Artemisinin resistance in rodent malaria - Mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Henriques, Gisela ^a,g   Martinelli, Axel ^a,b,h   Rodrigues, Louise ^a   Modrzynska, Katarzyna ^b,h   Fawcett, Richard ^b   Houston, Douglas R ^b   Borges, Sofia T ^a   D'Alessandro, Umberto ^c   Tinto, Halidou ^d   Karema, Corine ^e   Hunt, Paul ^b   Cravo, Pedro ^a,f  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d Institut de Recherche en Sciences de la Santé   (Burkina Faso)

^e National Malaria Control Program   (Rwanda)

^f FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^g LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^h WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Artemisinin; Drug resistance; Endocytic machinery; Genomics; Malaria; Mutation; Plasmodium chabaudi

Indexed keywords

AP2 ADAPTOR MU CHAIN; ARTEMISININ; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; ENDOCYTOSIS; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; IN VIVO STUDY; MEMBRANE BIOLOGY; MEMBRANE PROTEIN TRAFFICKING; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PLASMODIUM CHABAUDI; PLASMODIUM CHABAUDI INFECTION; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTITUTION REACTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIMALARIALS; ARTEMISININS; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE; GENETIC MARKERS; HUMANS; MICE; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTOZOAN PROTEINS;

EID: 84875870963     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-118     Document Type: Article

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