Neutrophil Extracellular Traps Kill Bacteria

Science

Volumn 303, Issue 5663, 2004, Pages 1532-1535

  Brinkmann, Volker ^a   Reichard, Ulrike ^a   Goosmann, Christian ^a   Fauler, Beatrix ^a   Uhlemann, Yvonne ^a   Weiss, David S ^a   Weinrauch, Yvette ^b   Zychlinsky, Arturo ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; DISEASES; PROTEINS;

EXTRACELLULAR TRAPS; PHAGOSOMES;

CELLS;

DNA; HISTONE; LEUKOCYTE ELASTASE; PROTEIN; VIRULENCE FACTOR;

BACTERIUM; IMMUNE RESPONSE;

ANIMAL MODEL; ANIMAL TISSUE; APPENDICITIS; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM; CHROMATIN; DYSENTERY; FIBER; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFLAMMATION; LEUKOCYTE ACTIVATION; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN SECRETION; RABBIT;

ANIMALS; APPENDICITIS; BACTERIAL PROTEINS; BLOOD BACTERICIDAL ACTIVITY; CYTOCHALASIN D; CYTOPLASMIC GRANULES; DNA; DYSENTERY, BACILLARY; ENDOPEPTIDASES; HISTONES; HUMANS; IMMUNITY, NATURAL; LEUKOCYTE ELASTASE; MICROSCOPY, ELECTRON; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHAGOCYTOSIS; RABBITS; SALMONELLA TYPHIMURIUM; SHIGELLA FLEXNERI; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA; ORYCTOLAGUS CUNICULUS; POSIBACTERIA;

EID: 1542287347     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092385     Document Type: Article

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21. The gift of M. Monestier, Temple University, the monodonal antibody against H2A-H2B-DNA, is gratefully acknowledged. The authors thank the help of M. Ingersoll, B. Raupach, C. Scharff, C. Heinz, and members of the Department of Cellular Microbiology, Max Planck Institute for Infection Biology. Supported in part by NIH grant AI037720.