Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis

Molecular and Cellular Biology

Volumn 28, Issue 2, 2008, Pages 718-731

  Guzy, Robert D ^a   Sharma, Bhumika ^a   Bell, Eric ^a   Chandel, Navdeep S ^a   Schumacker, Paul T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE A; SUCCINATE DEHYDROGENASE B; UNCLASSIFIED DRUG;

ARTICLE; BIOENERGY; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENE REPRESSION; GROWTH RATE; HUMAN; HUMAN CELL; HYPOXIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STABILITY; RNA INTERFERENCE;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ELECTRON TRANSPORT COMPLEX II; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON-SULFUR PROTEINS; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTEIN BINDING; PROTEIN SUBUNITS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SUCCINATE DEHYDROGENASE;

EID: 37849022071     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01338-07     Document Type: Article

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