Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome

Journal of the American Chemical Society

Volumn 136, Issue 39, 2014, Pages 13562-13565

  Li, Hao ^a   Tsu, Christopher ^b   Blackburn, Christopher ^b   Li, Gang ^b   Hales, Paul ^b   Dick, Lawrence ^b   Bogyo, Matthew ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MACHINERY; TOXICITY;

ANTIMALARIAL AGENT; CYCLIC PEPTIDES; HOST CELLS; NON-COVALENT; P. FALCIPARUM; PARASITE; PLASMODIUM FALCIPARUM; PROTEASOMES;

PEPTIDES;

BIPHENYL DERIVATIVE; CYCLOPEPTIDE; ETHER DERIVATIVE; PROTEASOME; PROTEASOME INHIBITOR; ANTIMALARIAL AGENT;

ARTICLE; DRUG POTENCY; GROWTH INHIBITION; HOST CELL; IC50; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; DRUG SENSITIVITY; ENZYMOLOGY; FIBROBLAST; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM;

ANTIMALARIALS; FIBROBLASTS; HUMANS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PEPTIDES, CYCLIC; PLASMODIUM FALCIPARUM; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS;

EID: 84949141033     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja507692y     Document Type: Article

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