메뉴 건너뛰기




Volumn 7, Issue 9, 2016, Pages

The telomere/telomerase system in chronic inflammatory diseases. Cause or effect?

Author keywords

Inflammation; Senescence; Telomerase; Telomeres

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; OXIDIZED LOW DENSITY LIPOPROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR NECROSIS FACTOR;

EID: 84989361058     PISSN: None     EISSN: 20734425     Source Type: Journal    
DOI: 10.3390/genes7090060     Document Type: Review
Times cited : (110)

References (212)
  • 1
    • 65349150505 scopus 로고    scopus 로고
    • A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix
    • Kaminker, P.G.; Kim, S.H.; Desprez, P.Y.; Campisi, J. A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle 2009, 8, 931–939.
    • (2009) Cell Cycle , vol.8 , pp. 931-939
    • Kaminker, P.G.1    Kim, S.H.2    Desprez, P.Y.3    Campisi, J.4
  • 2
    • 84891613470 scopus 로고    scopus 로고
    • On the origin of the eukaryotic chromosome: The role of noncanonical DNA structures in telomere evolution
    • Garavis, M.; Gonzalez, C.; Villasante, A. On the origin of the eukaryotic chromosome: The role of noncanonical DNA structures in telomere evolution. Genome Biol. Evol. 2013, 5, 1142–1150.
    • (2013) Genome Biol. Evol. , vol.5 , pp. 1142-1150
    • Garavis, M.1    Gonzalez, C.2    Villasante, A.3
  • 3
    • 84945200605 scopus 로고    scopus 로고
    • Beginning of the end: New insights into the functional organization of telomeres
    • Wood, A.M.; Laster, K.; Rice, E.L.; Kosak, S.T. A beginning of the end: New insights into the functional organization of telomeres. Nucleus 2015, 6, 172–178.
    • (2015) Nucleus , vol.6 , pp. 172-178
    • Wood, A.M.1    Laster, K.2    Rice, E.L.3    Kosak, S.4
  • 4
    • 84920163445 scopus 로고    scopus 로고
    • Telomeric repeat-containing RNA in telomere biology. Wiley Interdiscip
    • Cusanelli, E.; Chartrand, P. Telomeric noncoding RNA: Telomeric repeat-containing RNA in telomere biology. Wiley Interdiscip. Rev. RNA 2014, 5, 407–419.
    • (2014) Rev. RNA , vol.5 , pp. 407-419
    • Cusanelli, E.1    Chartrand, P.2    Telomeric Noncoding, R.3
  • 5
    • 84865369914 scopus 로고    scopus 로고
    • The role of telomere shortening in somatic stem cells and tissue aging: Lessons from telomerase model systems
    • Tumpel, S.; Rudolph, K.L. The role of telomere shortening in somatic stem cells and tissue aging: Lessons from telomerase model systems. Ann. N. Y. Acad. Sci. 2012, 1266, 28–39.
    • (2012) Ann. N. Y. Acad. Sci , vol.1266 , pp. 28-39
    • Tumpel, S.1    Rudolph, K.L.2
  • 6
    • 84924006883 scopus 로고    scopus 로고
    • Mechanisms of development of multimorbidity in the elderly
    • Barnes, P.J. Mechanisms of development of multimorbidity in the elderly. Eur. Respir. J. 2015, 4, 790–806.
    • (2015) Eur. Respir. J. , vol.4 , pp. 790-806
    • Barnes, P.J.1
  • 8
    • 0035989630 scopus 로고    scopus 로고
    • The disparity between human cell senescence in vitro and lifelong replication in vivo
    • Rubin, H. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat. Biotechnol. 2002, 20, 675–681.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 675-681
    • Rubin, H.1
  • 9
    • 84879985879 scopus 로고    scopus 로고
    • Telomere shortening in human diseases
    • Kong, C.M.; Lee, X.W.; Wang, X. Telomere shortening in human diseases. FEBS J. 2013, 280, 3180–3193.
    • (2013) FEBS J , vol.280 , pp. 3180-3193
    • Kong, C.M.1    Lee, X.W.2    Wang, X.3
  • 10
    • 84983078751 scopus 로고    scopus 로고
    • Telomerase RNA is more than a DNA template
    • Webb, C.J.; Zakian, V.A. Telomerase RNA is more than a DNA template. RNA Biol. 2016, 13, 1–7.
    • (2016) RNA Biol , vol.13 , pp. 1-7
    • Webb, C.J.1    Zakian, V.A.2
  • 12
    • 2042429168 scopus 로고    scopus 로고
    • Regulation of telomerase by telomeric proteins. Annu
    • Smogorzewska, A.; de Lange, T. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 2004, 73, 177–208.
    • (2004) Rev. Biochem , vol.73 , pp. 177-208
    • Smogorzewska, A.1    De Lange, T.2
  • 14
    • 84885079806 scopus 로고    scopus 로고
    • Telomerase regulation: A key to inhibition
    • Gomez, D.L.; Farina, H.G.; Gomez, D.E. Telomerase regulation: A key to inhibition? Int. J. Oncol. 2013, 43, 1351–1356.
    • (2013) Int. J. Oncol , vol.43 , pp. 1351-1356
    • Gomez, D.L.1    Farina, H.G.2    Gomez, D.E.3
  • 15
    • 84961054241 scopus 로고    scopus 로고
    • Questioning causal involvement of telomeres in aging
    • Simons, M.J. Questioning causal involvement of telomeres in aging. Ageing Res. Rev. 2015, 24, 191–196.
    • (2015) Ageing Res. Rev. , vol.24 , pp. 191-196
    • Simons, M.J.1
  • 16
    • 0032567975 scopus 로고    scopus 로고
    • Telomeres and senescence: The history, the experiment, the future
    • Greider, C.W. Telomeres and senescence: The history, the experiment, the future. Curr. Biol. 1998, 8, R178–R181.
    • (1998) Curr. Biol. , vol.8 , pp. R178-R181
    • Greider, C.W.1
  • 18
    • 77957220075 scopus 로고    scopus 로고
    • InTERTpreting telomerase structure and function
    • Wyatt, H.D.; West, S.C.; Beattie, T.L. InTERTpreting telomerase structure and function. Nucleic Acids Res. 2010, 38, 5609–5622.
    • (2010) Nucleic Acids Res , vol.38 , pp. 5609-5622
    • Wyatt, H.D.1    West, S.C.2    Beattie, T.L.3
  • 19
    • 84884167082 scopus 로고    scopus 로고
    • Feedback regulation of telomerase reverse transcriptase: New insight into the evolving field of telomerase in cancer
    • Wu, X.Q.; Huang, C.; He, X.; Tian, Y.Y.; Zhou, D.X.; He, Y.; Liu, X.H.; Li, J. Feedback regulation of telomerase reverse transcriptase: New insight into the evolving field of telomerase in cancer. Cell Signal 2013, 25, 2462–2468.
    • (2013) Cell Signal , vol.25 , pp. 2462-2468
    • Wu, X.Q.1    Huang, C.2    He, X.3    Tian, Y.Y.4    Zhou, D.X.5    He, Y.6    Liu, X.H.7    Li, J.8
  • 23
    • 84922400509 scopus 로고    scopus 로고
    • Carotenoids, inflammation, and oxidative stress—Implications of cellular signaling pathways and relation to chronic disease prevention
    • Kaulmann, A.; Bohn, T. Carotenoids, inflammation, and oxidative stress—Implications of cellular signaling pathways and relation to chronic disease prevention. Nutr. Res. 2014, 34, 907–929.
    • (2014) Nutr. Res. , vol.34 , pp. 907-929
    • Kaulmann, A.1    Bohn, T.2
  • 24
    • 84880575987 scopus 로고    scopus 로고
    • Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies—Novel tool for diagnostics and patient follow-up
    • Osnes, L.T.; Nakken, B.; Bodolay, E.; Szodoray, P. Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies—Novel tool for diagnostics and patient follow-up. Autoimmun Rev. 2013, 12, 967–971.
    • (2013) Autoimmun Rev , vol.12 , pp. 967-971
    • Osnes, L.T.1    Nakken, B.2    Bodolay, E.3    Szodoray, P.4
  • 25
    • 84958742100 scopus 로고    scopus 로고
    • The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging
    • Panickar, K.S.; Jewell, D.E. The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging. Horm. Mol. Biol. Clin. Investig. 2015, 23, 59–70.
    • (2015) Horm. Mol. Biol. Clin. Investig , vol.23 , pp. 59-70
    • Panickar, K.S.1    Jewell, D.E.2
  • 26
    • 84960272911 scopus 로고    scopus 로고
    • Immunocytokines: A novel class of products for the treatment of chronic inflammation and autoimmune conditions. Drug Discov
    • Bootz, F.; Neri, D. Immunocytokines: A novel class of products for the treatment of chronic inflammation and autoimmune conditions. Drug Discov. Today 2016, 21, 180–189.
    • (2016) Today , vol.21 , pp. 180-189
    • Bootz, F.1    Neri, D.2
  • 27
    • 84865298941 scopus 로고    scopus 로고
    • Telomere dysfunction, autoimmunity and aging
    • Hohensinner, P.J.; Goronzy, J.J.; Weyand, C.M. Telomere dysfunction, autoimmunity and aging. Aging Dis. 2011, 2, 524–537.
    • (2011) Aging Dis , vol.2 , pp. 524-537
    • Hohensinner, P.J.1    Goronzy, J.J.2    Weyand, C.M.3
  • 28
    • 79951795555 scopus 로고    scopus 로고
    • Healthy aging and disease: Role for telomere biology?
    • Zhu, H.; Belcher, M.; van der Harst, P. Healthy aging and disease: Role for telomere biology? Clin. Sci. 2011, 120, 427–440.
    • (2011) Clin. Sci. , vol.120 , pp. 427-440
    • Zhu, H.1    Belcher, M.2    Van Der Harst, P.3
  • 29
    • 65549111162 scopus 로고    scopus 로고
    • Kleemeier Award Lecture 2008—the canary in the coal mine: Telomeres and human healthspan
    • Effros, R.B. Kleemeier Award Lecture 2008—the canary in the coal mine: Telomeres and human healthspan. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64, 511–515.
    • (2009) J. Gerontol. a Biol. Sci. Med. Sci. , vol.64 , pp. 511-515
    • Effros, R.B.1
  • 31
    • 84978496636 scopus 로고    scopus 로고
    • Human Specific Regulation of the Telomerase Reverse Transcriptase Gene
    • Zhang, F.; Cheng, D.; Wang, S.; Zhu, J. Human Specific Regulation of the Telomerase Reverse Transcriptase Gene. Genes 2016.
    • (2016) Genes
    • Zhang, F.1    Cheng, D.2    Wang, S.3    Zhu, J.4
  • 32
    • 84964467075 scopus 로고    scopus 로고
    • Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
    • Bar, C.; Blasco, M.A. Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. F1000Research 2016.
    • (2016) F1000research
    • Bar, C.1    Blasco, M.A.2
  • 33
    • 82455198885 scopus 로고    scopus 로고
    • Chronic inflammation links cardiovascular, metabolic and renal diseases
    • Manabe, I. Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ. J. 2011, 75, 2739–2748.
    • (2011) Circ. J. , vol.75 , pp. 2739-2748
    • Manabe, I.1
  • 34
    • 34147190086 scopus 로고    scopus 로고
    • Chronic inflammation: A failure of resolution
    • Lawrence, T.; Gilroy, D.W. Chronic inflammation: A failure of resolution? Int. J. Exp. Pathol. 2007, 88, 85–94.
    • (2007) Int. J. Exp. Pathol , vol.88 , pp. 85-94
    • Lawrence, T.1    Gilroy, D.W.2
  • 37
    • 77950365906 scopus 로고    scopus 로고
    • Nonresolving inflammation
    • Nathan, C.; Ding, A. Nonresolving inflammation. Cell 2010, 140, 871–882.
    • (2010) Cell , vol.140 , pp. 871-882
    • Nathan, C.1    Ding, A.2
  • 38
    • 84883729969 scopus 로고    scopus 로고
    • Neutrophil cell surface receptors and their intracellular signal transduction pathways
    • Futosi, K.; Fodor, S.; Mocsai, A. Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int. Immunopharmacol. 2013, 17, 638–650.
    • (2013) Int. Immunopharmacol. , vol.17 , pp. 638-650
    • Futosi, K.1    Fodor, S.2    Mocsai, A.3
  • 39
    • 84925486323 scopus 로고    scopus 로고
    • Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways
    • Narayanan, K.B.; Park, H.H. Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways. Apoptosis 2015, 20, 196–209.
    • (2015) Apoptosis , vol.20 , pp. 196-209
    • Narayanan, K.B.1    Park, H.H.2
  • 40
    • 84960154302 scopus 로고    scopus 로고
    • The molecular mechanisms of TLR-signaling cooperation in cytokine regulation. Immunol
    • Liu, Q.; Ding, J.L. The molecular mechanisms of TLR-signaling cooperation in cytokine regulation. Immunol. Cell Biol. 2016, 94, 538–542.
    • (2016) Cell Biol , vol.94 , pp. 538-542
    • Liu, Q.1    Ding, J.L.2
  • 41
    • 0037203547 scopus 로고    scopus 로고
    • Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)
    • Lee, N.K.; Lee, S.Y. Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs). J. Biochem. Mol. Biol. 2002, 35, 61–66.
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 61-66
    • Lee, N.K.1    Lee, S.Y.2
  • 42
    • 84870199424 scopus 로고    scopus 로고
    • NF-kappaB as a target for modulating inflammatory responses
    • Gasparini, C.; Feldmann, M. NF-kappaB as a target for modulating inflammatory responses. Curr. Pharm. Des. 2012, 18, 5735–5745.
    • (2012) Curr. Pharm. Des , vol.18 , pp. 5735-5745
    • Gasparini, C.1    Feldmann, M.2
  • 43
    • 84860330618 scopus 로고    scopus 로고
    • Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease
    • Iyer, S.S.; Cheng, G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit. Rev. Immunol. 2012, 32, 23–63.
    • (2012) Crit. Rev. Immunol. , vol.32 , pp. 23-63
    • Iyer, S.S.1    Cheng, G.2
  • 44
    • 84951907181 scopus 로고    scopus 로고
    • Phosphatase regulation of macrophage activation
    • Kozicky, L.K.; Sly, L.M. Phosphatase regulation of macrophage activation. Semin Immunol 2015, 27, 276–285.
    • (2015) Semin Immunol , vol.27 , pp. 276-285
    • Kozicky, L.K.1    Sly, L.M.2
  • 45
    • 84885339072 scopus 로고    scopus 로고
    • Linear ubiquitination-mediated NF-kappaB regulation and its related disorders
    • Tokunaga, F. Linear ubiquitination-mediated NF-kappaB regulation and its related disorders. J. Biochem. 2013, 154, 313–323.
    • (2013) J. Biochem. , vol.154 , pp. 313-323
    • Tokunaga, F.1
  • 46
    • 84931068090 scopus 로고    scopus 로고
    • Targeting signaling factors for degradation, an emerging mechanism for TRAF functions
    • Yang, X.D.; Sun, S.C. Targeting signaling factors for degradation, an emerging mechanism for TRAF functions. Immunol. Rev. 2015, 266, 56–71.
    • (2015) Immunol. Rev. , vol.266 , pp. 56-71
    • Yang, X.D.1    Sun, S.C.2
  • 47
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases
    • Franceschi, C.; Campisi, J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J. Gerontol. A Biol. Sci. Med. Sci. 2014, 69, S4–S9.
    • (2014) J. Gerontol. a Biol. Sci. Med. Sci. , vol.69 , pp. S4-S9
    • Franceschi, C.1    Campisi, J.2
  • 49
  • 50
    • 78650243948 scopus 로고    scopus 로고
    • Impact of cellular senescence signature on ageing research
    • Sikora, E.; Arendt, T.; Bennett, M.; Narita, M. Impact of cellular senescence signature on ageing research. Ageing Res. Rev. 2011, 10, 146–152.
    • (2011) Ageing Res. Rev. , vol.10 , pp. 146-152
    • Sikora, E.1    Arendt, T.2    Bennett, M.3    Narita, M.4
  • 51
    • 84949555897 scopus 로고    scopus 로고
    • Cellular senescence in aging and age-related disease: From mechanisms to therapy
    • Childs, B.G.; Durik, M.; Baker, D.J.; van Deursen, J.M. Cellular senescence in aging and age-related disease: From mechanisms to therapy. Nat. Med. 2015, 21, 1424–1435.
    • (2015) Nat. Med. , vol.21 , pp. 1424-1435
    • Childs, B.G.1    Durik, M.2    Baker, D.J.3    Van Deursen, J.M.4
  • 52
    • 84924140282 scopus 로고    scopus 로고
    • Cellular senescence in ageing, age-related disease and longevity
    • Sikora, E.; Bielak-Zmijewska, A.; Mosieniak, G. Cellular senescence in ageing, age-related disease and longevity. Curr. Vasc. Pharmacol. 2014, 12, 698–706.
    • (2014) Curr. Vasc. Pharmacol. , vol.12 , pp. 698-706
    • Sikora, E.1    Bielak-Zmijewska, A.2    Mosieniak, G.3
  • 55
    • 84906218639 scopus 로고    scopus 로고
    • Senescent cells and their secretory phenotype as targets for cancer therapy
    • Velarde, M.C.; Demaria, M.; Campisi, J. Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip. Top Gerontol. 2013, 38, 17–27.
    • (2013) Interdiscip. Top Gerontol. , vol.38 , pp. 17-27
    • Velarde, M.C.1    Demaria, M.2    Campisi, J.3
  • 56
    • 84856209016 scopus 로고    scopus 로고
    • Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)
    • Salminen, A.; Kauppinen, A.; Kaarniranta, K. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 2012, 24, 835–845.
    • (2012) Cell Signal , vol.24 , pp. 835-845
    • Salminen, A.1    Kauppinen, A.2    Kaarniranta, K.3
  • 57
    • 84914818823 scopus 로고    scopus 로고
    • Senescent cells: SASPected drivers of age-related pathologies
    • Ovadya, Y.; Krizhanovsky, V. Senescent cells: SASPected drivers of age-related pathologies. Biogerontology 2014, 15, 627–642.
    • (2014) Biogerontology , vol.15 , pp. 627-642
    • Ovadya, Y.1    Krizhanovsky, V.2
  • 58
    • 84926523961 scopus 로고    scopus 로고
    • Senescence-associated inflammatory responses: Aging and cancer perspectives
    • Lasry, A.; Ben-Neriah, Y. Senescence-associated inflammatory responses: Aging and cancer perspectives. Trends Immunol. 2015, 36, 217–228.
    • (2015) Trends Immunol , vol.36 , pp. 217-228
    • Lasry, A.1    Ben-Neriah, Y.2
  • 59
    • 84902297367 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
    • Zhu, Y.; Armstrong, J.L.; Tchkonia, T.; Kirkland, J.L. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr. Opin. Clin. Nutr. Metab. Care 2014, 17, 324–328.
    • (2014) Curr. Opin. Clin. Nutr. Metab. Care , vol.17 , pp. 324-328
    • Zhu, Y.1    Armstrong, J.L.2    Tchkonia, T.3    Kirkland, J.L.4
  • 60
    • 84939975178 scopus 로고    scopus 로고
    • Cellular senescence: A hitchhiker’s guide
    • Aravinthan, A. Cellular senescence: A hitchhiker’s guide. Hum. Cell 2015, 28, 51–64.
    • (2015) Hum. Cell , vol.28 , pp. 51-64
    • Aravinthan, A.1
  • 62
    • 77958468469 scopus 로고    scopus 로고
    • Telomeres and inflammation: Rap1 joins the ends?
    • Ghosh, A.S.; Tergaonkar, V. Telomeres and inflammation: Rap1 joins the ends? Cell Cycle 2010, 9, 3834–3835.
    • (2010) Cell Cycle , vol.9 , pp. 3834-3835
    • Ghosh, A.S.1    Tergaonkar, V.2
  • 63
    • 84899452308 scopus 로고    scopus 로고
    • Telomeres, oxidative stress and inflammatory factors: Partners in cellular senescence?
    • Correia-Melo, C.; Hewitt, G.; Passos, J.F. Telomeres, oxidative stress and inflammatory factors: Partners in cellular senescence? Longev. Healthspan. 2014.
    • (2014) Longev. Healthspan.
    • Correia-Melo, C.1    Hewitt, G.2    Passos, J.F.3
  • 64
    • 78549237781 scopus 로고    scopus 로고
    • Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house
    • Rai, P. Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house. Mutat. Res. 2010, 703, 71–81.
    • (2010) Mutat. Res. , vol.703 , pp. 71-81
    • Rai, P.1
  • 65
    • 33745384267 scopus 로고    scopus 로고
    • Molecular mechanisms of aging-associated inflammation
    • Sarkar, D.; Fisher, P.B. Molecular mechanisms of aging-associated inflammation. Cancer Lett. 2006, 236, 13–23.
    • (2006) Cancer Lett , vol.236 , pp. 13-23
    • Sarkar, D.1    Fisher, P.B.2
  • 69
    • 84917737967 scopus 로고    scopus 로고
    • Targeting pro-resolution pathways to combat chronic inflammation in COPD
    • Bozinovski, S.; Anthony, D.; Vlahos, R. Targeting pro-resolution pathways to combat chronic inflammation in COPD. J. Thorac. Dis. 2014, 6, 1548–1556.
    • (2014) J. Thorac. Dis. , vol.6 , pp. 1548-1556
    • Bozinovski, S.1    Anthony, D.2    Vlahos, R.3
  • 70
    • 60649102339 scopus 로고    scopus 로고
    • Pulmonary fibrosis: Pathogenesis, etiology and regulation
    • Wilson, M.S.; Wynn, T.A. Pulmonary fibrosis: Pathogenesis, etiology and regulation. Mucosal Immunol. 2009, 2, 103–121.
    • (2009) Mucosal Immunol , vol.2 , pp. 103-121
    • Wilson, M.S.1    Wynn, T.A.2
  • 71
  • 72
    • 84990960707 scopus 로고    scopus 로고
    • Inflammatory mechanisms in patients with chronic obstructive pulmonary disease
    • Barnes, P.J. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 2016, 138, 16–27.
    • (2016) J. Allergy Clin. Immunol. , vol.138 , pp. 16-27
    • Barnes, P.J.1
  • 73
    • 84887990028 scopus 로고    scopus 로고
    • Telomeres in lung disease
    • Gansner, J.M.; Rosas, I.O. Telomeres in lung disease. Transl. Res. 2013, 162, 343–352.
    • (2013) Transl. Res. , vol.162 , pp. 343-352
    • Gansner, J.M.1    Rosas, I.O.2
  • 76
    • 84959365332 scopus 로고    scopus 로고
    • Serum telomerase levels and COPD exacerbations
    • Bozkus, F.; Guler, S.; Simsek, S. Serum telomerase levels and COPD exacerbations. Respir. Care 2016, 61, 359–365.
    • (2016) Respir. Care , vol.61 , pp. 359-365
    • Bozkus, F.1    Guler, S.2    Simsek, S.3
  • 77
    • 79958120387 scopus 로고    scopus 로고
    • Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
    • Zhou, F.; Onizawa, S.; Nagai, A.; Aoshiba, K. Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury. Respir. Res. 2011.
    • (2011) Respir. Res.
    • Zhou, F.1    Onizawa, S.2    Nagai, A.3    Aoshiba, K.4
  • 84
    • 84855844345 scopus 로고    scopus 로고
    • Pathogenesis of idiopathic pulmonary fibrosis: From initial apoptosis of epithelial cells to lung remodeling?
    • Jin, H.L.; Dong, J.C. Pathogenesis of idiopathic pulmonary fibrosis: From initial apoptosis of epithelial cells to lung remodeling? Chin. Med. J. 2011, 124, 4330–4338.
    • (2011) Chin. Med. J. , vol.124 , pp. 4330-4338
    • Jin, H.L.1    Dong, J.C.2
  • 86
    • 84874611617 scopus 로고    scopus 로고
    • Telomeres and age-related disease: How telomere biology informs clinical paradigms
    • Armanios, M. Telomeres and age-related disease: How telomere biology informs clinical paradigms. J. Clin. Investig. 2013, 123, 996–1002.
    • (2013) J. Clin. Investig. , vol.123 , pp. 996-1002
    • Armanios, M.1
  • 87
    • 84951797366 scopus 로고    scopus 로고
    • Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs
    • Chen, R.; Zhang, K.; Chen, H.; Zhao, X.; Wang, J.; Li, L.; Cong, Y.; Ju, Z.; Xu, D.; Williams, B.R., et al. Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs. J. Biol. Chem. 2015, 290, 30813–30829.
    • (2015) J. Biol. Chem. , vol.290 , pp. 30813-30829
    • Chen, R.1    Zhang, K.2    Chen, H.3    Zhao, X.4    Wang, J.5    Li, L.6    Cong, Y.7    Ju, Z.8    Xu, D.9    Williams, B.R.10
  • 88
    • 84863011263 scopus 로고    scopus 로고
    • Cigarette smoking and inflammation: Cellular and molecular mechanisms
    • Lee, J.; Taneja, V.; Vassallo, R. Cigarette smoking and inflammation: Cellular and molecular mechanisms. J. Dent. Res. 2012, 91, 142–149.
    • (2012) J. Dent. Res. , vol.91 , pp. 142-149
    • Lee, J.1    Taneja, V.2    Vassallo, R.3
  • 92
    • 82655171679 scopus 로고    scopus 로고
    • Immunology in the Clinic Review Series; focus on metabolic diseases: Development of islet autoimmune disease in type 2 diabetes patients: Potential sequelae of chronic inflammation. Clin. Exp
    • Brooks-Worrell, B.; Palmer, J.P. Immunology in the Clinic Review Series; focus on metabolic diseases: Development of islet autoimmune disease in type 2 diabetes patients: Potential sequelae of chronic inflammation. Clin. Exp. Immunol. 2012, 167, 40–46.
    • (2012) Immunol , vol.167 , pp. 40-46
    • Brooks-Worrell, B.1    Palmer, J.P.2
  • 93
    • 84899447285 scopus 로고    scopus 로고
    • Autoimmune aspects of type 2 diabetes mellitus—A mini-review
    • Itariu, B.K.; Stulnig, T.M. Autoimmune aspects of type 2 diabetes mellitus—A mini-review. Gerontology 2014, 60, 189–196.
    • (2014) Gerontology , vol.60 , pp. 189-196
    • Itariu, B.K.1    Stulnig, T.M.2
  • 94
    • 79551470814 scopus 로고    scopus 로고
    • Therapeutic approaches to target inflammation in type 2 diabetes
    • Goldfine, A.B.; Fonseca, V.; Shoelson, S.E. Therapeutic approaches to target inflammation in type 2 diabetes. Clin. Chem. 2011, 57, 162–167.
    • (2011) Clin. Chem. , vol.57 , pp. 162-167
    • Goldfine, A.B.1    Fonseca, V.2    Shoelson, S.E.3
  • 95
    • 70350309325 scopus 로고    scopus 로고
    • The roles of telomeres and telomerase in beta-cell regeneration
    • Liew, C.W.; Holman, A.; Kulkarni, R.N. The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes. Metab. 2009, 11, 21–29.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 21-29
    • Liew, C.W.1    Holman, A.2    Kulkarni, R.N.3
  • 96
    • 84929603267 scopus 로고    scopus 로고
    • The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications
    • Qi Nan, W.; Ling, Z.; Bing, C. The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications. Expert Opin. Ther. Targets 2015, 19, 849–864.
    • (2015) Expert Opin. Ther. Targets , vol.19 , pp. 849-864
    • Qi Nan, W.1    Ling, Z.2    Bing, C.3
  • 99
    • 79954539970 scopus 로고    scopus 로고
    • Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic?
    • Mulder, H. Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic? Aging 2010, 2, 634–636.
    • (2010) Aging , vol.2 , pp. 634-636
    • Mulder, H.1
  • 100
    • 84876007266 scopus 로고    scopus 로고
    • The effect of telomerase activity on vascular smooth muscle cell proliferation in type 2 diabetes in vivo and in vitro
    • Sun, X.; Han, F.; Yi, J.; Hou, N.; Cao, Z. The effect of telomerase activity on vascular smooth muscle cell proliferation in type 2 diabetes in vivo and in vitro. Mol. Med. Rep. 2013, 7, 1636–1640.
    • (2013) Mol. Med. Rep. , vol.7 , pp. 1636-1640
    • Sun, X.1    Han, F.2    Yi, J.3    Hou, N.4    Cao, Z.5
  • 101
    • 84891536097 scopus 로고    scopus 로고
    • Association between oxidative stress and telomere length in Type 1 and Type 2 diabetic patients
    • Ma, D.; Zhu, W.; Hu, S.; Yu, X.; Yang, Y. Association between oxidative stress and telomere length in Type 1 and Type 2 diabetic patients. J. Endocrinol. Invest. 2013, 36, 1032–1037.
    • (2013) J. Endocrinol. Invest , vol.36 , pp. 1032-1037
    • Ma, D.1    Zhu, W.2    Hu, S.3    Yu, X.4    Yang, Y.5
  • 103
    • 85044504191 scopus 로고    scopus 로고
    • Shortened leukocyte telomere length in type 2 diabetes mellitus: Genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways
    • Zhou, Y.; Ning, Z.; Lee, Y.; Hambly, B.D.; McLachlan, C.S. Shortened leukocyte telomere length in type 2 diabetes mellitus: Genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways. Clin. Transl. Med. 2016.
    • (2016) Clin. Transl. Med.
    • Zhou, Y.1    Ning, Z.2    Lee, Y.3    Hambly, B.D.4    McLachlan, C.S.5
  • 104
    • 75649128017 scopus 로고    scopus 로고
    • Cytokines in chronic rheumatic diseases: Is everything lack of homeostatic balance?
    • Chizzolini, C.; Dayer, J.M.; Miossec, P. Cytokines in chronic rheumatic diseases: Is everything lack of homeostatic balance? Arthritis Res. Ther. 2009.
    • (2009) Arthritis Res. Ther.
    • Chizzolini, C.1    Dayer, J.M.2    Miossec, P.3
  • 105
    • 70449441060 scopus 로고    scopus 로고
    • Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity
    • Kunz, M.; Ibrahim, S.M. Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm. 2009.
    • (2009) Mediators Inflamm.
    • Kunz, M.1    Ibrahim, S.M.2
  • 106
    • 81755161555 scopus 로고    scopus 로고
    • Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?
    • Santegoets, K.C.; van Bon, L.; van den Berg, W.B.; Wenink, M.H.; Radstake, T.R. Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs? FEBS Lett. 2011, 585, 3660–3666.
    • (2011) FEBS Lett , vol.585 , pp. 3660-3666
    • Santegoets, K.C.1    Van Bon, L.2    Van Den Berg, W.B.3    Wenink, M.H.4    Radstake, T.R.5
  • 109
    • 42449085252 scopus 로고    scopus 로고
    • Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis
    • Colmegna, I.; Diaz-Borjon, A.; Fujii, H.; Schaefer, L.; Goronzy, J.J.; Weyand, C.M. Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum. 2008, 58, 990–1000.
    • (2008) Arthritis Rheum , vol.58 , pp. 990-1000
    • Colmegna, I.1    Diaz-Borjon, A.2    Fujii, H.3    Schaefer, L.4    Goronzy, J.J.5    Weyand, C.M.6
  • 110
    • 84887914158 scopus 로고    scopus 로고
    • Accelerated telomere shortening in rheumatic diseases: Cause or consequence? Expert
    • Dehbi, A.Z.; Radstake, T.R.; Broen, J.C. Accelerated telomere shortening in rheumatic diseases: Cause or consequence? Expert Rev. Clin. Immunol. 2013, 9, 1193–1204.
    • (2013) Rev. Clin. Immunol , vol.9 , pp. 1193-1204
    • Dehbi, A.Z.1    Radstake, T.R.2    Broen, J.C.3
  • 113
    • 84887466496 scopus 로고    scopus 로고
    • Immunosenescence, aging, and systemic lupus erythematous
    • Montoya-Ortiz, G. Immunosenescence, aging, and systemic lupus erythematous. Autoimmune Dis. 2013.
    • (2013) Autoimmune Dis
    • Montoya-Ortiz, G.1
  • 114
    • 34249011458 scopus 로고    scopus 로고
    • Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity
    • Wu, C.H.; Hsieh, S.C.; Li, K.J.; Lu, M.C.; Yu, C.L. Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity. Lupus 2007, 16, 265–272.
    • (2007) Lupus , vol.16 , pp. 265-272
    • Wu, C.H.1    Hsieh, S.C.2    Li, K.J.3    Lu, M.C.4    Yu, C.L.5
  • 116
    • 84877896768 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and vitamin D deficiency are associated with shorter telomere length among African Americans: A case-control study
    • Hoffecker, B.M.; Raffield, L.M.; Kamen, D.L.; Nowling, T.K. Systemic lupus erythematosus and vitamin D deficiency are associated with shorter telomere length among African Americans: A case-control study. PLoS ONE 2013, 8, e63725.
    • (2013) Plos ONE , vol.8
    • Hoffecker, B.M.1    Raffield, L.M.2    Kamen, D.L.3    Nowling, T.K.4
  • 119
    • 9644264112 scopus 로고    scopus 로고
    • Telomerase activity in B and T lymphocytes of patients with systemic lupus erythematosus
    • Klapper, W.; Moosig, F.; Sotnikova, A.; Qian, W.; Schroder, J.O.; Parwaresch, R. Telomerase activity in B and T lymphocytes of patients with systemic lupus erythematosus. Ann. Rheum. Dis. 2004, 63, 1681–1683.
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 1681-1683
    • Klapper, W.1    Moosig, F.2    Sotnikova, A.3    Qian, W.4    Schroder, J.O.5    Parwaresch, R.6
  • 120
    • 80052707702 scopus 로고    scopus 로고
    • Changes in the expression of telomere maintenance genes might play a role in the pathogenesis of systemic lupus erythematosus
    • Zhou, J.G.; Qing, Y.F.; Yang, Q.B.; Xie, W.G.; Zhao, M.C. Changes in the expression of telomere maintenance genes might play a role in the pathogenesis of systemic lupus erythematosus. Lupus 2011, 20, 820–828.
    • (2011) Lupus , vol.20 , pp. 820-828
    • Zhou, J.G.1    Qing, Y.F.2    Yang, Q.B.3    Xie, W.G.4    Zhao, M.C.5
  • 121
    • 0034667816 scopus 로고    scopus 로고
    • Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis
    • Wu, K.; Higashi, N.; Hansen, E.R.; Lund, M.; Bang, K.; Thestrup-Pedersen, K. Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis. J. Immunol. 2000, 165, 4742–4747.
    • (2000) J. Immunol , vol.165 , pp. 4742-4747
    • Wu, K.1    Higashi, N.2    Hansen, E.R.3    Lund, M.4    Bang, K.5    Thestrup-Pedersen, K.6
  • 122
    • 39049119802 scopus 로고    scopus 로고
    • Telomerase activity in peripheral blood mononuclear cells of psoriatic patients correlates with disease severity
    • Liu, X.; Lin, J.; Wang, L.; Zhang, Z.; Hou, S.; Yang, G. Telomerase activity in peripheral blood mononuclear cells of psoriatic patients correlates with disease severity. Br. J. Dermatol. 2008, 158, 637–639.
    • (2008) Br. J. Dermatol , vol.158 , pp. 637-639
    • Liu, X.1    Lin, J.2    Wang, L.3    Zhang, Z.4    Hou, S.5    Yang, G.6
  • 123
    • 84959879484 scopus 로고    scopus 로고
    • Analysis of telomere length as predictive marker in psoriasis for comorbidities
    • Coussens, E.; Grine, L.; Bostoen, J.; Mielants, H.; Lambert, J. Analysis of telomere length as predictive marker in psoriasis for comorbidities. Exp. Dermatol. 2016, 25, 388–390.
    • (2016) Exp. Dermatol. , vol.25 , pp. 388-390
    • Coussens, E.1    Grine, L.2    Bostoen, J.3    Mielants, H.4    Lambert, J.5
  • 124
    • 84922104338 scopus 로고    scopus 로고
    • Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening
    • Guan, J.Z.; Guan, W.P.; Maeda, T.; Guoqing, X.; GuangZhi, W.; Makino, N. Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening. Mol. Cell Biochem. 2015, 400, 183–187.
    • (2015) Mol. Cell Biochem. , vol.400 , pp. 183-187
    • Guan, J.Z.1    Guan, W.P.2    Maeda, T.3    Guoqing, X.4    Guangzhi, W.5    Makino, N.6
  • 125
    • 71849118370 scopus 로고    scopus 로고
    • Differing patterns of peripheral blood leukocyte telomere length in rheumatologic diseases. Mutat
    • Tamayo, M.; Mosquera, A.; Rego, J.I.; Fernandez-Sueiro, J.L.; Blanco, F.J.; Fernandez, J.L. Differing patterns of peripheral blood leukocyte telomere length in rheumatologic diseases. Mutat. Res. 2010, 683, 68–73.
    • (2010) Res , vol.683 , pp. 68-73
    • Tamayo, M.1    Mosquera, A.2    Rego, J.I.3    Fernandez-Sueiro, J.L.4    Blanco, F.J.5    Fernandez, J.L.6
  • 126
    • 67649397446 scopus 로고    scopus 로고
    • Inflammation in chronic kidney disease: Role in the progression of renal and cardiovascular disease
    • Silverstein, D.M. Inflammation in chronic kidney disease: Role in the progression of renal and cardiovascular disease. Pediatr. Nephrol. 2009, 24, 1445–1452.
    • (2009) Pediatr. Nephrol. , vol.24 , pp. 1445-1452
    • Silverstein, D.M.1
  • 127
    • 84923104493 scopus 로고    scopus 로고
    • Update on inflammation in chronic kidney disease
    • Akchurin, O.M.; Kaskel, F. Update on inflammation in chronic kidney disease. Blood Purif. 2015, 39, 84–92.
    • (2015) Blood Purif , vol.39 , pp. 84-92
    • Akchurin, O.M.1    Kaskel, F.2
  • 128
    • 80054726333 scopus 로고    scopus 로고
    • Inflammation as a risk factor and target for therapy in chronic kidney disease
    • Miyamoto, T.; Carrero, J.J.; Stenvinkel, P. Inflammation as a risk factor and target for therapy in chronic kidney disease. Curr. Opin. Nephrol. Hypertens. 2011, 20, 662–668.
    • (2011) Curr. Opin. Nephrol. Hypertens. , vol.20 , pp. 662-668
    • Miyamoto, T.1    Carrero, J.J.2    Stenvinkel, P.3
  • 129
    • 84879313137 scopus 로고    scopus 로고
    • Immune and inflammatory role in renal disease
    • Imig, J.D.; Ryan, M.J. Immune and inflammatory role in renal disease. Compr. Physiol. 2013, 3, 957–976.
    • (2013) Compr. Physiol. , vol.3 , pp. 957-976
    • Imig, J.D.1    Ryan, M.J.2
  • 130
    • 84930661669 scopus 로고    scopus 로고
    • Is there a connection between inflammation, telomerase activity and the transcriptional status of telomerase reverse transcriptase in renal failure? Cell Mol
    • Kordinas, V.; Tsirpanlis, G.; Nicolaou, C.; Zoga, M.; Ioannidis, A.; Ioannidou, V.; Bersimis, S.; Petrihou, C.; Savva, L.; Legakis, N.J., et al. Is there a connection between inflammation, telomerase activity and the transcriptional status of telomerase reverse transcriptase in renal failure? Cell Mol. Biol. Lett. 2015, 20, 222–236.
    • (2015) Biol. Lett. , vol.20 , pp. 222-236
    • Kordinas, V.1    Tsirpanlis, G.2    Nicolaou, C.3    Zoga, M.4    Ioannidis, A.5    Ioannidou, V.6    Bersimis, S.7    Petrihou, C.8    Savva, L.9    Legakis, N.J.10
  • 132
  • 133
  • 134
    • 84940604547 scopus 로고    scopus 로고
    • Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is RelatedWith Telomerase Activity and Treatment Duration
    • Stefanidis, I.; Voliotis, G.; Papanikolaou, V.; Chronopoulou, I.; Eleftheriadis, T.; Kowald, A.; Zintzaras, E.; Tsezou, A. Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is RelatedWith Telomerase Activity and Treatment Duration. Artif. Organs. 2015, 39, 756–764.
    • (2015) Artif. Organs. , vol.39 , pp. 756-764
    • Stefanidis, I.1    Voliotis, G.2    Papanikolaou, V.3    Chronopoulou, I.4    Eleftheriadis, T.5    Kowald, A.6    Zintzaras, E.7    Tsezou, A.8
  • 135
    • 84936802472 scopus 로고    scopus 로고
    • Association of relative telomere length with progression of chronic kidney disease in two cohorts: Effect modification by smoking and diabetes
    • Raschenberger, J.; Kollerits, B.; Ritchie, J.; Lane, B.; Kalra, P.A.; Ritz, E.; Kronenberg, F. Association of relative telomere length with progression of chronic kidney disease in two cohorts: Effect modification by smoking and diabetes. Sci. Rep. 2015.
    • (2015) Sci. Rep.
    • Raschenberger, J.1    Kollerits, B.2    Ritchie, J.3    Lane, B.4    Kalra, P.A.5    Ritz, E.6    Kronenberg, F.7
  • 138
    • 0028158425 scopus 로고
    • The prevention of cardiovascular disease. Emphasis on secondary prevention
    • Robinson, J.G.; Leon, A.S. The prevention of cardiovascular disease. Emphasis on secondary prevention. Med. Clin. North. Am. 1994, 78, 69–98.
    • (1994) Med. Clin. North. Am , vol.78 , pp. 69-98
    • Robinson, J.G.1    Leon, A.S.2
  • 139
    • 84928501216 scopus 로고    scopus 로고
    • Modulation of autoimmunity and atherosclerosis—Common targets and promising translational approaches against disease
    • Ketelhuth, D.F.; Hansson, G.K. Modulation of autoimmunity and atherosclerosis—Common targets and promising translational approaches against disease. Circ. J. 2015, 79, 924–933.
    • (2015) Circ. J , vol.79 , pp. 924-933
    • Ketelhuth, D.F.1    Hansson, G.K.2
  • 140
    • 84876808529 scopus 로고    scopus 로고
    • Immunity, atherosclerosis and cardiovascular disease
    • Frostegard, J. Immunity, atherosclerosis and cardiovascular disease. BMC Med. 2013.
    • (2013) BMC Med
    • Frostegard, J.1
  • 142
    • 84971274406 scopus 로고    scopus 로고
    • Chronic Inflammatory Diseases and Endothelial Dysfunction
    • Castellon, X.; Bogdanova, V. Chronic Inflammatory Diseases and Endothelial Dysfunction. Aging Dis. 2016, 7, 81–89.
    • (2016) Aging Dis , vol.7 , pp. 81-89
    • Castellon, X.1    Bogdanova, V.2
  • 143
    • 84878409294 scopus 로고    scopus 로고
    • How can we cure a heart “in flame”? A translational view on inflammation in heart failure. Basic Res
    • Hofmann, U.; Frantz, S. How can we cure a heart “in flame”? A translational view on inflammation in heart failure. Basic Res. Cardiol. 2013.
    • (2013) Cardiol
    • Hofmann, U.1    Frantz, S.2
  • 144
    • 1642388491 scopus 로고    scopus 로고
    • Telomeres and cardiovascular disease: Does size matter?
    • Serrano, A.L.; Andres, V. Telomeres and cardiovascular disease: Does size matter? Circ. Res. 2004, 94, 575–584.
    • (2004) Circ. Res. , vol.94 , pp. 575-584
    • Serrano, A.L.1    Andres, V.2
  • 145
    • 37349061382 scopus 로고    scopus 로고
    • Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors. Mech
    • Voghel, G.; Thorin-Trescases, N.; Farhat, N.; Nguyen, A.; Villeneuve, L.; Mamarbachi, A.M.; Fortier, A.; Perrault, L.P.; Carrier, M.; Thorin, E. Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors. Mech. Ageing Dev. 2007, 128, 662–671.
    • (2007) Ageing Dev , vol.128 , pp. 662-671
    • Voghel, G.1    Thorin-Trescases, N.2    Farhat, N.3    Nguyen, A.4    Villeneuve, L.5    Mamarbachi, A.M.6    Fortier, A.7    Perrault, L.P.8    Carrier, M.9    Thorin, E.10
  • 146
    • 33751311529 scopus 로고    scopus 로고
    • Telomere biology and cardiovascular disease
    • Fuster, J.J.; Andres, V. Telomere biology and cardiovascular disease. Circ. Res. 2006, 99, 1167–1180.
    • (2006) Circ. Res. , vol.99 , pp. 1167-1180
    • Fuster, J.J.1    Andres, V.2
  • 150
    • 84922642868 scopus 로고    scopus 로고
    • From stress to inflammation and major depressive disorder: A social signal transduction theory of depression
    • Slavich, G.M.; Irwin, M.R. From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychol. Bull. 2014, 140, 774–815.
    • (2014) Psychol. Bull. , vol.140 , pp. 774-815
    • Slavich, G.M.1    Irwin, M.R.2
  • 152
    • 84956962598 scopus 로고    scopus 로고
    • Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers
    • Muneer, A. Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers. Psychiatry Investig. 2016, 13, 18–33.
    • (2016) Psychiatry Investig. , vol.13 , pp. 18-33
    • Muneer, A.1
  • 155
    • 84905047389 scopus 로고    scopus 로고
    • Major depressive disorder and accelerated cellular aging: Results from a large psychiatric cohort study
    • Verhoeven, J.E.; Revesz, D.; Epel, E.S.; Lin, J.; Wolkowitz, O.M.; Penninx, B.W. Major depressive disorder and accelerated cellular aging: Results from a large psychiatric cohort study. Mol. Psychiatry 2014, 19, 895–901.
    • (2014) Mol. Psychiatry , vol.19 , pp. 895-901
    • Verhoeven, J.E.1    Revesz, D.2    Epel, E.S.3    Lin, J.4    Wolkowitz, O.M.5    Penninx, B.W.6
  • 156
    • 84951776090 scopus 로고    scopus 로고
    • Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review
    • Deng, W.; Cheung, S.T.; Tsao, S.W.; Wang, X.M.; Tiwari, A.F. Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review. Psychoneuroendocrinology 2016, 64, 150–163.
    • (2016) Psychoneuroendocrinology , vol.64 , pp. 150-163
    • Deng, W.1    Cheung, S.T.2    Tsao, S.W.3    Wang, X.M.4    Tiwari, A.F.5
  • 157
    • 79952964129 scopus 로고    scopus 로고
    • Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress–preliminary findings
    • Wolkowitz, O.M.; Mellon, S.H.; Epel, E.S.; Lin, J.; Dhabhar, F.S.; Su, Y.; Reus, V.I.; Rosser, R.; Burke, H.M.; Kupferman, E., et al. Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress–preliminary findings. PLoS ONE 2011, 6, e17837.
    • (2011) Plos ONE , vol.6
    • Wolkowitz, O.M.1    Mellon, S.H.2    Epel, E.S.3    Lin, J.4    Dhabhar, F.S.5    Su, Y.6    Reus, V.I.7    Rosser, R.8    Burke, H.M.9    Kupferman, E.10
  • 158
    • 78751630035 scopus 로고    scopus 로고
    • Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation
    • Kiecolt-Glaser, J.K.; Gouin, J.P.; Weng, N.P.; Malarkey, W.B.; Beversdorf, D.Q.; Glaser, R. Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom. Med. 2011, 73, 16–22.
    • (2011) Psychosom. Med. , vol.73 , pp. 16-22
    • Kiecolt-Glaser, J.K.1    Gouin, J.P.2    Weng, N.P.3    Malarkey, W.B.4    Beversdorf, D.Q.5
  • 160
    • 71549154065 scopus 로고    scopus 로고
    • Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer’s disease
    • Lukens, J.N.; Van Deerlin, V.; Clark, C.M.; Xie, S.X.; Johnson, F.B. Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer’s disease. Alzheimers Dement. 2009, 5, 463–469.
    • (2009) Alzheimers Dement , vol.5 , pp. 463-469
    • Lukens, J.N.1    Van Deerlin, V.2    Clark, C.M.3    Xie, S.X.4    Johnson, F.B.5
  • 161
    • 84921911209 scopus 로고    scopus 로고
    • The role of telomerase protein TERT in Alzheimer’s disease and in tau-related pathology in vitro
    • Spilsbury, A.; Miwa, S.; Attems, J.; Saretzki, G. The role of telomerase protein TERT in Alzheimer’s disease and in tau-related pathology in vitro. J. Neurosci. 2015, 35, 1659–1674.
    • (2015) J. Neurosci , vol.35 , pp. 1659-1674
    • Spilsbury, A.1    Miwa, S.2    Attems, J.3    Saretzki, G.4
  • 162
    • 84963730243 scopus 로고    scopus 로고
    • Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system. Ageing Res
    • Gonzalez-Giraldo, Y.; Forero, D.A.; Echeverria, V.; Gonzalez, J.; Avila-Rodriguez, M.; Garcia-Segura, L.M.; Barreto, G.E. Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system. Ageing Res. Rev. 2016, 28, 37–45.
    • (2016) Rev , vol.28 , pp. 37-45
    • Gonzalez-Giraldo, Y.1    Forero, D.A.2    Echeverria, V.3    Gonzalez, J.4    Avila-Rodriguez, M.5    Garcia-Segura, L.M.6    Barreto, G.E.7
  • 164
    • 84899960174 scopus 로고    scopus 로고
    • Telomere shortening in neurological disorders: An abundance of unanswered questions
    • Eitan, E.; Hutchison, E.R.; Mattson, M.P. Telomere shortening in neurological disorders: An abundance of unanswered questions. Trends Neurosci. 2014, 37, 256–263.
    • (2014) Trends Neurosci , vol.37 , pp. 256-263
    • Eitan, E.1    Hutchison, E.R.2    Mattson, M.P.3
  • 166
  • 168
    • 34147095386 scopus 로고    scopus 로고
    • Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4 (+) T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1)
    • Franzese, O.; Adamo, R.; Pollicita, M.; Comandini, A.; Laudisi, A.; Perno, C.F.; Aquaro, S.; Bonmassar, E. Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4 (+) T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1). J. Med. Virol. 2007, 79, 639–646.
    • (2007) J. Med. Virol. , vol.79 , pp. 639-646
    • Franzese, O.1    Adamo, R.2    Pollicita, M.3    Comandini, A.4    Laudisi, A.5    Perno, C.F.6    Aquaro, S.7    Bonmassar, E.8
  • 169
    • 84878085003 scopus 로고    scopus 로고
    • Accelerated aging in HIV/AIDS: Novel biomarkers of senescent human CD8+ T cells
    • Chou, J.P.; Ramirez, C.M.; Wu, J.E.; Effros, R.B. Accelerated aging in HIV/AIDS: Novel biomarkers of senescent human CD8+ T cells. PLoS ONE 2013, 8, e64702.
    • (2013) Plos ONE , vol.8
    • Chou, J.P.1    Ramirez, C.M.2    Wu, J.E.3    Effros, R.B.4
  • 172
    • 84893255433 scopus 로고    scopus 로고
    • Aging and HIV/AIDS: Pathogenetic role of therapeutic side effects
    • Torres, R.A.; Lewis, W. Aging and HIV/AIDS: Pathogenetic role of therapeutic side effects. Lab. Investig. 2014, 94, 120–128.
    • (2014) Lab. Investig. , vol.94 , pp. 120-128
    • Torres, R.A.1    Lewis, W.2
  • 174
    • 55749102699 scopus 로고    scopus 로고
    • Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
    • Lichterfeld, M.; Mou, D.; Cung, T.D.; Williams, K.L.; Waring, M.T.; Huang, J.; Pereyra, F.; Trocha, A.; Freeman, G.J.; Rosenberg, E.S., et al. Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood 2008, 112, 3679–3687.
    • (2008) Blood , vol.112 , pp. 3679-3687
    • Lichterfeld, M.1    Mou, D.2    Cung, T.D.3    Williams, K.L.4    Waring, M.T.5    Huang, J.6    Pereyra, F.7    Trocha, A.8    Freeman, G.J.9    Rosenberg, E.S.10
  • 175
    • 72949092894 scopus 로고    scopus 로고
    • Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
    • Reynoso, R.; Laufer, N.; Bolcic, F.; Quarleri, J. Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients. Virus Res. 2010, 147, 284–287.
    • (2010) Virus Res , vol.147 , pp. 284-287
    • Reynoso, R.1    Laufer, N.2    Bolcic, F.3    Quarleri, J.4
  • 176
    • 84880041210 scopus 로고    scopus 로고
    • Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment
    • Bollmann, F.M. Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment. Med. Hypotheses 2013, 81, 285–287.
    • (2013) Med. Hypotheses , vol.81 , pp. 285-287
    • Bollmann, F.M.1
  • 177
    • 84874746841 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos (t) ide reverse transcriptase inhibitors: A potential factor contributing to HIV-associated accelerated aging
    • Leeansyah, E.; Cameron, P.U.; Solomon, A.; Tennakoon, S.; Velayudham, P.; Gouillou, M.; Spelman, T.; Hearps, A.; Fairley, C.; Smit de, V., et al. Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos (t) ide reverse transcriptase inhibitors: A potential factor contributing to HIV-associated accelerated aging. J. Infect. Dis. 2013, 207, 1157–1165.
    • (2013) J. Infect. Dis. , vol.207 , pp. 1157-1165
    • Leeansyah, E.1    Cameron, P.U.2    Solomon, A.3    Tennakoon, S.4    Velayudham, P.5    Gouillou, M.6    Spelman, T.7    Hearps, A.8    Fairley, C.9    Smit De, V.10
  • 178
    • 0034600739 scopus 로고    scopus 로고
    • Telomerase activity of peripheral blood lymphocytes in patients with chronic hepatitis B
    • Fan, X.G.; Huang, Y.; Tang, F.Q.; Yi, H. Telomerase activity of peripheral blood lymphocytes in patients with chronic hepatitis B. Immunol. Lett. 2000, 73, 7–11.
    • (2000) Immunol. Lett. , vol.73 , pp. 7-11
    • Fan, X.G.1    Huang, Y.2    Tang, F.Q.3    Yi, H.4
  • 181
    • 84870824631 scopus 로고    scopus 로고
    • Role for telomerase in Listeria monocytogenes infection
    • Samba-Louaka, A.; Stavru, F.; Cossart, P. Role for telomerase in Listeria monocytogenes infection. Infect. Immun. 2012, 80, 4257–4263.
    • (2012) Infect. Immun. , vol.80 , pp. 4257-4263
    • Samba-Louaka, A.1    Stavru, F.2    Cossart, P.3
  • 182
    • 38449104105 scopus 로고    scopus 로고
    • Regulation of telomerase and telomeres: Human tumor viruses take control
    • Bellon, M.; Nicot, C. Regulation of telomerase and telomeres: Human tumor viruses take control. J. Natl. Cancer Inst. 2008, 100, 98–108.
    • (2008) J. Natl. Cancer Inst. , vol.100 , pp. 98-108
    • Bellon, M.1    Nicot, C.2
  • 193
    • 84874114755 scopus 로고    scopus 로고
    • Telomere length and its relationship with chronic diseases—New perspectives for periodontal research
    • Steffens, J.P.; Masi, S.; D’Aiuto, F.; Spolidorio, L.C. Telomere length and its relationship with chronic diseases—New perspectives for periodontal research. Arch. Oral. Biol. 2013, 58, 111–117.
    • (2013) Arch. Oral. Biol. , vol.58 , pp. 111-117
    • Steffens, J.P.1    Masi, S.2    D’Aiuto, F.3    Spolidorio, L.C.4
  • 195
    • 0037928721 scopus 로고    scopus 로고
    • Telomeres and telomerase in aging, regeneration and cancer
    • Djojosubroto, M.W.; Choi, Y.S.; Lee, H.W.; Rudolph, K.L. Telomeres and telomerase in aging, regeneration and cancer. Mol. Cells 2003, 15, 164–175.
    • (2003) Mol. Cells , vol.15 , pp. 164-175
    • Djojosubroto, M.W.1    Choi, Y.S.2    Lee, H.W.3    Rudolph, K.L.4
  • 197
    • 11844258767 scopus 로고    scopus 로고
    • Lipid oxidative stress and the anti-inflammatory properties of statins and ACE inhibitors
    • Cattaneo, D.; Remuzzi, G. Lipid oxidative stress and the anti-inflammatory properties of statins and ACE inhibitors. J. Ren. Nutr. 2005, 15, 71–76.
    • (2005) J. Ren. Nutr , vol.15 , pp. 71-76
    • Cattaneo, D.1    Remuzzi, G.2
  • 198
    • 33645299329 scopus 로고    scopus 로고
    • Anti-inflammatory drugs and their effects on type 2 diabetes
    • Deans, K.A.; Sattar, N. “Anti-inflammatory” drugs and their effects on type 2 diabetes. Diabetes Technol. Ther. 2006, 8, 18–27.
    • (2006) Diabetes Technol. Ther. , vol.8 , pp. 18-27
    • Deans, K.A.1    Sattar, N.2
  • 200
    • 77249156241 scopus 로고    scopus 로고
    • Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk
    • Donnini, S.; Terzuoli, E.; Ziche, M.; Morbidelli, L. Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk. J. Pharmacol. Exp. Ther. 2010, 332, 776–784.
    • (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 776-784
    • Donnini, S.1    Terzuoli, E.2    Ziche, M.3    Morbidelli, L.4
  • 201
    • 77954192215 scopus 로고    scopus 로고
    • Effect of exercise training on chronic inflammation
    • Beavers, K.M.; Brinkley, T.E.; Nicklas, B.J. Effect of exercise training on chronic inflammation. Clin. Chim. Acta 2010, 411, 785–793.
    • (2010) Clin. Chim. Acta , vol.411 , pp. 785-793
    • Beavers, K.M.1    Brinkley, T.E.2    Nicklas, B.J.3
  • 202
    • 84899574075 scopus 로고    scopus 로고
    • Innate and adaptive inflammation as a therapeutic target in vascular disease: The emerging role of statins
    • Tousoulis, D.; Psarros, C.; Demosthenous, M.; Patel, R.; Antoniades, C.; Stefanadis, C. Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins. J. Am. Coll. Cardiol. 2014, 63, 2491–2502.
    • (2014) J. Am. Coll. Cardiol , vol.63 , pp. 2491-2502
    • Tousoulis, D.1    Psarros, C.2    Demosthenous, M.3    Patel, R.4    Antoniades, C.5    Stefanadis, C.6
  • 203
    • 84952639861 scopus 로고    scopus 로고
    • Therapeutics targeting persistent inflammation in chronic kidney disease
    • Machowska, A.; Carrero, J.J.; Lindholm, B.; Stenvinkel, P. Therapeutics targeting persistent inflammation in chronic kidney disease. Transl. Res. 2016, 167, 204–213.
    • (2016) Transl. Res. , vol.167 , pp. 204-213
    • Machowska, A.1    Carrero, J.J.2    Lindholm, B.3    Stenvinkel, P.4
  • 204
    • 79955826399 scopus 로고    scopus 로고
    • Sound mind and body: Depression, disease, and accelerated aging
    • Wolkowitz, O.M.; Reus, V.I.; Mellon, S.H. Of sound mind and body: Depression, disease, and accelerated aging. Dialogues Clin. Neurosci. 2011, 13, 25–39.
    • (2011) Dialogues Clin. Neurosci. , vol.13 , pp. 25-39
    • Wolkowitz, O.M.1    Reus, V.I.2
  • 205
    • 84957078654 scopus 로고    scopus 로고
    • Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
    • Sallam, N.; Laher, I. Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases. Oxid. Med. Cell Longev. 2016.
    • (2016) Oxid. Med. Cell Longev.
    • Sallam, N.1    Laher, I.2
  • 206
    • 55149091968 scopus 로고    scopus 로고
    • Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids
    • Das, U.N. Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids. Health Dis. 2008.
    • (2008) Health Dis
    • Das, U.N.1
  • 207
    • 84941004394 scopus 로고    scopus 로고
    • Stress, meditation, and Alzheimer’s disease prevention: Where the evidence stands
    • Khalsa, D.S. Stress, meditation, and Alzheimer’s disease prevention: Where the evidence stands. J. Alzheimers Dis. 2015, 48, 1–12.
    • (2015) J. Alzheimers Dis. , vol.48 , pp. 1-12
    • Khalsa, D.S.1
  • 208
    • 84874547315 scopus 로고    scopus 로고
    • Older adults with higher income or marriage have longer telomeres
    • Yen, Y.C.; Lung, F.W. Older adults with higher income or marriage have longer telomeres. Age Ageing 2013, 42, 234–239.
    • (2013) Age Ageing , vol.42 , pp. 234-239
    • Yen, Y.C.1    Lung, F.W.2
  • 209
    • 84855183935 scopus 로고    scopus 로고
    • Pharmaceutical regulation of telomerase and its clinical potential
    • Sprouse, A.A.; Steding, C.E.; Herbert, B.S. Pharmaceutical regulation of telomerase and its clinical potential. J. Cell Mol. Med. 2012, 16, 1–7.
    • (2012) J. Cell Mol. Med. , vol.16 , pp. 1-7
    • Sprouse, A.A.1    Steding, C.E.2    Herbert, B.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.