Correlation between plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 8, 2013, Pages 3998-4000

  Robert, Anne ^a,b   Claparols, Catherine ^a,b   Witkowski, Benoit ^a,b,c   Benoit Vicala, Françoise ^a,b,c  

^a LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; HEME;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMODIUM YOELII; PRIORITY JOURNAL;

ALKYLATION; ANIMALS; ANTIMALARIALS; ARTEMISININS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; ERYTHROCYTES; FEMALE; HEME; MALARIA; MICE; PLASMODIUM YOELII; PROTEIN BINDING; SPLEEN;

EID: 84880306767     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01064-13     Document Type: Article

References (13)

1. WHO. 13 December 2011. World Malaria Report 2011. World Health Organization, Geneva, Switzerland. http://www.who.int/malaria/world-malaria- report-2011/WMR2011-factsheet.pdf.
2. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NPJ, Lindegardh N, Socheat D, White NJ. 2009. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361:455-467
3. White N. 2010. Artemisinin resistance-the clock is ticking. Lancet 376: 2051-2052.
4. WHO Malaria Policy Advisory Committee. 2012. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2012 meeting. Malar. J. 11:424. doi:10.1186/1475-2875-11-424.
5. Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, Chy S, Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D. 2013. Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia. Antimicrob. Agents Chemother. 57:914-923.
6. Meunier B, Robert A. 2010. Heme as trigger and target for trioxanecontaining antimalarial drugs. Acc. Chem. Res. 43:1444-1451.
7. Robert A, Cazelles J, Meunier B. 2001. First Characterization of the alkylation product of heme by the antimalarial drug artemisinin. Angew. Chem. Int. Ed. Engl. 40:1954-1957.
8. Robert A, Coppel Y, Meunier B. 31 January 2002. Alkylation of heme by the antimalarial drug artemisinin. Chem. Commun. (Camb.) doi:10.1039/B110817B.
9. Robert A, Benoit-Vical F, Claparols C, Meunier B. 2006. 2005. The antimalarial drug artemisinin alkylates heme in infected mice. Proc. Natl. Acad. Sci. U. S. A. 102:13676-13680. (Erratum, 103:3943, 2006.)
10. Loup C, Lelievre J, Benoit-Vical F, Meunier B. 2007. Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine. Antimicrob. Agents Chemother. 51:3768-3770.
11. Witkowski B, Lelievre J, Nicolau-Travers ML, Iriart X, Njomnang Soh P, Bousejra-Elgarah F, Meunier B, Berry A, Benoit-Vical F. 2012. Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs. PLoS One 7:e32620. doi:10.1371/journal.pone.0032620.
12. Moll K, Ljungström I, Perlmann H, Scherf A, Wahlgren M (ed), 2008 Methods in malaria research, 5th ed. MR4/ATCC, Manassas, VA.
13. Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L. 2011. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc. Natl. Acad. Sci. U. S. A. 108:11405-11410.