Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Calvani, Maura ^a   Comito, Giuseppina ^a   Giannoni, Elisa ^a   Chiarugi, Paola ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Istituto Toscano Tumouri and Center for Research Transfer and High Education DenoTHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UBIQUINOL CYTOCHROME C REDUCTASE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CANCER CHEMOTHERAPY; CELL HYPOXIA; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MELANOMA CELL; POSITIVE FEEDBACK; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ELECTRON TRANSPORT COMPLEX III; ETOPOSIDE; HUMANS; HYDROGEN PEROXIDE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SPACE; MELANOMA; OXIDATION-REDUCTION; PROTEIN STABILITY; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; ROTENONE; TIME FACTORS; UNCOUPLING AGENTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84868147963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038388     Document Type: Article

References (45)

1. Kissel CK, Schadendorf D, Rockmann H, (2006) The altered apoptotic pathways in cisplatinand etoposide-resistant melanoma cells are drug specific. Melanoma Res 16: 527-535.
2. Maira F, Catania A, Candido S, Russo AE, McCubrey JA, et al. (2011) Molecular Targeted Therapy In Melanoma: A Way To Reverse Resistance To Conventional Drugs. Curr Drug Deliv.
3. Di PA, Bocci G, (2007) Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification. Curr Oncol Rep 9: 109-114.
4. Semenza GL, (2009) Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 24: 97-106.
5. Wu WS, (2006) The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 25: 695-705.
6. Vaupel P, Schlenger K, Knoop C, Hockel M, (1991) Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements3. Cancer Res 51: 3316-3322.
7. Hockel M, Vaupel P, (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93: 266-276.
8. Harris AL, (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
9. Semenza GL, (2009) Regulation of oxygen homeostasis by hypoxia-inducible factor 129. Physiology (Bethesda) 24: 97-106.
10. Dery MA, Michaud MD, Richard DE, (2005) Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int J Biochem Cell Biol 37: 535-540.
11. Semenza GL, (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
12. Klimova T, Chandel NS, (2008) Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ 15: 660-666.
13. Flashman E, Hoffart LM, Hamed RB, Bollinger JM Jr, Krebs C, et al. (2010) Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. FEBS J 4: 1742-4658.
14. Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, et al. (2005) Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem 280: 41928-41939.
15. Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, et al. (2007) HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 12: 230-238.
16. Aragones J, Fraisl P, Baes M, Carmeliet P, (2009) Oxygen sensors at the crossroad of metabolism. Cell Metab 9: 11-22.
17. Comito G, Calvani M, Giannoni E, Bianchini F, Calorini L, et al. (2011) HIF-1alpha stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med 51: 893-904.
18. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, et al. (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A 95: 11715-11720.
19. Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, et al. (2010) Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell 21: 3247-3257.
20. Lee HY, Lee T, Lee N, Yang EG, Lee C, et al. (2011) Src activates HIF-1alpha not through direct phosphorylation of HIF-1alpha specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway. Carcinogenesis 32: 703-712.
21. Moon EJ, Sonveaux P, Porporato PE, Danhier P, Gallez B, et al. (2010) NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. Proc Natl Acad Sci U S A 107: 20477-20482.
22. Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, et al. (2008) LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxid Redox Signal 10: 983-995.
23. Meyer M, Clauss M, Lepple-Wienhues A, Waltenberger J, Augustin HG, et al. (1999) A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J 18: 363-374.
24. Calvani M, Trisciuoglio D, Bergamaschi C, Shoemaker RH, Melillo G, (2008) Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. Cancer Res 68: 285-291.
25. Helmbach H, Rossmann E, Kern MA, Schadendorf D, (2001) Drug-resistance in human melanoma. Int J Cancer 93: 617-622.
26. Davar D, Tarhini A, Kirkwood JM, (2011) Adjuvant therapy: melanoma1. J Skin Cancer 2011: 274382.
27. Jiang YY, Huang H, Wang HJ, Wu D, Yang R, et al. (2011) Interruption of mitochondrial complex IV activity and cytochrome c expression activated O.-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC gamma-PKC pathways. Eur J Pharmacol 668: 78-87.
28. Snyder CM, Chandel NS, (2009) Mitochondrial regulation of cell survival and death during low-oxygen conditions. Antioxid Redox Signal 11: 2673-2683.
29. Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, et al. (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226.
30. Piret JP, Lecocq C, Toffoli S, Ninane N, Raes M, et al. (2004) Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1. Exp Cell Res 295: 340-349.
31. Giannoni E, Parri M, Chiarugi P, (2011) EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy. Antioxid Redox Signal 16: 1248-63.
32. Semenza GL, (2004) Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell 5: 405-406.
33. Pani G, Galeotti T, Chiarugi P, (2010) Metastasis: cancer cell's escape from oxidative stress. Cancer Metastasis Rev 29: 351-378.
34. Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P, (2008) Redox regulation of cell survival. Antioxid Redox Signal 10: 1343-1374.
35. Cataldi A, (2010) Cell responses to oxidative stressors. Curr Pharm Des 16: 1387-1395.
36. Kuphal S, Winklmeier A, Warnecke C, Bosserhoff AK, (2010) Constitutive HIF-1 activity in malignant melanoma. Eur J Cancer 46: 1159-1169.
37. Du J, Xu R, Hu Z, Tian Y, Zhu Y, et al. (2011) PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1alpha expression in MCF-7 breast cancer cells. PLoS One 6 (9):: e252113.
38. Mottet D, Dumont V, Deccache Y, Demazy C, Ninane N, et al. (2003) Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem 278: 31277-31285.
39. Hsieh CH, Shyu WC, Chiang CY, Kuo JW, Shen WC, et al. (2011) NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme. PLoS One 6: e23945.
40. Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G, (2006) Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 107: 2705-2712.
41. de GA, de GA, Chibaudel B, Bachet JB, Larsen AK, et al. (2011) From chemotherapy to targeted therapy in adjuvant treatment for stage III colon cancer. Semin Oncol 38: 521-532.
42. de Andrade DP, Lima JP, Lima AD, Sasse AD, Dos Santos LV, (2011) Bevacizumab in metastatic colorectal cancer and carcino-embryonic antigen kinetics: case report and review of literature. Anticancer Drugs 22 Suppl 2: S15-S17.
43. Cabarcas SM, Mathews LA, Farrar WL, (2011) The cancer stem cell niche-there goes the neighborhood? nt J Cancer 129: 2315-2327.
44. Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM, et al. (2011) HIF induces human embryonic stem cell markers in cancer cells. Cancer Res 71: 4640-4652.
45. Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, et al. (2011) A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature 478: 399-403.