A new pleiotropic effect of statins in elderly: Modulation of telomerase activity

FASEB Journal

Volumn 27, Issue 9, 2013, Pages 3879-3885

  Boccardi, Virginia ^a   Barbieri, Michelangela ^a   Rizzo, Maria Rosaria ^a   Marfella, Raffaele ^a   Esposito, Antonietta ^a   Marano, Luigi ^a   Paolisso, Giuseppe ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Aging; Cellular senescence; Health span

Indexed keywords

ATORVASTATIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; ROSUVASTATIN; SIMVASTATIN; TELOMERASE;

ADULT; AGED; AGING; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; DYSLIPIDEMIA; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLEIOTROPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SMOKING HABIT; TELOMERE HOMEOSTASIS;

AGING; CELLULAR SENESCENCE; HEALTH SPAN;

ADULT; AGED; AGED, 80 AND OVER; CELL AGING; CELLS, CULTURED; CROSS-SECTIONAL STUDIES; ENZYME ACTIVATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TELOMERASE; TELOMERE;

EID: 84883376547     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-232066     Document Type: Article

References (28)

1. Ludman, A., Venugopal, V., Yellon, D. M., and Hausenloy, D. J. (2009) Statins and cardioprotection - more than just lipid lowering? Pharmacol. Ther. 122, 30-43
2. Spindler, S. R., Li, R., Dhahbi, J. M., Yamakawa, A., Mote, P., Bodmer, R., Ocorr, K., Williams, R. T., Wang, Y., and Ablao, K. P. (2012) Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. PLoS One 7, e39581
3. Taylor, F., Ward, K., Moore, T. H., Burke, M., Davey, S. G., Casas, J. P., and Ebrahim, S. (2011) Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst. Rev. 19, CD004816
4. Brouilette, S. W., Moore, J. S., McMahon, A. D., Thompson, J. R., Ford, I., Shepherd, J., Packard, C. J., and Samani, N. J.; West of Scotland Coronary Prevention Study Group. (2007) Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case- control study. Lancet 369, 107-114
5. Spyridopoulos, I., Haendeler, J., Urbich, C., Brummendorf, T. H., Oh, H., Schneider, M. D., Zeiher, A. M., and Dimmeler, S. (2004) Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells. Circulation 110, 3136-3142
6. Silvestre, D. C., and Londoño-Vallejo, A. (2010) Telomere dynamics in mammals. Genome Dyn. 7, 29-45
7. Blackburn, E. H. (1991) Structure and function of telomeres. Nature 350, 569-573
8. Blackburn, E. H. (2005) Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett. 579, 859-862
9. Herbig, U., Ferreira, M., Carey, D., and Sedivy, J. M. (2006) Cellular senescence in aging primates. Science 311, 1257
10. Hewitt, G., Jurk, D., Marques, F. D., Correia-Melo, C., Hardy, T., Gackowska, A., Anderson, R., Taschuk, M., Mann, J., and Passos, J. F. (2012) Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat. Commun. 3, 708
11. García-Cao, I., García-Cao, M., Tomas-Loba, A., Martín-Caballero, J., Flores, J. M., Klatt, P., Blasco, M. A., and Serrano, M. (2006) Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep. 7, 546-552
12. Mitchell, J. R., Wood, E., and Collins, K. (1999) A telomerase component is defective in the human disease dyskeratosis congenital. Nature 402, 551-555
13. Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., and Blasco, M. A. (2012) Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol. Med. 4, 691-704
14. Bernardes de Jesus, B., Schneeberger, K., Vera, E., Tejera, A., Harley, C. B., and Blasco, M. A. (2011) The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 10, 604-621
15. Boccardi, V., Herbig, U. (2012) Telomerase gene therapy: a novel approach to combat aging. EMBO Mol. Med. 4, 685-687
16. Herrera, E., Samper, E., Martín-Caballero, J., Flores. J. M., Lee, H. W., and Blasco, M. A. (1999) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960
17. Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., and Dokal, I. (2001) The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenital. Nature 413, 432-435
18. Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., and Young, N. S. (2005) Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N. Engl. J. Med. 352, 1413-1424
19. Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., Dolbier, C., Mendes, W. B., and Blackburn, E. H. (2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31(3), 277-287
20. Assmus, B., Urbich, C., Aicher, A., Hofmann, W. K., Haendeler, J., Rössig, L., Spyridopoulos, I., Zeiher, A. M., and Dimmeler, S. (2003) HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ. Res. 92, 1049-1055
21. Satoh, M., Minami, Y., Takahashi, Y., Tabuchi, T., Itoh, T., and Nakamura, M. (2009) Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease. Clin. Sci. (Lond.) 116, 827-835
22. Saliques, S., Teyssier, J. R., Vergely, C., Lorgis, L., Lorin, J., Farnier, M., Donzel, A., Sicard, P., Berchoud, J., Lagrost, A. C., Touzery, C., Ragot, S., Cottin, Y., Rochette, L., and Zeller, M. (2012) Circulating leukocyte telomere length and oxidative stress: a new target for statin therapy. Atherosclerosis 219, 753-760
23. Grundy, S. M., Cleeman, J. I., Merz, C. N., Brewer, H. B., Jr., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., Jr., and Stone, N. J. (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110, 227-239
24. Cawthon, R. M. (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res. 30, e47
25. Serrano, A. L., and Andrés, V. (2004) Telomeres and cardiovascular disease: does size matter? Circ. Res. 94, 575-584
26. Zhu, J., Wang, H., Bishop, J. M., and Blackburn, E. H. (1999) Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. U. S. A. 96, 3723-3728
27. Müezzinler, A., Zaineddin, A. K., and Brenner, H. (2013) A systematic review of leukocyte telomere length and age in adults. Ageing Res. Rev. 12, 509-519
28. Daubenmier, J., Lin, J., Blackburn, E., Hecht, F. M., Kristeller, J., Maninger, N., Kuwata, M., Bacchetti, P., Havel, P. J., and Epel, E. (2012) Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology 37, 917-928