-
1
-
-
22144474788
-
Adverse drug event surveillance and drug withdrawals in the United States 1969-2002: The importance of reporting suspected reactions
-
Wysowski, D. K., Swartz, L. Adverse drug event surveillance and drug withdrawals in the united states, 1969-2002: The importance of reporting suspected reactions. Arch. Intern. Med. 165, 1363-1369 (2005).
-
(2005)
Arch. Intern. Med.
, vol.165
, pp. 1363-1369
-
-
Wysowski, D.K.1
Swartz, L.2
-
2
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay, M., Thomas, D. W., Craighead, J. L., Economides, C., Rosenthal, J. Clinical development success rates for investigational drugs. Nat Biotech. 32, 40-51 (2014).
-
(2014)
Nat Biotech
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
3
-
-
84899994032
-
How multi-organ microdevices can help foster drug development
-
Esch, M. B. et al. How multi-organ microdevices can help foster drug development. Adv. Drug Deliv. Rev. 69-70, 158-169 (2014).
-
(2014)
Adv. Drug Deliv. Rev.
, vol.69-70
, pp. 158-169
-
-
Esch, M.B.1
-
4
-
-
84862186471
-
Microengineered physiological biomimicry: Organs-on-chips
-
Huh, D., Torisawa, Y. S., Hamilton, G. A., Kim, H. J., Ingber, D. E. Microengineered physiological biomimicry: organs-on-chips. Lab Chip 12, 2156-2164 (2012).
-
(2012)
Lab Chip
, vol.12
, pp. 2156-2164
-
-
Huh, D.1
Torisawa, Y.S.2
Hamilton, G.A.3
Kim, H.J.4
Ingber, D.E.5
-
5
-
-
84874894377
-
Microfabricated mammalian organ systems and their integration into models of whole animals and humans
-
Sung, J. H. et al. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 13, 1201-1212 (2013).
-
(2013)
Lab Chip
, vol.13
, pp. 1201-1212
-
-
Sung, J.H.1
-
6
-
-
4143057306
-
Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability
-
Lau, Y. Y. et al. Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability. Drug Metab. Dispos. 32, 937-942 (2004).
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 937-942
-
-
Lau, Y.Y.1
-
7
-
-
38349104537
-
Three-dimensional cellular microarray for high-throughput toxicology assays
-
Lee, M. Y. et al. Three-dimensional cellular microarray for high-throughput toxicology assays. Proc. Natl. Acad. Sci. USA 105, 59-63 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 59-63
-
-
Lee, M.Y.1
-
8
-
-
7444259030
-
A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: Comparative cytotoxicology of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells
-
Li, A. P., Bode, C., Sakai, Y. A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicology of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chem. Biol. Interact. 150, 129-136 (2004).
-
(2004)
Chem. Biol. Interact.
, vol.150
, pp. 129-136
-
-
Li, A.P.1
Bode, C.2
Sakai, Y.3
-
9
-
-
84882252041
-
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
-
Wagner, I. et al. A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. Lab Chip 13, 3538-3547 (2013).
-
(2013)
Lab Chip
, vol.13
, pp. 3538-3547
-
-
Wagner, I.1
-
10
-
-
84859560833
-
Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo-and hyperglycaemia
-
Iori, E. et al. Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo-and hyperglycaemia. PloS One 7, e34704 (2012).
-
(2012)
PloS One
, vol.7
, pp. e34704
-
-
Iori, E.1
-
11
-
-
72049119863
-
Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
-
Zhang, C., Zhao, A., Rahim, N. A. A., van Noort, D., Yu, H. Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab Chip 9, 3185-3192 (2009).
-
(2009)
Lab Chip
, vol.9
, pp. 3185-3192
-
-
Zhang, C.1
Zhao, A.2
Rahim, N.A.A.3
Van Noort, D.4
Yu, H.5
-
12
-
-
66249113165
-
Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor
-
Vozzi, F., Heinrich, J. M., Bader, A., Ahluwalia, A. D. Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor. Tissue Eng. Part A 15, 1291-1299 (2009).
-
(2009)
Tissue Eng. Part A
, vol.15
, pp. 1291-1299
-
-
Vozzi, F.1
Heinrich, J.M.2
Bader, A.3
Ahluwalia, A.D.4
-
13
-
-
77952950585
-
Optimization of chemically defined cell culture media-replacing fetal bovine serum in mammalian in vitro methods
-
van der Valk, J. et al. Optimization of chemically defined cell culture media-replacing fetal bovine serum in mammalian in vitro methods. Toxicol. In Vitro 24, 1053-1063 (2010).
-
(2010)
Toxicol in Vitro
, vol.24
, pp. 1053-1063
-
-
Van Der Valk, J.1
-
14
-
-
75749153235
-
A microfludic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
-
Sung, J. H., Kam, C., Shuler, M. L. A microfludic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip 10, 446-455 (2010).
-
(2010)
Lab Chip
, vol.10
, pp. 446-455
-
-
Sung, J.H.1
Kam, C.2
Shuler, M.L.3
-
15
-
-
84904304750
-
Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
-
Esch, M. B., Mahler, G. J., Stokol, T., Shuler, M. L. Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury. Lab Chip 14, 3081-3092 (2014).
-
(2014)
Lab Chip
, vol.14
, pp. 3081-3092
-
-
Esch, M.B.1
Mahler, G.J.2
Stokol, T.3
Shuler, M.L.4
-
16
-
-
84883318737
-
Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based biomicroelectromechanical systems device
-
Pirozzi, K., Long, C. J., McAleer, C. W., Smith, A. S. T., Hickman, J. J. Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based biomicroelectromechanical systems device. Appl. Phys. Lett. 103, 083108 (2013).
-
(2013)
Appl. Phys. Lett.
, vol.103
, pp. 083108
-
-
Pirozzi, K.1
Long, C.J.2
McAleer, C.W.3
Smith, A.S.T.4
Hickman, J.J.5
-
17
-
-
70450215499
-
Doxorubicin: The good, the bad and the ugly effect
-
Carvalho, C. et al. Doxorubicin: the good, the bad and the ugly effect. Curr. Med. Chem. 16, 3267-3285 (2009).
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 3267-3285
-
-
Carvalho, C.1
-
18
-
-
84892570645
-
Rhabdomyolysis in an elderly multitreated patient: Multiple drug interactions after statin withdrawal
-
Ginanneschi, F. et al. Rhabdomyolysis in an elderly multitreated patient: multiple drug interactions after statin withdrawal. J. Neurol. Sci. 336, 284-287 (2014).
-
(2014)
J. Neurol. Sci.
, vol.336
, pp. 284-287
-
-
Ginanneschi, F.1
-
19
-
-
41349113141
-
Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro
-
Skottheim, I. B., Gedde-Dahl, A., Hejazifar, S., Hoel, K., Asberg, A. Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro. Eur. J. Pharm. Sci. 33, 317-325 (2008).
-
(2008)
Eur. J. Pharm. Sci.
, vol.33
, pp. 317-325
-
-
Skottheim, I.B.1
Gedde-Dahl, A.2
Hejazifar, S.3
Hoel, K.4
Asberg, A.5
-
20
-
-
0038701977
-
Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients
-
Lins, R. L. et al. Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients. Nephrol. Dial. Transplant. 18, 967-976 (2003).
-
(2003)
Nephrol. Dial. Transplant.
, vol.18
, pp. 967-976
-
-
Lins, R.L.1
-
21
-
-
70349381105
-
Study of plasma level of atorvastatin and its effect on lipid profile
-
Valera, H. R., Ganguly, B. Study of plasma level of atorvastatin and its effect on lipid profile. Indian J. Physiol. Pharmacol. 53, 73-82 (2009).
-
(2009)
Indian J. Physiol. Pharmacol.
, vol.53
, pp. 73-82
-
-
Valera, H.R.1
Ganguly, B.2
-
22
-
-
0036402177
-
Basic pharmacology of valproate: A review after 35 years of clinical use for the treatment of epilepsy
-
Loscher, W. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 16, 669-694 (2002).
-
(2002)
CNS Drugs
, vol.16
, pp. 669-694
-
-
Loscher, W.1
-
23
-
-
42649109021
-
Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors
-
Duenas-Gonzalez, A. et al. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treat. Rev. 34, 206-222 (2008).
-
(2008)
Cancer Treat. Rev.
, vol.34
, pp. 206-222
-
-
Duenas-Gonzalez, A.1
-
24
-
-
77956760372
-
Molecular and therapeutic potential and toxicity of valproic acid
-
Chateauvieux, S., Morceau, F., Dicato, M., Diederich, M. Molecular and therapeutic potential and toxicity of valproic acid. J. Biomed. Biotechnol. 2010, 479364 (2010).
-
(2010)
J. Biomed. Biotechnol.
, vol.2010
, pp. 479364
-
-
Chateauvieux, S.1
Morceau, F.2
Dicato, M.3
Diederich, M.4
-
25
-
-
84865991512
-
Acetaminophen: Beyond pain and Fever-relieving
-
Blough, E. R., Wu, M. Acetaminophen: beyond pain and Fever-relieving. Front. Pharmacol. 2, 72 (2011).
-
(2011)
Front. Pharmacol.
, vol.2
, pp. 72
-
-
Blough, E.R.1
Wu, M.2
-
26
-
-
36849007595
-
Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway
-
Hadzimichalis, N. M. et al. Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway. Am. J. Physiol. Heart Circ. Physiol. 293, H3348-3355 (2007).
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.293
, pp. H3348-3355
-
-
Hadzimichalis, N.M.1
-
27
-
-
0028884884
-
Plasma concentrations after high-dose (45 mg.kg?1) rectal acetaminophen in children
-
Montgomery, C. J., McCormack, J. P., Reichert, C. C., Marsland, C. P. Plasma concentrations after high-dose (45 mg.kg?1) rectal acetaminophen in children. Can. J. Anaesth. 42, 982-986 (1995).
-
(1995)
Can. J. Anaesth.
, vol.42
, pp. 982-986
-
-
Montgomery, C.J.1
McCormack, J.P.2
Reichert, C.C.3
Marsland, C.P.4
-
28
-
-
0016514757
-
Acetaminophen poisoning and toxicity
-
Rumack, B. H., Matthew, H. Acetaminophen poisoning and toxicity. Pediatrics 55, 871-876 (1975).
-
(1975)
Pediatrics
, vol.55
, pp. 871-876
-
-
Rumack, B.H.1
Matthew, H.2
-
29
-
-
77955603299
-
The comparison between conditioned media and serum-free media in human embryonic stem cell culture and differentiation
-
Hannoun, Z. et al. The comparison between conditioned media and serum-free media in human embryonic stem cell culture and differentiation. Cell Reprogram. 12, 133-140 (2010).
-
(2010)
Cell Reprogram
, vol.12
, pp. 133-140
-
-
Hannoun, Z.1
-
30
-
-
84905019978
-
Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study
-
Klein, S., Mueller, D., Schevchenko, V., Naar, F. Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study. J. Appl. Toxicol. 34, 1078-1086 (2014).
-
(2014)
J. Appl. Toxicol.
, vol.34
, pp. 1078-1086
-
-
Klein, S.1
Mueller, D.2
Schevchenko, V.3
Naar, F.4
-
31
-
-
1542310178
-
-
John Wiley & Sons
-
Roberts, S. M., James, R. C., Williams, P. L. Principles of Toxicology: Environmental and Industrial Applications. 3 edn, (John Wiley & Sons, 2015).
-
(2015)
Principles of Toxicology: Environmental and Industrial Applications. 3 Edn
-
-
Roberts, S.M.1
James, R.C.2
Williams, P.L.3
-
32
-
-
84908308106
-
Target organ profiles in toxicity studies supporting human dosing: An assessment of recovery and chronic dosing
-
Horner, S., Robinson, S., Lees, D., Callander, R., Roberts, R. Target organ profiles in toxicity studies supporting human dosing: An assessment of recovery and chronic dosing. Regul. Toxicol. Pharmacol. 70, 270-285 (2014).
-
(2014)
Regul. Toxicol. Pharmacol.
, vol.70
, pp. 270-285
-
-
Horner, S.1
Robinson, S.2
Lees, D.3
Callander, R.4
Roberts, R.5
-
33
-
-
84887152893
-
Accurate prediction of drug-induced liver injury using stem cell-derived populations
-
Szkolnicka, D. et al. Accurate prediction of drug-induced liver injury using stem cell-derived populations. Stem Cells Transl. Med. 3, 141-148 (2014).
-
(2014)
Stem Cells Transl. Med.
, vol.3
, pp. 141-148
-
-
Szkolnicka, D.1
-
34
-
-
84947806157
-
Bridging functional and structural cardiotoxicity assays using human embryonic stem-cell derived cardiomyocytes for a more comprehensive risk assessment
-
Clements, M., Millar, V., Williams, A., Kalinka, S. Bridging functional and structural cardiotoxicity assays using human embryonic stem-cell derived cardiomyocytes for a more comprehensive risk assessment. Toxicol. Sci. 148, 241-260 (2015).
-
(2015)
Toxicol. Sci.
, vol.148
, pp. 241-260
-
-
Clements, M.1
Millar, V.2
Williams, A.3
Kalinka, S.4
-
35
-
-
70249086620
-
HERG-related drug toxicity and models for predicting hERG liability and QT prolongation
-
Raschi, E., Ceccarini, L., De Ponti, F., Recanatini, M. hERG-related drug toxicity and models for predicting hERG liability and QT prolongation. Expert Opin. Drug Metab. Toxicol. 5, 1005-1021 (2009).
-
(2009)
Expert Opin. Drug Metab. Toxicol.
, vol.5
, pp. 1005-1021
-
-
Raschi, E.1
Ceccarini, L.2
De Ponti, F.3
Recanatini, M.4
-
37
-
-
84863116827
-
Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
-
Abassi, Y. A. et al. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br. J. Pharmacol. 165, 1424-1441 (2012).
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 1424-1441
-
-
Abassi, Y.A.1
-
38
-
-
0027409325
-
Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit
-
Cusack, B. J., Young, S. P., Driskell, J., Olson, R. D. Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit. Cancer Chemother. Pharmacol. 32, 53-58 (1993).
-
(1993)
Cancer Chemother. Pharmacol.
, vol.32
, pp. 53-58
-
-
Cusack, B.J.1
Young, S.P.2
Driskell, J.3
Olson, R.D.4
-
39
-
-
0013228058
-
Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol
-
Olson, R. D. et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc. Natl. Acad. Sci. USA 85, 3585-3589 (1988).
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 3585-3589
-
-
Olson, R.D.1
-
40
-
-
84907608299
-
An evaluation of hepatotoxicity in breast cancer patients receiving injection Doxorubicin
-
Damodar, G., Smitha, T., Gopinath, S., Vijayakumar, S., Rao, Y. An evaluation of hepatotoxicity in breast cancer patients receiving injection Doxorubicin. Ann. Med. Health Sci. Res. 4, 74-79 (2014).
-
(2014)
Ann. Med. Health Sci. Res.
, vol.4
, pp. 74-79
-
-
Damodar, G.1
Smitha, T.2
Gopinath, S.3
Vijayakumar, S.4
Rao, Y.5
-
41
-
-
34248167167
-
Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives
-
Aquilano, K. et al. Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives. J. Neurochem. 101, 1327-1337 (2007).
-
(2007)
J. Neurochem.
, vol.101
, pp. 1327-1337
-
-
Aquilano, K.1
-
42
-
-
73449104584
-
Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
-
Gilliam, L. A. et al. Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle. J. Appl. Physiol. 107, 1935-1942 (2009).
-
(2009)
J. Appl. Physiol.
, vol.107
, pp. 1935-1942
-
-
Gilliam, L.A.1
-
43
-
-
58749103330
-
Direct effects of doxorubicin on skeletal muscle contribute to fatigue
-
van Norren, K. et al. Direct effects of doxorubicin on skeletal muscle contribute to fatigue. Br. J. Cancer 100, 311-314 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 311-314
-
-
Van Norren, K.1
-
44
-
-
33748505645
-
Atorvastatin associated liver disease
-
Clarke, A. T., Mills, P. R. Atorvastatin associated liver disease. Dig. Liver Dis. 38, 772-777 (2006).
-
(2006)
Dig. Liver Dis.
, vol.38
, pp. 772-777
-
-
Clarke, A.T.1
Mills, P.R.2
-
45
-
-
0347988040
-
Liver function test abnormalities and pruritus in a patient treated with atorvastatin: Case report and review of the literature
-
Gershovich, O. E., Lyman, A. E. Jr. Liver function test abnormalities and pruritus in a patient treated with atorvastatin: case report and review of the literature. Pharmacotherapy 24, 150-154 (2004).
-
(2004)
Pharmacotherapy
, vol.24
, pp. 150-154
-
-
Gershovich, O.E.1
Lyman, A.E.2
-
46
-
-
78650804921
-
Atorvastatin-induced acute elevation of hepatic enzymes and the absence of cross-toxicity of pravastatin
-
Liu, Y. et al. Atorvastatin-induced acute elevation of hepatic enzymes and the absence of cross-toxicity of pravastatin. Int. J. Clin. Pharmacol. Ther. 48, 798-802 (2010).
-
(2010)
Int. J. Clin. Pharmacol. Ther.
, vol.48
, pp. 798-802
-
-
Liu, Y.1
-
47
-
-
84892822274
-
Protective role of atorvastatin against doxorubicininduced cardiotoxicity and testicular toxicity in mice
-
Ramanjaneyulu, S. V., Trivedi, P. P., Kushwaha, S., Vikram, A., Jena, G. B. Protective role of atorvastatin against doxorubicininduced cardiotoxicity and testicular toxicity in mice. J. Physiol. Biochem. 69, 513-525 (2013).
-
(2013)
J. Physiol. Biochem.
, vol.69
, pp. 513-525
-
-
Ramanjaneyulu, S.V.1
Trivedi, P.P.2
Kushwaha, S.3
Vikram, A.4
Jena, G.B.5
-
48
-
-
20144385721
-
Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones
-
Bösel, J. et al. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J. Neurochem. 92, 1386-1398 (2005).
-
(2005)
J. Neurochem.
, vol.92
, pp. 1386-1398
-
-
Bösel, J.1
-
49
-
-
77953971007
-
Statins and neuroprotection: A prescription to move the field forward
-
Wood, W. G., Eckert, G. P., Igbavboa, U., Muller, W. E. Statins and neuroprotection: a prescription to move the field forward. Ann. N. Y. Acad. Sci. 1199, 69-76 (2010).
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1199
, pp. 69-76
-
-
Wood, W.G.1
Eckert, G.P.2
Igbavboa, U.3
Muller, W.E.4
-
50
-
-
83455163746
-
Pharmacological actions of statins: A critical appraisal in the management of cancer
-
Gazzerro, P. et al. Pharmacological actions of statins: a critical appraisal in the management of cancer. Pharmacol. Rev. 64, 102-146 (2012).
-
(2012)
Pharmacol. Rev.
, vol.64
, pp. 102-146
-
-
Gazzerro, P.1
-
51
-
-
81255184994
-
Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol
-
Mailman, T., Hariharan, M., Karten, B. Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol. J. Neurochem. 119, 1002-1015 (2011).
-
(2011)
J. Neurochem.
, vol.119
, pp. 1002-1015
-
-
Mailman, T.1
Hariharan, M.2
Karten, B.3
-
52
-
-
84879600898
-
Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells
-
Li, X. et al. Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells. Biochem. Biophys. Res. Commun. 436, 259-264 (2013).
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.436
, pp. 259-264
-
-
Li, X.1
-
53
-
-
33644876853
-
Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95-and TRAIL receptor-mediated apoptosis and chemotherapy
-
Schuchmann, M. et al. Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95-and TRAIL receptor-mediated apoptosis and chemotherapy. Oncol. Rep. 15, 227-230 (2006).
-
(2006)
Oncol. Rep.
, vol.15
, pp. 227-230
-
-
Schuchmann, M.1
-
54
-
-
38749126396
-
Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores
-
Knapp, A. C. et al. Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores. J. Pharmacol. Exp. Ther. 324, 568-575 (2008).
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 568-575
-
-
Knapp, A.C.1
-
55
-
-
84896367457
-
Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury
-
Lee, J. Y. et al. Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury. J. Neurotrauma 31, 582-594 (2014).
-
(2014)
J. Neurotrauma
, vol.31
, pp. 582-594
-
-
Lee, J.Y.1
-
56
-
-
34547886153
-
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats American journal of physiology
-
Lee, T. M., Lin, M. S., Chang, N. C. Inhibition of histone deacetylase on ventricular remodeling in infarcted rats. American journal of physiology. Am. J. Physiol. Heart Circ. Physiol. 293, H968-977 (2007).
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.293
, pp. H968-977
-
-
Lee, T.M.1
Lin, M.S.2
Chang, N.C.3
-
57
-
-
0035132183
-
Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches
-
Bessems, J. G., Vermeulen, N. P. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit. Rev. Toxicol. 31, 55-138 (2001).
-
(2001)
Crit. Rev. Toxicol.
, vol.31
, pp. 55-138
-
-
Bessems, J.G.1
Vermeulen, N.P.2
-
58
-
-
84859708101
-
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
-
McGill, M. R. et al. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J. Clin. Invest. 122, 1574-1583 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1574-1583
-
-
McGill, M.R.1
-
59
-
-
62749110786
-
Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device
-
Ma, B., Zhang, G., Qin, J., Lin, B. Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device. Lab Chip 9, 232-238 (2009).
-
(2009)
Lab Chip
, vol.9
, pp. 232-238
-
-
Ma, B.1
Zhang, G.2
Qin, J.3
Lin, B.4
-
60
-
-
0025744509
-
Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes
-
Holme, J. A., Hongslo, J. K., Bjorge, C., Nelson, S. D. Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes. Biochem. Pharmacol. 42, 1137-1142 (1991).
-
(1991)
Biochem. Pharmacol.
, vol.42
, pp. 1137-1142
-
-
Holme, J.A.1
Hongslo, J.K.2
Bjorge, C.3
Nelson, S.D.4
-
61
-
-
84872308343
-
A new twist to an old tale: Novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetylmeta-aminophenol (AMAP
-
Kenna, J. G. A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetylmeta-aminophenol (AMAP). Arch. Toxicol. 87, 15-18 (2013).
-
(2013)
Arch. Toxicol.
, vol.87
, pp. 15-18
-
-
Kenna, J.G.1
-
62
-
-
0028950762
-
A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3?-hydroxyacetanilide
-
Myers, T. G. et al. A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3?-hydroxyacetanilide. Chem. Res. Toxicol. 8, 403-413 (1995).
-
(1995)
Chem. Res. Toxicol.
, vol.8
, pp. 403-413
-
-
Myers, T.G.1
-
63
-
-
79955102315
-
Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform
-
Natarajan, A. et al. Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform. Biomaterials 32, 4267-4274 (2011).
-
(2011)
Biomaterials
, vol.32
, pp. 4267-4274
-
-
Natarajan, A.1
-
64
-
-
84889686190
-
In vitro differentiation of functional human skeletal myotubes in a defined system
-
Guo, X. et al. In vitro differentiation of functional human skeletal myotubes in a defined system. Biomater. Sci. 2, 131-138 (2014).
-
(2014)
Biomater. Sci.
, vol.2
, pp. 131-138
-
-
Guo, X.1
-
65
-
-
0033104799
-
Tissue engineered human bioartificial muscles expressing a foreign recombinant protein for gene therapy
-
Powell, C. et al. Tissue engineered human bioartificial muscles expressing a foreign recombinant protein for gene therapy. Hum. Gene Ther. 10, 565-577 (1999).
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 565-577
-
-
Powell, C.1
-
66
-
-
77950664250
-
Characterization of a human fetal spinal cord stem cell line NSI-566RSC and its induction to functional motoneurons
-
Guo, X. F., Johe, K., Molnar, P., Davis, H., Hickman, J. J. Characterization of a human fetal spinal cord stem cell line NSI-566RSC and its induction to functional motoneurons. J. Tissue Eng. Regen. Med. 4, 181-193 (2010).
-
(2010)
J. Tissue Eng. Regen. Med.
, vol.4
, pp. 181-193
-
-
Guo, X.F.1
Johe, K.2
Molnar, P.3
Davis, H.4
Hickman, J.J.5
-
67
-
-
80054067251
-
Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system
-
Guo, X., Gonzalez, M., Stancescu, M., Vandenburgh, H., Hickman, J. J. Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system. Biomaterials 32, 9602-9611 (2011).
-
(2011)
Biomaterials
, vol.32
, pp. 9602-9611
-
-
Guo, X.1
Gonzalez, M.2
Stancescu, M.3
Vandenburgh, H.4
Hickman, J.J.5
-
68
-
-
77954218953
-
Addition of glutamate to serum free culture improves the electrical properties of adult hippocampal neurons in vitro
-
Edwards, D., Das, M., Molnar, P., Hickman, J. J. Addition of glutamate to serum free culture improves the electrical properties of adult hippocampal neurons in vitro. J. Neurosci. Methods 190, 155-163 (2010).
-
(2010)
J. Neurosci. Methods
, vol.190
, pp. 155-163
-
-
Edwards, D.1
Das, M.2
Molnar, P.3
Hickman, J.J.4
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