Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases

Nature Cell Biology

Volumn 5, Issue 11, 2003, Pages 1001-1007

  Furukawa, Manabu ^a   He, Yizhou Joseph ^a   Borchers, Christoph ^a   Xiong, Yue ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; CELL PROTEIN; CULLIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN TARGETING;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELLS, CULTURED; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 0242575197     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1056     Document Type: Article

References (31)

1. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439 (1996).
2. King, R. W., Deshaies, R. J., Peters, J.-M. & Kirschner, M. W. How proteolysis drives the cell cycle. Science 274, 1652-1659 (1996).
3. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425-79 (1998).
4. Zachariae, W. & Nasmyth, K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058 (1999).
5. Deshaies, R. J. SCF and cullin/RING H2-based ulbiquitin ligases. Annu. Rev. Cell Dev.Biol. 15, 435-467 (1999).
6. Pickart, C. M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533 (2001).
7. Zheng, N. et al. Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex. Nature 416, 703-709 (2002).
8. Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274 (1996).
9. Skowyra, D., Craig, K., Tyers, M., Elledge, S. J. & Harper, J. W. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219 (1997).
10. Feldman, R. M. R., Correll, C. C., Kaplan, K. B. & Deshaies, R. J. A complex of Cdc4p, Skp1p, and Cdc53p/Cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221-230 (1997).
11. Kipreos, E. T., Lander, L. E., Wing, J. P., He, W.-W. & Hedgecock, E. M. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85, 829-839 (1996).
12. Pause, A. et al. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl Acad. Sci. USA 94, 2156-2161 (1997).
13. Lonergan, K. M. et al. Regulation o fhypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell Biol. 18, 732-741 (1998).
14. Maxwell, P. H. et al. The tumor suppressor protein VHL targets hypoxia-inducible factor for oxygen-dependent proteolysis. Nature 399, 271-275 (1999).
15. Lisztwan, J., Imbert, G., Wirbelauer, C., Gstaiger, M. & Krek, W. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev. 13, 1822-1833 (1999).
16. Ohh, M. et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein. Nature Cell Biol. 2, 423-427 (2000).
17. Furukawa, M., Ohta, T. & Xiong, Y. Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J. Biol. Chem. 277, 15758-15765 (2002)
18. Michel, J. J. & Xiong, Y. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. Cell Growth Differ. 9, 435-449 (1998).
19. Michel, J. J., McCarville, J. F. & Xiong, Y. A role for Saccharomyces cerevisiae CUL8 ubiquitin ligase in proper anaphase progression. J. Biol. Chem. 278, 22828-22837 (2003).
20. Dias, D. C., Dolios, G., Wang, R. & Pan, Z. Q. CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc. Natl Acad. Sci. USA 99, 16601-16606 (2002).
21. Godt, D., Couderc, J. L., Cramton, S. E. & Laski, F. A. Pattern formation in the limbs of Drosophila: bric a brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus. Development 119, 799-812 (1993).
22. Zollman, S., Godt, D., Prive, G. G., Couderc, J. L. & Laski, F. A. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc. Natl Acad. Sci. USA 91, 10717-10721 (1994).
23. Bardwell, V. J. & Treisman, R. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8, 1664-1677 (1994).
24. . Xue, F. & Cooley, L. kelch encodes a component of intercellular bridges in Drosophila egg chambers. Cell 72, 681-693 (1993).
25. Clark-Maguire, S. & Mains, P. E. Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component. J. Cell Biol. 126, 199-209 (1994).
26. Srayko, M., Buster, D. W., Bazirgan, O. A., McNally, F. J. & Mains, P. E. MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. Genes Dev. 14, 1072-1084 (2000).
27. Kurz, T. et al. Cytoskeletal regulation by the nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298 (2002).
28. Pintard, L. et al. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Curr. Biol. 13, 911-921 (2003).
29. Collins, T., Stone, J. R. & Williams, A. J. All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol. Cell. Biol. 21, 3609-3615 (2001).
30. Ohta, T., Michel, J. J., Schottelius, A. J. & Xiong, Y. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol. Cell 3, 535-541 (1999).
31. Furukawa, M., Yanping, Z., McCarville, J., Ohta, T. & Xiong, Y. The C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Mol. Cell. Biol. 20, 8185-8197 (2000).