A. & Gao B. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology translational relevance and challenges. Am. J. Physiol. 306, G819-G823 (2014
    • (2014) Am. J. Physiol , vol.306 , pp. G819-G823
    • Mathews, S.1    Xu, M.2    Wang, H.3    Bertola, A.4    Gao, B.5
  • 132
    • 84873406215 scopus 로고    scopus 로고
    • Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis
    • Affo S., et al. Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. Gut 62, 452-460 (2013
    • (2013) Gut , vol.62 , pp. 452-460
    • Affo, S.1
  • 133
    • 84899409476 scopus 로고    scopus 로고
    • A histologic scoring system for prognosis of patients with alcoholic hepatitis
    • Altamirano J., et al. A histologic scoring system for prognosis of patients with alcoholic hepatitis. Gastroenterology 146, 1231-1239 (2014
    • (2014) Gastroenterology , vol.146 , pp. 1231-1239
    • Altamirano, J.1
  • 134
    • 84892469998 scopus 로고    scopus 로고
    • Ccl20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis
    • Affo S., et al. CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut 63, 1782-1792 (2014
    • (2014) Gut , vol.63 , pp. 1782-1792
    • Affo, S.1
  • 135
    • 65249087414 scopus 로고    scopus 로고
    • Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis
    • Dominguez M., et al. Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis. Gastroenterology 136, 1639-1650 (2009
    • (2009) Gastroenterology , vol.136 , pp. 1639-1650
    • Dominguez, M.1
  • 136
    • 84887026141 scopus 로고    scopus 로고
    • Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis
    • Morales-Ibanez O., et al. Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology 58, 1742-1756 (2013
    • (2013) Hepatology , vol.58 , pp. 1742-1756
    • Morales-Ibanez, O.1
  • 137
    • 84878887042 scopus 로고    scopus 로고
    • Oncofetal gene sall4 in aggressive hepatocellular carcinoma
    • Yong K. J., et al. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N. Engl. J. Med. 368, 2266-2276 (2013
    • (2013) N. Engl. J. Med , vol.368 , pp. 2266-2276
    • Yong, K.J.1
  • 139
    • 0036105350 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): Individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH
    • Mathurin P., et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J. Hepatol. 36, 480-487 (2002
    • (2002) J. Hepatol , vol.36 , pp. 480-487
    • Mathurin, P.1
  • 140
    • 78651071021 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: Meta-analysis of individual patient data
    • Mathurin P., et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 60, 255-260 (2011
    • (2011) Gut , vol.60 , pp. 255-260
    • Mathurin, P.1
  • 141
    • 22644432242 scopus 로고    scopus 로고
    • Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the glasgow alcoholic hepatitis score
    • Forrest E. H., et al. Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. Gut 54, 1174-1179 (2005
    • (2005) Gut , vol.54 , pp. 1174-1179
    • Forrest, E.H.1
  • 142
    • 55349133034 scopus 로고    scopus 로고
    • A new scoring system for prognostic stratification of patients with alcoholic hepatitis
    • Dominguez M., et al. A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Am. J. Gastroenterol. 103, 2747-2756 (2008
    • (2008) Am. J. Gastroenterol , vol.103 , pp. 2747-2756
    • Dominguez, M.1
  • 143
    • 34250340897 scopus 로고    scopus 로고
    • The Lille model: A new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids
    • Louvet A., et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 45, 1348-1354 (2007
    • (2007) Hepatology , vol.45 , pp. 1348-1354
    • Louvet, A.1
  • 144
    • 84926410656 scopus 로고    scopus 로고
    • Centre Hospitalier Regional Universitaire de Lille
    • Centre Hospitalier Regional Universitaire de Lille. Lille Model. LilleModel.com [online], http://www.lillemodel.com/(2015
    • (2015) Lille Model. LilleModel.com [Online
  • 145
    • 0345448987 scopus 로고    scopus 로고
    • Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone
    • Mathurin P., et al. Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. Hepatology 38, 1363-1369 (2003
    • (2003) Hepatology , vol.38 , pp. 1363-1369
    • Mathurin, P.1
  • 146
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Iimuro Y., Gallucci R. M., Luster M. I., Kono H. & Thurman R. G. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26, 1530-1537 (1997
    • (1997) Hepatology , vol.26 , pp. 1530-1537
    • Iimuro, Y.1    Gallucci, R.M.2    Luster, M.I.3    Kono, H.4    Thurman, R.G.5
  • 147
    • 0032835529 scopus 로고    scopus 로고
    • Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    • Yin M., et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 117, 942-952 (1999
    • (1999) Gastroenterology , vol.117 , pp. 942-952
    • Yin, M.1
  • 148
    • 0032079848 scopus 로고    scopus 로고
    • Plasma levels of soluble tumor necrosis factor receptors p55 and p75 in patients with alcoholic liver disease of increasing severity
    • Naveau S., et al. Plasma levels of soluble tumor necrosis factor receptors p55 and p75 in patients with alcoholic liver disease of increasing severity. J. Hepatol. 28, 778-784 (1998
    • (1998) J. Hepatol , vol.28 , pp. 778-784
    • Naveau, S.1
  • 149
    • 4444220877 scopus 로고    scopus 로고
    • Soluble TNF R1, but not tumor necrosis factor alpha predicts the 3 month mortality in patients with alcoholic hepatitis
    • Spahr L., et al. Soluble TNF R1, but not tumor necrosis factor alpha predicts the 3 month mortality in patients with alcoholic hepatitis. J. Hepatol. 41, 229-234 (2004
    • (2004) J. Hepatol , vol.41 , pp. 229-234
    • Spahr, L.1
  • 150
    • 77954224400 scopus 로고    scopus 로고
    • Theophylline improves steroid sensitivity in acute alcoholic hepatitis
    • Kendrick S. F., Henderson E., Palmer J., Jones D. E. & Day C. P. Theophylline improves steroid sensitivity in acute alcoholic hepatitis. Hepatology 52, 126-131 (2010
    • (2010) Hepatology , vol.52 , pp. 126-131
    • Kendrick, S.F.1    Henderson, E.2    Palmer, J.3    Jones, D.E.4    Day, C.P.5
  • 151
    • 79953747553 scopus 로고    scopus 로고
    • In vitro steroid resistance correlates with outcome in severe alcoholic hepatitis
    • di Mambro A. J., et al. In vitro steroid resistance correlates with outcome in severe alcoholic hepatitis. Hepatology 53, 1316-1322 (2011
    • (2011) Hepatology , vol.53 , pp. 1316-1322
    • Di Mambro, A.J.1
  • 152
    • 84923455758 scopus 로고    scopus 로고
    • Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity
    • Dhanda A. D., et al. Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity. Hepatology http://dx.doi.org/10.1002/hep.27211
    • Hepatology
    • Dhanda, A.D.1
  • 153
    • 77952695807 scopus 로고    scopus 로고
    • Acetate the key modulator of inflammatory responses in acute alcoholic hepatitis
    • Kendrick S. F., et al. Acetate the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology 51, 1988-1997 (2010
    • (2010) Hepatology , vol.51 , pp. 1988-1997
    • Kendrick, S.F.1
  • 154
    • 37749024790 scopus 로고    scopus 로고
    • Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis
    • Hamdi H., et al. Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis. Hepatology 46, 1986-1992 (2007
    • (2007) Hepatology , vol.46 , pp. 1986-1992
    • Hamdi, H.1
  • 155
    • 0038637373 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis
    • Mookerjee R. P., et al. Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis. Gut 52, 1182-1187 (2003
    • (2003) Gut , vol.52 , pp. 1182-1187
    • Mookerjee, R.P.1
  • 156
    • 0036784414 scopus 로고    scopus 로고
    • Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: A randomized controlled pilot study
    • Spahr L., et al. Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study. J. Hepatol. 37, 448-455 (2002
    • (2002) J. Hepatol , vol.37 , pp. 448-455
    • Spahr, L.1
  • 157
    • 0037386110 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    • Tilg H., et al. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J. Hepatol. 38, 419-425 (2003
    • (2003) J. Hepatol , vol.38 , pp. 419-425
    • Tilg, H.1
  • 158
    • 59549100657 scopus 로고    scopus 로고
    • Infliximab monotherapy for severe alcoholic hepatitis and predictors of survival: An open label trial
    • Sharma P., Kumar A., Sharma B. C. & Sarin S. K. Infliximab monotherapy for severe alcoholic hepatitis and predictors of survival: an open label trial. J. Hepatol. 50, 584-591 (2009
    • (2009) J. Hepatol , vol.50 , pp. 584-591
    • Sharma, P.1    Kumar, A.2    Sharma, B.C.3    Sarin, S.K.4
  • 159
    • 2342502025 scopus 로고    scopus 로고
    • A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis
    • Naveau S., et al. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology 39, 1390-1397 (2004
    • (2004) Hepatology , vol.39 , pp. 1390-1397
    • Naveau, S.1
  • 160
    • 57249086241 scopus 로고    scopus 로고
    • A randomized double-blinded placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis
    • Boetticher N. C., et al. A randomized double-blinded placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology 135, 1953-1960 (2008
    • (2008) Gastroenterology , vol.135 , pp. 1953-1960
    • Boetticher, N.C.1
  • 161
    • 78049506154 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor alpha treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C
    • Brenndorfer E. D., et al. Anti-tumor necrosis factor alpha treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C. Hepatology 52, 1553-1563 (2010
    • (2010) Hepatology , vol.52 , pp. 1553-1563
    • Brenndorfer, E.D.1
  • 162
    • 0034465251 scopus 로고    scopus 로고
    • Pentoxifylline improves short term survival in severe acute alcoholic hepatitis: A double-blind placebo-controlled trial
    • Akriviadis E., et al. Pentoxifylline improves short term survival in severe acute alcoholic hepatitis: a double-blind placebo-controlled trial. Gastroenterology 119, 1637-1648 (2000
    • (2000) Gastroenterology , vol.119 , pp. 1637-1648
    • Akriviadis, E.1
  • 163
    • 84864219469 scopus 로고    scopus 로고
    • Corticosteroid plus pentoxifylline is not better than corticosteroid alone for improving survival in severe alcoholic hepatitis (cope trial
    • Sidhu S. S., et al. Corticosteroid plus pentoxifylline is not better than corticosteroid alone for improving survival in severe alcoholic hepatitis (COPE trial). Dig. Dis. Sci. 57, 1664-1671 (2012
    • (2012) Dig. Dis. Sci , vol.57 , pp. 1664-1671
    • Sidhu, S.S.1
  • 164
    • 64549087112 scopus 로고    scopus 로고
    • Pentoxifylline versus prednisolone for severe alcoholic hepatitis: A randomized controlled trial
    • De B. K., et al. Pentoxifylline versus prednisolone for severe alcoholic hepatitis: a randomized controlled trial. World J. Gastroenterol. 15, 1613-1619 (2009
    • (2009) World J. Gastroenterol , vol.15 , pp. 1613-1619
    • De, B.K.1
  • 165
    • 0026344142 scopus 로고
    • Pentoxifylline suppression of tumor necrosis factor gene transcription
    • Doherty G. M., Jensen J. C., Alexander H. R., Buresh C. M. & Norton J. A. Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 110, 192-198 (1991
    • (1991) Surgery , vol.110 , pp. 192-198
    • Doherty, G.M.1    Jensen, J.C.2    Alexander, H.R.3    Buresh, C.M.4    Norton, J.A.5
  • 166
    • 0025282043 scopus 로고
    • Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
    • Han J., Thompson P. & Beutler B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J. Exp. Med. 172, 391-394 (1990
    • (1990) J. Exp. Med , vol.172 , pp. 391-394
    • Han, J.1    Thompson, P.2    Beutler, B.3
  • 167
    • 39149086057 scopus 로고    scopus 로고
    • Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids
    • Louvet A., et al. Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids. J. Hepatol. 48, 465-470 (2008
    • (2008) J. Hepatol , vol.48 , pp. 465-470
    • Louvet, A.1
  • 168
    • 84883734359 scopus 로고    scopus 로고
    • Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: A randomized clinical trial
    • Mathurin P., et al. Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. JAMA 310, 1033-1041 (2013
    • (2013) Jama , vol.310 , pp. 1033-1041
    • Mathurin, P.1
  • 169
    • 84938912078 scopus 로고    scopus 로고
    • Pentoxifylline vs corticosteroid to treat severe alcoholic hepatitis: A randomised non-inferiority open trial
    • Park S. H., et al. Pentoxifylline vs. corticosteroid to treat severe alcoholic hepatitis: a randomised non-inferiority open trial. J. Hepatol. 61, 792-798 (2014
    • (2014) J. Hepatol , vol.61 , pp. 792-798
    • Park, S.H.1
  • 170
    • 84926410654 scopus 로고    scopus 로고
    • Steroids or pentoxifylline for alcoholic hepatitis: Results of the stopah trial
    • LB1
    • Thursz M., et al. Steroids or Pentoxifylline for Alcoholic Hepatitis: Results of the STOPAH Trial. Hepatology 60, LB1 (2014
    • (2014) Hepatology , vol.60
    • Thursz, M.1
  • 171
    • 77951792200 scopus 로고    scopus 로고
    • Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis
    • Lebrec D., et al. Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis. Gastroenterology 138, 1755-1762 (2010
    • (2010) Gastroenterology , vol.138 , pp. 1755-1762
    • Lebrec, D.1
  • 172
    • 0036024249 scopus 로고    scopus 로고
    • Adenosyl l-methionine and alcoholic liver disease in animal models: Implications for early intervention in human beings
    • Lieber C. S. S Adenosyl l-methionine and alcoholic liver disease in animal models: implications for early intervention in human beings. Alcohol 27, 173-177 (2002
    • (2002) Alcohol , vol.27 , pp. 173-177
    • Lieber, C.S.S.1
  • 173
    • 0030819482 scopus 로고    scopus 로고
    • Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties and s adenosyl l-methionine
    • Colell A., et al. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S adenosyl l-methionine. Hepatology 26, 699-708 (1997
    • (1997) Hepatology , vol.26 , pp. 699-708
    • Colell, A.1
  • 174
    • 0028229899 scopus 로고
    • Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
    • Garcia-Ruiz C. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J. Clin. Invest. 94, 193-201 (1994
    • (1994) J. Clin. Invest , vol.94 , pp. 193-201
    • Garcia-Ruiz, C.1
  • 175
    • 33644882812 scopus 로고    scopus 로고
    • Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis- a randomised clinical trial
    • Phillips M., et al. Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis- a randomised clinical trial. J. Hepatol. 44, 784-790 (2006
    • (2006) J. Hepatol , vol.44 , pp. 784-790
    • Phillips, M.1
  • 176
    • 78049470733 scopus 로고    scopus 로고
    • Enteral nutrition with or without N acetylcysteine in the treatment of severe acute alcoholic hepatitis: A randomized multicenter controlled trial
    • Moreno C., et al. Enteral nutrition with or without N acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial. J. Hepatol. 53, 1117-1122 (2010
    • (2010) J. Hepatol , vol.53 , pp. 1117-1122
    • Moreno, C.1
  • 177
    • 34347401402 scopus 로고    scopus 로고
    • A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis
    • Stewart S., et al. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J. Hepatol. 47, 277-283 (2007
    • (2007) J. Hepatol , vol.47 , pp. 277-283
    • Stewart, S.1
  • 178
    • 80955166935 scopus 로고    scopus 로고
    • Glucocorticoids plus N acetylcysteine in severe alcoholic hepatitis
    • Nguyen-Khac E., et al. Glucocorticoids plus N acetylcysteine in severe alcoholic hepatitis. N. Engl. J. Med. 365, 1781-1789 (2011
    • (2011) N. Engl. J. Med , vol.365 , pp. 1781-1789
    • Nguyen-Khac, E.1
  • 180
    • 67650957725 scopus 로고    scopus 로고
    • Infection in patients with severe alcoholic hepatitis treated with steroids: Early response to therapy is the key factor
    • Louvet A., et al. Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor. Gastroenterology 137, 541-548 (2009
    • (2009) Gastroenterology , vol.137 , pp. 541-548
    • Louvet, A.1
  • 181
    • 19944431920 scopus 로고    scopus 로고
    • Patients with acute on chronic liver failure display sepsis-like immune paralysis
    • Wasmuth H. E., et al. Patients with acute on chronic liver failure display sepsis-like immune paralysis. J. Hepatol. 42, 195-201 (2005
    • (2005) J. Hepatol , vol.42 , pp. 195-201
    • Wasmuth, H.E.1
  • 182
    • 46749136744 scopus 로고    scopus 로고
    • Discovery and development of toll like receptor 4 (tlr4) antagonists: A new paradigm for treating sepsis and other diseases
    • Leon C. G., Tory R., Jia J., Sivak O. & Wasan K. M. Discovery and development of toll like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases. Pharm. Res. 25, 1751-1761 (2008
    • (2008) Pharm. Res , vol.25 , pp. 1751-1761
    • Leon, C.G.1    Tory, R.2    Jia, J.3    Sivak, O.4    Wasan, K.M.5
  • 183
    • 0025087535 scopus 로고
    • Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials
    • Imperiale T. F. & McCullough A. J. Do corticosteroids reduce mortality from alcoholic hepatitis?. A meta-analysis of the randomized trials. Ann. Intern. Med. 113, 299-307 (1990
    • (1990) Ann. Intern. Med , vol.113 , pp. 299-307
    • Imperiale, T.F.1    McCullough, A.J.2
  • 184
    • 0017809728 scopus 로고
    • Corticosteroid therapy of alcoholic hepatitis
    • Maddrey W. C., et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 75, 193-199 (1978
    • (1978) Gastroenterology , vol.75 , pp. 193-199
    • Maddrey, W.C.1
  • 185
    • 84875305045 scopus 로고    scopus 로고
    • White cell count and platelet count associate with histological alcoholic hepatitis in jaundiced harmful drinkers
    • Hardy T., et al. White cell count and platelet count associate with histological alcoholic hepatitis in jaundiced harmful drinkers. BMC Gastroenterol. 13, 55. (2013
    • (2013) BMC Gastroenterol , vol.13 , pp. 55
    • Hardy, T.1
  • 186
    • 80054749129 scopus 로고    scopus 로고
    • The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis
    • Mookerjee R. P., et al. The role of liver biopsy in the diagnosis and prognosis of patients with acute deterioration of alcoholic cirrhosis. J. Hepatol. 55, 1103-1111 (2011
    • (2011) J. Hepatol , vol.55 , pp. 1103-1111
    • Mookerjee, R.P.1
  • 200
    • 84869871354 scopus 로고    scopus 로고
    • US Department of Health and Human Services
    • US Department of Health and Human Services. NIH Research Portfolio Online Report Tools (RePORT) [online], http://projectreporter.nih.gov/Reporter-Viewsh.cfm?sl=13EBC0034F84C1DE7598B8961CAA4A01A2FFCEB861BF (2015
    • (2015) NIH Research Portfolio Online Report Tools (RePORT) [Online


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