Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening

Molecular and Cellular Biochemistry

Volumn 400, Issue 1-2, 2015, Pages 183-187

  Guan, Jing Zhi ^a   Guan, Wei Ping ^b   Maeda, Toyoki ^c   Guoqing, Xie ^a   GuangZhi, Wan ^a   Makino, Naoki ^c  

^a 309TH HOSPITAL OF PLA   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

Author keywords

Multiple sclerosis; Oxidative stress; Telomere

Indexed keywords

8-EPI-PROSTAGLANDIN F2ALPHA; PROSTAGLANDIN F2 ALPHA;

ADULT; ANALOGS AND DERIVATIVES; BLOOD; FEMALE; GENETICS; HUMAN; LIPID PEROXIDATION; MALE; MIDDLE AGED; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; OXIDATIVE STRESS; PATHOLOGY; TELOMERE SHORTENING; URINE;

ADULT; DINOPROST; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPID PEROXIDATION; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; OXIDATIVE STRESS; TELOMERE SHORTENING;

EID: 84922104338     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2274-1     Document Type: Article

References (26)

1. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG (2000) Multiple sclerosis. N Engl J Med 343:938–952
2. Zakian VA (1995) Telomeres: beginning to understand the end. Science 270:1601–1607
3. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ (2003) White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 23:842–846
4. Friedrich U, Gries E, Schwab M, Fritz P, Thon K, Klotz U (2000) Telomere length in different tissues of elderly patients. Mech Ageing 119:89–99
5. Gilgun-Sherki Y, Melamed E, Offen D (2004) The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J Neurol 251:261–268
6. LeVine SM (1992) The role of reactive oxygen species in the pathogenesis of multiple sclerosis. Med Hypotheses 39:271–274
7. LeVine SM, Wetzel DL (1998) Chemical analysis of multiple sclerosis lesions by FT-IR microspectroscopy. Free Radic Biol Med 25:33–41
8. Naidoo R, Knapp ML (1992) Studies of lipid peroxidation products in cerebrospinal fluid and serum in multiple sclerosis and other conditions. Clin Chem 38:2449–2454
9. Greco A, Minghetti L, Levi G (2000) Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases. Neurochem Res 25:1357–1364
10. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121–127
11. Cherif H, Tarry JL, Ozanne SE, Hales CN (2003) Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res 31:1576–1583
12. de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE (1990) Structure and variability of human chromosome ends. Mol Cell Biol 10:518–527
13. Esterbauer H, Striegl G, Puhl H, Rotheneder M (1989) Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 6:67–75
14. Gilgun-Sherki Y, Melamed E, Offen D (2001) Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 40:959–975
15. Rokach J, Khanapure SP, Hwang S-W, Adiyaman M, Lawson JA, FitzGerald GA (1997) The isoprostanes: a perspective. Prostaglandins 54:823–851
16. Greco A, Minghetti L, Sette G, Fieschi C, Levi G (1999) Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis. Neurology 53:1876–1879
17. Besler HT, Comoglu S (2003) Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci 6:189–196
18. Ferretti G, Bacchetti T, Principi F, Di Ludovico F, Viti B, Angeleri VA, Danni M, Provinciali L (2005) Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity. Mult Scler 11:677–682
19. Bassett CN, Montine TJ (2003) Lipoproteins and lipid peroxidation in Alzheimer’s disease. J Nutr Health Aging 7:24–29
20. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114–10118
21. Dandona P, Dhindsa S, Aljada A, Chaudhuri A (2004) Classical anti-oxidants (Scavengers) versus biological anti-oxidants (suppressors of ROS generation): a novel way to explain the anti-oxidant paradox. Metab Syndr Relat Disord 2:155–159
22. Aviv A (2004) Telomeres and human aging: facts and fibs. Sci Aging Knowledge Environ 51:pe43
23. Vladimirova O, Lu FM, Shawver L, Kalman B (1999) The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls. Inflamm Res 48:412–416
24. von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27:339–344
25. Hug A, Korporal M, Schroder I, Haas J, Glatz K, Storch-Hagenlocher B, Wildemann B (2003) Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J Immunol 171:432–437
26. Newcombe J, Li H, Cuzner ML (1994) Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis. Neuropathol Appl Neurobiol 20:152–162