Suppressors of superoxide production from mitochondrial complex III

Nature Chemical Biology

Volumn 11, Issue 11, 2015, Pages 834-836

  Orr, Adam L ^a,c   Vargas, Leonardo ^b   Turk, Carolina N ^b   Baaten, Janine E ^b   Matzen, Jason T ^b   Dardov, Victoria J ^b   Attle, Stephen J ^b   Li, Jing ^b   Quackenbush, Douglas C ^b   Goncalves, Renata L S ^a   Perevoshchikova, Irina V ^a   Petrassi, H Michael ^b   Meeusen, Shelly L ^b   Ainscow, Edward K ^b   Brand, Martin D ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c GLADSTONE INSTITUTES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; CITRININ; CYTOCHROME B; ENZYME INHIBITOR; GLUTAMIC ACID; GLUTAMINE; GLYCEROPHOSPHATE; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MALIC ACID; MYXOTHIAZOL; PALMITOYLCARNITINE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; ROTENONE; SEMIQUINONE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIMYCIN A1; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENERGY; CELL COUNT; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; DRUG EFFECT; ELECTRON TRANSPORT; EMBRYO; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPOXIC CELL; IC50; INS 1 CELL LINE; INTRACELLULAR SIGNALING; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MUSCLE MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; MITOCHONDRION; SPRAGUE DAWLEY RAT; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIMYCIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX III; FEMALE; FREE RADICAL SCAVENGERS; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN PEROXIDE; INSULIN-SECRETING CELLS; MALE; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 84945306969     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1910     Document Type: Article

References (31)

1. Sena, L.A. & Chandel, N.S. Mol. Cell 48, 158-167 (2012).
2. Quinlan, C.L., Perevoschikova, I.V., Goncalves, R.L.S., Hey-Mogensen, M. & Brand, M.D. Meth. Enzymol. 526, 189-217 (2013).
3. Quinlan, C.L., Perevoshchikova, I.V., Hey-Mogensen, M., Orr, A.L. & Brand, M.D. Redox Biol. 1, 304-312 (2013).
4. Sherer, T.B. et al. J. Neurosci. 23, 10756-10764 (2003).
5. Lambert, A.J., Buckingham, J.A., Boysen, H.M. & Brand, M.D. Aging Cell 9, 78-91 (2010).
6. Lin, M.T. & Beal, M.F. Nature 443, 787-795 (2006).
7. Ishii, T. et al. Cancer Res. 65, 203-209 (2005).
8. Quinlan, C.L. et al. J. Biol. Chem. 287, 27255-27264 (2012).
9. Heather, L.C. et al. Cardiovasc. Res. 85, 127-136 (2010).
10. Adam-Vizi, V. & Tretter, L. Neurochem. Int. 62, 757-763 (2013).
11. Chouchani, E.T. et al. Nat. Med. 19, 753-759 (2013).
12. Dröse, S. Biochim. Biophys. Acta 1827, 578-587 (2013).
13. Bleier, L. & Dröse, S. Biochim. Biophys. Acta 1827, 1320-1331 (2013).
14. Sena, L.A. et al. Immunity 38, 225-236 (2013).
15. Jain, M. et al. J. Biol. Chem. 288, 770-777 (2013).
16. Weinberg, F. et al. Proc. Natl. Acad. Sci. USA 107, 8788-8793 (2010).
17. Viola, H.M. & Hool, L.C. J. Mol. Cell. Cardiol. 49, 875-885 (2010).
18. Kaminski, M.M. et al. Cell Rep. 2, 1300-1315 (2012).
19. Srinivas, V. et al. J. Biol. Chem. 276, 21995-21998 (2001).
20. Chua, Y.L. et al. J. Biol. Chem. 285, 31277-31284 (2010).
21. Lee, S.-J., Hwang, A.B. & Kenyon, C. Curr. Biol. 20, 2131-2136 (2010).
22. Jung, H.J. et al. J. Biol. Chem. 285, 11584-11595 (2010).
23. Orr, A.L. et al. Free Rad. Biol. Med. 65, 1047-1059 (2013).
24. Win, S., Than, T.A., Fernandez-Checa, J.C. & Kaplowitz, N. Cell Death Dis. 5, e989 (2014).
25. Quinlan, C.L., Gerencser, A.A., Treberg, J.R. & Brand, M.D. J. Biol. Chem. 286, 31361-31372 (2011).
26. Swiss, R., Niles, A., Cali, J.J., Nadanaciva, S. & Will, Y. Toxicol. in Vitro 27, 1789-1797 (2013).
27. Orr, A.L. et al. PLoS ONE. 9, e89938 (2014).
28. Rogers, G.W. et al. PLoS ONE 6, e21746 (2011).
29. Kaluz, S., Kaluzová, M. & Stanbridge, E.J. Biochem. Biophys. Res. Commun. 370, 613-618 (2008).
30. Soberanes, S. et al. J. Biol. Chem. 284, 2176-2186 (2009).
31. Chambers, J.W. & LoGrasso, P.V. J. Biol. Chem. 286, 16052-16062 (2011).