Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action

Biochemical Pharmacology

Volumn 56, Issue 10, 1998, Pages 1305-1313

  Ginsburg, Hagai ^a   Famin, Oleg ^a   Zhang, Jianmin ^a   Krugliak, Miriam ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Amodiaquine; Chloroquine; Glutathione; Malaria; Mode of action; Plasmodium falciparum

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; CHLOROQUINE; GLUTATHIONE; HEME; HEMOGLOBIN; HEMOZOIN; ION;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; CYTOSOL; DEGRADATION; DRUG RESISTANCE; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; FOOD; HOMEOSTASIS; HUMAN; HUMAN CELL; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; PRIORITY JOURNAL; TROPHOZOITE;

AMODIAQUINE; ANIMALS; ANTIMALARIALS; CHLOROQUINE; GLUTATHIONE; HEME; PLASMODIUM FALCIPARUM;

EID: 0031792787     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00184-1     Document Type: Article

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