Real-time monitoring of metabolic function in liver-onchip microdevices tracks the dynamics of Mitochondrial dysfunction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 16, 2016, Pages E2231-E2240

  Bavli, Danny ^a   Prill, Sebastian ^b   Ezra, Elishai ^a   Levy, Gahl ^a   Cohen, Merav ^a   Vinken, Mathieu ^c   Vanfleteren, Jan ^d,e   Jaeger, Magnus ^b,f   Nahmias, Yaakov ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e IMEC   (Belgium)

^f FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Liver tissue engineering; Microfluidics; Organ on a chip; Toxicology

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTATE 2 MONOOXYGENASE; LACTIC ACID; ROTENONE; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CHROMAN DERIVATIVE;

ANAEROBIC GLYCOLYSIS; ARTICLE; BIOREACTOR; CELL STRESS; COMPUTER SYSTEM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTROCHEMICAL ANALYSIS; FINITE ELEMENT ANALYSIS; FREQUENCY MODULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LABORATORY DEVICE; LIVER MITOCHONDRION; LIVER ON CHIP; METABOLIC FLUX ANALYSIS; MICROELECTROMECHANICAL SYSTEM; MICROFLUIDICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL STRESS; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; CHEMICALLY INDUCED; DRUG EFFECTS; HEP-G2 CELL LINE; LAB ON A CHIP; LIVER; METABOLISM; OXYGEN CONSUMPTION; PATHOLOGY;

CHROMANS; HEP G2 CELLS; HUMANS; LAB-ON-A-CHIP DEVICES; LIVER; MITOCHONDRIA, LIVER; MITOCHONDRIAL DISEASES; OXYGEN CONSUMPTION; THIAZOLIDINEDIONES;

EID: 84964343834     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522556113     Document Type: Article

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